Itpkb Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Itpkb
inositol 1,4,5-trisphosphate 3-kinase B
MGI:109235

21 phenotypes from 2 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Itpkb^T-less/Itpkb^T-less C57BL/6-Itpkb^T-less	abnormal T cell physiology	J:89286
Itpkb^T-less/Itpkb^T-less C57BL/6-Itpkb^T-less	arrested T cell differentiation	J:89286
Itpkb^tm1Ssch/Itpkb^tm1Ssch involves: 129S1/Sv * 129X1/SvJ * CD-1	abnormal thymocyte activation	J:86257
	abnormal thymus involution	J:86257
	absent CD4-positive, alpha-beta T cells	J:86257
	absent CD8-positive, alpha-beta T cells	J:86257
	absent T cells	J:86257
	absent thymus medulla	J:86257
	arrested T cell differentiation	J:86257
	decreased IgG1 level	J:86257
	decreased IgG2a level	J:86257
	decreased IgG2b level	J:86257
	decreased IgG level	J:86257
	decreased locomotor activity	J:86257
	diarrhea	J:86257
	distended abdomen	J:86257
	distended stomach	J:86257
	increased double-positive T cell number	J:86257
	increased susceptibility to parasitic infection	J:86257
	postnatal growth retardation	J:86257
	premature death	J:86257
	sparse hair	J:86257

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23