Itch
Gene Detail

Symbol Name ID

Itch itchy, E3 ubiquitin protein ligase MGI:1202301

Synonyms

6720481N21Rik, 8030492O04Rik, AIP4, C230047C07Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 2

76.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr2:155133509-155226855 bp, + strand From VEGA annotation of GRCm38   93347 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:88442  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: E3 ubiquitin-protein ligase, SMURF1 type
Gene Tree: Itch

Human homologs

Human Homolog		ITCH, itchy E3 ubiquitin protein ligase
NCBI Gene ID		83737
neXtProt AC		NX_Q96J02
Human Synonyms		AIF4, AIP4, dJ468O1.1, NAPP1
Human Chr (Location)		20q11.22; chr20:32951041-33099198 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ITCH

Alleles and phenotypes

All alleles(64) : Targeted(3) Gene trapped(60) Chemically induced(1) Radiation induced(1)
 

The a^18H inversion mutation carries a distal breakpoint between exons 1 and 2 of the Itch gene. Mice homozygous for this mutation do not express a functional Itch gene product.

 

Gene Ontology (GO) classifications

All GO classifications: (41 annotations)

Process	apoptotic process, defense response to virus, ...
Component	cell cortex, cytoplasm, ...
Function	CXCR chemokine receptor binding, ligase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (169)    Tissues (20)    Images (26)
Theiler Stages: 11, 13, 21, 23

Assay Type	Results
RNA in situ	167
Western blot	2

cDNA source data(164)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(173) Genomic(4) cDNA(169)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000016008 (Evidence)
Ensembl Gene Model	ENSMUSG00000027598 (Evidence)
Entrez Gene	16396 (Evidence)
UniGene	208286
DFCI	TC1575110, TC1607651, TC1610930, TC1634663, TC1654637
DoTS	DT.101220951, DT.102556359, DT.103575413, DT.110743977, DT.40163278, DT.529752, DT.91369203, DT.97404771
NIA Mouse Gene Index	U002699
EC	6.3.2.-
PDB	1YIU, 2JOC, 2JO9
Consensus CDS Project	CCDS38293.1
International Mouse Knockout Project Status	Itch

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016008	VEGA Gene Model | MGI Sequence Detail	93347	C57BL/6J
transcript	OTTMUST00000038117	VEGA | MGI Sequence Detail	5159	Not Applicable
polypeptide	OTTMUSP00000017091	VEGA | MGI Sequence Detail	864	Not Applicable

All sequences(61) RefSeq(4) UniProt(4)

Polymorphisms

SNPs(397 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000008	C2 calcium-dependent membrane targeting
InterPro	IPR008973	C2 calcium/lipid-binding domain, CaLB
InterPro	IPR018029	C2 membrane targeting protein
InterPro	IPR024928	E3 ubiquitin-protein ligase, SMURF1 type
InterPro	IPR000569	HECT
InterPro	IPR001202	WW/Rsp5/WWP
Protein Ontology	PR:000003192	E3 ubiquitin-protein ligase itchy

References

(Earliest) J:163587 Cattanach BM, et al., Agouti locus mutations at Harwell. Mouse News Lett. 1987;77:123-125
(Latest) J:192843 Tigno-Aranjuez JT, et al., A discrete ubiquitin-mediated network regulates the strength of NOD2 signaling. Mol Cell Biol. 2013 Jan;33(1):146-58
All references(70)

Other accession IDs

MGI:1924982, MGI:2441729, MGI:2443666