E2f1
Gene Detail

Symbol Name ID

E2f1 E2F transcription factor 1 MGI:101941

Synonyms

E2F-1

Feature Type

protein coding gene

Genetic Map

Chromosome 2

76.79 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr2:154559407-154569892 bp, - strand From VEGA annotation of GRCm38   10486 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3828  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: transcription factor E2F
Gene Tree: E2f1

Human homologs

Human Homolog		E2F1, E2F transcription factor 1
NCBI Gene ID		1869
neXtProt AC		NX_Q01094
Human Synonyms		E2F-1, RBAP1, RBBP3, RBP3
Human Chr (Location)		20q11.2; chr20:32263292-32274210 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(2) Gene trapped(4)
 

Homozygous mutants exhibit defective T lymphocyte development, impaired pancreatic growth and beta cell function, testicular atrophy, salivary gland abnormalities including decreased salivation, adipose abnormalities, and glucose intolerance and insulin hypersensitivity.

 
Human Diseases Modeled Using Mouse E2f1 (2)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (40 annotations)

Process	anoikis, apoptotic process, ...
Component	cytoplasm, nucleus, ...
Function	core promoter binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (41 records)
Data Summary: Results (188)    Tissues (103)    Images (15)
Theiler Stages: 1, 2, 3, 4, 5, 15, 16, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	77
Western blot	44
RT-PCR	67

cDNA source data(39)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(54) Genomic(6) cDNA(40) Primer pair(6) Other(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000015917 (Evidence)
Ensembl Gene Model	ENSMUSG00000027490 (Evidence)
Entrez Gene	13555 (Evidence)
UniGene	18036
DFCI	TC1580685, TC1589446, TC1672614
DoTS	DT.487843, DT.55242765, DT.94214859
NIA Mouse Gene Index	U023524
Consensus CDS Project	CCDS16935.1
International Mouse Knockout Project Status	E2f1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000015917	VEGA Gene Model | MGI Sequence Detail	10486	C57BL/6J
transcript	OTTMUST00000037809	VEGA | MGI Sequence Detail	2732	Not Applicable
polypeptide	OTTMUSP00000016974	VEGA | MGI Sequence Detail	430	Not Applicable

All sequences(39) RefSeq(2) UniProt(4)

Polymorphisms

All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs(26 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR015633	E2F Family
InterPro	IPR003316	Transcription factor E2F/dimerisation partner (TDP)
InterPro	IPR011991	Winged helix-turn-helix DNA-binding domain
Protein Ontology	PR:000006852	transcription factor E2F1

References

(Earliest) J:16207 Carlsten H, et al., Histocompatibility complex gene products and exposure to oestrogen: two independent disease accelerating factors in murine lupus. Scand J Immunol. 1993 Oct;38(4):341-7
(Latest) J:195318 Lu Z, et al., pRb is an obesity suppressor in hypothalamus and high-fat diet inhibits pRb in this location. EMBO J. 2013 Mar 20;32(6):844-57
All references(225)

Other accession IDs

MGD-MRK-18775