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Itpkb Gene Detail
Summary
  • Symbol
    Itpkb
  • Name
    inositol 1,4,5-trisphosphate 3-kinase B
  • Synonyms
    1110033J02Rik, E130307H12Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:109235
    NCBI Gene: 320404
  • Gene Overview
    MyGene.info: ITPKB
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:180330485-180424802 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 84.27 cM, cytoband H5
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    572 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109235
protein coding gene Chr1:180330476-180424802 (.)
129S1/SvImJ MGP_129S1SvImJ_G0016868
protein coding gene Chr1:186753051-186854478 (+)
A/J MGP_AJ_G0016847
protein coding gene Chr1:179205091-179301214 (+)
AKR/J MGP_AKRJ_G0016813
protein coding gene Chr1:184535935-184630071 (+)
BALB/cJ MGP_BALBcJ_G0016805
protein coding gene Chr1:179827224-179924043 (+)
C3H/HeJ MGP_C3HHeJ_G0016630
protein coding gene Chr1:185297077-185395854 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017268
protein coding gene Chr1:192774377-192872710 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014976
protein coding gene Chr1:170185183-170280112 (+)
CAST/EiJ MGP_CASTEiJ_G0016211
protein coding gene Chr1:184627378-184728349 (+)
CBA/J MGP_CBAJ_G0016604
protein coding gene Chr1:199938798-200046483 (+)
DBA/2J MGP_DBA2J_G0016710
protein coding gene Chr1:178046214-178140786 (+)
FVB/NJ MGP_FVBNJ_G0016706
protein coding gene Chr1:176140723-176235851 (+)
LP/J MGP_LPJ_G0016784
protein coding gene Chr1:188016921-188117908 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016737
protein coding gene Chr1:207135509-207234818 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017305
protein coding gene Chr1:184306482-184407733 (+)
PWK/PhJ MGP_PWKPhJ_G0015999
protein coding gene Chr1:177133050-177230917 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015775
protein coding gene Chr1:183245756-183343252 (+)
WSB/EiJ MGP_WSBEiJ_G0016274
protein coding gene Chr1:184505362-184604349 (+)



Homology
more
  • Human Ortholog
    ITPKB, inositol-trisphosphate 3-kinase B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ITPKB, inositol-trisphosphate 3-kinase B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IP3-3KB, IP3K, IP3KB, IP3K-B, PIG37
  • Links
    NCBI Gene ID: 3707
    neXtProt AC: NX_P27987
    UniProt: P27987

  • Chr Location
    1q42.12; chr1:226631690-226739327 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 1672
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ITPKB
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in a block of thymocyte development at the double positive stage.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038855 Ensembl Gene Model | MGI Sequence Detail 94318 C57BL/6J ±  kb
    transcript ENSMUST00000070181 Ensembl | MGI Sequence Detail 6235 Not Applicable  
    polypeptide ENSMUSP00000069851 Ensembl | MGI Sequence Detail 942 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • PDB
    • EC
    • InterPro Domains
      IPR005522 Inositol polyphosphate kinase
      IPR038286 Inositol polyphosphate kinase superfamily
    Molecular
    Reagents
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    • All nucleic 12
      cDNA 10
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-38279, MGI:1915910, MGI:2443962
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 17
    • Earliest
      J:38300 Perou CM, et al., Comparative mapping in the beige-satin region of mouse chromosome 13. Genomics. 1997 Jan 15;39(2):136-46
    • Latest
      J:231012 Westernberg L, et al., Non-canonical antagonism of PI3K by the kinase Itpkb delays thymocyte beta-selection and renders it Notch-dependent. Elife. 2016;5

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory