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Il3 Gene Detail
Summary
  • Symbol
    Il3
  • Name
    interleukin 3
  • Synonyms
    BPA, Csfmu, HCGF, Il-3, MCGF, PSF
  • Feature Type
    protein coding gene
  • IDs
    MGI:96552
    NCBI Gene: 16187
  • Gene Overview
    MyGene.info: IL3
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:54265303-54267277 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1975 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 32.13 cM, cytoband B1
  • Mapping Data
    63 experiments
Homology
more
  • Human Ortholog
    IL3, interleukin 3
  • Vertebrate Orthologs
    2
  • Human Ortholog
    IL3, interleukin 3
    Orthology source: HGNC
  • Synonyms
    IL-3, MCGF, MULTI-CSF
  • Links
    NCBI Gene ID: 3562
    neXtProt AC: NX_P08700
    UniProt: P08700

  • Chr Location
    5q31.1; chr5:132060654-132063203 (+)  GRCh38.p7

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 2 genetic backgrounds
    30 phenotypes from multigenic genotypes
    53 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene show abnormal mast cell development. Contact hypersensitivity is reduced and resistance to parasitic invections is increased.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000005664 VEGA Gene Model | MGI Sequence Detail 1975 C57BL/6J ±  kb
    transcript OTTMUST00000012597 VEGA | MGI Sequence Detail 629 Not Applicable  
    polypeptide OTTMUSP00000005831 VEGA | MGI Sequence Detail 166 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      74 from dbSNP Build 142
    • PCR
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 44
      Genomic 22
      cDNA 18
      Primer pair 3
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11354, MGD-MRK-11379, MGD-MRK-2193
    References
    more
    • Summaries
      All 243
      Developmental Gene Expression 10
      Diseases 1
      Gene Ontology 24
      Phenotypes 53
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:265322 Proto JD, et al., Hypercholesterolemia induces T cell expansion in humanized immune mice. J Clin Invest. 2018 Jun 1;128(6):2370-2375

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory