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Htr2a Gene Detail
Summary
  • Symbol
    Htr2a
  • Name
    5-hydroxytryptamine (serotonin) receptor 2A
  • Synonyms
    5-HT2A receptor, Htr2, Htr-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:109521
    NCBI Gene: 15558
  • Gene Overview
    MyGene.info: HTR2A
Location & Maps
more
  • Sequence Map
    Chr14:74640840-74706859 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      66020 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 39.37 cM
  • Mapping Data
    9 experiments
Homology
more
  • Human Ortholog
    HTR2A, 5-hydroxytryptamine receptor 2A
  • Vertebrate Orthologs
    11
  • Human Ortholog
    HTR2A, 5-hydroxytryptamine receptor 2A
    Orthology source: HomoloGene
  • Synonyms
    5-HT2A, HTR2
  • Links
    NCBI Gene ID: 3356
    neXtProt AC: NX_P28223

  • Chr Location
    13q14-q21; chr13:46831542-46897076 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    5 with human HTR2A associations

Human Disease Mouse Models
       Alcohol Dependence   OMIM: 103780
Anorexia Nervosa, Susceptibility to, 1; ANON1   OMIM: 606788
Major Depressive Disorder; MDD   OMIM: 608516
Obsessive-Compulsive Disorder; OCD   OMIM: 164230
Schizophrenia; SCZD   OMIM: 181500
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 3 alleles in 5 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Targeted
    6
  • Genomic Mutations
    1 involving Htr2a
  • Incidental Mutations
Mice homozygous for a knock-out allele show altered anxiety-related responses and increased vertical activity. Mice homozygous for a different knock-out allele exhibit abnormal enterocyte, Paneth cell and smooth muscle morphology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 15558 NCBI Gene Model | MGI Sequence Detail 66020 C57BL/6J ±  kb
transcript NM_172812 RefSeq | MGI Sequence Detail 2971 C57BL/6  
polypeptide P35363 UniProt | EBI | MGI Sequence Detail 471 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    390 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000001166 5-hydroxytryptamine receptor 2A
  • InterPro Domains
    IPR000455 5-Hydroxytryptamine 2A receptor
    IPR002231 5-hydroxytryptamine receptor family
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
Molecular
Reagents
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  • All nucleic 27
    Genomic 13
    cDNA 11
    Primer pair 3

    Microarray probesets 1
Other
Accession IDs
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MGD-MRK-10998, MGD-MRK-11007, MGD-MRK-39520
References
more
  • Summaries
    All 72
    Developmental Gene Expression 10
    Gene Ontology 8
    Phenotypes 17
  • Earliest
    J:3246 Liu J, et al., The 5-HT2 serotonin receptor gene Htr-2 is tightly linked to Es-10 on mouse chromosome 14. Genomics. 1991 Sep;11(1):231-4
  • Latest
    J:227794 Nau F Jr, et al., Serotonin 5-HT(2) receptor activation prevents allergic asthma in a mouse model. Am J Physiol Lung Cell Mol Physiol. 2015 Jan 15;308(2):L191-8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory