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Ikbke
Gene Detail
 Symbol
Name
ID
Ikbke
inhibitor of kappaB kinase epsilon
MGI:1929612
Synonyms IKKepsilon, IKK-i
Feature Type protein coding gene
Genetic Map
Chromosome 1
56.93 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:131254343-131279606 bp, - strand
From VEGA annotation of GRCm38

  25264 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23168  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: inhibitor of nuclear factor kappa-B kinase subunit epsilon
Gene Tree: Ikbke

Human
homologs
Human Homolog IKBKE, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
NCBI Gene ID 9641
neXtProt AC  NX_Q14164
Human Synonyms  IKKE, IKK-E, IKK-i, IKKI
Human Chr (Location)  1q32.1; chr1:206470243-206496890 (+)  GRCh38
Alleles
and
phenotypes
All alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice are viable and fertile.
 
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process cellular response to DNA damage stimulus, I-kappaB phosphorylation, ...
Component cytoplasm, nucleus, ...
Function ATP binding, IkappaB kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (76)    Tissues (24)    Images (20)
Theiler Stages: 23
Assay TypeResults
RNA in situ 76
cDNA source data(32)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(33) cDNA(32) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000034782 (Evidence)
Ensembl Gene ModelENSMUSG00000042349 (Evidence)
Entrez Gene56489 (Evidence)
UniGene386783
DFCITC1579603
DoTSDT.40159067, DT.490579, DT.91434064
NIA Mouse Gene IndexU021750
EC2.7.11.10
Consensus CDS ProjectCCDS15269.1
International Mouse Knockout Project StatusIkbke
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034782 VEGA Gene Model | MGI Sequence Detail 25264 C57BL/6J ±  kb
transcript OTTMUST00000088400 VEGA | MGI Sequence Detail 3251 Not Applicable 
polypeptide OTTMUSP00000048170 VEGA | MGI Sequence Detail 717 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(11) UniProt(6)
Polymorphisms SNPs within 2kb(240 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
Protein Ontology PR:000001778 inhibitor of nuclear factor kappa-b kinase subunit epsilon
References (Earliest) J:66314 Shimada T, et al., IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases. Int Immunol. 1999 Aug;11(8):1357-62
(Latest) J:209894 Everts B, et al., TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKvarepsilon supports the anabolic demands of dendritic cell activation. Nat Immunol. 2014 Apr;15(4):323-32
All references(59)
Other
accession IDs
MGI:2138621

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory