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Dusp6
Gene Detail
Symbol

Name
ID
Dusp6
dual specificity phosphatase 6
MGI:1914853
Synonyms
1300019I03Rik, MKP3, MKP-3, PYST1
Feature Type
protein coding gene
Genetic Map
Chromosome 10
51.13 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:99263231-99267488 bp, + strand
From Ensembl annotation of GRCm38

  4258 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55621  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: DUSP6
Protein SuperFamily: dual specificity protein phosphatase (MAP kinase phosphatase)
Gene Tree: Dusp6

Human
homologs
DUSP6, dual specificity phosphatase 6
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1848
neXtProt AC: NX_Q16828

Human Synonyms: HH19, MKP3, PYST1

Human Chr (Location): 12q22-q23; chr12:89347825-89352859 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human DUSP6

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(2) Targeted(3) Transgenic(1)
Incidental mutations (data from Mutagenetix )
 
Mice homozygous or heterozygous for a null mutation display partial penetrance of postnatal lethality, reduced body weight, and abnormal growth plate morphology.
 
Phenotype Images(1)
Interactions
Dusp6 interacts with 216 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (76 records)
Data Summary: Results (410)    Tissues (212)    Images (119)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 405
RT-PCR 5
cDNA source data(208)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA DUSP6 ; Xenbase dusp6 ; ZFIN dusp6    NEW 
Molecular
reagents
All nucleic(213) cDNA(208) Primer pair(4) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000019960 (Evidence)
Entrez Gene 67603 (Evidence)
UniGene 1791
DFCI TC1573291, TC1596198
DoTS DT.101181359, DT.531090
NIA Mouse Gene Index U011954
EC 3.1.3.16, 3.1.3.48
Consensus CDS Project CCDS24147.1
International Mouse Phenotyping Consortium Status Dusp6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000019960 Ensembl Gene Model | MGI Sequence Detail 4258 C57BL/6J ±  kb
transcript ENSMUST00000020118 Ensembl | MGI Sequence Detail 2796 Not Applicable 
polypeptide ENSMUSP00000020118 Ensembl | MGI Sequence Detail 381 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(2) UniProt(4)
Polymorphisms
SNPs within 2kb(46 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024950 Dual specificity phosphatase
InterPro IPR000340 Dual specificity phosphatase, catalytic domain
InterPro IPR020422 Dual specificity phosphatase, subgroup, catalytic domain
InterPro IPR008343 Mitogen-activated protein (MAP) kinase phosphatase
InterPro IPR000387 Protein-tyrosine/Dual specificity phosphatase
InterPro IPR001763 Rhodanese-like domain
Protein Ontology PR:000006756 dual specificity protein phosphatase 6
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:217408 Green RM, et al., Tfap2a-dependent changes in mouse facial morphology result in clefting that can be ameliorated by a reduction in Fgf8 gene dosage. Dis Model Mech. 2015 Jan;8(1):31-43
All references(117)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory