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Crh
Gene Detail
Symbol

Name
ID
Crh
corticotropin releasing hormone
MGI:88496
Synonyms
corticotropin releasing factor, corticotropin-releasing factor, CRF, LOC383938
Feature Type
protein coding gene
Genetic Map
Chromosome 3
5.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr3:19693401-19695396 bp, - strand
From VEGA annotation of GRCm38

  1996 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:599  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 2 western clawed frog; 1 zebrafish

Protein SuperFamily: corticoliberin-endorpholiberin
Gene Tree: Crh

Human
homologs
Human Homolog   CRH, corticotropin releasing hormone
NCBI Gene ID 1392
neXtProt AC  NX_P06850
Human Synonyms  CRF, CRH1
Human Chr (Location)  8q13; chr8:66176377-66178611 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Chemically induced (ENU)(1) Targeted(8) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice have abnormal adrenal gland morphology, decreased corticosterone levels and abnormal corticosteroid responses to stress. Homozygous litters born from homozygous females display neonatal lethality, impaired lung maturation and delayed cornified and granular layer development.
 
Human Diseases Modeled in Mice Using Crh (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Crh interacts with 100 markers (Mir7-1, Mir10a, Mir19a, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (23 records)
Data Summary: Results (96)    Tissues (41)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 39
RNA in situ 57
cDNA source data(4)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(7) Genomic(2) cDNA(4) Other(1)
Microarray probesets(1)
Other database
links
VEGA Gene ModelOTTMUSG00000051234 (Evidence)
Ensembl Gene ModelENSMUSG00000049796 (Evidence)
Entrez Gene12918 (Evidence)
UniGene290689
DFCITC1589522
DoTSDT.101216076
NIA Mouse Gene IndexU056192
Consensus CDS ProjectCCDS17258.1
International Mouse Knockout Project StatusCrh
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000051234 VEGA Gene Model | MGI Sequence Detail 1996 C57BL/6J ±  kb
transcript OTTMUST00000129732 VEGA | MGI Sequence Detail 1320 Not Applicable 
polypeptide OTTMUSP00000069653 VEGA | MGI Sequence Detail 187 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(2) UniProt(1)
Polymorphisms
RFLP(2) : SNPs within 2kb(49 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018446 Corticotropin-releasing factor conserved site
InterPro IPR000187 Corticotropin-releasing factor, CRF
InterPro IPR003620 Urocortin/corticotropin-releasing factor
Protein Ontology PR:000005867 corticoliberin
References
(Earliest) J:19717 Vale W, et al., Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin. Science. 1981 Sep 18;213(4514):1394-7
(Latest) J:216397 Shah BP, et al., MC4R-expressing glutamatergic neurons in the paraventricular hypothalamus regulate feeding and are synaptically connected to the parabrachial nucleus. Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):13193-8
All references(134)
Other
accession IDs
MGD-MRK-2138, MGI:2686193

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/07/2015
MGI 5.21
The Jackson Laboratory