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Gene Ontology Browser
Term Detail
GO term:cell death
Synonym: accidental cell death
Synonym: necrosis
GO id:GO:0008219
Definition:Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538).
CommentsThis term should not be used for direct annotation. The only exception should be when experimental data (e.g., staining with trypan blue or propidium iodide) show that cell death has occurred, but fail to provide details on death modality (accidental versus programmed). When information is provided on the cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'). Also, if experimental data suggest that a gene product influences cell death indirectly, rather than being involved in the death process directly, consider annotating to a 'regulation' term.
Number of paths to term: 2

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


obsolete Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-a(+)-kotanin metabolic process +
                                is-a(-)-microperfuranone metabolic process +
                                is-a3-hydroxybenzyl alcohol metabolic process
                                is-a3alpha(S)-strictosidine biosynthetic process
                                is-a3alpha(S)-strictosidine catabolic process
                                is-a6-alpha-maltosylglucose metabolic process +
                                is-aacetyl-CoA biosynthetic process from ethanol
                                is-aacetylcholine metabolic process +
                                is-aactin cortical patch organization +
                                is-aactin filament-based process +
                                is-aalditol metabolic process +
                                is-aalpha-ribazole metabolic process +
                                is-aaminoglycoside antibiotic biosynthetic process +
                                is-aaminoglycoside antibiotic catabolic process +
                                is-aangiotensin catabolic process in blood
                                is-aansamycin metabolic process +
                                is-aaromatic primary alcohol metabolic process +
                                is-aascospore wall chitin metabolic process +
                                is-aaspyridone A metabolic process +
                                is-aaspyridone B metabolic process +
                                is-abeta-1,2-oligomannoside metabolic process +
                                is-ablood microparticle formation +
                                is-abrevianamide F metabolic process +
                                is-aC21-steroid hormone metabolic process +
                                is-acarbon fixation by acetyl-CoA pathway
                                is-acargo loading into vesicle +
                                is-acell activation +
                                is-acell adhesion molecule production +
                                is-acell communication +
                                is-acell competition in a multicellular organism
                                is-acell cycle +
                                is-acell death [GO:0008219] (1909 genes, 4507 annotations)
                                        is-acell death in response to oxidative stress +
                                        is-anecrotic cell death +
                                        negatively-regulatesnegative regulation of cell death +
                                        is-aneuron death +
                                        positively-regulatespositive regulation of cell death +
                                        is-aprogrammed cell death +
                                        regulatesregulation of cell death +
                                is-acell division +
                                is-acell growth +
                                is-acell junction organization +
                                is-acell projection organization +
                                is-acell recognition +
                                is-acell wall beta-glucan metabolic process +
                                is-acellular alcohol metabolic process +
                                is-acellular aldehyde metabolic process +
                                is-acellular alkane metabolic process +
                                is-acellular alkyne metabolic process +
                                is-acellular carbohydrate biosynthetic process +
                                is-acellular component assembly involved in morphogenesis +
                                is-acellular component disassembly +
                                is-acellular component maintenance +
                                is-acellular developmental process +
                                is-acellular homeostasis +
                                is-acellular ketone body metabolic process +
                                is-acellular ketone metabolic process +
                                is-acellular lactam metabolic process +
                                is-acellular lipid metabolic process +
                                is-acellular oligosaccharide metabolic process +
                                is-acellular pigmentation +
                                is-acellular potassium ion transport +
                                is-acellular process involved in reproduction in multicellular organism +
                                is-achanoclavine-I metabolic process +
                                is-achlorophyll biosynthetic process +
                                is-achlorophyll catabolic process +
                                is-achromosome number maintenance
                                is-achromosome segregation +
                                is-acobalamin metabolic process +
                                is-acoenzyme M metabolic process +
                                is-aconiferin metabolic process
                                is-acontact inhibition +
                                is-acordyol C metabolic process +
                                is-acyanide metabolic process +
                                is-acyanogenic glycoside biosynthetic process +
                                is-acyanogenic glycoside catabolic process
                                is-acyclohexanol metabolic process +
                                is-acytoplasm organization +
                                is-aD-arabinose catabolic process to xylulose 5-phosphate
                                is-ademethylkotanin metabolic process +
                                is-adibenzo-p-dioxin metabolic process +
                                is-adibenzofuran metabolic process +
                                is-adimethyl ether metabolic process
                                is-adimethyl sulfoxide metabolic process
                                is-adimethylsilanediol metabolic process +
                                is-adiorcinol metabolic process +
                                is-adisaccharide metabolic process +
                                is-aDNA clamp unloading
                                is-aDNA demethylation +
                                is-aelectron transport chain +
                                is-aemericellamide metabolic process +
                                is-aenergy derivation by oxidation of organic compounds +
                                is-aenergy derivation by oxidation of reduced inorganic compounds +
                                is-aensheathment of neurons +
                                is-aepoxide metabolic process +
                                is-aERAD pathway +
                                is-aergot alkaloid biosynthetic process +
                                is-aergot alkaloid catabolic process +
                                is-aestablishment or maintenance of cell polarity +
                                is-aestablishment or maintenance of cell type involved in phenotypic switching
                                is-aethanolamine-containing compound metabolic process +
                                is-aexecution phase of apoptosis +
                                is-aexecution phase of necroptosis
                                is-aextracellular structure organization +
                                is-aF-9775A metabolic process +
                                is-aF-9775B metabolic process +
                                is-afumitremorgin B metabolic process +
                                is-aGDP-mannose biosynthetic process from mannose
                                is-agene silencing +
                                is-aglutathione derivative metabolic process +
                                is-aglycerol ether biosynthetic process +
                                is-aglycerol ether catabolic process
                                is-ahalogenated hydrocarbon metabolic process +
                                is-aheme metabolic process +
                                is-ainositol metabolic process +
                                is-ainositol phosphate metabolic process +
                                is-aintermediate filament-based process +
                                is-aL-arabinose catabolic process to xylulose 5-phosphate
                                is-alight absorption +
                                is-amacrolide metabolic process +
                                is-amaintenance of location in cell +
                                is-amannose to fructose-6-phosphate metabolic process
                                is-amelanin metabolic process +
                                is-amembrane docking +
                                is-amethyl tert-butyl ether metabolic process
                                is-amicrotubule organizing center attachment site organization
                                is-amicrotubule-based process +
                                is-amineralocorticoid metabolic process +
                                is-amovement of cell or subcellular component +
                                is-amycothiol metabolic process +
                                is-anicotinamide metabolic process +
                                is-anucleobase-containing small molecule metabolic process +
                                is-anucleoid organization +
                                is-aommochrome metabolic process +
                                is-aone-carbon metabolic process +
                                is-aorcinol metabolic process +
                                is-aorganic acid metabolic process +
                                is-aorlandin metabolic process +
                                is-aoxidative RNA demethylation +
                                is-apeptidyl-glycine cholesteryl ester biosynthesis from peptidyl-glycine
                                is-aperiplasmic space organization
                                is-aphenolic phthiocerol biosynthetic process
                                is-aphenylpropanoid metabolic process +
                                is-apheromone metabolic process +
                                is-aphotoreceptor cell outer segment organization
                                is-aphytochelatin metabolic process +
                                is-aplasma lipoprotein particle organization +
                                is-aplasmid maintenance +
                                is-aplastoglobule organization
                                is-apolythionate oxidation
                                is-aprotein demethylation +
                                is-aprotein glycosylation +
                                is-aprotein halogenation +
                                is-aprotein oxidation +
                                is-apteridine biosynthetic process
                                is-areceptor internalization +
                                is-aregulation of cellular component size +
                                is-aregulation of translational initiation by eIF2 alpha dephosphorylation +
                                is-arhamnogalacturonan I biosynthetic process
                                is-arhodopsin metabolic process +
                                is-ariboflavin metabolic process +
                                is-aS-glycoside metabolic process +
                                is-asecretion by cell +
                                is-asiderophore metabolic process +
                                is-asignal maturation +
                                is-asignal transduction by protein phosphorylation +
                                is-asingle-organism intercellular transport +
                                is-asingle-organism membrane organization +
                                is-asingle-organism organelle organization +
                                is-astomatal movement +
                                is-asulfate reduction +
                                is-asulfide oxidation +
                                is-asulfur oxidation +
                                is-asynapse organization +
                                is-asyncytium formation +
                                is-ataurine metabolic process +
                                is-atensidol A metabolic process +
                                is-aterminal button organization +
                                is-atetracycline metabolic process +
                                is-athiamine-containing compound metabolic process +
                                is-atoluene oxidation +
                                is-atoxin metabolic process +
                                is-atransposition +
                                is-aurea metabolic process +
                                is-averruculogen metabolic process +
                                is-avesicle targeting +
                                is-avindoline metabolic process +
                                is-aviolaceol I metabolic process +
                                is-aviolaceol II metabolic process +
                                is-avistamycin metabolic process +
                                is-avitamin B6 metabolic process +
                                is-avitamin biosynthetic process +
                                is-avitamin catabolic process +
                                is-avitamin E metabolic process +
                                is-awybutosine biosynthetic process


obsolete Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-a(+)-kotanin metabolic process +
                                is-a(-)-microperfuranone metabolic process +
                                is-a3-hydroxybenzyl alcohol metabolic process
                                is-a3alpha(S)-strictosidine biosynthetic process
                                is-a3alpha(S)-strictosidine catabolic process
                                is-a6-alpha-maltosylglucose metabolic process +
                                is-aacetyl-CoA biosynthetic process from ethanol
                                is-aacetylcholine metabolic process +
                                is-aactin cortical patch organization +
                                is-aactin filament-based process +
                                is-aalditol metabolic process +
                                is-aalpha-ribazole metabolic process +
                                is-aaminoglycoside antibiotic biosynthetic process +
                                is-aaminoglycoside antibiotic catabolic process +
                                is-aangiotensin catabolic process in blood
                                is-aansamycin metabolic process +
                                is-aaromatic primary alcohol metabolic process +
                                is-aascospore wall chitin metabolic process +
                                is-aaspyridone A metabolic process +
                                is-aaspyridone B metabolic process +
                                is-abeta-1,2-oligomannoside metabolic process +
                                is-ablood microparticle formation +
                                is-abrevianamide F metabolic process +
                                is-aC21-steroid hormone metabolic process +
                                is-acarbon fixation by acetyl-CoA pathway
                                is-acargo loading into vesicle +
                                is-acell activation +
                                is-acell adhesion molecule production +
                                is-acell communication +
                                is-acell competition in a multicellular organism
                                is-acell cycle +
                                is-acell death [GO:0008219] (1909 genes, 4507 annotations)
                                        is-acell death in response to oxidative stress +
                                        is-anecrotic cell death +
                                        negatively-regulatesnegative regulation of cell death +
                                        is-aneuron death +
                                        positively-regulatespositive regulation of cell death +
                                        is-aprogrammed cell death +
                                        regulatesregulation of cell death +
                                is-acell division +
                                is-acell growth +
                                is-acell junction organization +
                                is-acell projection organization +
                                is-acell recognition +
                                is-acell wall beta-glucan metabolic process +
                                is-acellular alcohol metabolic process +
                                is-acellular aldehyde metabolic process +
                                is-acellular alkane metabolic process +
                                is-acellular alkyne metabolic process +
                                is-acellular carbohydrate biosynthetic process +
                                is-acellular component assembly involved in morphogenesis +
                                is-acellular component disassembly +
                                is-acellular component maintenance +
                                is-acellular developmental process +
                                is-acellular homeostasis +
                                is-acellular ketone body metabolic process +
                                is-acellular ketone metabolic process +
                                is-acellular lactam metabolic process +
                                is-acellular lipid metabolic process +
                                is-acellular oligosaccharide metabolic process +
                                is-acellular pigmentation +
                                is-acellular potassium ion transport +
                                is-acellular process involved in reproduction in multicellular organism +
                                is-achanoclavine-I metabolic process +
                                is-achlorophyll biosynthetic process +
                                is-achlorophyll catabolic process +
                                is-achromosome number maintenance
                                is-achromosome segregation +
                                is-acobalamin metabolic process +
                                is-acoenzyme M metabolic process +
                                is-aconiferin metabolic process
                                is-acontact inhibition +
                                is-acordyol C metabolic process +
                                is-acyanide metabolic process +
                                is-acyanogenic glycoside biosynthetic process +
                                is-acyanogenic glycoside catabolic process
                                is-acyclohexanol metabolic process +
                                is-acytoplasm organization +
                                is-aD-arabinose catabolic process to xylulose 5-phosphate
                                is-ademethylkotanin metabolic process +
                                is-adibenzo-p-dioxin metabolic process +
                                is-adibenzofuran metabolic process +
                                is-adimethyl ether metabolic process
                                is-adimethyl sulfoxide metabolic process
                                is-adimethylsilanediol metabolic process +
                                is-adiorcinol metabolic process +
                                is-adisaccharide metabolic process +
                                is-aDNA clamp unloading
                                is-aDNA demethylation +
                                is-aelectron transport chain +
                                is-aemericellamide metabolic process +
                                is-aenergy derivation by oxidation of organic compounds +
                                is-aenergy derivation by oxidation of reduced inorganic compounds +
                                is-aensheathment of neurons +
                                is-aepoxide metabolic process +
                                is-aERAD pathway +
                                is-aergot alkaloid biosynthetic process +
                                is-aergot alkaloid catabolic process +
                                is-aestablishment or maintenance of cell polarity +
                                is-aestablishment or maintenance of cell type involved in phenotypic switching
                                is-aethanolamine-containing compound metabolic process +
                                is-aexecution phase of apoptosis +
                                is-aexecution phase of necroptosis
                                is-aextracellular structure organization +
                                is-aF-9775A metabolic process +
                                is-aF-9775B metabolic process +
                                is-afumitremorgin B metabolic process +
                                is-aGDP-mannose biosynthetic process from mannose
                                is-agene silencing +
                                is-aglutathione derivative metabolic process +
                                is-aglycerol ether biosynthetic process +
                                is-aglycerol ether catabolic process
                                is-ahalogenated hydrocarbon metabolic process +
                                is-aheme metabolic process +
                                is-ainositol metabolic process +
                                is-ainositol phosphate metabolic process +
                                is-aintermediate filament-based process +
                                is-aL-arabinose catabolic process to xylulose 5-phosphate
                                is-alight absorption +
                                is-amacrolide metabolic process +
                                is-amaintenance of location in cell +
                                is-amannose to fructose-6-phosphate metabolic process
                                is-amelanin metabolic process +
                                is-amembrane docking +
                                is-amethyl tert-butyl ether metabolic process
                                is-amicrotubule organizing center attachment site organization
                                is-amicrotubule-based process +
                                is-amineralocorticoid metabolic process +
                                is-amovement of cell or subcellular component +
                                is-amycothiol metabolic process +
                                is-anicotinamide metabolic process +
                                is-anucleobase-containing small molecule metabolic process +
                                is-anucleoid organization +
                                is-aommochrome metabolic process +
                                is-aone-carbon metabolic process +
                                is-aorcinol metabolic process +
                                is-aorganic acid metabolic process +
                                is-aorlandin metabolic process +
                                is-aoxidative RNA demethylation +
                                is-apeptidyl-glycine cholesteryl ester biosynthesis from peptidyl-glycine
                                is-aperiplasmic space organization
                                is-aphenolic phthiocerol biosynthetic process
                                is-aphenylpropanoid metabolic process +
                                is-apheromone metabolic process +
                                is-aphotoreceptor cell outer segment organization
                                is-aphytochelatin metabolic process +
                                is-aplasma lipoprotein particle organization +
                                is-aplasmid maintenance +
                                is-aplastoglobule organization
                                is-apolythionate oxidation
                                is-aprotein demethylation +
                                is-aprotein glycosylation +
                                is-aprotein halogenation +
                                is-aprotein oxidation +
                                is-apteridine biosynthetic process
                                is-areceptor internalization +
                                is-aregulation of cellular component size +
                                is-aregulation of translational initiation by eIF2 alpha dephosphorylation +
                                is-arhamnogalacturonan I biosynthetic process
                                is-arhodopsin metabolic process +
                                is-ariboflavin metabolic process +
                                is-aS-glycoside metabolic process +
                                is-asecretion by cell +
                                is-asiderophore metabolic process +
                                is-asignal maturation +
                                is-asignal transduction by protein phosphorylation +
                                is-asingle-organism intercellular transport +
                                is-asingle-organism membrane organization +
                                is-asingle-organism organelle organization +
                                is-astomatal movement +
                                is-asulfate reduction +
                                is-asulfide oxidation +
                                is-asulfur oxidation +
                                is-asynapse organization +
                                is-asyncytium formation +
                                is-ataurine metabolic process +
                                is-atensidol A metabolic process +
                                is-aterminal button organization +
                                is-atetracycline metabolic process +
                                is-athiamine-containing compound metabolic process +
                                is-atoluene oxidation +
                                is-atoxin metabolic process +
                                is-atransposition +
                                is-aurea metabolic process +
                                is-averruculogen metabolic process +
                                is-avesicle targeting +
                                is-avindoline metabolic process +
                                is-aviolaceol I metabolic process +
                                is-aviolaceol II metabolic process +
                                is-avistamycin metabolic process +
                                is-avitamin B6 metabolic process +
                                is-avitamin biosynthetic process +
                                is-avitamin catabolic process +
                                is-avitamin E metabolic process +
                                is-awybutosine biosynthetic process


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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory