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Il3
Gene Detail
 Symbol
Name
ID
Il3
interleukin 3
MGI:96552
Synonyms BPA, Csfmu, HCGF, Il-3, MCGF, PSF
Feature Type protein coding gene
Genetic Map
Chromosome 11
32.13 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(63)
Sequence Map
Chr11:54265303-54267277 bp, - strand
From VEGA annotation of GRCm38

  1975 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:49243  Vertebrate Homology Class
1 mouse; 1 rat

Protein SuperFamily: interleukin-3
Gene Tree: Il3

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene show abnormal mast cell development. Contact hypersensitivity is reduced and resistance to parasitic invections is increased.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Il3 interacts with 38 markers (Mir1a-1, Mir1a-2, Mir142, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process cytokine-mediated signaling pathway, extrinsic apoptotic signaling pathway in absence of ligand, ...
Component extracellular region, extracellular space
Function cytokine activity, growth factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (75)    Tissues (49)   
Theiler Stages: 16, 18, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
RT-PCR 72
Nuclease S1 3
cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(43) Genomic(22) cDNA(17) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000005664 (Evidence)
Ensembl Gene ModelENSMUSG00000018914 (Evidence)
Entrez Gene16187 (Evidence)
UniGene983
DFCITC1592156
DoTSDT.60102972
NIA Mouse Gene IndexU032777
PDB2L3O
Consensus CDS ProjectCCDS24693.1
International Mouse Knockout Project StatusIl3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005664 VEGA Gene Model | MGI Sequence Detail 1975 C57BL/6J ±  kb
transcript OTTMUST00000012597 VEGA | MGI Sequence Detail 629 Not Applicable 
polypeptide OTTMUSP00000005831 VEGA | MGI Sequence Detail 166 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(3)
Polymorphisms All PCR and RFLP(18) : PCR(2) RFLP(16) SNPs within 2kb(74 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012351 Four-helical cytokine, core
InterPro IPR009079 Four-helical cytokine-like, core
InterPro IPR002183 Interleukin-3
Protein Ontology PR:000001387 interleukin-3
References (Earliest) J:14592 Ihle JN, et al., Procedures for the purification of interleukin 3 to homogeneity. J Immunol. 1982 Dec;129(6):2431-6
(Latest) J:209410 Auclair SR, et al., Interleukin-3-deficient mice have increased resistance to blood-stage malaria. Infect Immun. 2014 Mar;82(3):1308-14
All references(196)
Other
accession IDs
MGD-MRK-11354, MGD-MRK-11379, MGD-MRK-2193

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory