Itpkb MGI Mouse Gene Detail - MGI:109235 - inositol 1,4,5-trisphosphate 3-kinase B

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Itpkb Gene Detail

Symbol

Itpkb
Name

inositol 1,4,5-trisphosphate 3-kinase B
Synonyms

1110033J02Rik, E130307H12Rik

Feature Type

protein coding gene
IDs

MGI:109235
NCBI Gene: 320404
Alliance

gene page
Transcription Start Sites

26 TSS

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Sequence Map

Chr1:180158050-180252367 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 84.27 cM, cytoband H5
Mapping Data

6 experiments

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SNPs within 2kb

2366 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_109235	protein coding gene	Chr1:180156655-180252367 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016868	protein coding gene	Chr1:186753051-186854478 (+)
A/J	MGP_AJ_G0016847	protein coding gene	Chr1:179205091-179301214 (+)
AKR/J	MGP_AKRJ_G0016813	protein coding gene	Chr1:184535935-184630071 (+)
BALB/cJ	MGP_BALBcJ_G0016805	protein coding gene	Chr1:179827224-179924043 (+)
C3H/HeJ	MGP_C3HHeJ_G0016630	protein coding gene	Chr1:185297077-185395854 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017268	protein coding gene	Chr1:192774377-192872710 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014976	protein coding gene	Chr1:170185183-170280112 (+)
CAST/EiJ	MGP_CASTEiJ_G0016211	protein coding gene	Chr1:184627378-184728349 (+)
CBA/J	MGP_CBAJ_G0016604	protein coding gene	Chr1:199938798-200046483 (+)
DBA/2J	MGP_DBA2J_G0016710	protein coding gene	Chr1:178046214-178140786 (+)
FVB/NJ	MGP_FVBNJ_G0016706	protein coding gene	Chr1:176140723-176235851 (+)
LP/J	MGP_LPJ_G0016784	protein coding gene	Chr1:188016921-188117908 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016737	protein coding gene	Chr1:207135509-207234818 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017305	protein coding gene	Chr1:184306482-184407733 (+)
PWK/PhJ	MGP_PWKPhJ_G0015999	protein coding gene	Chr1:177133050-177230917 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015775	protein coding gene	Chr1:183245756-183343252 (+)
WSB/EiJ	MGP_WSBEiJ_G0016274	protein coding gene	Chr1:184505362-184604349 (+)

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Human Ortholog

ITPKB, inositol-trisphosphate 3-kinase B

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ITPKB, inositol-trisphosphate 3-kinase B
Synonyms

IP3-3KB, IP3K, IP3K-B, IP3KB, PIG37
Links

HGNC:6179

NCBI Gene ID: 3707

neXtProt AC: NX_P27987

UniProt: P27987
Chr Location

1q42.12; chr1:226631690-226739323 (-) GRCh38

MGI Vertebrate Homology

Itpkb stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ITPKB
Gene Tree

Itpkb

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Phenotype Summary

21 phenotypes from 2 alleles in 2 genetic backgrounds
4 phenotypes from multigenic genotypes
21 phenotype references

Phenotype Overview

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (ENU)

1
Chemically induced (other)

2
Endonuclease-mediated

2
Gene trapped

2
Targeted

4
Genomic Mutations

2 involving Itpkb
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

40 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutation of this gene results in a block of thymocyte development at the double positive stage.

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All GO Annotations

29
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

830
Tissues

96
cDNA Data

9
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase itpkb

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All Sequences

48
RefSeq

10
UniProt

2
CCDS

CCDS35808.1

Ensembl

ENSMUSG00000038855 (Evidence)
NCBI Gene

320404

Representative Sequences				Length	Strain/Species	Flank
	genomic	ENSMUSG00000038855	Ensembl Gene Model \| MGI Sequence Detail	94318	C57BL/6J	± kb
	transcript	ENSMUST00000070181	Ensembl \| MGI Sequence Detail	6235	Not Applicable
	polypeptide	ENSMUSP00000069851	Ensembl \| MGI Sequence Detail	942	Not Applicable

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UniProt

2 Sequences
PDB

2AQX
EC

2.7.-.-
InterPro Domains

IPR005522 Inositol polyphosphate kinase

IPR038286 Inositol polyphosphate kinase superfamily
GlyGen

B2RXC2 2 sites, 2 N-linked glycans (2 sites)

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All nucleic 12

cDNA 10

Primer pair 2

Microarray probesets 4

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MGD-MRK-38279, MGI:1915910, MGI:2443962

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Summaries

All 47

Developmental Gene Expression 2

Gene Ontology 6

Phenotypes 21
Earliest

J:38300 Perou CM, et al., Comparative mapping in the beige-satin region of mouse chromosome 13. Genomics. 1997 Jan 15;39(2):136-46
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Itpkb:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr10441	Chr1:180158035-180158058 (+)	-3 bp
Tssr10442	Chr1:180158060-180158101 (+)	31 bp
Tssr10443	Chr1:180159183-180159187 (+)	1,135 bp
Tssr10444	Chr1:180161452-180161475 (+)	3,414 bp
Tssr10445	Chr1:180161551-180161574 (+)	3,513 bp
Tssr10446	Chr1:180162389-180162406 (+)	4,348 bp
Tssr10447	Chr1:180169877-180169894 (+)	11,836 bp
Tssr10448	Chr1:180173498-180173509 (+)	15,454 bp
Tssr10449	Chr1:180173549-180173568 (+)	15,509 bp
Tssr10450	Chr1:180173596-180173610 (+)	15,553 bp
Tssr10455	Chr1:180192942-180192985 (+)	34,914 bp
Tssr10456	Chr1:180193343-180193347 (+)	35,295 bp
Tssr10457	Chr1:180195662-180195674 (+)	37,618 bp
Tssr10458	Chr1:180195697-180195719 (+)	37,658 bp
Tssr10460	Chr1:180209770-180209793 (+)	51,732 bp
Tssr10461	Chr1:180209870-180209899 (+)	51,835 bp
Tssr10462	Chr1:180209916-180209928 (+)	51,872 bp
Tssr10463	Chr1:180209938-180209965 (+)	51,902 bp
Tssr10464	Chr1:180215307-180215337 (+)	57,272 bp
Tssr10465	Chr1:180215564-180215569 (+)	57,517 bp
Tssr10466	Chr1:180220909-180220913 (+)	62,861 bp
Tssr10467	Chr1:180229606-180229628 (+)	71,567 bp
Tssr10468	Chr1:180247049-180247062 (+)	89,006 bp
Tssr10469	Chr1:180248597-180248607 (+)	90,552 bp
Tssr10470	Chr1:180248611-180248628 (+)	90,570 bp
Tssr10471	Chr1:180251005-180251031 (+)	92,968 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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