Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Crh

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes CRH
- Mouse genes Crh
- Rat genes Crh
- Zfish genes crhb
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Crh

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051430	corticotropin-releasing hormone receptor 1 binding	Crh	IDA		Rat	PMID:12942143\|RGD:1358326
Molecular Function	GO:0051430	corticotropin-releasing hormone receptor 1 binding	Crh	IPI	RGD:734061	Rat	PMID:7477349\|RGD:70047
Molecular Function	GO:0051431	corticotropin-releasing hormone receptor 2 binding	Crh	IPI	RGD:733139	Rat	PMID:11572971\|RGD:5508795
Molecular Function	GO:0051431	corticotropin-releasing hormone receptor 2 binding	Crh	IDA		Rat	PMID:12942143\|RGD:1358326
Molecular Function	GO:0051431	corticotropin-releasing hormone receptor 2 binding	Crh	IPI	RGD:733139	Rat	PMID:15223302\|RGD:5508815
Molecular Function	GO:0005515	protein binding	CRH	IPI	UniProtKB:P24387	Human	PMID:18234674
Molecular Function	GO:0005515	protein binding	CRH	IPI	UniProtKB:P34998	Human	PMID:18801728
Molecular Function	GO:0005515	protein binding	CRH	IPI	UniProtKB:P34998	Human	PMID:20966082
Molecular Function	GO:0005515	protein binding	CRH	IPI	UniProtKB:Q13324-1	Human	PMID:20966082
Molecular Function	GO:0005515	protein binding	CRH	IPI	UniProtKB:Q15323	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CRH	IPI	UniProtKB:A8MQ03	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CRH	IPI	UniProtKB:P0DPK4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CRH	IPI	UniProtKB:P26371	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CRH	IPI	UniProtKB:P60410	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CRH	IPI	UniProtKB:Q8IUG1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CRH	IPI	UniProtKB:Q99750	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CRH	IPI	UniProtKB:Q9BYQ3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CRH	IPI	UniProtKB:Q9BYS1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CRH	IPI	UniProtKB:P48730-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Crh	IPI	RGD:2403	Rat	PMID:11572971\|RGD:5508795
Molecular Function	GO:0005515	protein binding	Crh	IPI	RGD:730851	Rat	PMID:7477349\|RGD:70047
Cellular Component	GO:0005737	cytoplasm	Crh	IDA		Rat	PMID:21664419\|RGD:5490546
Cellular Component	GO:0005615	extracellular space	CRH	IDA		Human	PMID:18559919
Cellular Component	GO:0005615	extracellular space	Crh	IDA		Rat	PMID:21791239\|RGD:5490526
Cellular Component	GO:0043025	neuronal cell body	Crh	IDA		Mouse	PMID:32094113
Cellular Component	GO:0043025	neuronal cell body	Crh	IDA		Rat	PMID:20801165\|RGD:5508197
Cellular Component	GO:0043204	perikaryon	Crh	IDA		Rat	PMID:16457789\|RGD:5508812
Cellular Component	GO:0043196	varicosity	Crh	IDA		Rat	PMID:15796765\|RGD:5508814
Biological Process	GO:0030325	adrenal gland development	Crh	IMP	MGI:MGI:1857392	Mouse	PMID:10861000
Biological Process	GO:0008306	associative learning	Crh	IDA		Rat	PMID:10366634\|RGD:5508167
Biological Process	GO:0071314	cellular response to cocaine	Crh	IDA		Rat	PMID:14751291\|RGD:8553798
Biological Process	GO:0071549	cellular response to dexamethasone stimulus	Crh	IEP		Rat	PMID:21664419\|RGD:5490546
Biological Process	GO:0016101	diterpenoid metabolic process	Crh	IEP		Rat	PMID:21664419\|RGD:5490546
Biological Process	GO:0007565	female pregnancy	CRH	IDA		Human	PMID:18559919
Biological Process	GO:0006704	glucocorticoid biosynthetic process	Crh	IMP	MGI:MGI:1857392	Mouse	PMID:10861000
Biological Process	GO:0008628	hormone-mediated apoptotic signaling pathway	Crh	IDA		Rat	PMID:11790788\|RGD:1358682
Biological Process	GO:0021854	hypothalamus development	Crh	IEP		Rat	PMID:20002962\|RGD:5130950
Biological Process	GO:0006954	inflammatory response	CRH	IDA		Human	PMID:18559919
Biological Process	GO:0006954	inflammatory response	Crh	IMP	MGI:MGI:1857392	Mouse	PMID:15159534
Biological Process	GO:0007611	learning or memory	Crh	IMP		Rat	PMID:14642454\|RGD:5508816
Biological Process	GO:0035641	locomotory exploration behavior	Crh	IGI	MGI:MGI:97599	Mouse	PMID:17908177
Biological Process	GO:0060291	long-term synaptic potentiation	Crh	IDA		Rat	PMID:20807310\|RGD:5491009
Biological Process	GO:0030324	lung development	Crh	IMP	MGI:MGI:1857392	Mouse	PMID:10861000
Biological Process	GO:0032400	melanosome localization	crhb	IMP	ZFIN:ZDB-MRPHLNO-110112-4	Zfish	PMID:21209207
Biological Process	GO:0050801	monoatomic ion homeostasis	Crh	IEP		Rat	PMID:21539900\|RGD:5490586
Biological Process	GO:0033555	multicellular organismal response to stress	crhb	IEP		Zfish	PMID:25748166
Biological Process	GO:0032811	negative regulation of epinephrine secretion	Crh	IDA		Rat	PMID:12606499\|RGD:704397
Biological Process	GO:0010629	negative regulation of gene expression	Crh	IMP		Rat	PMID:20663987\|RGD:5508201
Biological Process	GO:0070093	negative regulation of glucagon secretion	Crh	IDA		Rat	PMID:12606499\|RGD:704397
Biological Process	GO:0033685	negative regulation of luteinizing hormone secretion	Crh	IMP		Rat	PMID:20663987\|RGD:5508201
Biological Process	GO:0010700	negative regulation of norepinephrine secretion	Crh	IDA		Rat	PMID:12606499\|RGD:704397
Biological Process	GO:0003085	negative regulation of systemic arterial blood pressure	Crh	IDA		Rat	PMID:7477349\|RGD:70047
Biological Process	GO:0051402	neuron apoptotic process	Crh	IDA		Rat	PMID:12941376\|RGD:5508198
Biological Process	GO:2000987	positive regulation of behavioral fear response	Crh	IDA		Rat	PMID:10366634\|RGD:5508167
Biological Process	GO:0090280	positive regulation of calcium ion import	Crh	IDA		Rat	PMID:16513211\|RGD:1626238
Biological Process	GO:0043950	positive regulation of cAMP-mediated signaling	Crh	IDA		Rat	PMID:7477349\|RGD:70047
Biological Process	GO:0008284	positive regulation of cell population proliferation	Crh	IDA		Rat	PMID:20080775\|RGD:5508172
Biological Process	GO:2000854	positive regulation of corticosterone secretion	Crh	IDA		Rat	PMID:12606499\|RGD:704397
Biological Process	GO:2000854	positive regulation of corticosterone secretion	Crh	IMP		Rat	PMID:20663987\|RGD:5508201
Biological Process	GO:0051461	positive regulation of corticotropin secretion	CRH	IDA		Human	PMID:11329063
Biological Process	GO:0051461	positive regulation of corticotropin secretion	Crh	IMP		Rat	PMID:20663987\|RGD:5508201
Biological Process	GO:0051461	positive regulation of corticotropin secretion	Crh	IDA		Rat	PMID:7477349\|RGD:70047
Biological Process	GO:0051464	positive regulation of cortisol secretion	CRH	IDA		Human	PMID:18329818
Biological Process	GO:0060456	positive regulation of digestive system process	Crh	IDA		Rat	PMID:17234701\|RGD:5491013
Biological Process	GO:0010628	positive regulation of gene expression	Crh	IMP		Rat	PMID:20663987\|RGD:5508201
Biological Process	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	Crh	IDA		Rat	PMID:20080775\|RGD:5508172
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Crh	IDA		Rat	PMID:20052275\|RGD:5508174
Biological Process	GO:1902036	regulation of hematopoietic stem cell differentiation	crhb	IMP	ZFIN:ZDB-MRPHLNO-110112-4	Zfish	PMID:27424782
Biological Process	GO:2000310	regulation of NMDA receptor activity	CRH	IDA		Human	PMID:12895416
Biological Process	GO:2000310	regulation of NMDA receptor activity	Crh	IDA		Rat	PMID:12895416\|RGD:8553912
Biological Process	GO:0014062	regulation of serotonin secretion	Crh	IDA		Rat	PMID:21947356\|RGD:5507821
Biological Process	GO:0042220	response to cocaine	Crh	IEP		Rat	PMID:21762287\|RGD:5490536
Biological Process	GO:0051412	response to corticosterone	Crh	IEP		Rat	PMID:21664419\|RGD:5490546
Biological Process	GO:0043627	response to estrogen	Crh	IEP		Rat	PMID:21585050\|RGD:5490557
Biological Process	GO:0045471	response to ethanol	Crh	IEP		Rat	PMID:21597991\|RGD:5490555
Biological Process	GO:0045472	response to ether	Crh	IEP		Rat	PMID:21621194\|RGD:5490550
Biological Process	GO:0035902	response to immobilization stress	Crh	IEP		Rat	PMID:9555067\|RGD:5490527
Biological Process	GO:0035902	response to immobilization stress	crhb	IDA		Zfish	PMID:21893154
Biological Process	GO:0048265	response to pain	Crh	IEP		Rat	PMID:21463663\|RGD:5490545
Biological Process	GO:0009410	response to xenobiotic stimulus	Crh	IEP		Rat	PMID:21872218\|RGD:5490525
Biological Process	GO:0008202	steroid metabolic process	Crh	IEP		Rat	PMID:21664419\|RGD:5490546
Biological Process	GO:0001963	synaptic transmission, dopaminergic	CRH	IDA		Human	PMID:12895416
Biological Process	GO:0001963	synaptic transmission, dopaminergic	Crh	IDA		Rat	PMID:12895416\|RGD:8553912

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/14/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.