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Dusp6 Gene Detail
Summary
  • Symbol
    Dusp6
  • Name
    dual specificity phosphatase 6
  • Synonyms
    1300019I03Rik, MKP3, MKP-3, PYST1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914853
    NCBI Gene: 67603
  • Gene Overview
    MyGene.info: DUSP6
Location & Maps
more
  • Sequence Map
    Chr10:99263231-99267489 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4259 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 51.13 cM, cytoband C3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    DUSP6, dual specificity phosphatase 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DUSP6, dual specificity phosphatase 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HH19, MKP3, PYST1
  • Links
    NCBI Gene ID: 1848
    neXtProt AC: NX_Q16828
    UniProt: Q16828

  • Chr Location
    12q21.33; chr12:89347825-89352859 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with human DUSP6 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    27 phenotypes from 3 alleles in 3 genetic backgrounds
    1 images
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous or heterozygous for a null mutation display partial penetrance of postnatal lethality, reduced body weight, and abnormal growth plate morphology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 67603 NCBI Gene Model | MGI Sequence Detail 4259 C57BL/6J ±  kb
transcript NM_026268 RefSeq | MGI Sequence Detail 2814 C57BL/6  
polypeptide Q9DBB1 UniProt | EBI | MGI Sequence Detail 381 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    46 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 216
    cDNA 210
    Primer pair 4
    Other 2

    Microarray probesets 4
References
more
  • Summaries
    All 134
    Developmental Gene Expression 86
    Gene Ontology 9
    Phenotypes 16
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:241037 Clarke M, et al., Transcriptional regulation of SPROUTY2 by MYB influences myeloid cell proliferation and stem cell properties by enhancing responsiveness to IL-3. Leukemia. 2017 Apr;31(4):957-966

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/15/2017
MGI 6.10
The Jackson Laboratory