Lamp2
Gene Detail

Symbol Name ID

Lamp2 lysosomal-associated membrane protein 2 MGI:96748

Synonyms

CD107b, Lamp-2, Lamp-2a, Lamp-2b, Lamp-2c, Mac3

Feature Type

protein coding gene

Genetic Map

Chromosome X

22.67 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

ChrX:38401357-38456454 bp, - strand From VEGA annotation of GRCm38   55098 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7809  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: lysosome-associated membrane protein
Gene Tree: Lamp2

Human homologs

Human Homolog		LAMP2, lysosomal-associated membrane protein 2
NCBI Gene ID		3920
neXtProt AC		NX_P13473
Human Synonyms		CD107b, LAMP-2, LAMPB, LGP110
Human Chr (Location)		Xq24; chrX:119560003-119603204 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human LAMP2

Alleles and phenotypes

All alleles(18) : Targeted(5) Gene trapped(13)
 

The majority of hemizygous or homozygous mutant mice die prematurely displaying cardiomyopathy and accumulation of autophagic vacuoles in several tissues including liver, pancreas, spleen, kidney and skeletal and cardiac muscle.

 
Human Diseases Modeled Using Mouse Lamp2 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Component

endosome, integral to membrane, ...

External Resources: FuncBase

Expression

Literature Summary: (19 records)
Data Summary: Results (33)    Tissues (31)    Images (12)
Theiler Stages: 19, 23, 28

Assay Type	Results
Immunohistochemistry	4
RNA in situ	29

cDNA source data(380)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(384) Genomic(1) cDNA(382) Primer pair(1)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000017230 (Evidence)
Ensembl Gene Model	ENSMUSG00000016534 (Evidence)
Entrez Gene	16784 (Evidence)
UniGene	486
DFCI	TC1573110, TC1576539, TC1771164
DoTS	DT.101141171, DT.101141189, DT.101374521, DT.494232, DT.91300066, DT.94177299, DT.97376290
NIA Mouse Gene Index	U039326
Consensus CDS Project	CCDS30092.1, CCDS30093.1
International Mouse Knockout Project Status	Lamp2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000017230	VEGA Gene Model | MGI Sequence Detail	55098	C57BL/6J
transcript	OTTMUST00000041814	VEGA | MGI Sequence Detail	2184	Not Applicable
polypeptide	OTTMUSP00000018802	VEGA | MGI Sequence Detail	416	Not Applicable

All sequences(63) RefSeq(4) UniProt(5)

Polymorphisms

PCR(1) : SNPs(74 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002000	Lysosome-associated membrane glycoprotein
InterPro	IPR018134	Lysosome-associated membrane glycoprotein, conserved site
Protein Ontology	PR:000002061	lysosome-associated membrane glycoprotein 2

References

(Earliest) J:10386 Cha Y, et al., The cDNA sequence of mouse LAMP-2. Evidence for two classes of lysosomal membrane glycoproteins. J Biol Chem. 1990 Mar 25;265(9):5008-13
(Latest) J:193551 Eriksson I, et al., The histone deacetylase inhibitor trichostatin A reduces lysosomal pH and enhances cisplatin-induced apoptosis. Exp Cell Res. 2013 Jan 1;319(1):12-20
All references(86)

Other accession IDs

MGD-MRK-11741, MGD-MRK-11745