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Erap1
Gene Detail
 Symbol
Name
ID
Erap1
endoplasmic reticulum aminopeptidase 1
MGI:1933403
Synonyms Arts1, ERAAP, PILSAP
Feature Type protein coding gene
Genetic Map
Chromosome 13
40.48 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr13:74639872-74691875 bp, + strand
From NCBI annotation of GRCm38

  52004 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56754  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Erap1

Human
homologs
Human Homolog ERAP1, endoplasmic reticulum aminopeptidase 1
NCBI Gene ID 51752
neXtProt AC  NX_Q9NZ08
Human Synonyms  ALAP, A-LAP, APPILS, ARTS1, ARTS-1, ERAAP, ERAAP1, PILSAP, PILS-AP
Human Chr (Location)  5q15; chr5:96760810-96814145 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Targeted(10)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted mutation may exhibit extramedullary hematopoiesis of the spleen, thymus hyperplasia, or enlarged kidneys at older ages.
 
Interactions
Erap1 interacts with 217 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process immune system process, membrane protein ectodomain proteolysis, ...
Component cytoplasm, endoplasmic reticulum, ...
Function aminopeptidase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (115)    Tissues (65)    Images (36)
Theiler Stages: 23, 28
Assay TypeResults
RNA in situ 5
In situ reporter (knock in) 72
RT-PCR 38
cDNA source data(75)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(77) cDNA(76) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000021583 (Evidence)
Entrez Gene80898 (Evidence)
UniGene83526
EC3.4.11.-
Consensus CDS ProjectCCDS26647.1
International Mouse Knockout Project StatusErap1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 80898 NCBI Gene Model | MGI Sequence Detail 52004 C57BL/6J ±  kb
transcript NM_030711 RefSeq | MGI Sequence Detail 4014 C57BL/6 
polypeptide Q9EQH2 UniProt | EBI | MGI Sequence Detail 930 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(4) UniProt(3)
Polymorphisms SNPs within 2kb(242 from dbSNP Build 137)    SNPs within 2kb including multiple locations(244)
Protein-related
information
ResourceIDDescription
InterPro IPR024571 Domain of unknown function DUF3358
InterPro IPR001930 Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase
InterPro IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal
Protein Ontology PR:000007155 endoplasmic reticulum aminopeptidase 1
Graphical View of Protein Domain Structure
References (Earliest) J:68745 Miyashita H, et al., A mouse orthologue of puromycin-insensitive leucyl-specific aminopeptidase is expressed in endothelial cells and plays an important role in angiogenesis. Blood. 2002 May 1;99(9):3241-9
(Latest) J:209965 Goto Y, et al., TLR-mediated secretion of endoplasmic reticulum aminopeptidase 1 from macrophages. J Immunol. 2014 May 1;192(9):4443-52
All references(47)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory