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Dusp6 Gene Detail
Summary
  • Symbol
    Dusp6
  • Name
    dual specificity phosphatase 6
  • Synonyms
    1300019I03Rik, MKP3, MKP-3, PYST1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914853
    NCBI Gene: 67603
  • Gene Overview
    MyGene.info: DUSP6
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:99263231-99267489 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 51.13 cM, cytoband C3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    46 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914853
protein coding gene Chr10:99263231-99267489 (.)
129S1/SvImJ MGP_129S1SvImJ_G0017686
protein coding gene Chr10:101082727-101086984 (+)
A/J MGP_AJ_G0017665
protein coding gene Chr10:97428349-97432602 (+)
AKR/J MGP_AKRJ_G0017625
protein coding gene Chr10:100232870-100237121 (+)
BALB/cJ MGP_BALBcJ_G0017629
protein coding gene Chr10:97714061-97718318 (+)
C3H/HeJ MGP_C3HHeJ_G0017452
protein coding gene Chr10:100241834-100246085 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018085
protein coding gene Chr10:104566711-104570968 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015765
protein coding gene Chr10:92863555-92867777 (+)
CAST/EiJ MGP_CASTEiJ_G0017015
protein coding gene Chr10:100327421-100331679 (+)
CBA/J MGP_CBAJ_G0017421
protein coding gene Chr10:108665814-108670065 (+)
DBA/2J MGP_DBA2J_G0017527
protein coding gene Chr10:96511763-96516020 (+)
FVB/NJ MGP_FVBNJ_G0017520
protein coding gene Chr10:95728531-95732788 (+)
LP/J MGP_LPJ_G0017601
protein coding gene Chr10:101677813-101682070 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017550
protein coding gene Chr10:109943643-109947900 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018123
protein coding gene Chr10:100134625-100138882 (+)
PWK/PhJ MGP_PWKPhJ_G0016797
protein coding gene Chr10:96651165-96655396 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016586
protein coding gene Chr10:99048671-99052924 (+)
WSB/EiJ MGP_WSBEiJ_G0017075
protein coding gene Chr10:100144815-100149066 (+)



Homology
more
  • Human Ortholog
    DUSP6, dual specificity phosphatase 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DUSP6, dual specificity phosphatase 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HH19, MKP3, PYST1
  • Links
    NCBI Gene ID: 1848
    neXtProt AC: NX_Q16828
    UniProt: Q16828

  • Chr Location
    12q21.33; chr12:89347825-89352859 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with human DUSP6 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 3 alleles in 3 genetic backgrounds
    1 images
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous or heterozygous for a null mutation display partial penetrance of postnatal lethality, reduced body weight, and abnormal growth plate morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67603 NCBI Gene Model | MGI Sequence Detail 4259 C57BL/6J ±  kb
    transcript NM_026268 RefSeq | MGI Sequence Detail 2814 C57BL/6  
    polypeptide Q9DBB1 UniProt | EBI | MGI Sequence Detail 381 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 218
      cDNA 211
      Primer pair 5
      Other 2

      Microarray probesets 4
    References
    more
    • Summaries
      All 145
      Developmental Gene Expression 91
      Gene Ontology 10
      Phenotypes 17
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:266214 Garg A, et al., FGF-induced Pea3 transcription factors program the genetic landscape for cell fate determination. PLoS Genet. 2018 Sep;14(9):e1007660

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory