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Htr2a
Gene Detail
 Symbol
Name
ID
Htr2a
5-hydroxytryptamine (serotonin) receptor 2A
MGI:109521
Synonyms 5-HT2A receptor, Htr2, Htr-2
Feature Type protein coding gene
Genetic Map
Chromosome 14
39.37 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr14:74640840-74706859 bp, + strand
From NCBI annotation of GRCm38

  66020 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68073  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: 5-hydroxytryptamine receptor 2
Gene Tree: Htr2a

Human
homologs
Human Homolog HTR2A, 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
NCBI Gene ID 3356
neXtProt AC  NX_P28223
Human Synonyms  5-HT2A, HTR2
Human Chr (Location)  13q14-q21; chr13:46831542-46897076 (-)  GRCh38
Disease Associations  (5) Diseases Associated with Human HTR2A
Alleles
and
phenotypes
All alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele show altered anxiety-related responses and increased vertical activity. Mice homozygous for a different knock-out allele exhibit abnormal enterocyte, Paneth cell and smooth muscle morphology.
 
Gene Ontology
(GO)
classifications
All GO classifications: (62 annotations)
Process activation of phospholipase C activity, artery smooth muscle contraction, ...
Component cell body fiber, cell projection, ...
Function 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding, drug binding, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (116)    Tissues (71)    Images (15)
Theiler Stages: 12, 14, 16, 19, 21, 23, 26, 28
Assay TypeResults
RNA in situ 37
RT-PCR 79
cDNA source data(9)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(27) Genomic(13) cDNA(11) Primer pair(3)
Microarray probesets(1)
Other database
links
Ensembl Gene ModelENSMUSG00000034997 (Evidence)
Entrez Gene15558 (Evidence)
UniGene214351
DFCITC1587888
DoTSDT.91421257
NIA Mouse Gene IndexU015850
Consensus CDS ProjectCCDS27275.1
International Mouse Knockout Project StatusHtr2a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 15558 NCBI Gene Model | MGI Sequence Detail 66020 C57BL/6J ±  kb
transcript NM_172812 RefSeq | MGI Sequence Detail 2971 C57BL/6 
polypeptide P35363 UniProt | EBI | MGI Sequence Detail 471 Not Applicable 

For the selected sequences
All sequences(15) RefSeq(2) UniProt(2)
Polymorphisms RFLP(2) : SNPs within 2kb(393 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000455 5-Hydroxytryptamine 2A receptor
InterPro IPR002231 5-Hydroxytryptamine receptor family
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001166 5-hydroxytryptamine receptor 2A
Graphical View of Protein Domain Structure
References (Earliest) J:10923 Hsieh CL, et al., The serotonin receptor subtype 2 locus HTR2 is on human chromosome 13 near genes for esterase D and retinoblastoma-1 and on mouse chromosome 14. Somat Cell Mol Genet. 1990 Nov;16(6):567-74
(Latest) J:195791 Kang BN, et al., Regulation of serotonin-induced trafficking and migration of eosinophils. PLoS One. 2013;8(1):e54840
All references(78)
Other
accession IDs
MGD-MRK-10998, MGD-MRK-11007, MGD-MRK-39520

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory