Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IAPP
  • Mouse genes Iapp
  • Rat genes Iapp
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Iapp

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	IAPP	IPI	UniProtKB:P10997	Human	PMID:17640888
Molecular Function	GO:0042802	identical protein binding	IAPP	IPI	UniProtKB:P10997	Human	PMID:18408164
Molecular Function	GO:0042802	identical protein binding	IAPP	IPI	UniProtKB:P10997	Human	PMID:21130765
Molecular Function	GO:0042802	identical protein binding	IAPP	IPI	UniProtKB:P10997	Human	PMID:24042052
Molecular Function	GO:0042802	identical protein binding	IAPP	IPI	UniProtKB:P10997	Human	PMID:24561193
Molecular Function	GO:0042802	identical protein binding	IAPP	IPI	UniProtKB:P10997	Human	PMID:26840340
Molecular Function	GO:0042802	identical protein binding	IAPP	IPI	UniProtKB:P10997	Human	PMID:32541895
Molecular Function	GO:0008289	lipid binding	IAPP	EXP		Human	PMID:32077246
Molecular Function	GO:0005515	protein binding	IAPP	IPI	UniProtKB:P14735-1	Human	PMID:17051221
Molecular Function	GO:0005515	protein binding	IAPP	IPI	UniProtKB:P56817	Human	PMID:26840340
Molecular Function	GO:0005515	protein binding	IAPP	IPI	UniProtKB:Q9Y5Z0	Human	PMID:26840340
Cellular Component	GO:0005615	extracellular space	Iapp	IDA		Mouse	PMID:17693256
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	Iapp	IGI	ComplexPortal:CPX-2173|UniProtKB:O60894,UniProtKB:P30988	Rat	PMID:22500019|RGD:12907560
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	Iapp	IGI	ComplexPortal:CPX-3186|UniProtKB:O60895,UniProtKB:P30988	Rat	PMID:22500019|RGD:12907560
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	Iapp	IGI	ComplexPortal:CPX-3187|UniProtKB:O60896,UniProtKB:P30988	Rat	PMID:22500019|RGD:12907560
Biological Process	GO:0097647	amylin receptor signaling pathway	Iapp	IGI	ComplexPortal:CPX-2173	Rat	PMID:22500019|RGD:12907560
Biological Process	GO:0097647	amylin receptor signaling pathway	Iapp	IGI	ComplexPortal:CPX-3186	Rat	PMID:22500019|RGD:12907560
Biological Process	GO:0097647	amylin receptor signaling pathway	Iapp	IGI	UniProtKB:O60894,UniProtKB:P30988	Rat	PMID:22500019|RGD:12907560
Biological Process	GO:0097647	amylin receptor signaling pathway	Iapp	IGI	UniProtKB:O60895,UniProtKB:P30988	Rat	PMID:22500019|RGD:12907560
Biological Process	GO:0045453	bone resorption	Iapp	IMP	MGI:MGI:2656235	Mouse	PMID:14970190
Biological Process	GO:0042755	eating behavior	Iapp	IMP		Rat	PMID:15130879|RGD:1625223
Biological Process	GO:0045779	negative regulation of bone resorption	Iapp	IMP	MGI:MGI:2656235	Mouse	PMID:14970190
Biological Process	GO:0045671	negative regulation of osteoclast differentiation	Iapp	IMP	MGI:MGI:2656235	Mouse	PMID:14970190
Biological Process	GO:0045671	negative regulation of osteoclast differentiation	Iapp	IGI	MGI:MGI:1346858	Mouse	PMID:14970190
Biological Process	GO:0030316	osteoclast differentiation	Iapp	IMP	MGI:MGI:2656235	Mouse	PMID:14970190
Biological Process	GO:0030316	osteoclast differentiation	Iapp	IGI	MGI:MGI:1346858	Mouse	PMID:14970190
Biological Process	GO:0019233	sensory perception of pain	Iapp	IMP	MGI:MGI:2656235	Mouse	PMID:9838101

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern