Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Grem1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes GREM1
- Mouse genes Grem1
- Rat genes Grem1
- Zfish genes grem1a,grem1b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Grem1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0036122	BMP binding	GREM1	IDA		Human	PMID:27036124
Molecular Function	GO:0005515	protein binding	GREM1	IPI	UniProtKB:Q04917	Human	PMID:16545136
Molecular Function	GO:0005515	protein binding	GREM1	IPI	UniProtKB:P35968	Human	PMID:20660291
Molecular Function	GO:0005515	protein binding	GREM1	IPI	UniProtKB:O60565	Human	PMID:27036124
Molecular Function	GO:0005515	protein binding	GREM1	IPI	UniProtKB:P59991	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GREM1	IPI	UniProtKB:Q99750	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Grem1	IPI	RGD:730832	Rat	PMID:10722723\|RGD:2303398
Molecular Function	GO:0005515	protein binding	Grem1	IPI	RGD:733848\|RGD:733021	Rat	PMID:15528323\|RGD:2303400
Molecular Function	GO:0005515	protein binding	Grem1	IPI	UniProtKB:O88279	Rat	PMID:15528323\|RGD:2303400
Molecular Function	GO:0005515	protein binding	Grem1	IPI	UniProtKB:Q9WVC1	Rat	PMID:15528323\|RGD:2303400
Molecular Function	GO:0042803	protein homodimerization activity	GREM1	IPI	UniProtKB:O60565	Human	PMID:27036124
Molecular Function	GO:0048018	receptor ligand activity	Grem1	IPI	UniProtKB:P35918	Mouse	MGI:MGI:4845816\|PMID:20660291
Molecular Function	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity	Grem1	IDA		Mouse	MGI:MGI:4845816\|PMID:20660291
Molecular Function	GO:0043184	vascular endothelial growth factor receptor 2 binding	Grem1	IPI	UniProtKB:P35968-2	Mouse	MGI:MGI:4845816\|PMID:20660291
Cellular Component	GO:0009986	cell surface	Grem1	IDA		Mouse	MGI:MGI:3834346\|PMID:17077323
Cellular Component	GO:0009986	cell surface	Grem1	IDA		Rat	PMID:10722723\|RGD:2303398
Cellular Component	GO:0062023	collagen-containing extracellular matrix	GREM1	HDA		Human	PMID:28327460
Cellular Component	GO:0062023	collagen-containing extracellular matrix	GREM1	HDA		Human	PMID:25037231
Cellular Component	GO:0005615	extracellular space	Grem1	IDA		Mouse	MGI:MGI:3834346\|PMID:17077323
Cellular Component	GO:0005615	extracellular space	Grem1	IDA		Rat	PMID:10722723\|RGD:2303398
Biological Process	GO:0001525	angiogenesis	Grem1	IDA		Mouse	PMID:18505784
Biological Process	GO:0009887	animal organ morphogenesis	Grem1	IMP	MGI:MGI:1856289	Mouse	PMID:15198975
Biological Process	GO:0006915	apoptotic process	Grem1	IEP		Rat	PMID:9234736\|RGD:69808
Biological Process	GO:0055007	cardiac muscle cell differentiation	Grem1	IDA		Mouse	MGI:MGI:5315691\|PMID:18545679
Biological Process	GO:0060379	cardiac muscle cell myoblast differentiation	Grem1	IDA		Mouse	MGI:MGI:5315691\|PMID:18545679
Biological Process	GO:0002042	cell migration involved in sprouting angiogenesis	Grem1	IDA		Mouse	MGI:MGI:3834346\|PMID:17077323
Biological Process	GO:0002042	cell migration involved in sprouting angiogenesis	Grem1	IDA		Mouse	MGI:MGI:4845816\|PMID:20660291
Biological Process	GO:0000902	cell morphogenesis	GREM1	IDA		Human	PMID:16545136
Biological Process	GO:0007267	cell-cell signaling	Grem1	IMP	MGI:MGI:3046937	Mouse	PMID:15201225
Biological Process	GO:0030199	collagen fibril organization	GREM1	IMP		Human	PMID:15539560
Biological Process	GO:0048263	determination of dorsal identity	GREM1	IMP		Human	PMID:9660951
Biological Process	GO:0030326	embryonic limb morphogenesis	Grem1	IMP	MGI:MGI:3054923	Mouse	PMID:12808456
Biological Process	GO:0043542	endothelial cell migration	Grem1	IDA		Mouse	MGI:MGI:3834346\|PMID:17077323
Biological Process	GO:0060173	limb development	GREM1	IMP		Human	PMID:10556075
Biological Process	GO:0003337	mesenchymal to epithelial transition involved in metanephros morphogenesis	Grem1	IDA		Mouse	MGI:MGI:3714585\|PMID:17522159
Biological Process	GO:0043066	negative regulation of apoptotic process	GREM1	IMP		Human	PMID:10556075
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	GREM1	IDA		Human	PMID:15539560
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	GREM1	IMP		Human	PMID:16816361
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	GREM1	IMP		Human	PMID:27036124
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	Grem1	IMP	MGI:MGI:3046937	Mouse	PMID:17522159
Biological Process	GO:0030502	negative regulation of bone mineralization	GREM1	IMP		Human	PMID:15539560
Biological Process	GO:1900158	negative regulation of bone mineralization involved in bone maturation	GREM1	IMP		Human	PMID:15539560
Biological Process	GO:0046851	negative regulation of bone remodeling	GREM1	IMP		Human	PMID:15539560
Biological Process	GO:1900155	negative regulation of bone trabecula formation	GREM1	IMP		Human	PMID:15539560
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	GREM1	IDA		Human	PMID:15539560
Biological Process	GO:0030308	negative regulation of cell growth	Grem1	IMP		Rat	PMID:9234736\|RGD:69808
Biological Process	GO:0032331	negative regulation of chondrocyte differentiation	GREM1	IMP		Human	PMID:10556075
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Grem1	IMP		Mouse	MGI:MGI:3714585\|PMID:17522159
Biological Process	GO:0002689	negative regulation of leukocyte chemotaxis	Grem1	IDA		Rat	PMID:15528323\|RGD:2303400
Biological Process	GO:0090027	negative regulation of monocyte chemotaxis	Grem1	IDA		Rat	PMID:15528323\|RGD:2303400
Biological Process	GO:0045668	negative regulation of osteoblast differentiation	GREM1	IMP		Human	PMID:27036124
Biological Process	GO:0045668	negative regulation of osteoblast differentiation	Grem1	IMP		Rat	PMID:27910957\|RGD:38501075
Biological Process	GO:0033689	negative regulation of osteoblast proliferation	GREM1	IMP		Human	PMID:15539560
Biological Process	GO:0090291	negative regulation of osteoclast proliferation	GREM1	IMP		Human	PMID:15539560
Biological Process	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation	GREM1	IDA		Human	PMID:15539560
Biological Process	GO:0045766	positive regulation of angiogenesis	Grem1	IMP		Mouse	MGI:MGI:3834346\|PMID:17077323
Biological Process	GO:0045766	positive regulation of angiogenesis	Grem1	IMP		Rat	PMID:17077323\|RGD:8553524
Biological Process	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	Grem1	IDA		Mouse	MGI:MGI:3714585\|PMID:17522159
Biological Process	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	Grem1	IDA		Mouse	PMID:21281623
Biological Process	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	Grem1	IGI	MGI:MGI:88180	Mouse	PMID:17522159
Biological Process	GO:0008284	positive regulation of cell population proliferation	GREM1	IDA		Human	PMID:16545136
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Grem1	IDA		Mouse	MGI:MGI:3714585\|PMID:17522159
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	Grem1	IDA		Mouse	PMID:18505784
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	Grem1	IDA		Mouse	PMID:18505784
Biological Process	GO:1900086	positive regulation of peptidyl-tyrosine autophosphorylation	Grem1	IDA		Mouse	MGI:MGI:4845816\|PMID:20660291
Biological Process	GO:0061098	positive regulation of protein tyrosine kinase activity	Grem1	IDA		Mouse	MGI:MGI:3834346\|PMID:17077323
Biological Process	GO:0002092	positive regulation of receptor internalization	Grem1	IDA		Mouse	MGI:MGI:4845816\|PMID:20660291
Biological Process	GO:2000273	positive regulation of signaling receptor activity	Grem1	IDA		Mouse	MGI:MGI:4845816\|PMID:20660291
Biological Process	GO:0051973	positive regulation of telomerase activity	GREM1	IDA		Human	PMID:16545136
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Grem1	IDA		Mouse	MGI:MGI:5318033\|PMID:12135612
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Grem1	IDA		Mouse	MGI:MGI:5315691\|PMID:18545679
Biological Process	GO:0009954	proximal/distal pattern formation	Grem1	IMP	MGI:MGI:3054923	Mouse	PMID:12808456
Biological Process	GO:0010717	regulation of epithelial to mesenchymal transition	GREM1	IMP		Human	PMID:16816361
Biological Process	GO:0051893	regulation of focal adhesion assembly	Grem1	IDA		Mouse	MGI:MGI:3834346\|PMID:17077323
Biological Process	GO:0007165	signal transduction	Grem1	IDA		Mouse	MGI:MGI:4845816\|PMID:20660291
Biological Process	GO:0060676	ureteric bud formation	Grem1	IDA		Mouse	MGI:MGI:3714585\|PMID:17522159

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/07/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.