| GO term: | nucleotide-excision repair |
| Synonym: | intrastrand cross-link repair |
| Synonym: | NER |
| Synonym: | pyrimidine-dimer repair, DNA damage excision |
| GO id: | GO:0006289 |
| Definition: | A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). |
| Comments | Note that although intrastrand cross-link repair is not exactly synonymous with nucleotide excision repair, nucleotide excision repair includes the repair of intrastrand cross-links. The synonym field is being used to reflect the broad substrate specificity of nucleotide excision repair. |
| Number of paths to term: | 17 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship
biological_processcellular processcellular metabolic processcellular aromatic compound metabolic processnucleobase-containing compound metabolic processnucleic acid metabolic processDNA metabolic processDNA repairbase-excision repair +DNA dealkylation involved in DNA repairDNA ligation involved in DNA repair +DNA replication proofreadingDNA synthesis involved in DNA repair +double-strand break repair +interstrand cross-link repair +mismatch repair +mitochondrial DNA repairnegative regulation of DNA repair +non-photoreactive DNA repairnon-recombinational repair +nucleotide-excision repair [GO:0006289] (41 genes, 70 annotations)global genome nucleotide-excision repairnucleotide-excision repair involved in interstrand cross-link repairnucleotide-excision repair, DNA damage recognition +nucleotide-excision repair, DNA damage removalnucleotide-excision repair, DNA duplex unwindingnucleotide-excision repair, DNA gap fillingnucleotide-excision repair, DNA incision +nucleotide-excision repair, preincision complex assemblynucleotide-excision repair, preincision complex stabilizationpyrimidine dimer repair by nucleotide-excision repairregulation of nucleotide-excision repair +transcription-coupled nucleotide-excision repair +positive regulation of DNA repair +postreplication repair +pyrimidine dimer repair +recombinational repair +regulation of DNA repair +single strand break repairUV-damage excision repairviral DNA repair +biological_processcellular processcellular metabolic processcellular macromolecule metabolic processDNA metabolic processDNA repairbase-excision repair +DNA dealkylation involved in DNA repairDNA ligation involved in DNA repair +DNA replication proofreadingDNA synthesis involved in DNA repair +double-strand break repair +interstrand cross-link repair +mismatch repair +mitochondrial DNA repairnegative regulation of DNA repair +non-photoreactive DNA repairnon-recombinational repair +nucleotide-excision repair [GO:0006289] (41 genes, 70 annotations)global genome nucleotide-excision repairnucleotide-excision repair involved in interstrand cross-link repairnucleotide-excision repair, DNA damage recognition +nucleotide-excision repair, DNA damage removalnucleotide-excision repair, DNA duplex unwindingnucleotide-excision repair, DNA gap fillingnucleotide-excision repair, DNA incision +nucleotide-excision repair, preincision complex assemblynucleotide-excision repair, preincision complex stabilizationpyrimidine dimer repair by nucleotide-excision repairregulation of nucleotide-excision repair +transcription-coupled nucleotide-excision repair +positive regulation of DNA repair +postreplication repair +pyrimidine dimer repair +recombinational repair +regulation of DNA repair +single strand break repairUV-damage excision repairviral DNA repair +biological_processcellular processcellular metabolic processcellular nitrogen compound metabolic processnucleobase-containing compound metabolic processnucleic acid metabolic processDNA metabolic processDNA repairbase-excision repair +DNA dealkylation involved in DNA repairDNA ligation involved in DNA repair +DNA replication proofreadingDNA synthesis involved in DNA repair +double-strand break repair +interstrand cross-link repair +mismatch repair +mitochondrial DNA repairnegative regulation of DNA repair +non-photoreactive DNA repairnon-recombinational repair +nucleotide-excision repair [GO:0006289] (41 genes, 70 annotations)global genome nucleotide-excision repairnucleotide-excision repair involved in interstrand cross-link repairnucleotide-excision repair, DNA damage recognition +nucleotide-excision repair, DNA damage removalnucleotide-excision repair, DNA duplex unwindingnucleotide-excision repair, DNA gap fillingnucleotide-excision repair, DNA incision +nucleotide-excision repair, preincision complex assemblynucleotide-excision repair, preincision complex stabilizationpyrimidine dimer repair by nucleotide-excision repairregulation of nucleotide-excision repair +transcription-coupled nucleotide-excision repair +positive regulation of DNA repair +postreplication repair +pyrimidine dimer repair +recombinational repair +regulation of DNA repair +single strand break repairUV-damage excision repairviral DNA repair +biological_processcellular processcellular metabolic processheterocycle metabolic processnucleobase-containing compound metabolic processnucleic acid metabolic processDNA metabolic processDNA repairbase-excision repair +DNA dealkylation involved in DNA repairDNA ligation involved in DNA repair +DNA replication proofreadingDNA synthesis involved in DNA repair +double-strand break repair +interstrand cross-link repair +mismatch repair +mitochondrial DNA repairnegative regulation of DNA repair +non-photoreactive DNA repairnon-recombinational repair +nucleotide-excision repair [GO:0006289] (41 genes, 70 annotations)global genome nucleotide-excision repairnucleotide-excision repair involved in interstrand cross-link repairnucleotide-excision repair, DNA damage recognition +nucleotide-excision repair, DNA damage removalnucleotide-excision repair, DNA duplex unwindingnucleotide-excision repair, DNA gap fillingnucleotide-excision repair, DNA incision +nucleotide-excision repair, preincision complex assemblynucleotide-excision repair, preincision complex stabilizationpyrimidine dimer repair by nucleotide-excision repairregulation of nucleotide-excision repair +transcription-coupled nucleotide-excision repair +positive regulation of DNA repair +postreplication repair +pyrimidine dimer repair +recombinational repair +regulation of DNA repair +single strand break repairUV-damage excision repairviral DNA repair +biological_processcellular processsingle-organism cellular processcellular response to stimuluscellular response to stressresponse to DNA damage stimulusDNA repairbase-excision repair +DNA dealkylation involved in DNA repairDNA ligation involved in DNA repair +DNA replication proofreadingDNA synthesis involved in DNA repair +double-strand break repair +interstrand cross-link repair +mismatch repair +mitochondrial DNA repairnegative regulation of DNA repair +non-photoreactive DNA repairnon-recombinational repair +nucleotide-excision repair [GO:0006289] (41 genes, 70 annotations)global genome nucleotide-excision repairnucleotide-excision repair involved in interstrand cross-link repairnucleotide-excision repair, DNA damage recognition +nucleotide-excision repair, DNA damage removalnucleotide-excision repair, DNA duplex unwindingnucleotide-excision repair, DNA gap fillingnucleotide-excision repair, DNA incision +nucleotide-excision repair, preincision complex assemblynucleotide-excision repair, preincision complex stabilizationpyrimidine dimer repair by nucleotide-excision repairregulation of nucleotide-excision repair +transcription-coupled nucleotide-excision repair +positive regulation of DNA repair +postreplication repair +pyrimidine dimer repair +recombinational repair +regulation of DNA repair +single strand break repairUV-damage excision repairviral DNA repair +biological_processmetabolic processcellular metabolic processcellular aromatic compound metabolic processnucleobase-containing compound metabolic processnucleic acid metabolic processDNA metabolic processDNA repairbase-excision repair +DNA dealkylation involved in DNA repairDNA ligation involved in DNA repair +DNA replication proofreadingDNA synthesis involved in DNA repair +double-strand break repair +interstrand cross-link repair +mismatch repair +mitochondrial DNA repairnegative regulation of DNA repair +non-photoreactive DNA repairnon-recombinational repair +nucleotide-excision repair [GO:0006289] (41 genes, 70 annotations)global genome nucleotide-excision repairnucleotide-excision repair involved in interstrand cross-link repairnucleotide-excision repair, DNA damage recognition +nucleotide-excision repair, DNA damage removalnucleotide-excision repair, DNA duplex unwindingnucleotide-excision repair, DNA gap fillingnucleotide-excision repair, DNA incision +nucleotide-excision repair, preincision complex assemblynucleotide-excision repair, preincision complex stabilizationpyrimidine dimer repair by nucleotide-excision repairregulation of nucleotide-excision repair +transcription-coupled nucleotide-excision repair +positive regulation of DNA repair +postreplication repair +pyrimidine dimer repair +recombinational repair +regulation of DNA repair +single strand break repairUV-damage excision repairviral DNA repair +biological_processmetabolic processcellular metabolic processcellular macromolecule metabolic processDNA metabolic processDNA repairbase-excision repair +DNA dealkylation involved in DNA repairDNA ligation involved in DNA repair +DNA replication proofreadingDNA synthesis involved in DNA repair +double-strand break repair +interstrand cross-link repair +mismatch repair +mitochondrial DNA repairnegative regulation of DNA repair +non-photoreactive DNA repairnon-recombinational repair +nucleotide-excision repair [GO:0006289] (41 genes, 70 annotations)global genome nucleotide-excision repairnucleotide-excision repair involved in interstrand cross-link repairnucleotide-excision repair, DNA damage recognition +nucleotide-excision repair, DNA damage removalnucleotide-excision repair, DNA duplex unwindingnucleotide-excision repair, DNA gap fillingnucleotide-excision repair, DNA incision +nucleotide-excision repair, preincision complex assemblynucleotide-excision repair, preincision complex stabilizationpyrimidine dimer repair by nucleotide-excision repairregulation of nucleotide-excision repair +transcription-coupled nucleotide-excision repair +positive regulation of DNA repair +postreplication repair +pyrimidine dimer repair +recombinational repair +regulation of DNA repair +single strand break repairUV-damage excision repairviral DNA repair +biological_processmetabolic processcellular metabolic processcellular nitrogen compound metabolic processnucleobase-containing compound metabolic processnucleic acid metabolic processDNA metabolic processDNA repairbase-excision repair +DNA dealkylation involved in DNA repairDNA ligation involved in DNA repair +DNA replication proofreadingDNA synthesis involved in DNA repair +double-strand break repair +interstrand cross-link repair +mismatch repair +mitochondrial DNA repairnegative regulation of DNA repair +non-photoreactive DNA repairnon-recombinational repair +nucleotide-excision repair [GO:0006289] (41 genes, 70 annotations)global genome nucleotide-excision repairnucleotide-excision repair involved in interstrand cross-link repairnucleotide-excision repair, DNA damage recognition +nucleotide-excision repair, DNA damage removalnucleotide-excision repair, DNA duplex unwindingnucleotide-excision repair, DNA gap fillingnucleotide-excision repair, DNA incision +nucleotide-excision repair, preincision complex assemblynucleotide-excision repair, preincision complex stabilizationpyrimidine dimer repair by nucleotide-excision repairregulation of nucleotide-excision repair +transcription-coupled nucleotide-excision repair +positive regulation of DNA repair +postreplication repair +pyrimidine dimer repair +recombinational repair +regulation of DNA repair +single strand break repairUV-damage excision repairviral DNA repair +biological_processmetabolic processcellular metabolic processheterocycle metabolic processnucleobase-containing compound metabolic processnucleic acid metabolic processDNA metabolic processDNA repairbase-excision repair +DNA dealkylation involved in DNA repairDNA ligation involved in DNA repair +DNA replication proofreadingDNA synthesis involved in DNA repair +double-strand break repair +interstrand cross-link repair +mismatch repair +mitochondrial DNA repairnegative regulation of DNA repair +non-photoreactive DNA repairnon-recombinational repair +nucleotide-excision repair [GO:0006289] (41 genes, 70 annotations)global genome nucleotide-excision repairnucleotide-excision repair involved in interstrand cross-link repairnucleotide-excision repair, DNA damage recognition +nucleotide-excision repair, DNA damage removalnucleotide-excision repair, DNA duplex unwindingnucleotide-excision repair, DNA gap fillingnucleotide-excision repair, DNA incision +nucleotide-excision repair, preincision complex assemblynucleotide-excision repair, preincision complex stabilizationpyrimidine dimer repair by nucleotide-excision repairregulation of nucleotide-excision repair +transcription-coupled nucleotide-excision repair +positive regulation of DNA repair +postreplication repair +pyrimidine dimer repair +recombinational repair +regulation of DNA repair +single strand break repairUV-damage excision repairviral DNA repair +biological_processmetabolic processnitrogen compound metabolic processcellular nitrogen compound metabolic processnucleobase-containing compound metabolic processnucleic acid metabolic processDNA metabolic processDNA repairbase-excision repair +DNA dealkylation involved in DNA repairDNA ligation involved in DNA repair +DNA replication proofreadingDNA synthesis involved in DNA repair +double-strand break repair +interstrand cross-link repair +mismatch repair +mitochondrial DNA repairnegative regulation of DNA repair +non-photoreactive DNA repairnon-recombinational repair +nucleotide-excision repair [GO:0006289] (41 genes, 70 annotations)global genome nucleotide-excision repairnucleotide-excision repair involved in interstrand cross-link repairnucleotide-excision repair, DNA damage recognition +nucleotide-excision repair, DNA damage removalnucleotide-excision repair, DNA duplex unwindingnucleotide-excision repair, DNA gap fillingnucleotide-excision repair, DNA incision +nucleotide-excision repair, preincision complex assemblynucleotide-excision repair, preincision complex stabilizationpyrimidine dimer repair by nucleotide-excision repairregulation of nucleotide-excision repair +transcription-coupled nucleotide-excision repair +positive regulation of DNA repair +postreplication repair +pyrimidine dimer repair +recombinational repair +regulation of DNA repair +single strand break repairUV-damage excision repairviral DNA repair +biological_processmetabolic processorganic substance metabolic processmacromolecule metabolic processcellular macromolecule metabolic processDNA metabolic processDNA repairbase-excision repair +DNA dealkylation involved in DNA repairDNA ligation involved in DNA repair +DNA replication proofreadingDNA synthesis involved in DNA repair +double-strand break repair +interstrand cross-link repair +mismatch repair +mitochondrial DNA repairnegative regulation of DNA repair +non-photoreactive DNA repairnon-recombinational repair +nucleotide-excision repair [GO:0006289] (41 genes, 70 annotations)global genome nucleotide-excision repairnucleotide-excision repair involved in interstrand cross-link repairnucleotide-excision repair, DNA damage recognition +nucleotide-excision repair, DNA damage removalnucleotide-excision repair, DNA duplex unwindingnucleotide-excision repair, DNA gap fillingnucleotide-excision repair, DNA incision +nucleotide-excision repair, preincision complex assemblynucleotide-excision repair, preincision complex stabilizationpyrimidine dimer repair by nucleotide-excision repairregulation of nucleotide-excision repair +transcription-coupled nucleotide-excision repair +positive regulation of DNA repair +postreplication repair +pyrimidine dimer repair +recombinational repair +regulation of DNA repair +single strand break repairUV-damage excision repairviral DNA repair +biological_processmetabolic processorganic substance metabolic processmacromolecule metabolic processnucleic acid metabolic processDNA metabolic processDNA repairbase-excision repair +DNA dealkylation involved in DNA repairDNA ligation involved in DNA repair +DNA replication proofreadingDNA synthesis involved in DNA repair +double-strand break repair +interstrand cross-link repair +mismatch repair +mitochondrial DNA repairnegative regulation of DNA repair +non-photoreactive DNA repairnon-recombinational repair +nucleotide-excision repair [GO:0006289] (41 genes, 70 annotations)global genome nucleotide-excision repairnucleotide-excision repair involved in interstrand cross-link repairnucleotide-excision repair, DNA damage recognition +nucleotide-excision repair, DNA damage removalnucleotide-excision repair, DNA duplex unwindingnucleotide-excision repair, DNA gap fillingnucleotide-excision repair, DNA incision +nucleotide-excision repair, preincision complex assemblynucleotide-excision repair, preincision complex stabilizationpyrimidine dimer repair by nucleotide-excision repairregulation of nucleotide-excision repair +transcription-coupled nucleotide-excision repair +positive regulation of DNA repair +postreplication repair +pyrimidine dimer repair +recombinational repair +regulation of DNA repair +single strand break repairUV-damage excision repairviral DNA repair +biological_processmetabolic processorganic substance metabolic processorganic cyclic compound metabolic processnucleobase-containing compound metabolic processnucleic acid metabolic processDNA metabolic processDNA repairbase-excision repair +DNA dealkylation involved in DNA repairDNA ligation involved in DNA repair +DNA replication proofreadingDNA synthesis involved in DNA repair +double-strand break repair +interstrand cross-link repair +mismatch repair +mitochondrial DNA repairnegative regulation of DNA repair +non-photoreactive DNA repairnon-recombinational repair +nucleotide-excision repair [GO:0006289] (41 genes, 70 annotations)global genome nucleotide-excision repairnucleotide-excision repair involved in interstrand cross-link repairnucleotide-excision repair, DNA damage recognition +nucleotide-excision repair, DNA damage removalnucleotide-excision repair, DNA duplex unwindingnucleotide-excision repair, DNA gap fillingnucleotide-excision repair, DNA incision +nucleotide-excision repair, preincision complex assemblynucleotide-excision repair, preincision complex stabilizationpyrimidine dimer repair by nucleotide-excision repairregulation of nucleotide-excision repair +transcription-coupled nucleotide-excision repair +positive regulation of DNA repair +postreplication repair +pyrimidine dimer repair +recombinational repair +regulation of DNA repair +single strand break repairUV-damage excision repairviral DNA repair +biological_processmetabolic processprimary metabolic processnucleobase-containing compound metabolic processnucleic acid metabolic processDNA metabolic processDNA repairbase-excision repair +DNA dealkylation involved in DNA repairDNA ligation involved in DNA repair +DNA replication proofreadingDNA synthesis involved in DNA repair +double-strand break repair +interstrand cross-link repair +mismatch repair +mitochondrial DNA repairnegative regulation of DNA repair +non-photoreactive DNA repairnon-recombinational repair +nucleotide-excision repair [GO:0006289] (41 genes, 70 annotations)global genome nucleotide-excision repairnucleotide-excision repair involved in interstrand cross-link repairnucleotide-excision repair, DNA damage recognition +nucleotide-excision repair, DNA damage removalnucleotide-excision repair, DNA duplex unwindingnucleotide-excision repair, DNA gap fillingnucleotide-excision repair, DNA incision +nucleotide-excision repair, preincision complex assemblynucleotide-excision repair, preincision complex stabilizationpyrimidine dimer repair by nucleotide-excision repairregulation of nucleotide-excision repair +transcription-coupled nucleotide-excision repair +positive regulation of DNA repair +postreplication repair +pyrimidine dimer repair +recombinational repair +regulation of DNA repair +single strand break repairUV-damage excision repairviral DNA repair +biological_processresponse to stimuluscellular response to stimuluscellular response to stressresponse to DNA damage stimulusDNA repairbase-excision repair +DNA dealkylation involved in DNA repairDNA ligation involved in DNA repair +DNA replication proofreadingDNA synthesis involved in DNA repair +double-strand break repair +interstrand cross-link repair +mismatch repair +mitochondrial DNA repairnegative regulation of DNA repair +non-photoreactive DNA repairnon-recombinational repair +nucleotide-excision repair [GO:0006289] (41 genes, 70 annotations)global genome nucleotide-excision repairnucleotide-excision repair involved in interstrand cross-link repairnucleotide-excision repair, DNA damage recognition +nucleotide-excision repair, DNA damage removalnucleotide-excision repair, DNA duplex unwindingnucleotide-excision repair, DNA gap fillingnucleotide-excision repair, DNA incision +nucleotide-excision repair, preincision complex assemblynucleotide-excision repair, preincision complex stabilizationpyrimidine dimer repair by nucleotide-excision repairregulation of nucleotide-excision repair +transcription-coupled nucleotide-excision repair +positive regulation of DNA repair +postreplication repair +pyrimidine dimer repair +recombinational repair +regulation of DNA repair +single strand break repairUV-damage excision repairviral DNA repair +biological_processresponse to stimulusresponse to stresscellular response to stressresponse to DNA damage stimulusDNA repairbase-excision repair +DNA dealkylation involved in DNA repairDNA ligation involved in DNA repair +DNA replication proofreadingDNA synthesis involved in DNA repair +double-strand break repair +interstrand cross-link repair +mismatch repair +mitochondrial DNA repairnegative regulation of DNA repair +non-photoreactive DNA repairnon-recombinational repair +nucleotide-excision repair [GO:0006289] (41 genes, 70 annotations)global genome nucleotide-excision repairnucleotide-excision repair involved in interstrand cross-link repairnucleotide-excision repair, DNA damage recognition +nucleotide-excision repair, DNA damage removalnucleotide-excision repair, DNA duplex unwindingnucleotide-excision repair, DNA gap fillingnucleotide-excision repair, DNA incision +nucleotide-excision repair, preincision complex assemblynucleotide-excision repair, preincision complex stabilizationpyrimidine dimer repair by nucleotide-excision repairregulation of nucleotide-excision repair +transcription-coupled nucleotide-excision repair +positive regulation of DNA repair +postreplication repair +pyrimidine dimer repair +recombinational repair +regulation of DNA repair +single strand break repairUV-damage excision repairviral DNA repair +biological_processsingle-organism processsingle-organism cellular processcellular response to stimuluscellular response to stressresponse to DNA damage stimulusDNA repairbase-excision repair +DNA dealkylation involved in DNA repairDNA ligation involved in DNA repair +DNA replication proofreadingDNA synthesis involved in DNA repair +double-strand break repair +interstrand cross-link repair +mismatch repair +mitochondrial DNA repairnegative regulation of DNA repair +non-photoreactive DNA repairnon-recombinational repair +nucleotide-excision repair [GO:0006289] (41 genes, 70 annotations)global genome nucleotide-excision repairnucleotide-excision repair involved in interstrand cross-link repairnucleotide-excision repair, DNA damage recognition +nucleotide-excision repair, DNA damage removalnucleotide-excision repair, DNA duplex unwindingnucleotide-excision repair, DNA gap fillingnucleotide-excision repair, DNA incision +nucleotide-excision repair, preincision complex assemblynucleotide-excision repair, preincision complex stabilizationpyrimidine dimer repair by nucleotide-excision repairregulation of nucleotide-excision repair +transcription-coupled nucleotide-excision repair +positive regulation of DNA repair +postreplication repair +pyrimidine dimer repair +recombinational repair +regulation of DNA repair +single strand break repairUV-damage excision repairviral DNA repair +Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 05/08/2013 MGI 5.13 |
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