68 phenotypes from 3 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
E2f1tm1.1Dgj/E2f1tm1.1Dgj FVB.Cg-E2f1tm1.1Dgj	increased incidence of tumors by UV-induction	J:212453
E2f1tm1.1Dgj/E2f1tm1.1Dgj involves: FVB	abnormal base-excision repair	J:212453
	abnormal double-strand DNA break repair	J:212453
	normal cellular phenotype	J:212453
	normal endocrine/exocrine gland phenotype	J:212453
E2f1tm1Meg/E2f1tm1Meg either: (involves: 129/Sv * 129S4/SvJae) or (involves: 129/Sv * 129S4/SvJae * C57BL/6)	abnormal double-positive T cell morphology	J:33100
	decreased apoptosis	J:33100
	decreased body weight	J:33100
	decreased salivation	J:93708
	enlarged thymus	J:33100
	normal hearing/vestibular/ear phenotype	J:98518
	increased CD4-positive, alpha-beta T cell number	J:33100
	increased CD8-positive, alpha-beta T cell number	J:33100
	increased T cell derived lymphoma incidence	J:33100
	increased thymocyte number	J:33100
	increased thymus weight	J:33100
	premature death	J:33100
	testicular atrophy	J:33100
E2f1tm1Meg/E2f1tm1Meg involves: 129 * C57BL/6 * FVB/N * NMRI	abnormal cone electrophysiology	J:124204
	abnormal retina bipolar cell morphology	J:124204
	abnormal retina progenitor cell morphology	J:124204
	decreased retina ganglion cell number	J:124204
	thin retina outer nuclear layer	J:124204
E2f1tm1Meg/E2f1tm1Meg involves: 129S4/SvJae * C57BL/6	abnormal cell death	J:75726
	decreased T cell proliferation	J:76318
E2f1tm1Meg/E2f1tm1Meg NOD.Cg-E2f1tm1Meg	abnormal CD4-positive, alpha beta T cell morphology	J:93708
	abnormal CD8-positive, alpha beta T cell morphology	J:93708
	abnormal cell cycle	J:93708
	abnormal double-positive T cell morphology	J:93708
	abnormal pancreatic islet morphology	J:93708
	decreased double-positive T cell number	J:93708
	decreased regulatory T cell number	J:93708
	decreased salivation	J:93708
	enlarged thymus	J:93708
	increased interferon-gamma secretion	J:93708
	increased interleukin-4 secretion	J:93708
	increased susceptibility to autoimmune diabetes	J:93708
	increased T cell number	J:93708
	increased thymocyte number	J:93708
	insulitis	J:93708
	salivary gland inflammation	J:93708
E2f1tm1Njd/E2f1tm1Njd involves: 129S2/SvPas * C57BL/6	abnormal circulating insulin level	J:89720
	abnormal exocrine pancreas morphology	J:33099
	abnormal exorbital lacrimal gland morphology	J:33099
	abnormal fat cell differentiation	J:89720
	abnormal gland morphology	J:89720
	abnormal pancreas morphology	J:89720
	abnormal pancreatic beta cell morphology	J:89720
	abnormal pancreatic islet morphology	J:89720
	abnormal parotid gland morphology	J:33099
	abnormal salivary gland morphology	J:33099
	abnormal submandibular gland morphology	J:33099
	decreased body weight	J:33099, J:89720
	decreased circulating glucose level	J:89720
	decreased circulating insulin level	J:89720
	decreased insulin secretion	J:89720
	decreased pancreas weight	J:89720
	decreased pancreatic islet number	J:89720
	decreased testis weight	J:33099
	decreased total body fat amount	J:89720
	impaired glucose tolerance	J:89720
	increased adipocyte glucose uptake	J:89720
	increased histiocytic sarcoma incidence	J:33099
	increased insulin sensitivity	J:89720
	increased Leydig cell number	J:33099
	increased lung adenocarcinoma incidence	J:33099
	increased lung non-small cell carcinoma incidence	J:33099
	increased lymphoma incidence	J:33099
	increased metastatic potential	J:33099
	increased reproductive system tumor incidence	J:33099
	increased tumor incidence	J:33099
	seminiferous tubule degeneration	J:33099
	small pancreatic islets	J:89720
	testicular atrophy	J:33099
E2f1tm1Njd/E2f1tm1Njd involves: 129S2/SvPas * SKH1	increased sensitivity to skin irradiation	J:97525