Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DUSP6
  • Mouse genes Dusp6
  • Rat genes Dusp6
  • Zfish genes dusp6
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Dusp6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	DUSP6	IDA		Human	PMID:8670865
Molecular Function	GO:0016791	phosphatase activity	dusp6	IMP	ZFIN:ZDB-GENO-150828-13	Zfish	PMID:25124925
Molecular Function	GO:0004721	phosphoprotein phosphatase activity	Dusp6	IDA		Mouse	PMID:15284227
Molecular Function	GO:0004721	phosphoprotein phosphatase activity	dusp6	IDA		Zfish	PMID:16672336
Molecular Function	GO:0005515	protein binding	DUSP6	IPI	UniProtKB:P27361	Human	PMID:12840032
Molecular Function	GO:0005515	protein binding	DUSP6	IPI	UniProtKB:P28482	Human	PMID:12840032
Molecular Function	GO:0005515	protein binding	DUSP6	IPI	UniProtKB:P28482	Human	PMID:18060821
Molecular Function	GO:0005515	protein binding	DUSP6	IPI	UniProtKB:P27361	Human	PMID:27880917
Molecular Function	GO:0005515	protein binding	DUSP6	IPI	UniProtKB:P28482	Human	PMID:27880917
Molecular Function	GO:0005515	protein binding	DUSP6	IPI	UniProtKB:P27361	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	DUSP6	IPI	UniProtKB:P28482	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	DUSP6	IPI	UniProtKB:P42681	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DUSP6	IPI	UniProtKB:P27361	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	DUSP6	IPI	UniProtKB:P28482	Human	PMID:32721402
Molecular Function	GO:0005515	protein binding	DUSP6	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	DUSP6	IPI	UniProtKB:Q99623	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Dusp6	IPI	UniProtKB:P63085	Mouse	MGI:MGI:5508262|PMID:16148006
Molecular Function	GO:0005515	protein binding	Dusp6	IPI	PR:Q91YS8	Mouse	PMID:15284227
Molecular Function	GO:0005515	protein binding	Dusp6	IPI	PR:P60202	Mouse	PMID:15284227
Molecular Function	GO:0005515	protein binding	Dusp6	IPI	PR:P62259	Mouse	PMID:15284227
Molecular Function	GO:0005515	protein binding	Dusp6	IPI	PR:Q60737	Mouse	PMID:15284227
Molecular Function	GO:0005515	protein binding	Dusp6	IPI	PR:P63085	Mouse	PMID:15284227
Molecular Function	GO:0005515	protein binding	Dusp6	IPI	PR:Q9CQE5	Mouse	PMID:15284227
Molecular Function	GO:0008138	protein tyrosine/serine/threonine phosphatase activity	Dusp6	IDA		Rat	PMID:8631996|RGD:70726
Cellular Component	GO:0005737	cytoplasm	DUSP6	IDA		Human	PMID:8670865
Cellular Component	GO:0005737	cytoplasm	DUSP6	IDA		Human	PMID:9788880
Cellular Component	GO:0005737	cytoplasm	Dusp6	IDA		Rat	PMID:8631996|RGD:70726
Cellular Component	GO:0005829	cytosol	DUSP6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	Dusp6	IDA		Rat	PMID:21300799|RGD:7771586
Cellular Component	GO:0005829	cytosol	Dusp6	IDA		Rat	PMID:8626780|RGD:728656
Cellular Component	GO:0005654	nucleoplasm	DUSP6	IDA		Human	GO_REF:0000052
Biological Process	GO:0030154	cell differentiation	Dusp6	IEP		Rat	PMID:8631996|RGD:70726
Biological Process	GO:0009953	dorsal/ventral pattern formation	dusp6	IMP		Zfish	PMID:15142973
Biological Process	GO:1905179	negative regulation of cardiac muscle tissue regeneration	dusp6	IMP	ZFIN:ZDB-GENO-181206-10	Zfish	PMID:29444893
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	DUSP6	IMP		Human	PMID:18771677
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	Dusp6	IDA		Rat	PMID:8626780|RGD:728656
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	dusp6	IMP	ZFIN:ZDB-GENO-150828-13	Zfish	PMID:25124925
Biological Process	GO:0043409	negative regulation of MAPK cascade	DUSP6	IDA		Human	PMID:8670865
Biological Process	GO:0001933	negative regulation of protein phosphorylation	Dusp6	IMP	MGI:MGI:3827011	Mouse	PMID:18753132
Biological Process	GO:0035335	peptidyl-tyrosine dephosphorylation	DUSP6	IDA		Human	PMID:8670865
Biological Process	GO:0043065	positive regulation of apoptotic process	DUSP6	IDA		Human	PMID:10846176
Biological Process	GO:0006470	protein dephosphorylation	Dusp6	IMP	MGI:MGI:3827011	Mouse	PMID:18753132
Biological Process	GO:0006470	protein dephosphorylation	Dusp6	IDA		Mouse	PMID:15284227
Biological Process	GO:0006470	protein dephosphorylation	dusp6	IDA		Zfish	PMID:16672336
Biological Process	GO:0042663	regulation of endodermal cell fate specification	dusp6	IGI	ZFIN:ZDB-GENE-011026-1	Zfish	PMID:16672336
Biological Process	GO:0040036	regulation of fibroblast growth factor receptor signaling pathway	dusp6	IMP	ZFIN:ZDB-GENO-980202-822	Zfish	PMID:15142973
Biological Process	GO:0060420	regulation of heart growth	Dusp6	IMP	MGI:MGI:3827011	Mouse	PMID:18753132
Biological Process	GO:0070848	response to growth factor	Dusp6	IEP		Rat	PMID:9559664|RGD:2316093
Biological Process	GO:0051409	response to nitrosative stress	DUSP6	IEP		Human	PMID:10846176
Biological Process	GO:0014070	response to organic cyclic compound	Dusp6	IEP		Rat	PMID:17881770|RGD:2316086
Biological Process	GO:0010033	response to organic substance	Dusp6	IEP		Rat	PMID:11027531|RGD:2301725
Biological Process	GO:0009410	response to xenobiotic stimulus	Dusp6	IEP		Rat	PMID:11701771|RGD:2316090
Biological Process	GO:0009410	response to xenobiotic stimulus	Dusp6	IEP		Rat	PMID:16799812|RGD:2316088
Biological Process	GO:0009410	response to xenobiotic stimulus	Dusp6	IEP		Rat	PMID:18958736|RGD:2316085

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern