Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ERCC2
  • Mouse genes Ercc2
  • Rat genes Ercc2
  • Zfish genes ercc2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ercc2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0043139	5'-3' DNA helicase activity	ERCC2	IDA		Human	PMID:11445587
Molecular Function	GO:0043139	5'-3' DNA helicase activity	ERCC2	IDA		Human	PMID:8663148
Molecular Function	GO:0005515	protein binding	ERCC2	IPI	UniProtKB:P51948	Human	PMID:10801852
Molecular Function	GO:0005515	protein binding	ERCC2	IPI	UniProtKB:P51948	Human	PMID:11445587
Molecular Function	GO:0005515	protein binding	ERCC2	IPI	UniProtKB:Q13888	Human	PMID:11445587
Molecular Function	GO:0005515	protein binding	ERCC2	IPI	UniProtKB:P19447	Human	PMID:16669699
Molecular Function	GO:0005515	protein binding	ERCC2	IPI	UniProtKB:P19447	Human	PMID:19934020
Molecular Function	GO:0005515	protein binding	ERCC2	IPI	UniProtKB:Q13888	Human	PMID:19934020
Molecular Function	GO:0005515	protein binding	ERCC2	IPI	UniProtKB:Q9Y3D0	Human	PMID:20797633
Molecular Function	GO:0005515	protein binding	ERCC2	IPI	UniProtKB:O76071	Human	PMID:23585563
Molecular Function	GO:0005515	protein binding	ERCC2	IPI	UniProtKB:Q96T76	Human	PMID:23585563
Molecular Function	GO:0005515	protein binding	ERCC2	IPI	UniProtKB:Q96T76|UniProtKB:Q9Y3D0	Human	PMID:23585563
Molecular Function	GO:0005515	protein binding	ERCC2	IPI	UniProtKB:Q9Y3D0	Human	PMID:23585563
Molecular Function	GO:0005515	protein binding	ERCC2	IPI	UniProtKB:O76071	Human	PMID:23891004
Molecular Function	GO:0005515	protein binding	ERCC2	IPI	UniProtKB:Q9Y3D0	Human	PMID:23891004
Molecular Function	GO:0005515	protein binding	ERCC2	IPI	UniProtKB:Q6P1K8	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ERCC2	IPI	UniProtKB:P19447	Human	PMID:27193682
Molecular Function	GO:0005515	protein binding	ERCC2	IPI	UniProtKB:Q13888	Human	PMID:27193682
Molecular Function	GO:0005515	protein binding	ERCC2	IPI	UniProtKB:O76071	Human	PMID:28178521
Molecular Function	GO:0005515	protein binding	ERCC2	IPI	UniProtKB:Q96T76	Human	PMID:28178521
Molecular Function	GO:0005515	protein binding	ERCC2	IPI	UniProtKB:Q9Y3D0	Human	PMID:28178521
Molecular Function	GO:0005515	protein binding	ERCC2	IPI	UniProtKB:P04637	Human	PMID:7663514
Molecular Function	GO:0005515	protein binding	ERCC2	IPI	UniProtKB:P19447	Human	PMID:8652557
Molecular Function	GO:0005515	protein binding	ERCC2	IPI	UniProtKB:P28715	Human	PMID:8652557
Molecular Function	GO:0005515	protein binding	ERCC2	IPI	UniProtKB:P32780	Human	PMID:8652557
Molecular Function	GO:0005515	protein binding	ERCC2	IPI	UniProtKB:Q13888	Human	PMID:8652557
Molecular Function	GO:0005515	protein binding	ERCC2	IPI	UniProtKB:Q13889	Human	PMID:8652557
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	ERCC2	IPI	UniProtKB:P51948,UniProtKB:Q13888	Human	PMID:11445587
Cellular Component	GO:0070516	CAK-ERCC2 complex	ERCC2	IDA		Human	PMID:11445587
Cellular Component	GO:0070516	CAK-ERCC2 complex	ERCC2	IDA		Human	PMID:8692841
Cellular Component	GO:0070516	CAK-ERCC2 complex	ERCC2	IDA		Human	PMID:8692842
Cellular Component	GO:0005737	cytoplasm	ERCC2	IDA		Human	PMID:20797633
Cellular Component	GO:0005737	cytoplasm	ERCC2	IDA		Human	PMID:23585563
Cellular Component	GO:0005829	cytosol	ERCC2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0071817	MMXD complex	ERCC2	IDA		Human	PMID:20797633
Cellular Component	GO:0005654	nucleoplasm	ERCC2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	ERCC2	IDA		Human	PMID:20797633
Cellular Component	GO:0005634	nucleus	ERCC2	IDA		Human	PMID:23585563
Cellular Component	GO:0005634	nucleus	Ercc2	IDA		Mouse	PMID:17952069
Cellular Component	GO:0005819	spindle	ERCC2	IDA		Human	PMID:20797633
Cellular Component	GO:0005669	transcription factor TFIID complex	ERCC2	IDA		Human	PMID:27193682
Cellular Component	GO:0000439	transcription factor TFIIH core complex	ERCC2	IDA		Human	PMID:8692841
Cellular Component	GO:0000439	transcription factor TFIIH core complex	ERCC2	IDA		Human	PMID:8692842
Cellular Component	GO:0000439	transcription factor TFIIH core complex	Ercc2	IDA		Rat	PMID:8855220|RGD:1642642
Cellular Component	GO:0005675	transcription factor TFIIH holo complex	ERCC2	IDA		Human	PMID:9852112
Biological Process	GO:0006915	apoptotic process	ERCC2	IMP		Human	PMID:8675009
Biological Process	GO:0030282	bone mineralization	Ercc2	IMP	MGI:MGI:2183949	Mouse	PMID:17020410
Biological Process	GO:0032289	central nervous system myelin formation	Ercc2	IMP	MGI:MGI:2183949	Mouse	PMID:17952069
Biological Process	GO:0007059	chromosome segregation	ERCC2	IMP		Human	PMID:20797633
Biological Process	GO:0008340	determination of adult lifespan	Ercc2	IMP	MGI:MGI:2183949	Mouse	PMID:17020410
Biological Process	GO:0008340	determination of adult lifespan	Ercc2	IMP	MGI:MGI:2183949	Mouse	PMID:11950998
Biological Process	GO:0006281	DNA repair	Ercc2	IMP	MGI:MGI:2183949	Mouse	PMID:11950998
Biological Process	GO:0040016	embryonic cleavage	Ercc2	IMP	MGI:MGI:2183947	Mouse	PMID:9426063
Biological Process	GO:0048568	embryonic organ development	Ercc2	IEP		Rat	PMID:11425516|RGD:2313673
Biological Process	GO:0043249	erythrocyte maturation	Ercc2	IMP	MGI:MGI:2183949	Mouse	PMID:17020410
Biological Process	GO:0030198	extracellular matrix organization	Ercc2	IMP	MGI:MGI:2183949	Mouse	PMID:9651581
Biological Process	GO:0035315	hair cell differentiation	ERCC2	IMP		Human	PMID:11335038
Biological Process	GO:0035315	hair cell differentiation	Ercc2	IMP	MGI:MGI:2183949	Mouse	PMID:17020410
Biological Process	GO:0022405	hair cycle process	Ercc2	IMP	MGI:MGI:2183949	Mouse	PMID:17020410
Biological Process	GO:0048820	hair follicle maturation	Ercc2	IMP	MGI:MGI:2183949	Mouse	PMID:9651581
Biological Process	GO:0060218	hematopoietic stem cell differentiation	Ercc2	IMP	MGI:MGI:2183947	Mouse	PMID:17554309
Biological Process	GO:0071425	hematopoietic stem cell proliferation	Ercc2	IMP	MGI:MGI:2183947	Mouse	PMID:17554309
Biological Process	GO:0001701	in utero embryonic development	Ercc2	IMP	MGI:MGI:3693615	Mouse	PMID:17020410
Biological Process	GO:0001701	in utero embryonic development	Ercc2	IMP	MGI:MGI:3696121	Mouse	PMID:17020410
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	Ercc2	IMP	MGI:MGI:2183949	Mouse	PMID:18545656
Biological Process	GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	Ercc2	IMP	MGI:MGI:2183949	Mouse	PMID:18545656
Biological Process	GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	Ercc2	IMP	MGI:MGI:2183949	Mouse	PMID:23562818
Biological Process	GO:0035264	multicellular organism growth	Ercc2	IMP	MGI:MGI:2183949	Mouse	PMID:17020410
Biological Process	GO:0006289	nucleotide-excision repair	ERCC2	IMP		Human	PMID:8692841
Biological Process	GO:0006289	nucleotide-excision repair	Ercc2	IMP	MGI:MGI:2183949	Mouse	PMID:11950998
Biological Process	GO:0006289	nucleotide-excision repair	Ercc2	IMP	MGI:MGI:2183949	Mouse	PMID:9651581
Biological Process	GO:0043388	positive regulation of DNA binding	Ercc2	IMP	MGI:MGI:2183949	Mouse	PMID:17952069
Biological Process	GO:0009791	post-embryonic development	Ercc2	IMP	MGI:MGI:2183949	Mouse	PMID:17020410
Biological Process	GO:0009791	post-embryonic development	Ercc2	IMP	MGI:MGI:2183949	Mouse	PMID:11950998
Biological Process	GO:1901990	regulation of mitotic cell cycle phase transition	ERCC2	IMP		Human	PMID:17088560
Biological Process	GO:0001666	response to hypoxia	Ercc2	IEP		Rat	PMID:9763211|RGD:2302855
Biological Process	GO:0006979	response to oxidative stress	ERCC2	IMP		Human	PMID:17614221
Biological Process	GO:0006979	response to oxidative stress	Ercc2	IMP	MGI:MGI:2183949	Mouse	PMID:11950998
Biological Process	GO:0009411	response to UV	Ercc2	IMP	MGI:MGI:2183949	Mouse	PMID:17020410
Biological Process	GO:0042274	ribosomal small subunit biogenesis	Ercc2	IMP	MGI:MGI:2183949	Mouse	PMID:23562818
Biological Process	GO:0043588	skin development	Ercc2	IMP	MGI:MGI:2183949	Mouse	PMID:17020410
Biological Process	GO:0043588	skin development	Ercc2	IMP	MGI:MGI:2183949	Mouse	PMID:9651581
Biological Process	GO:0021510	spinal cord development	Ercc2	IMP	MGI:MGI:2183949	Mouse	PMID:17020410
Biological Process	GO:0006366	transcription by RNA polymerase II	ERCC2	IDA		Human	PMID:8692841
Biological Process	GO:0006366	transcription by RNA polymerase II	ERCC2	IDA		Human	PMID:8692842
Biological Process	GO:0006366	transcription by RNA polymerase II	ERCC2	IDA		Human	PMID:9852112
Biological Process	GO:0006362	transcription elongation by RNA polymerase I	Ercc2	IMP	MGI:MGI:2183949	Mouse	PMID:23562818
Biological Process	GO:0006283	transcription-coupled nucleotide-excision repair	ERCC2	IDA		Human	PMID:8663148
Biological Process	GO:0009650	UV protection	Ercc2	IMP	MGI:MGI:2183949	Mouse	PMID:9651581

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern