Crh
Gene Detail

Symbol Name ID

Crh corticotropin releasing hormone MGI:88496

Synonyms

corticotropin releasing factor, corticotropin-releasing factor, CRF, LOC383938

Feature Type

protein coding gene

Genetic Map

Chromosome 3

5.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr3:19693401-19695396 bp, - strand From NCBI annotation of GRCm38   1996 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:599  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: corticoliberin-endorpholiberin
Gene Tree: Crh

Human homologs

Human Homolog		CRH, corticotropin releasing hormone
NCBI Gene ID		1392
neXtProt AC		NX_P06850
Human Synonyms		CRF
Human Chr (Location)		8q13; chr8:67088612-67090846 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(6)
 

Homozygous null mice have abnormal adrenal gland morphology, decreased corticosterone levels and abnormal corticosteroid responses to stress. Homozygous litters born from homozygous females display neonatal lethality, impaired lung maturation and delayed cornified and granular layer development.

 

Gene Ontology (GO) classifications

All GO classifications: (53 annotations)

Process	adrenal gland development, associative learning, ...
Component	cytoplasm, extracellular region, ...
Function	corticotropin-releasing hormone activity, corticotropin-releasing hormone receptor 1 binding, ...

External Resources: FuncBase

Expression

Literature Summary: (20 records)
Data Summary: Results (82)    Tissues (35)    Images (13)
Theiler Stages: 17, 19, 20, 21, 22, 23, 25, 28

Assay Type	Results
Immunohistochemistry	39
RNA in situ	43

cDNA source data(4)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(6) Genomic(2) cDNA(4)
Microarray probesets(1)

Other database links

Ensembl Gene Model	ENSMUSG00000049796 (Evidence)
Entrez Gene	12918 (Evidence)
UniGene	290689
DFCI	TC1589522
DoTS	DT.101216076
NIA Mouse Gene Index	U056192
Consensus CDS Project	CCDS17258.1
International Mouse Knockout Project Status	Crh

Sequences

Length	Strain/Species
genomic	12918	NCBI Gene Model | MGI Sequence Detail	1996	C57BL/6J
transcript	NM_205769	RefSeq | MGI Sequence Detail	1320	C57BL/6
polypeptide	Q8CIT0	UniProt | EBI | MGI Sequence Detail	187	Not Applicable

All sequences(14) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(2) : SNPs(23 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR018446	Corticotropin-releasing factor conserved site
InterPro	IPR000187	Corticotropin-releasing factor, CRF
InterPro	IPR003620	Urocortin/corticotropin-releasing factor
Protein Ontology	PR:000005867	corticoliberin

Graphical View of Protein Domain Structure

References

(Earliest) J:19717 Vale W, et al., Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin. Science. 1981 Sep 18;213(4514):1394-7
(Latest) J:191801 Huang CC, et al., Fetal glucocorticoid synthesis is required for development of fetal adrenal medulla and hypothalamus feedback suppression. Endocrinology. 2012 Oct;153(10):4749-56
All references(119)

Other accession IDs

MGD-MRK-2138, MGI:2686193