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Itch
Gene Detail
Symbol

Name
ID
Itch
itchy, E3 ubiquitin protein ligase
MGI:1202301
Synonyms
6720481N21Rik, 8030492O04Rik, AIP4, C230047C07Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 2
76.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:155133509-155226855 bp, + strand
From VEGA annotation of GRCm38

  93347 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:88442  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: E3 ubiquitin-protein ligase, SMURF1 type
Gene Tree: Itch

Human
homologs
Human Homolog ITCH, itchy E3 ubiquitin protein ligase
NCBI Gene ID 83737
neXtProt AC  NX_Q96J02
Human Synonyms  ADMFD, AIF4, AIP4, dJ468O1.1, NAPP1
Human Chr (Location)  20q11.22; chr20:34363235-34515451 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human ITCH
Mutations,
alleles, and
phenotypes
All mutations/alleles(65) : Chemically and radiation induced(1) Gene trapped(60) Targeted(4)
Genomic Mutations involving Itch (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for an induced inversion that eliminates gene function exhibit premature death, lung inflammation and skin lesions.
 
Interactions
Itch interacts with 366 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (57 annotations)
Process apoptotic process, defense response to virus, ...
Component cell cortex, cytoplasm, ...
Function coenzyme F420-0 gamma-glutamyl ligase activity, coenzyme F420-2 alpha-glutamyl ligase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (169)    Tissues (20)    Images (26)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 167
Western blot 2
cDNA source data(20)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(29) Genomic(4) cDNA(25)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000016008 (Evidence)
Ensembl Gene ModelENSMUSG00000027598 (Evidence)
Entrez Gene16396 (Evidence)
DFCITC1575110, TC1607651, TC1610930, TC1634663, TC1654637
DoTSDT.101220951, DT.102556359, DT.103575413, DT.110743977, DT.40163278, DT.529752, DT.91369203, DT.97404771
NIA Mouse Gene IndexU002699
EC6.3.2.-
PDB1YIU, 2JOC, 2JO9
Consensus CDS ProjectCCDS38293.1
International Mouse Knockout Project StatusItch
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016008 VEGA Gene Model | MGI Sequence Detail 93347 C57BL/6J ±  kb
transcript OTTMUST00000038117 VEGA | MGI Sequence Detail 5159 Not Applicable 
polypeptide OTTMUSP00000017091 VEGA | MGI Sequence Detail 864 Not Applicable 

For the selected sequences
All sequences(64) RefSeq(8) UniProt(3)
Polymorphisms
SNPs within 2kb(583 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR024928 E3 ubiquitin-protein ligase, SMURF1 type
InterPro IPR000569 HECT
InterPro IPR001202 WW domain
Protein Ontology PR:000003192 E3 ubiquitin-protein ligase Itchy
References
(Earliest) J:163587 Cattanach BM, et al., Agouti locus mutations at Harwell. Mouse News Lett. 1987;77:123-125
(Latest) J:209014 Marino A, et al., ITCH deficiency protects from diet-induced obesity. Diabetes. 2014 Feb;63(2):550-61
All references(76)
Other
accession IDs
MGI:1924982, MGI:2441729, MGI:2443666

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory