Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IL3
  • Mouse genes Il3
  • Rat genes Il3
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Il3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005125	cytokine activity	IL3	IDA		Human	PMID:35281014
Molecular Function	GO:0005125	cytokine activity	Il3	IDA		Mouse	PMID:1350248
Molecular Function	GO:0005125	cytokine activity	Il3	IDA		Mouse	PMID:10872802
Molecular Function	GO:0005125	cytokine activity	Il3	IDA		Mouse	PMID:7736574
Molecular Function	GO:0005125	cytokine activity	Il3	IDA		Mouse	PMID:14967141
Molecular Function	GO:0005125	cytokine activity	Il3	IDA		Mouse	PMID:7957045
Molecular Function	GO:0005125	cytokine activity	Il3	IDA		Mouse	PMID:10652277
Molecular Function	GO:0005125	cytokine activity	Il3	IDA		Mouse	PMID:7519779
Molecular Function	GO:0005125	cytokine activity	Il3	IDA		Mouse	PMID:12714518
Molecular Function	GO:0005125	cytokine activity	Il3	IMP		Rat	PMID:3086845|RGD:728966
Molecular Function	GO:0005125	cytokine activity	Il3	IDA		Rat	PMID:3263940|RGD:2303497
Molecular Function	GO:0008083	growth factor activity	Il3	IDA		Mouse	PMID:12714518
Molecular Function	GO:0008083	growth factor activity	Il3	IDA		Mouse	PMID:7957045
Molecular Function	GO:0005135	interleukin-3 receptor binding	Il3	IPI	PR:P26952-1	Mouse	PMID:19109256
Molecular Function	GO:0005135	interleukin-3 receptor binding	Il3	IPI	PR:P26952-3	Mouse	PMID:19109256
Molecular Function	GO:0005135	interleukin-3 receptor binding	Il3	IMP		Rat	PMID:3086845|RGD:728966
Cellular Component	GO:0005615	extracellular space	IL3	IDA		Human	PMID:35281014
Cellular Component	GO:0005615	extracellular space	Il3	IDA		Mouse	PMID:7690439
Cellular Component	GO:0005615	extracellular space	Il3	IDA		Rat	PMID:9573350|RGD:729209
Biological Process	GO:0042976	activation of Janus kinase activity	Il3	IDA		Mouse	PMID:8378315
Biological Process	GO:0001783	B cell apoptotic process	Il3	IDA		Mouse	PMID:7736574
Biological Process	GO:0042100	B cell proliferation	Il3	IDA		Mouse	PMID:7736574
Biological Process	GO:0008283	cell population proliferation	Il3	IDA		Mouse	PMID:1350248
Biological Process	GO:0008283	cell population proliferation	Il3	IDA		Mouse	PMID:7957045
Biological Process	GO:0008283	cell population proliferation	Il3	IGI	MGI:MGI:96974	Mouse	PMID:7690439
Biological Process	GO:0019221	cytokine-mediated signaling pathway	Il3	IDA		Mouse	PMID:7519779
Biological Process	GO:0035162	embryonic hemopoiesis	IL3	IDA		Human	PMID:21149635
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	Il3	IDA		Mouse	PMID:14967141
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	Il3	IDA		Mouse	PMID:12124386
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	Il3	IDA		Mouse	PMID:12944463
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	Il3	IDA		Mouse	PMID:15680329
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	Il3	IDA		Mouse	PMID:11527400
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	Il3	IDA		Mouse	PMID:15231831
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation	Il3	IGI	MGI:MGI:96974	Mouse	PMID:1375116
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation	Il3	IGI	MGI:MGI:96974	Mouse	PMID:7690439
Biological Process	GO:0030097	hemopoiesis	Il3	IMP		Rat	PMID:9573350|RGD:729209
Biological Process	GO:0038156	interleukin-3-mediated signaling pathway	IL3	IDA		Human	PMID:35281014
Biological Process	GO:0038156	interleukin-3-mediated signaling pathway	Il3	IDA		Mouse	PMID:19109256
Biological Process	GO:0007254	JNK cascade	Il3	IDA		Mouse	PMID:14967141
Biological Process	GO:0007254	JNK cascade	Il3	IMP		Mouse	PMID:14967141
Biological Process	GO:0033024	mast cell apoptotic process	Il3	IDA		Mouse	PMID:12714518
Biological Process	GO:0070662	mast cell proliferation	Il3	IDA		Mouse	PMID:15947484
Biological Process	GO:0070662	mast cell proliferation	Il3	IDA		Mouse	PMID:12714518
Biological Process	GO:0030224	monocyte differentiation	Il3	IGI	MGI:MGI:96553	Mouse	PMID:19109256
Biological Process	GO:0033028	myeloid cell apoptotic process	Il3	IDA		Mouse	PMID:9202146
Biological Process	GO:0033028	myeloid cell apoptotic process	Il3	IDA		Mouse	PMID:10652277
Biological Process	GO:0002573	myeloid leukocyte differentiation	Il3	IGI	MGI:MGI:96974	Mouse	PMID:7690439
Biological Process	GO:0002573	myeloid leukocyte differentiation	Il3	IGI	MGI:MGI:96974	Mouse	PMID:1375116
Biological Process	GO:0010507	negative regulation of autophagy	Il3	IDA		Mouse	PMID:15680329
Biological Process	GO:0002903	negative regulation of B cell apoptotic process	Il3	IDA		Mouse	PMID:7736574
Biological Process	GO:0033026	negative regulation of mast cell apoptotic process	Il3	IDA		Mouse	PMID:12714518
Biological Process	GO:0033033	negative regulation of myeloid cell apoptotic process	Il3	IDA		Mouse	PMID:10652277
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	Il3	IDA		Mouse	PMID:10872802
Biological Process	GO:0030890	positive regulation of B cell proliferation	Il3	IDA		Mouse	PMID:7736574
Biological Process	GO:0008284	positive regulation of cell population proliferation	IL3	IDA		Human	PMID:9722506
Biological Process	GO:0008284	positive regulation of cell population proliferation	Il3	IDA		Mouse	PMID:1350248
Biological Process	GO:0008284	positive regulation of cell population proliferation	Il3	IDA		Mouse	PMID:7957045
Biological Process	GO:0008284	positive regulation of cell population proliferation	Il3	IGI	MGI:MGI:96974	Mouse	PMID:7690439
Biological Process	GO:0008284	positive regulation of cell population proliferation	Il3	IDA		Rat	PMID:3263940|RGD:2303497
Biological Process	GO:0008284	positive regulation of cell population proliferation	Il3	IMP		Rat	PMID:9573350|RGD:729209
Biological Process	GO:1901534	positive regulation of hematopoietic progenitor cell differentiation	Il3	IGI	MGI:MGI:96974	Mouse	PMID:1375116
Biological Process	GO:1901534	positive regulation of hematopoietic progenitor cell differentiation	Il3	IGI	MGI:MGI:96974	Mouse	PMID:7690439
Biological Process	GO:0046330	positive regulation of JNK cascade	Il3	IDA		Mouse	PMID:14967141
Biological Process	GO:0046330	positive regulation of JNK cascade	Il3	IMP		Mouse	PMID:14967141
Biological Process	GO:0070668	positive regulation of mast cell proliferation	Il3	IDA		Mouse	PMID:12714518
Biological Process	GO:0070668	positive regulation of mast cell proliferation	Il3	IDA		Mouse	PMID:15947484
Biological Process	GO:0002763	positive regulation of myeloid leukocyte differentiation	Il3	IGI	MGI:MGI:96974	Mouse	PMID:1375116
Biological Process	GO:0002763	positive regulation of myeloid leukocyte differentiation	Il3	IGI	MGI:MGI:96974	Mouse	PMID:7690439
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	Il3	IDA		Mouse	PMID:10872802
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	Il3	IDA		Mouse	PMID:7519779
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Il3	IDA		Mouse	PMID:14967141
Biological Process	GO:0042102	positive regulation of T cell proliferation	Il3	IDA		Mouse	PMID:12714518
Biological Process	GO:0042102	positive regulation of T cell proliferation	Il3	IDA		Mouse	PMID:15947484
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	IL3	IDA		Human	PMID:9722506
Biological Process	GO:0006468	protein phosphorylation	Il3	IDA		Mouse	PMID:14967141
Biological Process	GO:0001558	regulation of cell growth	Il3	IGI	MGI:MGI:96553	Mouse	PMID:19109256
Biological Process	GO:0001558	regulation of cell growth	Il3	IMP		Rat	PMID:3086845|RGD:728966
Biological Process	GO:0010468	regulation of gene expression	Il3	IDA		Mouse	PMID:9697835
Biological Process	GO:0006110	regulation of glycolytic process	Il3	IGI	MGI:MGI:106918	Mouse	PMID:17437992
Biological Process	GO:0035304	regulation of protein dephosphorylation	Il3	IDA		Mouse	PMID:12944463
Biological Process	GO:0009725	response to hormone	Il3	IMP		Rat	PMID:3086845|RGD:728966
Biological Process	GO:0001666	response to hypoxia	Il3	IGI	MGI:MGI:106918	Mouse	PMID:17437992
Biological Process	GO:0042098	T cell proliferation	Il3	IDA		Mouse	PMID:12714518
Biological Process	GO:0042098	T cell proliferation	Il3	IDA		Mouse	PMID:15947484

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern