Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Htr2a

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes HTR2A
- Mouse genes Htr2a
- Rat genes Htr2a
- Zfish genes htr2aa,htr2ab
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Htr2a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0071886	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding	HTR2A	IDA		Human	PMID:19057895
Molecular Function	GO:0004993	G protein-coupled serotonin receptor activity	HTR2A	IDA		Human	PMID:15862800
Molecular Function	GO:0004993	G protein-coupled serotonin receptor activity	HTR2A	IDA		Human	PMID:7582481
Molecular Function	GO:0001587	Gq/11-coupled serotonin receptor activity	HTR2A	IDA		Human	PMID:18703043
Molecular Function	GO:0042802	identical protein binding	HTR2A	IPI	UniProtKB:P28223	Human	PMID:19279328
Molecular Function	GO:0042802	identical protein binding	HTR2A	IPI	UniProtKB:P28223	Human	PMID:28258217
Molecular Function	GO:0005515	protein binding	HTR2A	IPI	UniProtKB:O88910	Human	PMID:14988405
Molecular Function	GO:0005515	protein binding	HTR2A	IPI	UniProtKB:P28335	Human	PMID:28258217
Molecular Function	GO:0005515	protein binding	HTR2A	IPI	UniProtKB:P41595	Human	PMID:28258217
Molecular Function	GO:0005515	protein binding	HTR2A	IPI	UniProtKB:P28335	Human	PMID:30157263
Molecular Function	GO:0005515	protein binding	Htr2a	IPI	UniProtKB:P31421	Rat	PMID:19590495\|RGD:8553550
Molecular Function	GO:0005515	protein binding	Htr2a	IPI	RGD:2505\|RGD:68424	Rat	PMID:20531396\|RGD:7257680
Molecular Function	GO:0044877	protein-containing complex binding	Htr2a	IPI	RGD:2280\|RGD:2953	Rat	PMID:16527989\|RGD:1582161
Molecular Function	GO:0051378	serotonin binding	HTR2A	IDA		Human	PMID:15831837
Molecular Function	GO:0051378	serotonin binding	HTR2A	IDA		Human	PMID:15862800
Molecular Function	GO:0051378	serotonin binding	HTR2A	IDA		Human	PMID:18703043
Molecular Function	GO:0051378	serotonin binding	HTR2A	IDA		Human	PMID:19057895
Molecular Function	GO:0051378	serotonin binding	HTR2A	IDA		Human	PMID:7582481
Cellular Component	GO:0070852	cell body fiber	Htr2a	IDA		Rat	PMID:23390419\|RGD:7257659
Cellular Component	GO:0005737	cytoplasm	Htr2a	IDA		Rat	PMID:10379914\|RGD:1624400
Cellular Component	GO:0005829	cytosol	Htr2a	IDA		Rat	PMID:14534355\|RGD:1601365
Cellular Component	GO:0030425	dendrite	Htr2a	IDA		Rat	PMID:10524335\|RGD:1624398
Cellular Component	GO:0043198	dendritic shaft	Htr2a	IDA		Rat	PMID:18622042\|RGD:2303638
Cellular Component	GO:0098666	G protein-coupled serotonin receptor complex	HTR2A	IDA		Human	PMID:18703043
Cellular Component	GO:0098978	glutamatergic synapse	Htr2a	EXP		Rat	PMID:12196574\|RGD:13702246
Cellular Component	GO:0098978	glutamatergic synapse	Htr2a	IDA		Rat	PMID:12196574\|RGD:13702246
Cellular Component	GO:0043025	neuronal cell body	Htr2a	IDA		Rat	PMID:23390419\|RGD:7257659
Cellular Component	GO:0005886	plasma membrane	HTR2A	IDA		Human	PMID:15862800
Cellular Component	GO:0005886	plasma membrane	HTR2A	IDA		Human	PMID:18703043
Cellular Component	GO:0005886	plasma membrane	Htr2a	IDA		Rat	PMID:14534355\|RGD:1601365
Cellular Component	GO:0045211	postsynaptic membrane	Htr2a	IDA		Rat	PMID:12535944\|RGD:13702151
Cellular Component	GO:0042734	presynaptic membrane	Htr2a	IDA		Rat	PMID:12535944\|RGD:13702151
Biological Process	GO:0007202	activation of phospholipase C activity	HTR2A	IDA		Human	PMID:16517693
Biological Process	GO:0007568	aging	Htr2a	IEP		Rat	PMID:17374516\|RGD:1624378
Biological Process	GO:0014824	artery smooth muscle contraction	Htr2a	IMP		Rat	PMID:14752059\|RGD:7257678
Biological Process	GO:0048148	behavioral response to cocaine	Htr2a	IDA		Rat	PMID:23390419\|RGD:7257659
Biological Process	GO:0008219	cell death	Htr2a	IMP		Rat	PMID:16504407\|RGD:1624391
Biological Process	GO:0071679	commissural neuron axon guidance	htr2ab	IMP	ZFIN:ZDB-CRISPR-170425-2	Zfish	PMID:26538650
Biological Process	GO:0050966	detection of mechanical stimulus involved in sensory perception of pain	Htr2a	IMP		Rat	PMID:20531396\|RGD:7257680
Biological Process	GO:0050965	detection of temperature stimulus involved in sensory perception of pain	Htr2a	IMP		Rat	PMID:20531396\|RGD:7257680
Biological Process	GO:0098664	G protein-coupled serotonin receptor signaling pathway	HTR2A	IDA		Human	PMID:18703043
Biological Process	GO:0098664	G protein-coupled serotonin receptor signaling pathway	HTR2A	IMP		Human	PMID:18703043
Biological Process	GO:0006096	glycolytic process	Htr2a	IMP		Mouse	PMID:17408640
Biological Process	GO:0006874	intracellular calcium ion homeostasis	HTR2A	IDA		Human	PMID:16517693
Biological Process	GO:0006874	intracellular calcium ion homeostasis	HTR2A	IDA		Human	PMID:19057895
Biological Process	GO:0007613	memory	Htr2a	IMP		Rat	PMID:16149040\|RGD:1624394
Biological Process	GO:0043267	negative regulation of potassium ion transport	Htr2a	IMP		Rat	PMID:16527989\|RGD:1582161
Biological Process	GO:0051967	negative regulation of synaptic transmission, glutamatergic	Htr2a	IMP		Rat	PMID:17016851\|RGD:1624386
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	Htr2a	IMP		Mouse	PMID:17720578
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	HTR2A	IDA		Human	PMID:16517693
Biological Process	GO:0007208	phospholipase C-activating serotonin receptor signaling pathway	Htr2a	IDA		Rat	PMID:17010161\|RGD:1624387
Biological Process	GO:0008284	positive regulation of cell population proliferation	Htr2a	IMP		Rat	PMID:15087293\|RGD:1624373
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	Htr2a	IMP		Rat	PMID:20531396\|RGD:7257680
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	HTR2A	IDA		Human	PMID:19057895
Biological Process	GO:0045600	positive regulation of fat cell differentiation	Htr2a	IMP		Mouse	PMID:20719859
Biological Process	GO:0045821	positive regulation of glycolytic process	Htr2a	IMP		Mouse	PMID:17408640
Biological Process	GO:0033674	positive regulation of kinase activity	Htr2a	IMP		Mouse	PMID:17720578
Biological Process	GO:0043406	positive regulation of MAP kinase activity	Htr2a	IMP		Rat	PMID:15087293\|RGD:1624373
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	Htr2a	IMP		Mouse	PMID:17720578
Biological Process	GO:0010513	positive regulation of phosphatidylinositol biosynthetic process	HTR2A	IDA		Human	PMID:19057895
Biological Process	GO:0045907	positive regulation of vasoconstriction	Htr2a	IMP		Rat	PMID:16527989\|RGD:1582161
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	Htr2a	EXP		Rat	PMID:12196574\|RGD:13702246
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	Htr2a	IDA		Rat	PMID:12196574\|RGD:13702246
Biological Process	GO:0044380	protein localization to cytoskeleton	Htr2a	IDA		Mouse	PMID:17720578
Biological Process	GO:0014059	regulation of dopamine secretion	Htr2a	IMP		Rat	PMID:15999145\|RGD:1624397
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	HTR2A	IDA		Human	PMID:15862800
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	HTR2A	IMP		Human	PMID:18703043
Biological Process	GO:0009410	response to xenobiotic stimulus	HTR2A	IDA		Human	PMID:15862800
Biological Process	GO:0009410	response to xenobiotic stimulus	Htr2a	IMP		Rat	PMID:17077317\|RGD:1624381
Biological Process	GO:0019233	sensory perception of pain	Htr2a	IMP		Rat	PMID:16527395\|RGD:1624390
Biological Process	GO:0030431	sleep	Htr2a	IMP		Rat	PMID:17059817\|RGD:1624384
Biological Process	GO:0001659	temperature homeostasis	Htr2a	IMP		Rat	PMID:17067560\|RGD:1624383
Biological Process	GO:0014832	urinary bladder smooth muscle contraction	Htr2a	IMP		Rat	PMID:23274492\|RGD:7257664

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/07/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.