Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ITCH
  • Mouse genes Itch
  • Rat genes Itch
  • Zfish genes itcha,itchb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Itch

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:1990763	arrestin family protein binding	ITCH	IPI	UniProtKB:Q8N5I2	Human	PMID:23886940
Molecular Function	GO:1990763	arrestin family protein binding	ITCH	IPI	UniProtKB:Q96B67	Human	PMID:23886940
Molecular Function	GO:0045236	CXCR chemokine receptor binding	ITCH	IPI	UniProtKB:P61073	Human	PMID:19116316
Molecular Function	GO:0016874	ligase activity	Itch	IMP		Mouse	MGI:MGI:3774677|PMID:18246070
Molecular Function	GO:0005515	protein binding	ITCH	IPI	UniProtKB:P84022,UniProtKB:Q14511	Human	PMID:15051726
Molecular Function	GO:0005515	protein binding	ITCH	IPI	UniProtKB:O15350	Human	PMID:15678106
Molecular Function	GO:0005515	protein binding	ITCH	IPI	UniProtKB:O15350-1	Human	PMID:15678106
Molecular Function	GO:0005515	protein binding	ITCH	IPI	UniProtKB:O15350-8	Human	PMID:15678106
Molecular Function	GO:0005515	protein binding	ITCH	IPI	UniProtKB:Q96BR1	Human	PMID:16888620
Molecular Function	GO:0005515	protein binding	ITCH	IPI	UniProtKB:Q9H3D4	Human	PMID:16908849
Molecular Function	GO:0005515	protein binding	ITCH	IPI	UniProtKB:Q86Y01	Human	PMID:17028573
Molecular Function	GO:0005515	protein binding	ITCH	IPI	UniProtKB:P13285	Human	PMID:17174309
Molecular Function	GO:0005515	protein binding	ITCH	IPI	UniProtKB:O15350	Human	PMID:17592138
Molecular Function	GO:0005515	protein binding	ITCH	IPI	UniProtKB:O75113	Human	PMID:17592138
Molecular Function	GO:0005515	protein binding	ITCH	IPI	UniProtKB:Q6A037	Human	PMID:17592138
Molecular Function	GO:0005515	protein binding	ITCH	IPI	UniProtKB:Q8N0X7	Human	PMID:19580544
Molecular Function	GO:0005515	protein binding	ITCH	IPI	UniProtKB:Q9H3M7	Human	PMID:20068034
Molecular Function	GO:0005515	protein binding	ITCH	IPI	UniProtKB:P70444	Human	PMID:20392206
Molecular Function	GO:0005515	protein binding	ITCH	IPI	UniProtKB:Q9Y5X1	Human	PMID:20491914
Molecular Function	GO:0005515	protein binding	ITCH	IPI	UniProtKB:Q9Y3C5	Human	PMID:20676133
Molecular Function	GO:0005515	protein binding	ITCH	IPI	UniProtKB:P08151	Human	PMID:20818436
Molecular Function	GO:0005515	protein binding	ITCH	IPI	UniProtKB:Q9QZS3-2	Human	PMID:20818436
Molecular Function	GO:0005515	protein binding	ITCH	IPI	UniProtKB:Q15303	Human	PMID:20858735
Molecular Function	GO:0005515	protein binding	ITCH	IPI	UniProtKB:Q13571	Human	PMID:22009753
Molecular Function	GO:0005515	protein binding	ITCH	IPI	UniProtKB:Q9NQC7	Human	PMID:22057290
Molecular Function	GO:0005515	protein binding	ITCH	IPI	UniProtKB:P13285	Human	PMID:22810586
Molecular Function	GO:0005515	protein binding	ITCH	IPI	UniProtKB:Q9BTU6	Human	PMID:23146885
Molecular Function	GO:0005515	protein binding	ITCH	IPI	UniProtKB:Q96B67	Human	PMID:23236378
Molecular Function	GO:0005515	protein binding	ITCH	IPI	UniProtKB:O14964,UniProtKB:Q8TDB6,UniProtKB:Q92783	Human	PMID:24790097
Molecular Function	GO:0005515	protein binding	ITCH	IPI	UniProtKB:Q13625	Human	PMID:25436413
Molecular Function	GO:0005515	protein binding	ITCH	IPI	UniProtKB:Q86YD5	Human	PMID:26854353
Molecular Function	GO:0005515	protein binding	ITCH	IPI	UniProtKB:Q96B67	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	ITCH	IPI	UniProtKB:P54259	Human	PMID:9647693
Molecular Function	GO:0005515	protein binding	Itch	IPI	UniProtKB:Q80TQ2	Mouse	MGI:MGI:5300860|PMID:22057290
Molecular Function	GO:0005515	protein binding	Itch	IPI	UniProtKB:O89091	Mouse	MGI:MGI:3775527|PMID:18278048
Molecular Function	GO:0005515	protein binding	Itch	IPI	UniProtKB:A2AR95	Mouse	MGI:MGI:6810814|PMID:26854353
Molecular Function	GO:0005515	protein binding	Itch	IPI	UniProtKB:Q3UKC1	Mouse	MGI:MGI:3774677|PMID:18246070
Molecular Function	GO:0005515	protein binding	Itch	IPI	PR:Q8R0W6	Mouse	PMID:17137798
Molecular Function	GO:0005515	protein binding	Itch	IPI	PR:Q8BGW2	Mouse	PMID:31845480
Molecular Function	GO:0005515	protein binding	Itch	IPI	PR:Q61146	Mouse	PMID:11782481
Molecular Function	GO:0043021	ribonucleoprotein complex binding	ITCH	IPI	UniProtKB:Q15366	Human	PMID:19881509
Molecular Function	GO:0061630	ubiquitin protein ligase activity	ITCH	IMP		Human	PMID:15051726
Molecular Function	GO:0061630	ubiquitin protein ligase activity	ITCH	IDA		Human	PMID:15678106
Molecular Function	GO:0061630	ubiquitin protein ligase activity	ITCH	IMP		Human	PMID:22009753
Molecular Function	GO:0061630	ubiquitin protein ligase activity	ITCH	IDA		Human	PMID:34927784
Molecular Function	GO:0044389	ubiquitin-like protein ligase binding	ITCH	IPI	UniProtKB:Q8TDB6	Human	PMID:24790097
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	ITCH	IDA		Human	PMID:17592138
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	ITCH	IMP		Human	PMID:24790097
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	ITCH	EXP		Human	PMID:34999730
Cellular Component	GO:0005938	cell cortex	Itch	IDA		Mouse	PMID:17137798
Cellular Component	GO:0005737	cytoplasm	Itch	IDA		Mouse	PMID:14973438
Cellular Component	GO:0031410	cytoplasmic vesicle	ITCH	IDA		Human	PMID:22009753
Cellular Component	GO:0031410	cytoplasmic vesicle	Itch	IDA		Mouse	PMID:17137798
Cellular Component	GO:0005769	early endosome	ITCH	IDA		Human	PMID:24790097
Cellular Component	GO:0070062	extracellular exosome	ITCH	HDA		Human	PMID:23533145
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ITCH	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016020	membrane	ITCH	HDA		Human	PMID:19946888
Cellular Component	GO:0016020	membrane	Itch	IDA		Mouse	PMID:14973438
Cellular Component	GO:0005654	nucleoplasm	ITCH	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Itch	IDA		Mouse	PMID:11555636
Cellular Component	GO:0005886	plasma membrane	ITCH	IDA		Human	PMID:34927784
Cellular Component	GO:0005886	plasma membrane	ITCH	IDA		Human	PMID:14602072
Cellular Component	GO:0032991	protein-containing complex	ITCH	IDA		Human	PMID:24790097
Biological Process	GO:0035739	CD4-positive, alpha-beta T cell proliferation	Itch	IMP	MGI:MGI:1856404	Mouse	PMID:14973438
Biological Process	GO:0043066	negative regulation of apoptotic process	ITCH	IMP		Human	PMID:20068034
Biological Process	GO:2000562	negative regulation of CD4-positive, alpha-beta T cell proliferation	Itch	IMP	MGI:MGI:1856404	Mouse	PMID:14973438
Biological Process	GO:0050687	negative regulation of defense response to virus	ITCH	IMP		Human	PMID:19881509
Biological Process	GO:0050687	negative regulation of defense response to virus	Itch	IMP		Mouse	MGI:MGI:4436832|PMID:19881509
Biological Process	GO:0046329	negative regulation of JNK cascade	Itch	IMP		Mouse	MGI:MGI:3774677|PMID:18246070
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	Itch	IMP		Mouse	MGI:MGI:3774677|PMID:18246070
Biological Process	GO:0045732	positive regulation of protein catabolic process	Itch	IMP	MGI:MGI:1856404	Mouse	PMID:14973438
Biological Process	GO:0045732	positive regulation of protein catabolic process	Itch	IDA		Mouse	PMID:14973438
Biological Process	GO:2000646	positive regulation of receptor catabolic process	ITCH	IMP		Human	PMID:24790097
Biological Process	GO:0002669	positive regulation of T cell anergy	Itch	IMP	MGI:MGI:1856404	Mouse	PMID:14973438
Biological Process	GO:0048920	posterior lateral line neuromast primordium migration	itchb	IMP	ZFIN:ZDB-MRPHLNO-150318-7	Zfish	PMID:25369329
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	ITCH	IMP		Human	PMID:22009753
Biological Process	GO:0051865	protein autoubiquitination	ITCH	IMP		Human	PMID:24790097
Biological Process	GO:0030163	protein catabolic process	Itch	IMP	MGI:MGI:1856404	Mouse	PMID:14973438
Biological Process	GO:0035519	protein K29-linked ubiquitination	ITCH	IDA		Human	PMID:17028573
Biological Process	GO:0035519	protein K29-linked ubiquitination	ITCH	IDA		Human	PMID:18628966
Biological Process	GO:0070936	protein K48-linked ubiquitination	ITCH	IDA		Human	PMID:19881509
Biological Process	GO:0070936	protein K48-linked ubiquitination	ITCH	IDA		Human	PMID:30328013
Biological Process	GO:0070936	protein K48-linked ubiquitination	Itch	IMP		Mouse	MGI:MGI:3774677|PMID:18246070
Biological Process	GO:0070534	protein K63-linked ubiquitination	ITCH	IDA		Human	PMID:18718448
Biological Process	GO:0070534	protein K63-linked ubiquitination	ITCH	IDA		Human	PMID:19592251
Biological Process	GO:0006513	protein monoubiquitination	ITCH	IDA		Human	PMID:34927784
Biological Process	GO:0000209	protein polyubiquitination	Itch	IDA		Mouse	PMID:14973438
Biological Process	GO:0016567	protein ubiquitination	ITCH	IDA		Human	PMID:17592138
Biological Process	GO:0016567	protein ubiquitination	ITCH	IMP		Human	PMID:24790097
Biological Process	GO:0016567	protein ubiquitination	ITCH	IDA		Human	PMID:25631046
Biological Process	GO:0031623	receptor internalization	ITCH	IMP		Human	PMID:34927784
Biological Process	GO:0090085	regulation of protein deubiquitination	Itch	IMP		Mouse	MGI:MGI:3774677|PMID:18246070
Biological Process	GO:0002870	T cell anergy	Itch	IMP	MGI:MGI:1856404	Mouse	PMID:14973438
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	ITCH	IDA		Human	PMID:15678106
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	ITCH	IMP		Human	PMID:22009753
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	ITCH	IMP		Human	PMID:25518932
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	Itch	IDA		Mouse	PMID:14973438
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	Itch	IDA		Mouse	PMID:15678106

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern