Go Annotations as Summary Text (Tabular View) (GO Graph)

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Automated description from the Alliance of Genome Resources (Release 8.3.0)

Enables DNA-binding transcription factor activity and transcription cis-regulatory region binding activity. Involved in DNA-templated transcription; negative regulation of fat cell differentiation; and negative regulation of fat cell proliferation. Acts upstream of or within several processes, including anoikis; intrinsic apoptotic signaling pathway by p53 class mediator; and lens fiber cell apoptotic process. Located in chromatin; cytoplasm; and nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and lung. Used to study Sjogren's syndrome and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in lung carcinoma (multiple); osteosarcoma; and pancreatic adenocarcinoma (multiple). Orthologous to human E2F1 (E2F transcription factor 1).

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Gene Ontology Evidence Code Abbreviations:

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