Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ERAP1
  • Mouse genes Erap1
  • Rat genes Erap1
  • Zfish genes erap1a,erap1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Erap1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004177	aminopeptidase activity	ERAP1	IDA		Human	PMID:10220586
Molecular Function	GO:0004177	aminopeptidase activity	ERAP1	IDA		Human	PMID:12748171
Molecular Function	GO:0004177	aminopeptidase activity	Erap1	IDA		Mouse	PMID:11964289
Molecular Function	GO:0004177	aminopeptidase activity	Erap1	IMP		Rat	PMID:10824104|RGD:1299521
Molecular Function	GO:0004175	endopeptidase activity	ERAP1	EXP		Human	PMID:12436109
Molecular Function	GO:0004175	endopeptidase activity	ERAP1	EXP		Human	PMID:12436110
Molecular Function	GO:0004175	endopeptidase activity	ERAP1	EXP		Human	PMID:17088086
Molecular Function	GO:0005138	interleukin-6 receptor binding	ERAP1	IPI	UniProtKB:P08887	Human	PMID:12748171
Molecular Function	GO:0008235	metalloexopeptidase activity	ERAP1	IDA		Human	PMID:10220586
Molecular Function	GO:0008233	peptidase activity	Erap1	IMP		Mouse	PMID:23610143
Molecular Function	GO:0005515	protein binding	ERAP1	IPI	UniProtKB:P38159	Human	PMID:18445477
Molecular Function	GO:0005164	tumor necrosis factor receptor binding	Erap1	IPI	RGD:621237	Rat	PMID:20649583|RGD:5130976
Molecular Function	GO:0008270	zinc ion binding	Erap1	IMP		Rat	PMID:10824104|RGD:1299521
Cellular Component	GO:0005737	cytoplasm	Erap1	IDA		Mouse	PMID:11964289
Cellular Component	GO:0005788	endoplasmic reticulum lumen	Erap1	IDA		Rat	PMID:12436109|RGD:1299520
Cellular Component	GO:0070062	extracellular exosome	ERAP1	HDA		Human	PMID:19199708
Cellular Component	GO:0005576	extracellular region	ERAP1	IDA		Human	PMID:11056387
Cellular Component	GO:0005615	extracellular space	ERAP1	HDA		Human	PMID:16502470
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Erap1	IDA		Rat	PMID:12436109|RGD:1299520
Cellular Component	GO:0016020	membrane	ERAP1	HDA		Human	PMID:19946888
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	ERAP1	IDA		Human	PMID:12748171
Biological Process	GO:0045766	positive regulation of angiogenesis	Erap1	IMP		Mouse	PMID:11964289
Biological Process	GO:0030163	protein catabolic process	Erap1	IMP		Rat	PMID:10824104|RGD:1299521
Biological Process	GO:0006508	proteolysis	Erap1	IDA		Mouse	PMID:23610143

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern