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Crh Gene Detail
Summary
  • Symbol
    Crh
  • Name
    corticotropin releasing hormone
  • Synonyms
    corticotropin releasing factor, corticotropin-releasing factor, CRF, LOC383938
  • Feature Type
    protein coding gene
  • IDs
    MGI:88496
    NCBI Gene: 12918
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr3:19693401-19695396 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1996 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 5.75 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    CRH, corticotropin releasing hormone
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CRH, corticotropin releasing hormone
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CRF, CRH1
  • Links
    NCBI Gene ID: 1392
    neXtProt AC: NX_P06850
    UniProt: P06850

  • Chr Location
    8q13.1; chr8:66176377-66186685 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Crh mouse models

Human Disease Mouse Models
      
IDs
View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    89 phenotypes from 6 alleles in 7 genetic backgrounds
    16 phenotypes from multigenic genotypes
    116 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice have abnormal adrenal gland morphology, decreased corticosterone levels and abnormal corticosteroid responses to stress. Homozygous litters born from homozygous females display neonatal lethality, impaired lung maturation and delayedcornified and granular layer development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000051234 VEGA Gene Model | MGI Sequence Detail 1996 C57BL/6J ±  kb
    transcript OTTMUST00000129732 VEGA | MGI Sequence Detail 1320 Not Applicable  
    polypeptide OTTMUSP00000069653 VEGA | MGI Sequence Detail 187 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      49 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      Genomic 2
      cDNA 6
      Primer pair 1
      Other 2

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGD-MRK-2138, MGI:2686193
    References
    more
    • Summaries
      All 212
      Developmental Gene Expression 29
      Diseases 3
      Gene Ontology 8
      Phenotypes 116
    • Earliest
      J:19717 Vale W, et al., Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin. Science. 1981 Sep 18;213(4514):1394-7
    • Latest
      J:265324 Russell AL, et al., Differential Responses of the HPA Axis to Mild Blast Traumatic Brain Injury in Male and Female Mice. Endocrinology. 2018 Jun 1;159(6):2363-2375

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory