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Lamp2 Gene Detail
Summary
  • Symbol
    Lamp2
  • Name
    lysosomal-associated membrane protein 2
  • Synonyms
    CD107b, Lamp-2, Lamp-2a, Lamp-2b, Lamp-2c, Mac3
  • Feature Type
    protein coding gene
  • IDs
    MGI:96748
    NCBI Gene: 16784
  • Gene Overview
    MyGene.info: LAMP2
Location & Maps
more
  • Sequence Map
    ChrX:38401357-38456454 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      55098 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome X, 22.67 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    LAMP2, lysosomal associated membrane protein 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    LAMP2, lysosomal associated membrane protein 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD107b, LAMP-2, LAMPB, LGP110
  • Links
    NCBI Gene ID: 3920
    neXtProt AC: NX_P13473

  • Chr Location
    Xq24; chrX:120426148-120469349 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Lamp2 mouse models; 1 with human LAMP2 associations

Human Disease Mouse Models
       Danon Disease   OMIM: 300257 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    40 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    19
  • Gene trapped
    13
  • Targeted
    6
  • Incidental Mutations
    APF , CvDC
The majority of hemizygous or homozygous mutant mice die prematurely displaying cardiomyopathy and accumulation of autophagic vacuoles in several tissues including liver, pancreas, spleen, kidney and skeletal and cardiac muscle.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017230 VEGA Gene Model | MGI Sequence Detail 55098 C57BL/6J ±  kb
transcript OTTMUST00000041814 VEGA | MGI Sequence Detail 2184 Not Applicable  
polypeptide OTTMUSP00000018802 VEGA | MGI Sequence Detail 416 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    100 from dbSNP Build 142
  • PCR
Protein
Information
less
  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000002061 lysosome-associated membrane glycoprotein 2
  • InterPro Domains
    IPR002000 Lysosome-associated membrane glycoprotein
    IPR018134 Lysosome-associated membrane glycoprotein, conserved site
Molecular
Reagents
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  • All nucleic 27
    Genomic 1
    cDNA 25
    Primer pair 1

    Microarray probesets 7
Other
Accession IDs
less
MGD-MRK-11741, MGD-MRK-11745
References
more
  • Summaries
    All 102
    Developmental Gene Expression 29
    Diseases 1
    Gene Ontology 21
    Phenotypes 18
  • Earliest
    J:10386 Cha Y, et al., The cDNA sequence of mouse LAMP-2. Evidence for two classes of lysosomal membrane glycoproteins. J Biol Chem. 1990 Mar 25;265(9):5008-13
  • Latest
    J:226026 Deuve JL, et al., Antagonist Xist and Tsix co-transcription during mouse oogenesis and maternal Xist expression during pre-implantation development calls into question the nature of the maternal imprint on the X chromosome. Epigenetics. 2015 Oct 3;10(10):931-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory