Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Kdm6a

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes KDM6A
- Mouse genes Kdm6a
- Rat genes Kdm6a
- Zfish genes kdm6a,kdm6al
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Kdm6a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0031490	chromatin DNA binding	Kdm6a	IDA		Mouse	PMID:23658530
Molecular Function	GO:0071558	histone H3K27me2/H3K27me3 demethylase activity	Kdm6a	IDA		Mouse	PMID:22949634
Molecular Function	GO:0042802	identical protein binding	Kdm6a	IDA		Mouse	PMID:23028370
Molecular Function	GO:1990841	promoter-specific chromatin binding	Kdm6a	IDA		Rat	PMID:31907922\|RGD:151665135
Molecular Function	GO:0005515	protein binding	KDM6A	IPI	UniProtKB:P61964	Human	PMID:17178841
Molecular Function	GO:0005515	protein binding	KDM6A	IPI	UniProtKB:P61964	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	KDM6A	IPI	UniProtKB:P61964	Human	PMID:27705803
Molecular Function	GO:0005515	protein binding	KDM6A	IPI	UniProtKB:O15499	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KDM6A	IPI	UniProtKB:Q6FHY5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KDM6A	IPI	UniProtKB:Q86XN7	Human	PMID:34667079
Molecular Function	GO:0005515	protein binding	Kdm6a	IPI	UniProtKB:Q62383	Mouse	MGI:MGI:5484727\|PMID:23503590
Molecular Function	GO:0005515	protein binding	Kdm6a	IPI	UniProtKB:Q61321	Mouse	MGI:MGI:5508570\|PMID:20300060
Molecular Function	GO:0005515	protein binding	Kdm6a	IPI	UniProtKB:Q3TKT4	Mouse	MGI:MGI:4866963\|PMID:21095589
Molecular Function	GO:0005515	protein binding	Kdm6a	IPI	PR:P79457	Mouse	PMID:23028370
Molecular Function	GO:0005515	protein binding	Kdm6a	IPI	PR:Q8BX09	Mouse	PMID:23028370
Molecular Function	GO:0005515	protein binding	Kdm6a	IPI	PR:Q99L02	Mouse	PMID:22949634
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Kdm6a	IDA		Mouse	PMID:22949634
Cellular Component	GO:0035097	histone methyltransferase complex	KDM6A	IDA		Human	PMID:17500065
Cellular Component	GO:0035097	histone methyltransferase complex	Kdm6a	IDA		Mouse	PMID:23028370
Cellular Component	GO:0044666	MLL3/4 complex	KDM6A	IPI		Human	PMID:23508102
Cellular Component	GO:0044666	MLL3/4 complex	KDM6A	IDA		Human	PMID:17500065
Cellular Component	GO:0005634	nucleus	KDM6A	IDA		Human	PMID:17500065
Cellular Component	GO:0005634	nucleus	Kdm6a	IDA		Mouse	PMID:22949634
Biological Process	GO:0009952	anterior/posterior pattern specification	kdm6al	IMP	ZFIN:ZDB-MRPHLNO-071029-3	Zfish	PMID:17851529
Biological Process	GO:0009952	anterior/posterior pattern specification	kdm6al	IMP	ZFIN:ZDB-MRPHLNO-071029-2	Zfish	PMID:17851529
Biological Process	GO:0007420	brain development	kdm6al	IMP	ZFIN:ZDB-MRPHLNO-071029-3,ZFIN:ZDB-MRPHLNO-150930-8	Zfish	PMID:25972376
Biological Process	GO:0007420	brain development	kdm6a	IMP	ZFIN:ZDB-MRPHLNO-150930-4,ZFIN:ZDB-MRPHLNO-150930-7	Zfish	PMID:25972376
Biological Process	GO:1904385	cellular response to angiotensin	Kdm6a	IEP		Rat	PMID:27722168\|RGD:151665139
Biological Process	GO:1990859	cellular response to endothelin	Kdm6a	IEP		Rat	PMID:27722168\|RGD:151665139
Biological Process	GO:0071456	cellular response to hypoxia	Kdm6a	IEP		Rat	PMID:30887465\|RGD:151665136
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	Kdm6a	IEP		Rat	PMID:31266808\|RGD:151665138
Biological Process	GO:0071305	cellular response to vitamin D	Kdm6a	IDA		Rat	PMID:31907922\|RGD:151665135
Biological Process	GO:0006338	chromatin remodeling	Kdm6a	IMP		Mouse	MGI:MGI:4866963\|PMID:21095589
Biological Process	GO:0072359	circulatory system development	Kdm6a	IMP	MGI:MGI:5516011	Mouse	PMID:23028370
Biological Process	GO:0072359	circulatory system development	Kdm6a	IMP	MGI:MGI:4126347	Mouse	PMID:23028370
Biological Process	GO:0060026	convergent extension	kdm6a	IMP	ZFIN:ZDB-MRPHLNO-141121-14	Zfish	PMID:26280580
Biological Process	GO:0060027	convergent extension involved in gastrulation	kdm6a	IMP	ZFIN:ZDB-MRPHLNO-141121-14	Zfish	PMID:30018450
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	kdm6a	IMP	ZFIN:ZDB-MRPHLNO-141121-14	Zfish	PMID:30018450
Biological Process	GO:0048568	embryonic organ development	Kdm6a	IMP	MGI:MGI:4126347	Mouse	PMID:23028370
Biological Process	GO:0048568	embryonic organ development	Kdm6a	IMP	MGI:MGI:5516011	Mouse	PMID:23028370
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	kdm6a	IMP	ZFIN:ZDB-MRPHLNO-150930-4,ZFIN:ZDB-MRPHLNO-150930-7	Zfish	PMID:25972376
Biological Process	GO:0060324	face development	kdm6a	IMP	ZFIN:ZDB-MRPHLNO-130521-1	Zfish	PMID:23354975
Biological Process	GO:0008354	germ cell migration	kdm6al	IMP	ZFIN:ZDB-MRPHLNO-071029-3	Zfish	PMID:23365460
Biological Process	GO:0008354	germ cell migration	kdm6a	IMP	ZFIN:ZDB-MRPHLNO-130521-1	Zfish	PMID:23365460
Biological Process	GO:0007507	heart development	Kdm6a	IMP	MGI:MGI:5448825	Mouse	PMID:22949634
Biological Process	GO:0007507	heart development	kdm6al	IMP	ZFIN:ZDB-MRPHLNO-071029-3,ZFIN:ZDB-MRPHLNO-150930-8	Zfish	PMID:25972376
Biological Process	GO:0003007	heart morphogenesis	Kdm6a	IMP	MGI:MGI:5516011	Mouse	PMID:23028370
Biological Process	GO:0003007	heart morphogenesis	Kdm6a	IMP	MGI:MGI:4126347	Mouse	PMID:23028370
Biological Process	GO:0071557	histone H3-K27 demethylation	Kdm6a	IMP		Rat	PMID:30887465\|RGD:151665136
Biological Process	GO:0071557	histone H3-K27 demethylation	Kdm6a	IMP		Rat	PMID:31907922\|RGD:151665135
Biological Process	GO:0001701	in utero embryonic development	Kdm6a	IMP	MGI:MGI:5448825	Mouse	PMID:22949634
Biological Process	GO:0001701	in utero embryonic development	Kdm6a	IMP	MGI:MGI:4126347	Mouse	PMID:23028370
Biological Process	GO:0001701	in utero embryonic development	Kdm6a	IMP	MGI:MGI:5516011	Mouse	PMID:23028370
Biological Process	GO:0048333	mesodermal cell differentiation	Kdm6a	IMP	MGI:MGI:5448825	Mouse	PMID:22949634
Biological Process	GO:0048333	mesodermal cell differentiation	Kdm6a	IMP	MGI:MGI:5448754	Mouse	PMID:22949634
Biological Process	GO:0035264	multicellular organism growth	Kdm6a	IMP	MGI:MGI:5516011	Mouse	PMID:23028370
Biological Process	GO:0035264	multicellular organism growth	Kdm6a	IMP	MGI:MGI:4126347	Mouse	PMID:23028370
Biological Process	GO:1903298	negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway	Kdm6a	IMP		Rat	PMID:30887465\|RGD:151665136
Biological Process	GO:0001843	neural tube closure	Kdm6a	IMP	MGI:MGI:5448825	Mouse	PMID:22949634
Biological Process	GO:0021915	neural tube development	Kdm6a	IMP	MGI:MGI:4126347	Mouse	PMID:23028370
Biological Process	GO:0021915	neural tube development	Kdm6a	IMP	MGI:MGI:5516011	Mouse	PMID:23028370
Biological Process	GO:0048570	notochord morphogenesis	Kdm6a	IMP	MGI:MGI:5448825	Mouse	PMID:22949634
Biological Process	GO:0045793	positive regulation of cell size	Kdm6a	IMP		Rat	PMID:31266808\|RGD:151665138
Biological Process	GO:0010628	positive regulation of gene expression	Kdm6a	IMP		Mouse	PMID:23658530
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Kdm6a	IMP		Rat	PMID:30887465\|RGD:151665136
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Kdm6a	IMP		Rat	PMID:31907922\|RGD:151665135
Biological Process	GO:0010468	regulation of gene expression	Kdm6a	IMP	MGI:MGI:4126347	Mouse	PMID:23028370
Biological Process	GO:0003016	respiratory system process	Kdm6a	IMP	MGI:MGI:5448825	Mouse	PMID:22949634
Biological Process	GO:0001666	response to hypoxia	Kdm6a	IEP		Rat	PMID:33075501\|RGD:151665134
Biological Process	GO:0032525	somite rostral/caudal axis specification	Kdm6a	IMP	MGI:MGI:5448825	Mouse	PMID:22949634

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.