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Iapp
Gene Detail
 Symbol
Name
ID
Iapp
islet amyloid polypeptide
MGI:96382
Synonyms amylin
Feature Type protein coding gene
Genetic Map
Chromosome 6
73.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr6:142298423-142303961 bp, + strand
From VEGA annotation of GRCm38

  5539 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:36024  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

Protein SuperFamily: calcitonin/calcitonin gene-related protein/amylin
Gene Tree: Iapp

Human
homologs
Human Homolog IAPP, islet amyloid polypeptide
NCBI Gene ID 3375
neXtProt AC  NX_P10997
Human Synonyms  DAP, IAP
Human Chr (Location)  12p12.1; chr12:21372868-21379980 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(2) Targeted(3)
Incidental mutations (data from APF )
 
Homozygous inactivation of this locus increases glucose tolerance in a gender-dependent manner and results in decreased bone density due to increased bone resorption.
 
Interactions
Iapp interacts with 53 markers (Mir33, Mir142, Mir181b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process eating behavior, negative regulation of bone resorption, ...
Component extracellular region, extracellular space, ...
Function hormone activity, identical protein binding
External Resources: FuncBase
Expression
Literature Summary: (19 records)
Data Summary: Results (13)    Tissues (8)    Images (7)
Theiler Stages: 18, 20, 21, 22, 23, 24
Assay TypeResults
RNA in situ 7
RT-PCR 6
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) Genomic(1) cDNA(10) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000024215 (Evidence)
Ensembl Gene ModelENSMUSG00000041681 (Evidence)
Entrez Gene15874 (Evidence)
UniGene415
DFCITC1571965, TC1681510
DoTSDT.101263651, DT.40158173
NIA Mouse Gene IndexU007537
Consensus CDS ProjectCCDS39694.1
International Mouse Knockout Project StatusIapp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024215 VEGA Gene Model | MGI Sequence Detail 5539 C57BL/6J ±  kb
transcript OTTMUST00000059257 VEGA | MGI Sequence Detail 839 Not Applicable 
polypeptide OTTMUSP00000028810 VEGA | MGI Sequence Detail 93 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(1)
Polymorphisms RFLP(2) : SNPs within 2kb(114 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018360 Calcitonin, conserved site
InterPro IPR001693 Calcitonin peptide-like
InterPro IPR021116 Procalcitonin/adrenomedullin
InterPro IPR021117 Procalcitonin-like
InterPro IPR000443 Pro-islet amyloid polypeptide
Protein Ontology PR:000008875 islet amyloid polypeptide
References (Earliest) J:9937 Nishi M, et al., Conservation of the sequence of islet amyloid polypeptide in five mammals is consistent with its putative role as an islet hormone. Proc Natl Acad Sci U S A. 1989 Aug;86(15):5738-42
(Latest) J:206266 Baker RL, et al., Cutting edge: CD4 T cells reactive to an islet amyloid polypeptide peptide accumulate in the pancreas and contribute to disease pathogenesis in nonobese diabetic mice. J Immunol. 2013 Oct 15;191(8):3990-4
All references(73)
Other
accession IDs
MGD-MRK-11135

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory