Il3
Gene Detail

Symbol Name ID

Il3 interleukin 3 MGI:96552

Synonyms

BPA, Csfmu, HCGF, Il-3, MCGF, PSF

Feature Type

protein coding gene

Genetic Map

Chromosome 11

32.13 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(64)

Sequence Map

Chr11:54265303-54267277 bp, - strand From VEGA annotation of GRCm38   1975 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:49243  Vertebrate Homology Class
1 mouse; 1 rat

Protein SuperFamily: interleukin-3
Gene Tree: Il3

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Mice homozygous for disruptions in this gene show abnormal mast cell development. Contact hypersensitivity is reduced and resistance to parasitic invections is increased.

 
Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (32 annotations)

Process	cytokine-mediated signaling pathway, extrinsic apoptotic signaling pathway in absence of ligand, ...
Component	extracellular region, extracellular space
Function	cytokine activity, growth factor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (9 records)
Data Summary: Results (75)    Tissues (45)   
Theiler Stages: 16, 18, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RT-PCR	72
Nuclease S1	3

cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(43) Genomic(22) cDNA(17) Primer pair(3) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000005664 (Evidence)
Ensembl Gene Model	ENSMUSG00000018914 (Evidence)
Entrez Gene	16187 (Evidence)
UniGene	983
DFCI	TC1592156
DoTS	DT.60102972
NIA Mouse Gene Index	U032777
PDB	2L3O
Consensus CDS Project	CCDS24693.1
International Mouse Knockout Project Status	Il3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005664	VEGA Gene Model | MGI Sequence Detail	1975	C57BL/6J
transcript	OTTMUST00000012597	VEGA | MGI Sequence Detail	629	Not Applicable
polypeptide	OTTMUSP00000005831	VEGA | MGI Sequence Detail	166	Not Applicable

All sequences(23) RefSeq(2) UniProt(3)

Polymorphisms

All PCR and RFLP(18) : PCR(2) RFLP(16) SNPs(56 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR012351	Four-helical cytokine, core
InterPro	IPR009079	Four-helical cytokine-like, core
InterPro	IPR002183	Interleukin-3
Protein Ontology	PR:000001387	interleukin-3

References

(Earliest) J:14592 Ihle JN, et al., Procedures for the purification of interleukin 3 to homogeneity. J Immunol. 1982 Dec;129(6):2431-6
(Latest) J:192528 Olejniczak SH, et al., Long-lived microRNA-Argonaute complexes in quiescent cells can be activated to regulate mitogenic responses. Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):157-62
All references(193)

Other accession IDs

MGD-MRK-11354, MGD-MRK-11379, MGD-MRK-2193