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Lamp2
Gene Detail
Symbol

Name
ID
Lamp2
lysosomal-associated membrane protein 2
MGI:96748
Synonyms
CD107b, Lamp-2, Lamp-2a, Lamp-2b, Lamp-2c, Mac3
Feature Type
protein coding gene
Genetic Map
Chromosome X
22.67 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
ChrX:38401357-38456454 bp, - strand
From VEGA annotation of GRCm38

  55098 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7809  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: LAMP2
Protein SuperFamily: lysosome-associated membrane protein
Gene Tree: Lamp2

Human
homologs
LAMP2, lysosomal-associated membrane protein 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3920
neXtProt AC: NX_P13473

Human Synonyms: CD107b, LAMP-2, LAMPB, LGP110

Human Chr (Location): Xq24; chrX:120426148-120469349 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human LAMP2

Mutations,
alleles, and
phenotypes
All mutations/alleles(19) : Gene trapped(13) Targeted(6)
Incidental mutations (data from APF , CvDC )
 
The majority of hemizygous or homozygous mutant mice die prematurely displaying cardiomyopathy and accumulation of autophagic vacuoles in several tissues including liver, pancreas, spleen, kidney and skeletal and cardiac muscle.
 
Human Diseases Modeled in Mice Using Lamp2 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Lamp2 interacts with 366 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process protein stabilization
Component endosome, extracellular exosome, ...
Function enzyme binding, protein domain specific binding
External Resources: FuncBase
Expression
Literature Summary: (25 records)
Data Summary: Results (33)    Tissues (31)    Images (12)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 29
cDNA source data(23)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase lamp2 ; ZFIN lamp2    NEW 
Molecular
reagents
All nucleic(27) Genomic(1) cDNA(25) Primer pair(1)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000017230 (Evidence)
Ensembl Gene Model ENSMUSG00000016534 (Evidence)
Entrez Gene 16784 (Evidence)
DFCI TC1573110, TC1576539, TC1589157, TC1771164
DoTS DT.101141171, DT.101141189, DT.101256604, DT.101374521, DT.494232, DT.91300066, DT.94177299, DT.97376290, DT.99864374
NIA Mouse Gene Index U039326
Consensus CDS Project CCDS30092.1, CCDS30093.1, CCDS72369.1
International Mouse Phenotyping Consortium Status Lamp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017230 VEGA Gene Model | MGI Sequence Detail 55098 C57BL/6J ±  kb
transcript OTTMUST00000041814 VEGA | MGI Sequence Detail 2184 Not Applicable 
polypeptide OTTMUSP00000018802 VEGA | MGI Sequence Detail 416 Not Applicable 

For the selected sequences
All sequences(73) RefSeq(6) UniProt(6)
Polymorphisms
PCR(1) : SNPs within 2kb(105 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002000 Lysosome-associated membrane glycoprotein
InterPro IPR018134 Lysosome-associated membrane glycoprotein, conserved site
Protein Ontology PR:000002061 lysosome-associated membrane glycoprotein 2
References
(Earliest) J:10386 Cha Y, et al., The cDNA sequence of mouse LAMP-2. Evidence for two classes of lysosomal membrane glycoproteins. J Biol Chem. 1990 Mar 25;265(9):5008-13
(Latest) J:216097 Reibring CG, et al., Expression patterns and subcellular localization of carbonic anhydrases are developmentally regulated during tooth formation. PLoS One. 2014;9(5):e96007
All references(95)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-11741, MGD-MRK-11745

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory