Erap1
Gene Detail

Symbol Name ID

Erap1 endoplasmic reticulum aminopeptidase 1 MGI:1933403

Synonyms

Arts1, ERAAP, PILSAP

Feature Type

protein coding gene

Genetic Map

Chromosome 13

40.48 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr13:74639872-74691875 bp, + strand From NCBI annotation of GRCm38   52004 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Erap1 ± 2 cM)

Gene Tree: Erap1

Human ortholog

ERAP1 endoplasmic reticulum aminopeptidase 1 NCBI Gene ID 51752
Human Synonyms: ALAP, A-LAP, APPILS, ARTS1, ARTS-1, ERAAP, ERAAP1, PILSAP, PILS-AP
Human Chr5:96096514-96143892 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(9) : Targeted(9)
 

Mice homozygous for a targeted mutation may exhibit extramedullary hematopoiesis of the spleen, thymus hyperplasia, or enlarged kidneys at older ages.

 

Gene Ontology (GO) classifications

All GO classifications: (25 annotations)

Process	membrane protein ectodomain proteolysis, metabolic process, ...
Component	cytoplasm, endoplasmic reticulum, ...
Function	aminopeptidase activity, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (115)    Tissues (65)    Images (36)
Theiler Stages: 23, 28

Assay Type	Results
RNA in situ	5
In situ reporter (knock in)	72
RT-PCR	38

cDNA source data(75)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(77) cDNA(76) Primer pair(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000021583 (Evidence)
Entrez Gene	80898 (Evidence)
UniGene	83526
EC	3.4.11.-
Consensus CDS Project	CCDS26647.1
International Mouse Knockout Project Status	Erap1

Sequences

Length	Strain/Species
genomic	80898	NCBI Gene Model | MGI Sequence Detail	52004	C57BL/6J
transcript	NM_030711	RefSeq | MGI Sequence Detail	4014	C57BL/6
polypeptide	Q9EQH2	UniProt | EBI | MGI Sequence Detail	930	Not Applicable

All sequences(20) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(213 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR024571	Domain of unknown function DUF3358
InterPro	IPR001930	Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase
InterPro	IPR014782	Peptidase M1, membrane alanine aminopeptidase, N-terminal
Protein Ontology	PR:000007155	endoplasmic reticulum aminopeptidase 1

Graphical View of Protein Domain Structure

References

(Earliest) J:68745 Miyashita H, et al., A mouse orthologue of puromycin-insensitive leucyl-specific aminopeptidase is expressed in endothelial cells and plays an important role in angiogenesis. Blood. 2002 May 1;99(9):3241-9
(Latest) J:186455 Nagarajan NA, et al., Nonclassical MHC class Ib-restricted cytotoxic T cells monitor antigen processing in the endoplasmic reticulum. Nat Immunol. 2012 Jun;13(6):579-86
All references(41)