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E2f1 Gene Detail
Summary
  • Symbol
    E2f1
  • Name
    E2F transcription factor 1
  • Synonyms
    E2F-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:101941
    NCBI Gene: 13555
  • Gene Overview
    MyGene.info: E2F1
Location & Maps
more
  • Sequence Map
    Chr2:154559407-154569892 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10486 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 76.79 cM
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    E2F1, E2F transcription factor 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    E2F1, E2F transcription factor 1
    Orthology source: HomoloGene
  • Synonyms
    E2F-1, RBAP1, RBBP3, RBP3
  • Links
    NCBI Gene ID: 1869
    neXtProt AC: NX_Q01094

  • Chr Location
    20q11.2; chr20:33675486-33686404 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with E2f1 mouse models

Human Disease Mouse Models
       Diabetes Mellitus, Insulin-Dependent; IDDM   OMIM: 222100 View 1 model
Sjogren Syndrome   OMIM: 270150 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    68 phenotypes from 3 alleles in 8 genetic backgrounds
    73 phenotypes from multigenic genotypes
    120 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Gene trapped
    4
  • Targeted
    4
  • Transgenic
    1
  • Incidental Mutations
Homozygous mutants show defective T lymphocyte development, impaired pancreatic growth and beta cell function, altered glucose homeostasis, testicular atrophy, salivary gland and adipose tissue defects, and increased tumor induction.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015917 VEGA Gene Model | MGI Sequence Detail 10486 C57BL/6J ±  kb
transcript OTTMUST00000037809 VEGA | MGI Sequence Detail 2732 Not Applicable  
polypeptide OTTMUSP00000016974 VEGA | MGI Sequence Detail 430 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    56 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000006852 transcription factor E2F1
  • InterPro Domains
    IPR003316 E2F/DP family, winged-helix DNA-binding domain
    IPR015633 E2F Family
    IPR032198 E2F transcription factor, CC-MB domain
    IPR011991 Winged helix-turn-helix DNA-binding domain
Molecular
Reagents
less
  • All nucleic 28
    Genomic 6
    cDNA 14
    Primer pair 6
    Other 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-18775
References
more
  • Summaries
    All 261
    Developmental Gene Expression 46
    Diseases 4
    Gene Ontology 23
    Phenotypes 120
  • Earliest
    J:16207 Carlsten H, et al., Histocompatibility complex gene products and exposure to oestrogen: two independent disease accelerating factors in murine lupus. Scand J Immunol. 1993 Oct;38(4):341-7
  • Latest
    J:230033 Lagarrigue S, et al., CDK4 is an essential insulin effector in adipocytes. J Clin Invest. 2016 Jan;126(1):335-48

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory