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Iapp
Gene Detail
Symbol

Name
ID
Iapp
islet amyloid polypeptide
MGI:96382
Synonyms
amylin
Feature Type
protein coding gene
Genetic Map
Chromosome 6
73.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr6:142298423-142303961 bp, + strand
From VEGA annotation of GRCm38

  5539 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:36024  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

HCOP human homology predictions: IAPP
Protein SuperFamily: calcitonin/calcitonin gene-related protein/amylin
Gene Tree: Iapp

Human
homologs
IAPP, islet amyloid polypeptide
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 3375
neXtProt AC: NX_P10997

Human Synonyms: DAP, IAP

Human Chr (Location): 12p12.1; chr12:21372868-21379980 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(2) Targeted(3) Transgenic(1)
Incidental mutations (data from APF )
 
Homozygous inactivation of this locus increases glucose tolerance in a gender-dependent manner and results in decreased bone density due to increased bone resorption.
 
Interactions
Iapp interacts with 53 markers (Mir33, Mir142, Mir181b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process eating behavior, negative regulation of bone resorption, ...
Component extracellular region, extracellular space, ...
Function hormone activity, identical protein binding
External Resources: FuncBase
Expression
Literature Summary: (19 records)
Data Summary: Results (13)    Tissues (8)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 7
RT-PCR 6
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) Genomic(1) cDNA(10) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000024215 (Evidence)
Ensembl Gene Model ENSMUSG00000041681 (Evidence)
Entrez Gene 15874 (Evidence)
UniGene 415
DFCI TC1571965, TC1681510
DoTS DT.101263651, DT.40158173
NIA Mouse Gene Index U007537
Consensus CDS Project CCDS39694.1
International Mouse Phenotyping Consortium Status Iapp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024215 VEGA Gene Model | MGI Sequence Detail 5539 C57BL/6J ±  kb
transcript OTTMUST00000059257 VEGA | MGI Sequence Detail 839 Not Applicable 
polypeptide OTTMUSP00000028810 VEGA | MGI Sequence Detail 93 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(1)
Polymorphisms
RFLP(2) : SNPs within 2kb(114 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018360 Calcitonin, conserved site
InterPro IPR001693 Calcitonin peptide-like
InterPro IPR021116 Procalcitonin/adrenomedullin
InterPro IPR021117 Procalcitonin-like
InterPro IPR000443 Pro-islet amyloid polypeptide
Protein Ontology PR:000008875 islet amyloid polypeptide
References
(Earliest) J:9937 Nishi M, et al., Conservation of the sequence of islet amyloid polypeptide in five mammals is consistent with its putative role as an islet hormone. Proc Natl Acad Sci U S A. 1989 Aug;86(15):5738-42
(Latest) J:220250 Oskarsson ME, et al., In vivo seeding and cross-seeding of localized amyloidosis: a molecular link between type 2 diabetes and Alzheimer disease. Am J Pathol. 2015 Mar;185(3):834-46
All references(73)
Other
accession IDs
MGD-MRK-11135

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory