Symbol
Name
ID

Lamp2
lysosomal-associated membrane protein 2
MGI:96748

Phenotype annotations related to homeostasis/metabolism

Darker colors indicate more annotations

Human Phenotypes	Elevated circulating creatine kinase concentration	Exercise intolerance
Disease(s) Associated with LAMP2	Elevated circulating creatine kinase concentration	Exercise intolerance
Danon disease

Mouse Phenotypes

increased cardiac muscle glycogen level

abnormal autophagy

abnormal mitophagy

impaired autophagy

abnormal circulating amino acid level

decreased fasting circulating glucose level

increased circulating alanine transaminase level

increased circulating troponin T level

increased energy expenditure

increased carbon dioxide production

increased oxygen consumption

increased respiratory quotient

abnormal glucose homeostasis

improved glucose tolerance

decreased liver glycogen level

decreased hepatic glucose production

abnormal lipid homeostasis

increased liver triglyceride level

abnormal enzyme/coenzyme activity

Availability

Mouse Genotype

Lamp2^tm1Psa/Lamp2^tm1Psa

Lamp2^tm1.2Ces/Y

Lamp2^tm1Amcu/Y
Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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