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Il3
Gene Detail
Symbol

Name
ID
Il3
interleukin 3
MGI:96552
Synonyms
BPA, Csfmu, HCGF, Il-3, MCGF, PSF
Feature Type
protein coding gene
Genetic Map
Chromosome 11
32.13 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(63)
Sequence Map
Chr11:54265303-54267277 bp, - strand
From VEGA annotation of GRCm38

  1975 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:49243  Vertebrate Homology Class
1 mouse; 1 rat

HCOP human homology predictions: IL3
Protein SuperFamily: interleukin-3
Gene Tree: Il3

Human
homologs
IL3, interleukin 3
Orthology source: HGNC

IDs:
NCBI Gene ID: 3562
neXtProt AC: NX_P08700

Human Synonyms: IL-3, MCGF, MULTI-CSF

Human Chr (Location): 5q31.1; chr5:132060654-132063203 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Targeted(6) Transgenic(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene show abnormal mast cell development. Contact hypersensitivity is reduced and resistance to parasitic invections is increased.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Il3 interacts with 38 markers (Mir1a-1, Mir1a-2, Mir142, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (9 records)
Data Summary: Results (75)    Tissues (49)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 72
Nuclease S1 3
cDNA source data(16)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(43) Genomic(22) cDNA(17) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000005664 (Evidence)
Ensembl Gene Model ENSMUSG00000018914 (Evidence)
Entrez Gene 16187 (Evidence)
UniGene 983
DFCI TC1592156
DoTS DT.60102972
NIA Mouse Gene Index U032777
PDB 2L3O
Consensus CDS Project CCDS24693.1
International Mouse Phenotyping Consortium Status Il3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005664 VEGA Gene Model | MGI Sequence Detail 1975 C57BL/6J ±  kb
transcript OTTMUST00000012597 VEGA | MGI Sequence Detail 629 Not Applicable 
polypeptide OTTMUSP00000005831 VEGA | MGI Sequence Detail 166 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(3)
Polymorphisms
All PCR and RFLP(18) : PCR(2) RFLP(16) SNPs within 2kb(74 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012351 Four-helical cytokine, core
InterPro IPR009079 Four-helical cytokine-like, core
InterPro IPR002183 Interleukin-3
Protein Ontology PR:000001387 interleukin-3
References
(Earliest) J:14592 Ihle JN, et al., Procedures for the purification of interleukin 3 to homogeneity. J Immunol. 1982 Dec;129(6):2431-6
(Latest) J:215908 Happle C, et al., Pulmonary transplantation of macrophage progenitors as effective and long-lasting therapy for hereditary pulmonary alveolar proteinosis. Sci Transl Med. 2014 Aug 20;6(250):250ra113
All references(193)
Other
accession IDs
MGD-MRK-11354, MGD-MRK-11379, MGD-MRK-2193

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory