Htr2a
Gene Detail

Symbol Name ID

Htr2a 5-hydroxytryptamine (serotonin) receptor 2A MGI:109521

Synonyms

5-HT2A receptor, Htr2, Htr-2

Feature Type

protein coding gene

Genetic Map

Chromosome 14

39.37 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)

Sequence Map

Chr14:74640840-74706859 bp, + strand From NCBI annotation of GRCm38   66020 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic; hamster, Chinese    (Mammalian Orthology)
Comparative Map (Mouse/Human Htr2a ± 2 cM)

Protein SuperFamily: 5-hydroxytryptamine receptor 2
Gene Tree: Htr2a

Human ortholog

HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled NCBI Gene ID 3356
Human Synonyms: 5-HT2A, HTR2
Human Chr13:47407513-47471169 bp, - strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human HTR2A (5)

Alleles and phenotypes

All alleles(6) : Targeted(6)
 

Mice homozygous for a knock-out allele show altered anxiety-related responses and increased vertical activity. Mice homozygous for a different knock-out allele exhibit abnormal enterocyte, Paneth cell and smooth muscle morphology.

 

Gene Ontology (GO) classifications

All GO classifications: (54 annotations)

Process	behavior, calcium ion transport into cytosol, ...
Component	cytoplasm, cytosol, ...
Function	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding, drug binding, ...

External Resources: FuncBase

Expression

Literature Summary: (9 records)
Data Summary: Results (116)    Tissues (71)    Images (15)
Theiler Stages: 12, 14, 16, 19, 21, 23, 26, 28

Assay Type	Results
RNA in situ	37
RT-PCR	79

cDNA source data(9)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(27) Genomic(13) cDNA(11) Primer pair(3)
Microarray probesets(1)

Other database links

Ensembl Gene Model	ENSMUSG00000034997 (Evidence)
Entrez Gene	15558 (Evidence)
UniGene	214351
DFCI	TC1587888
DoTS	DT.91421257
NIA Mouse Gene Index	U015850
Consensus CDS Project	CCDS27275.1
International Mouse Knockout Project Status	Htr2a

Sequences

Length	Strain/Species
genomic	15558	NCBI Gene Model | MGI Sequence Detail	66020	C57BL/6J
transcript	NM_172812	RefSeq | MGI Sequence Detail	2971	C57BL/6
polypeptide	P35363	UniProt | EBI | MGI Sequence Detail	471	Not Applicable

All sequences(15) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(2) : SNPs(318 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000455	5-Hydroxytryptamine 2A receptor
InterPro	IPR002231	5-Hydroxytryptamine receptor
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
Protein Ontology	PR:000001166	5-hydroxytryptamine receptor 2A

Graphical View of Protein Domain Structure

References

(Earliest) J:10923 Hsieh CL, et al., The serotonin receptor subtype 2 locus HTR2 is on human chromosome 13 near genes for esterase D and retinoblastoma-1 and on mouse chromosome 14. Somat Cell Mol Genet. 1990 Nov;16(6):567-74
(Latest) J:193789 Li Q, et al., Activation of Akt through 5-HT2A receptor ameliorates serotonin-induced degradation of insulin receptor substrate-1 in adipocytes. Mol Cell Endocrinol. 2013 Jan 5;365(1):25-35
All references(76)

Other accession IDs

MGD-MRK-10998, MGD-MRK-11007, MGD-MRK-39520