Dusp6
Gene Detail

Symbol Name ID

Dusp6 dual specificity phosphatase 6 MGI:1914853

Synonyms

1300019I03Rik, MKP3, MKP-3, PYST1

Feature Type

protein coding gene

Genetic Map

Chromosome 10

51.13 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr10:99263231-99267488 bp, + strand From Ensembl annotation of GRCm38   4258 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55621  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: dual specificity protein phosphatase (MAP kinase phosphatase)
Gene Tree: Dusp6

Human homologs

Human Homolog		DUSP6, dual specificity phosphatase 6
NCBI Gene ID		1848
neXtProt AC		NX_Q16828
Human Synonyms		MKP3, PYST1
Human Chr (Location)		12q22-q23; chr12:89741837-89746296 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(3) Gene trapped(2)
 

Mice homozygous or heterozygous for a null mutation display partial penetrance of postnatal lethality, reduced body weight, and abnormal growth plate morphology.

 

Gene Ontology (GO) classifications

All GO classifications: (29 annotations)

Process	dephosphorylation, dorsal/ventral pattern formation, ...
Component	cytoplasm, cytosol
Function	hydrolase activity, MAP kinase tyrosine/serine/threonine phosphatase activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (60 records)
Data Summary: Results (408)    Tissues (211)    Images (118)
Theiler Stages: 11, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	405
RT-PCR	3

cDNA source data(206)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(210) cDNA(206) Primer pair(3) Other(1)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000019960 (Evidence)
Entrez Gene	67603 (Evidence)
UniGene	1791
DFCI	TC1573291, TC1596198
DoTS	DT.101181359, DT.531090
NIA Mouse Gene Index	U011954
EC	3.1.3.16, 3.1.3.48
Consensus CDS Project	CCDS24147.1
International Mouse Knockout Project Status	Dusp6

Sequences

Length	Strain/Species
genomic	ENSMUSG00000019960	Ensembl Gene Model | MGI Sequence Detail	4258	C57BL/6J
transcript	ENSMUST00000020118	Ensembl | MGI Sequence Detail	2796	Not Applicable
polypeptide	ENSMUSP00000020118	Ensembl | MGI Sequence Detail	381	Not Applicable

All sequences(31) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(15 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR024950	Dual specificity phosphatase
InterPro	IPR000340	Dual specificity phosphatase, catalytic domain
InterPro	IPR020422	Dual specificity phosphatase, subgroup, catalytic domain
InterPro	IPR008343	Mitogen-activated protein (MAP) kinase phosphatase
InterPro	IPR000387	Protein-tyrosine/Dual specificity phosphatase
InterPro	IPR001763	Rhodanese-like domain
Protein Ontology	PR:000006756	dual specificity protein phosphatase 6

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:190460 Le Grand F, et al., Six1 regulates stem cell repair potential and self-renewal during skeletal muscle regeneration. J Cell Biol. 2012 Sep 3;198(5):815-32
All references(100)