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Dusp6 Gene Detail
Summary
  • Symbol
    Dusp6
  • Name
    dual specificity phosphatase 6
  • Synonyms
    1300019I03Rik, MKP3, MKP-3, PYST1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914853
    NCBI Gene: 67603
  • Gene Overview
    MyGene.info: DUSP6
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr10:99263231-99267489 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4259 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 51.13 cM, cytoband C3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    DUSP6, dual specificity phosphatase 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DUSP6, dual specificity phosphatase 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HH19, MKP3, PYST1
  • Links
    NCBI Gene ID: 1848
    neXtProt AC: NX_Q16828
    UniProt: Q16828

  • Chr Location
    12q21.33; chr12:89347825-89352859 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with human DUSP6 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    27 phenotypes from 3 alleles in 3 genetic backgrounds
    1 images
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous or heterozygous for a null mutation display partial penetrance of postnatal lethality, reduced body weight, and abnormal growth plate morphology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67603 NCBI Gene Model | MGI Sequence Detail 4259 C57BL/6J ±  kb
    transcript NM_026268 RefSeq | MGI Sequence Detail 2814 C57BL/6  
    polypeptide Q9DBB1 UniProt | EBI | MGI Sequence Detail 381 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      46 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 216
      cDNA 210
      Primer pair 4
      Other 2

      Microarray probesets 4
    References
    more
    • Summaries
      All 139
      Developmental Gene Expression 88
      Gene Ontology 9
      Phenotypes 16
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:252262 Rodrigues BA, et al., Overexpression of Mitogen-activated protein kinase phosphatase-3 (MKP-3) reduces FoxO1 phosphorylation in mice hypothalamus. Neurosci Lett. 2017 Oct 17;659:14-17

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory