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Htr2a Gene Detail
Summary
  • Symbol
    Htr2a
  • Name
    5-hydroxytryptamine (serotonin) receptor 2A
  • Synonyms
    5-HT2A receptor, Htr2, Htr-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:109521
    NCBI Gene: 15558
  • Gene Overview
    MyGene.info: HTR2A
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr14:74640840-74706859 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      66020 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 39.37 cM
  • Mapping Data
    9 experiments
Homology
more
  • Human Ortholog
    HTR2A, 5-hydroxytryptamine receptor 2A
  • Vertebrate Orthologs
    11
  • Human Ortholog
    HTR2A, 5-hydroxytryptamine receptor 2A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    5-HT2A, HTR2
  • Links
    NCBI Gene ID: 3356
    neXtProt AC: NX_P28223
    UniProt: P28223

  • Chr Location
    13q14.2; chr13:46831542-46897076 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    3 with human HTR2A associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 3 alleles in 5 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show altered anxiety-related responses and increased vertical activity. Mice homozygous for a different knock-out allele exhibit abnormal enterocyte, Paneth cell and smooth muscle morphology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15558 NCBI Gene Model | MGI Sequence Detail 66020 C57BL/6J ±  kb
    transcript NM_172812 RefSeq | MGI Sequence Detail 2937 C57BL/6  
    polypeptide P35363 UniProt | EBI | MGI Sequence Detail 471 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      390 from dbSNP Build 142
    • RFLP
    Protein
    Information
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    Molecular
    Reagents
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    • All nucleic 30
      Genomic 13
      cDNA 13
      Primer pair 3
      Other 1

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGD-MRK-10998, MGD-MRK-11007, MGD-MRK-39520
    References
    more
    • Summaries
      All 103
      Developmental Gene Expression 13
      Gene Ontology 9
      Phenotypes 22
    • Earliest
      J:10923 Hsieh CL, et al., The serotonin receptor subtype 2 locus HTR2 is on human chromosome 13 near genes for esterase D and retinoblastoma-1 and on mouse chromosome 14. Somat Cell Mol Genet. 1990 Nov;16(6):567-74
    • Latest
      J:258028 Ibi D, et al., Antipsychotic-induced Hdac2 transcription via NF-kappaB leads to synaptic and cognitive side effects. Nat Neurosci. 2017 Sep;20(9):1247-1259

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory