Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ITPKB
  • Mouse genes Itpkb
  • Rat genes Itpkb
  • Zfish genes itpkb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Itpkb

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity	ITPKB	IDA		Human	PMID:12747803
Molecular Function	GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity	ITPKB	IDA		Human	PMID:1654894
Molecular Function	GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity	Itpkb	IDA		Mouse	PMID:14517551
Molecular Function	GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity	Itpkb	IMP	MGI:MGI:3039799	Mouse	PMID:15064401
Molecular Function	GO:0005515	protein binding	ITPKB	IPI	UniProtKB:Q08379	Human	PMID:21516116
Molecular Function	GO:0005515	protein binding	ITPKB	IPI	UniProtKB:Q08495	Human	PMID:23060452
Molecular Function	GO:0005515	protein binding	ITPKB	IPI	UniProtKB:Q08379	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ITPKB	IPI	UniProtKB:O76011	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ITPKB	IPI	UniProtKB:Q08209-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ITPKB	IPI	UniProtKB:Q13099	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ITPKB	IPI	UniProtKB:Q8N9R8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ITPKB	IPI	UniProtKB:Q8NHQ1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ITPKB	IPI	UniProtKB:Q9BYV2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ITPKB	IPI	UniProtKB:Q9GZU7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ITPKB	IPI	UniProtKB:Q9UHD9	Human	PMID:32296183
Cellular Component	GO:0005737	cytoplasm	ITPKB	IDA		Human	PMID:12747803
Cellular Component	GO:0005856	cytoskeleton	ITPKB	IDA		Human	PMID:12747803
Cellular Component	GO:0005829	cytosol	Itpkb	IDA		Mouse	PMID:15381088
Cellular Component	GO:0005783	endoplasmic reticulum	ITPKB	IDA		Human	PMID:12747803
Cellular Component	GO:0016020	membrane	Itpkb	IDA		Mouse	PMID:15381088
Cellular Component	GO:0005634	nucleus	Itpkb	IDA		Mouse	PMID:15381088
Biological Process	GO:0007166	cell surface receptor signaling pathway	Itpkb	IMP	MGI:MGI:3039799	Mouse	PMID:15064401
Biological Process	GO:0071277	cellular response to calcium ion	ITPKB	IDA		Human	PMID:12747803
Biological Process	GO:0071277	cellular response to calcium ion	ITPKB	IDA		Human	PMID:1654894
Biological Process	GO:0035726	common myeloid progenitor cell proliferation	Itpkb	IMP	MGI:MGI:2680720	Mouse	PMID:18339802
Biological Process	GO:0032957	inositol trisphosphate metabolic process	ITPKB	IDA		Human	PMID:1654894
Biological Process	GO:0000165	MAPK cascade	Itpkb	IMP	MGI:MGI:3039799	Mouse	PMID:15064401
Biological Process	GO:0002262	myeloid cell homeostasis	Itpkb	IMP	MGI:MGI:2680720	Mouse	PMID:18339802
Biological Process	GO:0045638	negative regulation of myeloid cell differentiation	Itpkb	IMP	MGI:MGI:2680720	Mouse	PMID:18339802
Biological Process	GO:0033030	negative regulation of neutrophil apoptotic process	Itpkb	IMP	MGI:MGI:2680720	Mouse	PMID:18339802
Biological Process	GO:0046854	phosphatidylinositol phosphate biosynthetic process	ITPKB	IDA		Human	PMID:12747803
Biological Process	GO:0046638	positive regulation of alpha-beta T cell differentiation	Itpkb	IMP	MGI:MGI:3039799	Mouse	PMID:15064401
Biological Process	GO:0046579	positive regulation of Ras protein signal transduction	Itpkb	IMP	MGI:MGI:3039799	Mouse	PMID:15064401
Biological Process	GO:0045059	positive thymic T cell selection	Itpkb	IMP	MGI:MGI:3039799	Mouse	PMID:15064401
Biological Process	GO:0001932	regulation of protein phosphorylation	Itpkb	IMP	MGI:MGI:2680720	Mouse	PMID:18339802
Biological Process	GO:0030217	T cell differentiation	Itpkb	IMP	MGI:MGI:2680720	Mouse	PMID:14517551
Biological Process	GO:0045061	thymic T cell selection	Itpkb	IMP	MGI:MGI:2680720	Mouse	PMID:14517551

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern