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Htr2a
Gene Detail
Symbol

Name
ID
Htr2a
5-hydroxytryptamine (serotonin) receptor 2A
MGI:109521
Synonyms
5-HT2A receptor, Htr2, Htr-2
Feature Type
protein coding gene
Genetic Map
Chromosome 14
39.37 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr14:74640840-74706859 bp, + strand
From NCBI annotation of GRCm38

  66020 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68073  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: HTR2A
Protein SuperFamily: 5-hydroxytryptamine receptor 2
Gene Tree: Htr2a

Human
homologs
HTR2A, 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3356
neXtProt AC: NX_P28223

Human Synonyms: 5-HT2A, HTR2

Human Chr (Location): 13q14-q21; chr13:46831542-46897076 (-)  GRCh38.p2

Disease Associations: (5) Diseases Associated with Human HTR2A

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele show altered anxiety-related responses and increased vertical activity. Mice homozygous for a different knock-out allele exhibit abnormal enterocyte, Paneth cell and smooth muscle morphology.
 
Interactions
Htr2a interacts with 116 markers (Mir7-2, Mir7b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (10 records)
Data Summary: Results (116)    Tissues (72)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 37
RT-PCR 79
cDNA source data(9)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase htr2a    NEW 
Molecular
reagents
All nucleic(27) Genomic(13) cDNA(11) Primer pair(3)
Microarray probesets(1)
Other database
links
Ensembl Gene Model ENSMUSG00000034997 (Evidence)
Entrez Gene 15558 (Evidence)
UniGene 214351
DFCI TC1587888
DoTS DT.91421257
NIA Mouse Gene Index U015850
Consensus CDS Project CCDS27275.1
International Mouse Phenotyping Consortium Status Htr2a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 15558 NCBI Gene Model | MGI Sequence Detail 66020 C57BL/6J ±  kb
transcript NM_172812 RefSeq | MGI Sequence Detail 2971 C57BL/6 
polypeptide P35363 UniProt | EBI | MGI Sequence Detail 471 Not Applicable 

For the selected sequences
All sequences(15) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(2) : SNPs within 2kb(393 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000455 5-Hydroxytryptamine 2A receptor
InterPro IPR002231 5-Hydroxytryptamine receptor family
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001166 5-hydroxytryptamine receptor 2A
Graphical View of Protein Domain Structure
References
(Earliest) J:3246 Liu J, et al., The 5-HT2 serotonin receptor gene Htr-2 is tightly linked to Es-10 on mouse chromosome 14. Genomics. 1991 Sep;11(1):231-4
(Latest) J:205103 Bulley S, et al., Taurine activates delayed rectifier Kv channels via a metabotropic pathway in retinal neurons. J Physiol. 2013 Jan 1;591(Pt 1):123-32
All references(74)
Other
accession IDs
MGD-MRK-10998, MGD-MRK-11007, MGD-MRK-39520

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory