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Dusp6
Gene Detail
 Symbol
Name
ID
Dusp6
dual specificity phosphatase 6
MGI:1914853
Synonyms 1300019I03Rik, MKP3, MKP-3, PYST1
Feature Type protein coding gene
Genetic Map
Chromosome 10
51.13 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:99263231-99267488 bp, + strand
From Ensembl annotation of GRCm38

  4258 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55621  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: dual specificity protein phosphatase (MAP kinase phosphatase)
Gene Tree: Dusp6

Human
homologs
Human Homolog DUSP6, dual specificity phosphatase 6
NCBI Gene ID 1848
neXtProt AC  NX_Q16828
Human Synonyms  HH19, MKP3, PYST1
Human Chr (Location)  12q22-q23; chr12:89348060-89352519 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human DUSP6
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(2) Targeted(3)
Incidental mutations (data from Mutagenetix )
 
Mice homozygous or heterozygous for a null mutation display partial penetrance of postnatal lethality, reduced body weight, and abnormal growth plate morphology.
 
Phenotype Images(1)
Interactions
Dusp6 interacts with 216 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process dephosphorylation, dorsal/ventral pattern formation, ...
Component cytoplasm, cytosol
Function hydrolase activity, MAP kinase tyrosine/serine/threonine phosphatase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (65 records)
Data Summary: Results (408)    Tissues (211)    Images (118)
Theiler Stages: 11, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 405
RT-PCR 3
cDNA source data(208)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(212) cDNA(208) Primer pair(3) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000019960 (Evidence)
Entrez Gene67603 (Evidence)
UniGene1791
DFCITC1573291, TC1596198
DoTSDT.531090, DT.101181359
NIA Mouse Gene IndexU011954
EC3.1.3.16, 3.1.3.48
Consensus CDS ProjectCCDS24147.1
International Mouse Knockout Project StatusDusp6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000019960 Ensembl Gene Model | MGI Sequence Detail 4258 C57BL/6J ±  kb
transcript ENSMUST00000020118 Ensembl | MGI Sequence Detail 2796 Not Applicable 
polypeptide ENSMUSP00000020118 Ensembl | MGI Sequence Detail 381 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(2) UniProt(4)
Polymorphisms SNPs within 2kb(46 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024950 Dual specificity phosphatase
InterPro IPR000340 Dual specificity phosphatase, catalytic domain
InterPro IPR020422 Dual specificity phosphatase, subgroup, catalytic domain
InterPro IPR008343 Mitogen-activated protein (MAP) kinase phosphatase
InterPro IPR000387 Protein-tyrosine/Dual specificity phosphatase
InterPro IPR001763 Rhodanese-like domain
Protein Ontology PR:000006756 dual specificity protein phosphatase 6
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:204669 Saha M, et al., Spinal mitogen-activated protein kinase phosphatase-3 (MKP-3) is necessary for the normal resolution of mechanical allodynia in a mouse model of acute postoperative pain. J Neurosci. 2013 Oct 23;33(43):17182-7
All references(107)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory