Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CST7
  • Mouse genes Cst7
  • Rat genes Cst7
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cst7

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004869	cysteine-type endopeptidase inhibitor activity	Cst7	IMP	MGI:MGI:5910746	Mouse	PMID:28251676
Molecular Function	GO:0030414	peptidase inhibitor activity	CST7	IDA		Human	PMID:15752368
Molecular Function	GO:0030414	peptidase inhibitor activity	CST7	IDA		Human	PMID:18256700
Molecular Function	GO:0030414	peptidase inhibitor activity	CST7	IDA		Human	PMID:22365146
Molecular Function	GO:0030414	peptidase inhibitor activity	Cst7	IDA		Mouse	MGI:MGI:6294189|PMID:18256700
Molecular Function	GO:0005515	protein binding	CST7	IPI	UniProtKB:P53634	Human	PMID:18256700
Molecular Function	GO:0042803	protein homodimerization activity	CST7	IDA		Human	PMID:15212960
Molecular Function	GO:0042803	protein homodimerization activity	CST7	IDA		Human	PMID:15752368
Molecular Function	GO:0042803	protein homodimerization activity	CST7	IDA		Human	PMID:18256700
Cellular Component	GO:0005737	cytoplasm	Cst7	IDA		Mouse	PMID:28251676
Cellular Component	GO:0031410	cytoplasmic vesicle	CST7	IDA		Human	PMID:12423348
Cellular Component	GO:0031410	cytoplasmic vesicle	CST7	IDA		Human	PMID:15212960
Cellular Component	GO:0031410	cytoplasmic vesicle	Cst7	IMP		Mouse	MGI:MGI:6294233|PMID:15212960
Cellular Component	GO:0005783	endoplasmic reticulum	CST7	IDA		Human	PMID:15212960
Cellular Component	GO:0005783	endoplasmic reticulum	CST7	IDA		Human	PMID:18256700
Cellular Component	GO:0005783	endoplasmic reticulum	Cst7	IMP		Mouse	MGI:MGI:6294233|PMID:15212960
Cellular Component	GO:0005768	endosome	CST7	IDA		Human	PMID:15752368
Cellular Component	GO:0005615	extracellular space	CST7	IDA		Human	PMID:12423348
Cellular Component	GO:0005615	extracellular space	CST7	IDA		Human	PMID:15212960
Cellular Component	GO:0005615	extracellular space	Cst7	IDA		Mouse	PMID:28178353
Cellular Component	GO:0005794	Golgi apparatus	CST7	IDA		Human	PMID:18256700
Cellular Component	GO:0005794	Golgi apparatus	CST7	IDA		Human	PMID:22365146
Cellular Component	GO:0005794	Golgi apparatus	Cst7	IDA		Mouse	MGI:MGI:6294189|PMID:18256700
Cellular Component	GO:0005770	late endosome	Cst7	IMP		Mouse	MGI:MGI:6294233|PMID:15212960
Cellular Component	GO:0005764	lysosome	CST7	IDA		Human	PMID:15752368
Cellular Component	GO:0005764	lysosome	CST7	IDA		Human	PMID:18256700
Cellular Component	GO:0005764	lysosome	CST7	IDA		Human	PMID:22365146
Cellular Component	GO:0005764	lysosome	Cst7	IMP		Mouse	MGI:MGI:6294233|PMID:15212960
Cellular Component	GO:0005771	multivesicular body	CST7	IDA		Human	PMID:22365146
Biological Process	GO:0097340	inhibition of cysteine-type endopeptidase activity	Cst7	IMP	MGI:MGI:5910746	Mouse	PMID:28251676
Biological Process	GO:1903979	negative regulation of microglial cell activation	Cst7	IMP	MGI:MGI:5910746	Mouse	PMID:28251676
Biological Process	GO:0010466	negative regulation of peptidase activity	CST7	IDA		Human	PMID:15752368
Biological Process	GO:0010466	negative regulation of peptidase activity	CST7	IDA		Human	PMID:18256700
Biological Process	GO:0010466	negative regulation of peptidase activity	CST7	IDA		Human	PMID:22365146
Biological Process	GO:0010466	negative regulation of peptidase activity	Cst7	IDA		Mouse	MGI:MGI:6294189|PMID:18256700
Biological Process	GO:0031643	positive regulation of myelination	Cst7	IMP	MGI:MGI:5910746	Mouse	PMID:28251676

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern