E2f1^tm1.1Dgj
Targeted Allele Detail

Summary

• Symbol: E2f1^tm1.1Dgj
• Name: E2F transcription factor 1; targeted mutation 1.1, David G Johnson
• MGI ID: MGI:5637520
• Synonyms: E2f1^S29A, E2f1^tm1Dgj
• Gene: E2f1 Location: Chr2:154401327-154411812 bp, - strand Genetic Position: Chr2, 76.79 cM
• Alliance: E2f1^tm1.1Dgj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:212453
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A serine to alanine mutation at codon 29 (S29A) was inserted in exon 1 and an FRT flanked neo cassette was inserted in intron 1 via homologous recombination. Flp mediated recombination removed the neo cassette. Sequencing of exon 1 confirmed the presence of the S29A mutation and no other mutation. (J:212453)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any E2f1 Mutation: 25 strains or lines available

References

• Original: J:212453 Biswas AK, et al., E2F1 responds to ultraviolet radiation by directly stimulating DNA repair and suppressing carcinogenesis. Cancer Res. 2014 Jun 15;74(12):3369-77
• All: 2 reference(s)