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Erap1 Gene Detail
Summary
  • Symbol
    Erap1
  • Name
    endoplasmic reticulum aminopeptidase 1
  • Synonyms
    Arts1, ERAAP, PILSAP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933403
    NCBI Gene: 80898
  • Gene Overview
    MyGene.info: ERAP1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:74639624-74692537 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 40.48 cM, cytoband C1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    230 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1933403
protein coding gene Chr13:74639568-74693201 (.)
129S1/SvImJ MGP_129S1SvImJ_G0020768
protein coding gene Chr13:75169592-75222247 (+)
A/J MGP_AJ_G0020723
protein coding gene Chr13:72556666-72617226 (+)
AKR/J MGP_AKRJ_G0020697
protein coding gene Chr13:74784216-74835665 (+)
BALB/cJ MGP_BALBcJ_G0020720
protein coding gene Chr13:73044577-73095888 (+)
C3H/HeJ MGP_C3HHeJ_G0020514
protein coding gene Chr13:74476299-74529849 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021157
protein coding gene Chr13:77691087-77744498 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018725
protein coding gene Chr13:69468158-69513354 (+)
CAST/EiJ MGP_CASTEiJ_G0020032
protein coding gene Chr13:73578706-73627695 (+)
CBA/J MGP_CBAJ_G0020473
protein coding gene Chr13:80591352-80661426 (+)
DBA/2J MGP_DBA2J_G0020598
protein coding gene Chr13:72314864-72364874 (+)
FVB/NJ MGP_FVBNJ_G0020578
protein coding gene Chr13:71361716-71409280 (+)
LP/J MGP_LPJ_G0020671
protein coding gene Chr13:75421563-75471118 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020607
protein coding gene Chr13:78989896-79044189 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021197
protein coding gene Chr13:74104675-74161937 (+)
PWK/PhJ MGP_PWKPhJ_G0019785
protein coding gene Chr13:71196533-71242718 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019608
protein coding gene Chr13:70479468-70537294 (+)
WSB/EiJ MGP_WSBEiJ_G0020089
protein coding gene Chr13:74624855-74675004 (+)



Homology
more
  • Human Ortholog
    ERAP1, endoplasmic reticulum aminopeptidase 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    ERAP1, endoplasmic reticulum aminopeptidase 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ALAP, A-LAP, APPILS, ARTS1, ARTS-1, ERAAP, ERAAP1, PILSAP, PILS-AP
  • Links
    NCBI Gene ID: 51752
    neXtProt AC: NX_Q9NZ08
    UniProt: Q9NZ08

  • Chr Location
    5q15; chr5:96759245-96935983 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 56754
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ERAP1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 5 alleles in 5 genetic backgrounds
    2 phenotypes from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted mutation may exhibit extramedullary hematopoiesis of the spleen, thymus hyperplasia, or enlarged kidneys at older ages.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 80898 NCBI Gene Model | MGI Sequence Detail 52914 C57BL/6J ±  kb
    transcript NM_030711 RefSeq | MGI Sequence Detail 5363 C57BL/6  
    polypeptide Q9EQH2 UniProt | EBI | MGI Sequence Detail 930 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 78
      cDNA 77
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 2
      Gene Ontology 8
      Phenotypes 25
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:262587 Schmidt K, et al., ERAP1-Dependent Antigen Cross-Presentation Determines Efficacy of Adoptive T-cell Therapy in Mice. Cancer Res. 2018 Jun 15;78(12):3243-3254

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory