Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse E2f1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes E2F1
- Mouse genes E2f1
- Rat genes E2f1
- Zfish genes e2f1
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set E2f1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	E2F1	IDA		Human	PMID:15735762
Molecular Function	GO:0003677	DNA binding	E2F1	IMP		Human	PMID:11418595
Molecular Function	GO:0003677	DNA binding	E2F1	IDA		Human	PMID:15073182
Molecular Function	GO:0003677	DNA binding	E2F1	IDA		Human	PMID:15731768
Molecular Function	GO:0001216	DNA-binding transcription activator activity	E2F1	IDA		Human	PMID:17062573
Molecular Function	GO:0001216	DNA-binding transcription activator activity	E2F1	IDA		Human	PMID:28992046
Molecular Function	GO:0003700	DNA-binding transcription factor activity	E2F1	IDA		Human	PMID:15731768
Molecular Function	GO:0003700	DNA-binding transcription factor activity	E2f1	IDA		Mouse	PMID:11095619
Molecular Function	GO:0003700	DNA-binding transcription factor activity	E2f1	IDA		Mouse	PMID:10779331
Molecular Function	GO:0003700	DNA-binding transcription factor activity	E2f1	IDA		Mouse	PMID:14667810
Molecular Function	GO:0003700	DNA-binding transcription factor activity	E2f1	IDA		Mouse	PMID:15722552
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	E2F1	IMP		Human	PMID:20040599
Molecular Function	GO:0140297	DNA-binding transcription factor binding	E2F1	IPI	UniProtKB:Q14186	Human	PMID:16360038
Molecular Function	GO:0140297	DNA-binding transcription factor binding	E2F1	IPI	UniProtKB:P05554	Human	PMID:20176812
Molecular Function	GO:0060090	molecular adaptor activity	E2F1	EXP		Human	PMID:16360038
Molecular Function	GO:0005515	protein binding	E2F1	IPI	UniProtKB:Q9Y4A5	Human	PMID:11418595
Molecular Function	GO:0005515	protein binding	E2F1	IPI	UniProtKB:O60934	Human	PMID:11486038
Molecular Function	GO:0005515	protein binding	E2F1	IPI	UniProtKB:P06400	Human	PMID:12502741
Molecular Function	GO:0005515	protein binding	E2F1	IPI	UniProtKB:P09874	Human	PMID:14627987
Molecular Function	GO:0005515	protein binding	E2F1	IPI	UniProtKB:P03129	Human	PMID:16061792
Molecular Function	GO:0005515	protein binding	E2F1	IPI	UniProtKB:P06400	Human	PMID:16249186
Molecular Function	GO:0005515	protein binding	E2F1	IPI	UniProtKB:P06400	Human	PMID:16360038
Molecular Function	GO:0005515	protein binding	E2F1	IPI	UniProtKB:Q14186	Human	PMID:16360038
Molecular Function	GO:0005515	protein binding	E2F1	IPI	UniProtKB:P06400	Human	PMID:16374512
Molecular Function	GO:0005515	protein binding	E2F1	IPI	UniProtKB:Q923E4	Human	PMID:16892051
Molecular Function	GO:0005515	protein binding	E2F1	IPI	UniProtKB:Q96EB6	Human	PMID:16892051
Molecular Function	GO:0005515	protein binding	E2F1	IPI	UniProtKB:Q92547	Human	PMID:17006541
Molecular Function	GO:0005515	protein binding	E2F1	IPI	UniProtKB:Q5H9I0	Human	PMID:17062573
Molecular Function	GO:0005515	protein binding	E2F1	IPI	UniProtKB:P06400	Human	PMID:17380128
Molecular Function	GO:0005515	protein binding	E2F1	IPI	UniProtKB:Q96JM7	Human	PMID:17517653
Molecular Function	GO:0005515	protein binding	E2F1	IPI	UniProtKB:Q14201	Human	PMID:17690688
Molecular Function	GO:0005515	protein binding	E2F1	IPI	UniProtKB:Q13263	Human	PMID:17704056
Molecular Function	GO:0005515	protein binding	E2F1	IPI	UniProtKB:Q13547	Human	PMID:17704056
Molecular Function	GO:0005515	protein binding	E2F1	IPI	UniProtKB:Q96IZ0	Human	PMID:18660514
Molecular Function	GO:0005515	protein binding	E2F1	IPI	UniProtKB:Q8NEM0	Human	PMID:18660752
Molecular Function	GO:0005515	protein binding	E2F1	IPI	UniProtKB:P49336	Human	PMID:18794899
Molecular Function	GO:0005515	protein binding	E2F1	IPI	UniProtKB:Q96EB6	Human	PMID:19188449
Molecular Function	GO:0005515	protein binding	E2F1	IPI	UniProtKB:P06400	Human	PMID:19249677
Molecular Function	GO:0005515	protein binding	E2F1	IPI	UniProtKB:Q14684	Human	PMID:20040599
Molecular Function	GO:0005515	protein binding	E2F1	IPI	UniProtKB:P09874	Human	PMID:20133863
Molecular Function	GO:0005515	protein binding	E2F1	IPI	UniProtKB:P42224	Human	PMID:20195357
Molecular Function	GO:0005515	protein binding	E2F1	IPI	UniProtKB:Q9Y618	Human	PMID:20195357
Molecular Function	GO:0005515	protein binding	E2F1	IPI	UniProtKB:Q14186	Human	PMID:20211142
Molecular Function	GO:0005515	protein binding	E2F1	IPI	UniProtKB:P13405	Human	PMID:20224733
Molecular Function	GO:0005515	protein binding	E2F1	IPI	UniProtKB:Q9UPP1	Human	PMID:20622854
Molecular Function	GO:0005515	protein binding	E2F1	IPI	UniProtKB:O95361	Human	PMID:20729920
Molecular Function	GO:0005515	protein binding	E2F1	IPI	UniProtKB:P06400	Human	PMID:20871633
Molecular Function	GO:0005515	protein binding	E2F1	IPI	UniProtKB:Q92830	Human	PMID:20972224
Molecular Function	GO:0005515	protein binding	E2F1	IPI	UniProtKB:Q13490	Human	PMID:21653699
Molecular Function	GO:0005515	protein binding	E2F1	IPI	UniProtKB:O14744	Human	PMID:22327218
Molecular Function	GO:0005515	protein binding	E2F1	IPI	UniProtKB:Q14186	Human	PMID:22327218
Molecular Function	GO:0005515	protein binding	E2F1	IPI	UniProtKB:P03129	Human	PMID:22810586
Molecular Function	GO:0005515	protein binding	E2F1	IPI	UniProtKB:P06400	Human	PMID:23472054
Molecular Function	GO:0005515	protein binding	E2F1	IPI	UniProtKB:P51610	Human	PMID:23629655
Molecular Function	GO:0005515	protein binding	E2F1	IPI	UniProtKB:Q92830	Human	PMID:24502362
Molecular Function	GO:0005515	protein binding	E2F1	IPI	UniProtKB:Q14186	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	E2F1	IPI	UniProtKB:Q14186	Human	PMID:27705803
Molecular Function	GO:0005515	protein binding	E2F1	IPI	UniProtKB:P06400	Human	PMID:29521627
Molecular Function	GO:0005515	protein binding	E2F1	IPI	UniProtKB:Q96JM7	Human	PMID:29691401
Molecular Function	GO:0005515	protein binding	E2F1	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	E2F1	IPI	UniProtKB:P06400	Human	PMID:34591612
Molecular Function	GO:0005515	protein binding	E2F1	IPI	UniProtKB:P06400	Human	PMID:35140242
Molecular Function	GO:0005515	protein binding	E2F1	IPI	UniProtKB:Q14186	Human	PMID:35140242
Molecular Function	GO:0005515	protein binding	E2F1	IPI	UniProtKB:Q92830	Human	PMID:35140242
Molecular Function	GO:0005515	protein binding	E2F1	IPI	UniProtKB:Q14188	Human	PMID:7784053
Molecular Function	GO:0005515	protein binding	E2F1	IPI	UniProtKB:P13405	Human	PMID:8336704
Molecular Function	GO:0005515	protein binding	E2F1	IPI	UniProtKB:P08047	Human	PMID:8657141
Molecular Function	GO:0005515	protein binding	E2F1	IPI	UniProtKB:Q92466	Human	PMID:9418871
Molecular Function	GO:0005515	protein binding	E2F1	IPI	UniProtKB:Q13547	Human	PMID:9468139
Molecular Function	GO:0005515	protein binding	E2F1	IPI	UniProtKB:Q13547	Human	PMID:9468140
Molecular Function	GO:0005515	protein binding	E2f1	IPI	UniProtKB:P25233	Mouse	MGI:MGI:3691954\|PMID:17108174
Molecular Function	GO:0005515	protein binding	E2f1	IPI	UniProtKB:P42669	Mouse	MGI:MGI:3687670\|PMID:10597240
Molecular Function	GO:0005515	protein binding	E2f1	IPI	PR:Q9QZ04	Mouse	PMID:14593116
Molecular Function	GO:0005515	protein binding	E2f1	IPI	PR:Q9CPR8	Mouse	PMID:14593116
Molecular Function	GO:0005515	protein binding	E2f1	IPI	PR:P25233	Mouse	PMID:12198120
Molecular Function	GO:0005515	protein binding	E2f1	IPI	PR:Q08639	Mouse	PMID:15448153
Molecular Function	GO:0005515	protein binding	E2f1	IPI	UniProtKB:P23396	Rat	PMID:20605787\|RGD:10402036
Molecular Function	GO:0005515	protein binding	E2f1	IPI	RGD:3540	Rat	PMID:9697699\|RGD:69955
Molecular Function	GO:0005515	protein binding	E2f1	IPI	UniProtKB:P33568	Rat	PMID:9697699\|RGD:69955
Molecular Function	GO:0019901	protein kinase binding	E2f1	IPI	RGD:70982	Rat	PMID:18367454\|RGD:8693614
Molecular Function	GO:0043565	sequence-specific DNA binding	E2F1	IDA		Human	PMID:23332764
Molecular Function	GO:0043565	sequence-specific DNA binding	E2f1	IDA		Mouse	MGI:MGI:2152476\|PMID:11672531
Molecular Function	GO:0043565	sequence-specific DNA binding	E2f1	IDA		Rat	PMID:18096822\|RGD:2316264
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	E2F1	IDA		Human	PMID:28473536
Molecular Function	GO:0000976	transcription cis-regulatory region binding	E2f1	IDA		Mouse	PMID:24014029
Cellular Component	GO:0005813	centrosome	E2F1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0000785	chromatin	E2F1	IDA		Human	PMID:21454377
Cellular Component	GO:0000785	chromatin	E2f1	IDA		Mouse	MGI:MGI:2178490\|PMID:12007404
Cellular Component	GO:0005737	cytoplasm	E2f1	IDA		Mouse	PMID:8918469
Cellular Component	GO:0005737	cytoplasm	E2f1	IDA		Rat	PMID:18367454\|RGD:8693614
Cellular Component	GO:0000228	nuclear chromosome	E2f1	IDA		Rat	PMID:24250814\|RGD:151356618
Cellular Component	GO:0005654	nucleoplasm	E2F1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	E2F1	IDA		Human	PMID:28992046
Cellular Component	GO:0005634	nucleus	E2F1	IDA		Human	PMID:12717439
Cellular Component	GO:0005634	nucleus	E2F1	IDA		Human	PMID:20040599
Cellular Component	GO:0005634	nucleus	E2f1	IDA		Mouse	PMID:8918469
Cellular Component	GO:0005634	nucleus	E2f1	IDA		Mouse	PMID:10082561
Cellular Component	GO:0005634	nucleus	E2f1	IDA		Rat	PMID:19088195\|RGD:2316261
Cellular Component	GO:0032991	protein-containing complex	E2F1	IDA		Human	PMID:23629655
Cellular Component	GO:0035189	Rb-E2F complex	E2F1	IPI		Human	PMID:16360038
Cellular Component	GO:0035189	Rb-E2F complex	E2F1	IDA		Human	PMID:20224733
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	E2F1	IPI		Human	PMID:16360038
Cellular Component	GO:0005667	transcription regulator complex	E2f1	IDA		Mouse	PMID:10082561
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	e2f1	IMP	ZFIN:ZDB-MRPHLNO-180531-4	Zfish	PMID:29229770
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	e2f1	IGI	ZFIN:ZDB-GENE-040428-1	Zfish	PMID:29229770
Biological Process	GO:0043276	anoikis	E2f1	IDA		Mouse	PMID:14667810
Biological Process	GO:0048469	cell maturation	e2f1	IMP	ZFIN:ZDB-MRPHLNO-180531-4	Zfish	PMID:29229770
Biological Process	GO:0048469	cell maturation	e2f1	IMP	ZFIN:ZDB-GENO-181101-1	Zfish	PMID:29229770
Biological Process	GO:0048469	cell maturation	e2f1	IGI	ZFIN:ZDB-GENE-040428-1	Zfish	PMID:29229770
Biological Process	GO:0048469	cell maturation	e2f1	IGI	ZFIN:ZDB-GENE-131024-3	Zfish	PMID:29229770
Biological Process	GO:0071398	cellular response to fatty acid	E2f1	IEP		Rat	PMID:19180667\|RGD:2316259
Biological Process	GO:0071456	cellular response to hypoxia	E2f1	IEP		Rat	PMID:19088195\|RGD:2316261
Biological Process	GO:1990090	cellular response to nerve growth factor stimulus	E2f1	IDA		Rat	PMID:18367454\|RGD:8693614
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	E2f1	IDA		Mouse	PMID:24726645
Biological Process	GO:0000077	DNA damage checkpoint signaling	E2F1	IMP		Human	PMID:12717439
Biological Process	GO:0006351	DNA-templated transcription	E2f1	IDA		Mouse	MGI:MGI:2152476\|PMID:11672531
Biological Process	GO:0006351	DNA-templated transcription	E2f1	IDA		Mouse	MGI:MGI:3581091\|PMID:15722552
Biological Process	GO:0030900	forebrain development	E2f1	IMP	MGI:MGI:1857424	Mouse	PMID:15525772
Biological Process	GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	E2f1	IDA		Mouse	PMID:11095619
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	E2F1	IMP		Human	PMID:12717439
Biological Process	GO:1990086	lens fiber cell apoptotic process	E2f1	IDA		Mouse	PMID:11095619
Biological Process	GO:0048255	mRNA stabilization	E2F1	IDA		Human	PMID:15766563
Biological Process	GO:0043392	negative regulation of DNA binding	E2F1	IDA		Human	PMID:20176812
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	E2F1	IDA		Human	PMID:1531329
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	E2F1	IDA		Human	PMID:20176812
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	E2F1	IMP		Human	PMID:20224733
Biological Process	GO:0045599	negative regulation of fat cell differentiation	E2f1	IDA		Mouse	MGI:MGI:2152476\|PMID:11672531
Biological Process	GO:0070345	negative regulation of fat cell proliferation	E2f1	IMP		Mouse	MGI:MGI:4461077\|PMID:20176812
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	E2F1	IMP		Human	PMID:20224733
Biological Process	GO:0071930	negative regulation of transcription involved in G1/S transition of mitotic cell cycle	E2F1	IMP		Human	PMID:20224733
Biological Process	GO:0043065	positive regulation of apoptotic process	E2F1	IDA		Human	PMID:15565177
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	E2F1	IMP		Human	PMID:15565177
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	E2F1	IMP		Human	PMID:20224733
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	E2F1	IDA		Human	PMID:21454377
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	E2F1	IDA		Human	PMID:22476863
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	E2f1	IDA		Mouse	PMID:11331592
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	E2f1	IDA		Mouse	PMID:15722552
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	E2f1	IDA		Mouse	PMID:12893818
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	E2F1	IMP		Human	PMID:20224733
Biological Process	GO:0010628	positive regulation of gene expression	E2F1	IDA		Human	PMID:15766563
Biological Process	GO:0060252	positive regulation of glial cell proliferation	E2f1	IMP		Rat	PMID:21637599\|RGD:13702469
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	E2F1	IMP		Human	PMID:20040599
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	E2F1	IMP		Human	PMID:20224733
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	E2F1	IDA		Human	PMID:28992046
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	E2f1	IDA		Mouse	PMID:11004506
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	E2f1	IGI	MGI:MGI:101934	Mouse	PMID:7797074
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	E2f1	IDA		Mouse	PMID:24014029
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	E2f1	IDA		Mouse	PMID:12198120
Biological Process	GO:0051726	regulation of cell cycle	E2f1	IDA		Mouse	PMID:11095619
Biological Process	GO:0006355	regulation of DNA-templated transcription	E2F1	IDA		Human	PMID:12717439
Biological Process	GO:0006355	regulation of DNA-templated transcription	E2f1	IDA		Mouse	MGI:MGI:3581091\|PMID:15722552
Biological Process	GO:0006355	regulation of DNA-templated transcription	E2f1	IDA		Mouse	PMID:14667810
Biological Process	GO:0006355	regulation of DNA-templated transcription	E2f1	IDA		Mouse	PMID:14593116
Biological Process	GO:0006355	regulation of DNA-templated transcription	E2f1	IDA		Mouse	PMID:11071387
Biological Process	GO:2000045	regulation of G1/S transition of mitotic cell cycle	E2F1	IMP		Human	PMID:20224733
Biological Process	GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle	E2F1	IDA		Human	PMID:23934193
Biological Process	GO:0007283	spermatogenesis	E2f1	IEP		Rat	PMID:17147820\|RGD:2316265

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.