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E2f1
Gene Detail
 Symbol
Name
ID
E2f1
E2F transcription factor 1
MGI:101941
Synonyms E2F-1
Feature Type protein coding gene
Genetic Map
Chromosome 2
76.79 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr2:154559407-154569892 bp, - strand
From VEGA annotation of GRCm38

  10486 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3828  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: transcription factor E2F
Gene Tree: E2f1

Human
homologs
Human Homolog E2F1, E2F transcription factor 1
NCBI Gene ID 1869
neXtProt AC  NX_Q01094
Human Synonyms  E2F-1, RBAP1, RBBP3, RBP3
Human Chr (Location)  20q11.2; chr20:33675486-33686404 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(4) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutants exhibit defective T lymphocyte development, impaired pancreatic growth and beta cell function, testicular atrophy, salivary gland abnormalities including decreased salivation, adipose abnormalities, and glucose intolerance and insulin hypersensitivity.
 
Human Diseases Modeled Using Mouse E2f1 (2)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)
Interactions
E2f1 interacts with 214 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (41 annotations)
Process anoikis, apoptotic process, ...
Component cytoplasm, nucleus, ...
Function core promoter binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (41 records)
Data Summary: Results (174)    Tissues (98)    Images (15)
Theiler Stages: 1, 2, 3, 4, 5, 15, 16, 17, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
RNA in situ 77
Western blot 44
RT-PCR 53
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(28) Genomic(6) cDNA(14) Primer pair(6) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000015917 (Evidence)
Ensembl Gene ModelENSMUSG00000027490 (Evidence)
Entrez Gene13555 (Evidence)
DFCITC1580685, TC1589446, TC1672614
DoTSDT.487843, DT.55242765, DT.94214859
NIA Mouse Gene IndexU023524
Consensus CDS ProjectCCDS16935.1, CCDS71165.1
International Mouse Knockout Project StatusE2f1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015917 VEGA Gene Model | MGI Sequence Detail 10486 C57BL/6J ±  kb
transcript OTTMUST00000037809 VEGA | MGI Sequence Detail 2732 Not Applicable 
polypeptide OTTMUSP00000016974 VEGA | MGI Sequence Detail 430 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(4) UniProt(4)
Polymorphisms All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(61 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015633 E2F Family
InterPro IPR003316 Transcription factor E2F/dimerisation partner (TDP)
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000006852 transcription factor E2F1
References (Earliest) J:16207 Carlsten H, et al., Histocompatibility complex gene products and exposure to oestrogen: two independent disease accelerating factors in murine lupus. Scand J Immunol. 1993 Oct;38(4):341-7
(Latest) J:211680 Matsumoto A, et al., p57 regulates T-cell development and prevents lymphomagenesis by balancing p53 activity and pre-TCR signaling. Blood. 2014 May 29;123(22):3429-39
All references(233)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-18775

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory