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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Lamp2
lysosomal-associated membrane protein 2
MGI:96748
63 phenotypes from 3 alleles in 4 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background
Annotated Term Reference
Lamp2tm1.2Ces/Y
involves: 129 * 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * SJL
abnormal autophagy J:328713
abnormal myocardial fiber morphology J:328713
abnormal myocardial fiber physiology J:328713
abnormal sinoatrial node conduction J:328713
atrioventricular block J:328713
normal behavior/neurological phenotype J:328713
cardiac fibrosis J:328713
cardiac hypertrophy J:328713
cardiomyopathy J:328713
decreased birth body size J:328713
decreased cardiac muscle contractility J:328713
dilated heart left ventricle J:328713
heart left ventricle hypertrophy J:328713
increased cardiac muscle glycogen level J:328713
increased circulating troponin T level J:328713
increased heart weight J:328713
irregular heartbeat J:328713
neonatal lethality, incomplete penetrance J:328713
prolonged PR interval J:328713
Lamp2tm1Amcu/Y
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J
abnormal autophagy J:215605
abnormal enzyme/coenzyme activity J:215605
abnormal glucose homeostasis J:215605
abnormal lipid homeostasis J:215605
abnormal liver physiology J:215605
normal cellular phenotype J:215605
decreased body weight J:215605
decreased brown fat cell lipid droplet size J:215605
decreased fasting circulating glucose level J:215605
decreased gonadal fat pad weight J:215605
decreased hepatic glucose production J:215605
decreased liver function J:215605
decreased liver glycogen level J:215605
decreased locomotor activity J:215605
decreased percent body fat/body weight J:215605
decreased white fat cell lipid droplet size J:215605
enhanced behavioral response to xenobiotic J:215605
enlarged liver J:215605
hepatic steatosis J:215605
improved glucose tolerance J:215605
increased carbon dioxide production J:215605
increased cellular glucose import J:215605
increased circulating alanine transaminase level J:215605
increased energy expenditure J:215605
increased hepatocyte apoptosis J:215605
increased liver triglyceride level J:215605
increased liver weight J:215605
increased oxygen consumption J:215605
increased respiratory quotient J:215605
increased susceptibility to weight gain J:215605
pale liver J:215605
weight loss J:215605
Lamp2tm1Psa/Lamp2tm1Psa
either: (involves: 129P2/OlaHsd * 129/Sv * C57BL/6J) or (involves: 129P2/OlaHsd * 129/Sv)
abnormal cell physiology J:64151
abnormal circulating amino acid level J:64151
abnormal thymus morphology J:64151
decreased body weight J:64151
decreased cardiac muscle contractility J:64151
decreased litter size J:64151
increased heart weight J:64151
intermingled spleen red and white pulp J:64151
premature death J:64151
Lamp2tm1Psa/Lamp2tm1Psa
involves: 129P2/OlaHsd
abnormal cardiovascular system physiology J:253728
abnormal cellular respiration J:253728
abnormal mitochondrial morphology J:253728
abnormal mitophagy J:253728
abnormal myocardial fiber physiology J:253728
impaired autophagy J:253728
increased heart left ventricle wall thickness J:253728
increased myocardial fiber size J:253728

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory