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Lamp2
Gene Detail
 Symbol
Name
ID
Lamp2
lysosomal-associated membrane protein 2
MGI:96748
Synonyms CD107b, Lamp-2, Lamp-2a, Lamp-2b, Lamp-2c, Mac3
Feature Type protein coding gene
Genetic Map
Chromosome X
22.67 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
ChrX:38401357-38456454 bp, - strand
From VEGA annotation of GRCm38

  55098 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7809  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: lysosome-associated membrane protein
Gene Tree: Lamp2

Human
homologs
Human Homolog LAMP2, lysosomal-associated membrane protein 2
NCBI Gene ID 3920
neXtProt AC  NX_P13473
Human Synonyms  CD107b, LAMP-2, LAMPB, LGP110
Human Chr (Location)  Xq24; chrX:120426148-120469349 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human LAMP2
Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(13) Targeted(5)
Incidental mutations (data from APF )
 
The majority of hemizygous or homozygous mutant mice die prematurely displaying cardiomyopathy and accumulation of autophagic vacuoles in several tissues including liver, pancreas, spleen, kidney and skeletal and cardiac muscle.
 
Human Diseases Modeled Using Mouse Lamp2 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Lamp2 interacts with 367 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process protein stabilization
Component endosome, extracellular vesicular exosome, ...
Function enzyme binding, protein domain specific binding
External Resources: FuncBase
Expression
Literature Summary: (21 records)
Data Summary: Results (33)    Tissues (31)    Images (12)
Theiler Stages: 19, 23, 28
Assay TypeResults
Immunohistochemistry 4
RNA in situ 29
cDNA source data(23)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(27) Genomic(1) cDNA(25) Primer pair(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000017230 (Evidence)
Ensembl Gene ModelENSMUSG00000016534 (Evidence)
Entrez Gene16784 (Evidence)
DFCITC1573110, TC1576539, TC1589157, TC1771164
DoTSDT.101141171, DT.101141189, DT.101256604, DT.101374521, DT.494232, DT.91300066, DT.94177299, DT.97376290, DT.99864374
NIA Mouse Gene IndexU039326
Consensus CDS ProjectCCDS30092.1, CCDS30093.1, CCDS72369.1
International Mouse Knockout Project StatusLamp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017230 VEGA Gene Model | MGI Sequence Detail 55098 C57BL/6J ±  kb
transcript OTTMUST00000041814 VEGA | MGI Sequence Detail 2184 Not Applicable 
polypeptide OTTMUSP00000018802 VEGA | MGI Sequence Detail 416 Not Applicable 

For the selected sequences
All sequences(72) RefSeq(6) UniProt(5)
Polymorphisms PCR(1) : SNPs within 2kb(105 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002000 Lysosome-associated membrane glycoprotein
InterPro IPR018134 Lysosome-associated membrane glycoprotein, conserved site
Protein Ontology PR:000002061 lysosome-associated membrane glycoprotein 2
References (Earliest) J:10386 Cha Y, et al., The cDNA sequence of mouse LAMP-2. Evidence for two classes of lysosomal membrane glycoproteins. J Biol Chem. 1990 Mar 25;265(9):5008-13
(Latest) J:202536 Villalpando Rodriguez GE, et al., Calpain 1 induce lysosomal permeabilization by cleavage of lysosomal associated membrane protein 2. Biochim Biophys Acta. 2013 Oct;1833(10):2244-53
All references(92)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-11741, MGD-MRK-11745

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory