About   Help   FAQ
Erap1 Gene Detail
Summary
  • Symbol
    Erap1
  • Name
    endoplasmic reticulum aminopeptidase 1
  • Synonyms
    Arts1, ERAAP, PILSAP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933403
    NCBI Gene: 80898
  • Gene Overview
    MyGene.info: ERAP1
Location & Maps
more
  • Sequence Map
    Chr13:74639872-74691875 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      52004 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 40.48 cM, cytoband C1
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ERAP1, endoplasmic reticulum aminopeptidase 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    ERAP1, endoplasmic reticulum aminopeptidase 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ALAP, A-LAP, APPILS, ARTS1, ARTS-1, ERAAP, ERAAP1, PILSAP, PILS-AP
  • Links
    NCBI Gene ID: 51752
    neXtProt AC: NX_Q9NZ08

  • Chr Location
    5q15; chr5:96760810-96935924 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 56754
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;2 zebrafish
  • HCOP
    human homology predictions: ERAP1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 5 alleles in 5 genetic backgrounds
    2 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    1
  • Targeted
    10
  • Genomic Mutations
    1 involving Erap1
  • Incidental Mutations
Mice homozygous for a targeted mutation may exhibit extramedullary hematopoiesis of the spleen, thymus hyperplasia, or enlarged kidneys at older ages.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021583 Ensembl Gene Model | MGI Sequence Detail 52004 C57BL/6J ±  kb
transcript ENSMUST00000169114 Ensembl | MGI Sequence Detail 4014 Not Applicable  
polypeptide ENSMUSP00000133166 Ensembl | MGI Sequence Detail 930 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    229 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000007155 endoplasmic reticulum aminopeptidase 1
  • EC
  • InterPro Domains
    IPR024571 ERAP1-like C-terminal domain
    IPR001930 Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase
    IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal
Molecular
Reagents
less
  • All nucleic 77
    cDNA 76
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 47
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 21
  • Earliest
    J:68745 Miyashita H, et al., A mouse orthologue of puromycin-insensitive leucyl-specific aminopeptidase is expressed in endothelial cells and plays an important role in angiogenesis. Blood. 2002 May 1;99(9):3241-9
  • Latest
    J:209965 Goto Y, et al., TLR-mediated secretion of endoplasmic reticulum aminopeptidase 1 from macrophages. J Immunol. 2014 May 1;192(9):4443-52

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/24/2016
MGI 6.04
The Jackson Laboratory