Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IKBKE
  • Mouse genes Ikbke
  • Rat genes Ikbke
  • Zfish genes ikbke
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ikbke

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	IKBKE	IPI	UniProtKB:Q14164	Human	PMID:24882218
Molecular Function	GO:0008384	IkappaB kinase activity	Ikbke	IDA		Mouse	PMID:10421793
Molecular Function	GO:0036435	K48-linked polyubiquitin modification-dependent protein binding	IKBKE	IMP	UniProtKB:Q9C030	Human	PMID:24882218
Molecular Function	GO:0036435	K48-linked polyubiquitin modification-dependent protein binding	Ikbke	IDA		Mouse	MGI:MGI:5645191|PMID:24882218
Molecular Function	GO:0004704	NF-kappaB-inducing kinase activity	IKBKE	IDA		Human	PMID:10882136
Molecular Function	GO:0005515	protein binding	IKBKE	IPI	UniProtKB:P08238	Human	PMID:14743216
Molecular Function	GO:0005515	protein binding	IKBKE	IPI	UniProtKB:Q16543	Human	PMID:14743216
Molecular Function	GO:0005515	protein binding	IKBKE	IPI	UniProtKB:Q7Z434	Human	PMID:16177806
Molecular Function	GO:0005515	protein binding	IKBKE	IPI	UniProtKB:O95786	Human	PMID:16281057
Molecular Function	GO:0005515	protein binding	IKBKE	IPI	UniProtKB:A7MCY6	Human	PMID:17568778
Molecular Function	GO:0005515	protein binding	IKBKE	IPI	UniProtKB:Q92844	Human	PMID:17568778
Molecular Function	GO:0005515	protein binding	IKBKE	IPI	UniProtKB:Q9UHD2	Human	PMID:17599067
Molecular Function	GO:0005515	protein binding	IKBKE	IPI	UniProtKB:Q9BYX4	Human	PMID:17600090
Molecular Function	GO:0005515	protein binding	IKBKE	IPI	UniProtKB:Q9NQC7	Human	PMID:18636086
Molecular Function	GO:0005515	protein binding	IKBKE	IPI	UniProtKB:O00571	Human	PMID:18636090
Molecular Function	GO:0005515	protein binding	IKBKE	IPI	UniProtKB:Q05127	Human	PMID:19153231
Molecular Function	GO:0005515	protein binding	IKBKE	IPI	UniProtKB:Q14653	Human	PMID:19153231
Molecular Function	GO:0005515	protein binding	IKBKE	IPI	UniProtKB:Q7Z434	Human	PMID:19153231
Molecular Function	GO:0005515	protein binding	IKBKE	IPI	UniProtKB:Q9NS56	Human	PMID:20188669
Molecular Function	GO:0005515	protein binding	IKBKE	IPI	UniProtKB:O00571	Human	PMID:20657822
Molecular Function	GO:0005515	protein binding	IKBKE	IPI	UniProtKB:Q92844	Human	PMID:21212807
Molecular Function	GO:0005515	protein binding	IKBKE	IPI	UniProtKB:A7MCY6	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	IKBKE	IPI	UniProtKB:Q16543	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	IKBKE	IPI	UniProtKB:Q7Z434	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	IKBKE	IPI	UniProtKB:Q9UHD2	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	IKBKE	IPI	UniProtKB:A7MCY6	Human	PMID:21931555
Molecular Function	GO:0005515	protein binding	IKBKE	IPI	UniProtKB:Q92844	Human	PMID:21931555
Molecular Function	GO:0005515	protein binding	IKBKE	IPI	UniProtKB:P08238	Human	PMID:22939624
Molecular Function	GO:0005515	protein binding	IKBKE	IPI	UniProtKB:K7Y1A2	Human	PMID:23096996
Molecular Function	GO:0005515	protein binding	IKBKE	IPI	UniProtKB:P27958:PRO_0000037572	Human	PMID:23096996
Molecular Function	GO:0005515	protein binding	IKBKE	IPI	UniProtKB:Q7Z434	Human	PMID:24706939
Molecular Function	GO:0005515	protein binding	IKBKE	IPI	UniProtKB:Q16543	Human	PMID:25036637
Molecular Function	GO:0005515	protein binding	IKBKE	IPI	UniProtKB:Q92624	Human	PMID:25852190
Molecular Function	GO:0005515	protein binding	IKBKE	IPI	UniProtKB:Q92844	Human	PMID:25852190
Molecular Function	GO:0005515	protein binding	IKBKE	IPI	UniProtKB:O00571	Human	PMID:27980081
Molecular Function	GO:0005515	protein binding	IKBKE	IPI	UniProtKB:Q13114	Human	PMID:27980081
Molecular Function	GO:0005515	protein binding	IKBKE	IPI	UniProtKB:Q14166	Human	PMID:28011935
Molecular Function	GO:0005515	protein binding	IKBKE	IPI	UniProtKB:Q7Z434	Human	PMID:28011935
Molecular Function	GO:0005515	protein binding	IKBKE	IPI	UniProtKB:Q9UHD2	Human	PMID:29251827
Molecular Function	GO:0005515	protein binding	IKBKE	IPI	UniProtKB:P09936	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Ikbke	IPI	UniProtKB:Q8N7N6	Mouse	PMID:21822257
Molecular Function	GO:0004672	protein kinase activity	Ikbke	IDA		Mouse	PMID:21822257
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IKBKE	IDA		Human	PMID:12692549
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IKBKE	EXP		Human	PMID:30420664
Molecular Function	GO:0031625	ubiquitin protein ligase binding	IKBKE	IPI	UniProtKB:Q9C030	Human	PMID:24882218
Molecular Function	GO:0031625	ubiquitin protein ligase binding	Ikbke	IPI	UniProtKB:Q8BGE7	Mouse	MGI:MGI:5645191|PMID:24882218
Cellular Component	GO:0005737	cytoplasm	IKBKE	IDA		Human	PMID:12692549
Cellular Component	GO:0005737	cytoplasm	IKBKE	IDA		Human	PMID:20188669
Cellular Component	GO:0005737	cytoplasm	IKBKE	IDA		Human	PMID:24882218
Cellular Component	GO:0031966	mitochondrial membrane	IKBKE	IMP		Human	PMID:16876765
Cellular Component	GO:0005634	nucleus	IKBKE	IDA		Human	PMID:20188669
Cellular Component	GO:0016605	PML body	IKBKE	IDA		Human	PMID:20188669
Biological Process	GO:0098586	cellular response to virus	Ikbke	IDA		Mouse	MGI:MGI:5645191|PMID:24882218
Biological Process	GO:0010467	gene expression	Ikbke	IMP	MGI:MGI:3707541	Mouse	PMID:21822257
Biological Process	GO:0007252	I-kappaB phosphorylation	Ikbke	IDA		Mouse	MGI:MGI:1928258|PMID:10421793
Biological Process	GO:0006955	immune response	Ikbke	IMP	MGI:MGI:3707541	Mouse	PMID:21822257
Biological Process	GO:0097400	interleukin-17-mediated signaling pathway	Ikbke	IDA		Mouse	PMID:21822257
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	IKBKE	IMP		Human	PMID:20188669
Biological Process	GO:0048255	mRNA stabilization	Ikbke	IMP	MGI:MGI:3707541	Mouse	PMID:21822257
Biological Process	GO:0018105	peptidyl-serine phosphorylation	Ikbke	IDA		Mouse	PMID:21822257
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	IKBKE	IMP		Human	PMID:26934326
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IKBKE	IEP		Human	PMID:12761501
Biological Process	GO:0010884	positive regulation of lipid storage	Ikbke	IMP		Mouse	MGI:MGI:5517507|PMID:23741427
Biological Process	GO:0032481	positive regulation of type I interferon production	IKBKE	IDA		Human	PMID:12692549
Biological Process	GO:0060340	positive regulation of type I interferon-mediated signaling pathway	IKBKE	IDA		Human	PMID:24882218
Biological Process	GO:0060340	positive regulation of type I interferon-mediated signaling pathway	Ikbke	IMP		Mouse	MGI:MGI:5792628|PMID:27129230
Biological Process	GO:0006468	protein phosphorylation	IKBKE	IDA		Human	PMID:10882136
Biological Process	GO:0006468	protein phosphorylation	IKBKE	IDA		Human	PMID:20188669
Biological Process	GO:0006468	protein phosphorylation	IKBKE	IDA		Human	PMID:24882218
Biological Process	GO:0043254	regulation of protein-containing complex assembly	Ikbke	IMP	MGI:MGI:3707541	Mouse	PMID:21822257
Biological Process	GO:0035456	response to interferon-beta	IKBKE	IMP		Human	PMID:24882218
Biological Process	GO:0034340	response to type I interferon	Ikbke	IDA		Mouse	MGI:MGI:5645191|PMID:24882218

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern