| GO term: | IkappaB kinase activity |
| Synonym: | ATP:IkappaB protein phosphotransferase activity |
| Synonym: | CHUK |
| Synonym: | ikappaB kinase activity |
| Synonym: | IKBKA |
| Synonym: | IKBKB |
| Synonym: | IKK |
| Synonym: | IKK-1 |
| Synonym: | IKK-2 |
| Synonym: | inhibitor of NF-kappaB kinase activity |
| Synonym: | inhibitor of NFkappaB kinase activity |
| Synonym: | STK12 |
| Synonym: | TANK-binding kinase 1 activity |
| Synonym: | TBK1 |
| GO id: | GO:0008384 |
| Definition: | Catalysis of the reaction: ATP + IkappaB protein = ADP + IkappaB phosphoprotein. |
| Comments | Note that phosphorylation of IkappaB targets it for proteasomal degradation and allows the nuclear translocation of kB. |
| Number of paths to term: | 2 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship
molecular_functioncatalytic activitytransferase activitytransferase activity, transferring phosphorus-containing groupskinase activityprotein kinase activityprotein serine/threonine kinase activity3-phosphoinositide-dependent protein kinase activityAMP-activated protein kinase activitycalcium-dependent protein serine/threonine kinase activity +calmodulin-dependent protein kinase activity +cyclic nucleotide-dependent protein kinase activity +cyclin-dependent protein serine/threonine kinase activityDNA-dependent protein kinase activityeukaryotic translation initiation factor 2alpha kinase activityFas-activated serine/threonine kinase activityG-protein coupled receptor kinase activityGoodpasture-antigen-binding protein kinase activityGTP-dependent protein kinase activityhistone serine kinase activity +histone threonine kinase activity +IkappaB kinase activity [GO:0008384] (3 genes, 3 annotations)myosin light chain kinase activityprotein kinase C activity +receptor signaling protein serine/threonine kinase activity +Rho-dependent protein serine/threonine kinase activityribosomal protein S6 kinase activityRNA polymerase II carboxy-terminal domain kinase activitytransmembrane receptor protein serine/threonine kinase activity +molecular_functioncatalytic activitytransferase activitytransferase activity, transferring phosphorus-containing groupsphosphotransferase activity, alcohol group as acceptorprotein kinase activityprotein serine/threonine kinase activity3-phosphoinositide-dependent protein kinase activityAMP-activated protein kinase activitycalcium-dependent protein serine/threonine kinase activity +calmodulin-dependent protein kinase activity +cyclic nucleotide-dependent protein kinase activity +cyclin-dependent protein serine/threonine kinase activityDNA-dependent protein kinase activityeukaryotic translation initiation factor 2alpha kinase activityFas-activated serine/threonine kinase activityG-protein coupled receptor kinase activityGoodpasture-antigen-binding protein kinase activityGTP-dependent protein kinase activityhistone serine kinase activity +histone threonine kinase activity +IkappaB kinase activity [GO:0008384] (3 genes, 3 annotations)myosin light chain kinase activityprotein kinase C activity +receptor signaling protein serine/threonine kinase activity +Rho-dependent protein serine/threonine kinase activityribosomal protein S6 kinase activityRNA polymerase II carboxy-terminal domain kinase activitytransmembrane receptor protein serine/threonine kinase activity +Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 05/08/2013 MGI 5.13 |
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