Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CREB3
  • Mouse genes Creb3
  • Rat genes Creb3
  • Zfish genes creb3l3l
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Creb3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	CREB3	IMP		Human	PMID:16940180
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	CREB3	IDA		Human	PMID:16940180
Molecular Function	GO:0042802	identical protein binding	CREB3	IPI	UniProtKB:O43889	Human	PMID:21516116
Molecular Function	GO:0042802	identical protein binding	CREB3	IPI	UniProtKB:O43889	Human	PMID:23661758
Molecular Function	GO:0005515	protein binding	CREB3	IPI	UniProtKB:P51610	Human	PMID:10629049
Molecular Function	GO:0005515	protein binding	CREB3	IPI	UniProtKB:P51610	Human	PMID:10871379
Molecular Function	GO:0005515	protein binding	CREB3	IPI	UniProtKB:P51610	Human	PMID:15705566
Molecular Function	GO:0005515	protein binding	CREB3	IPI	UniProtKB:Q9NS37	Human	PMID:15705566
Molecular Function	GO:0005515	protein binding	CREB3	IPI	UniProtKB:O00268	Human	PMID:17483474
Molecular Function	GO:0005515	protein binding	CREB3	IPI	UniProtKB:Q8IUR6-1	Human	PMID:18391022
Molecular Function	GO:0005515	protein binding	CREB3	IPI	UniProtKB:P35638	Human	PMID:20102225
Molecular Function	GO:0005515	protein binding	CREB3	IPI	UniProtKB:Q68CJ9	Human	PMID:20102225
Molecular Function	GO:0005515	protein binding	CREB3	IPI	UniProtKB:P05412	Human	PMID:20195357
Molecular Function	GO:0005515	protein binding	CREB3	IPI	UniProtKB:Q92685	Human	PMID:21516116
Molecular Function	GO:0005515	protein binding	CREB3	IPI	UniProtKB:P35638	Human	PMID:23661758
Molecular Function	GO:0005515	protein binding	CREB3	IPI	UniProtKB:Q68CJ9	Human	PMID:23661758
Molecular Function	GO:0005515	protein binding	CREB3	IPI	UniProtKB:Q9NS37	Human	PMID:23661758
Molecular Function	GO:0005515	protein binding	CREB3	IPI	UniProtKB:Q92685	Human	PMID:29547901
Molecular Function	GO:0005515	protein binding	CREB3	IPI	UniProtKB:Q92685	Human	PMID:31515488
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	CREB3	IDA		Human	PMID:16940180
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	CREB3	IDA		Human	PMID:16940180
Molecular Function	GO:0043565	sequence-specific DNA binding	Creb3	IDA		Mouse	PMID:8112612
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	CREB3	IDA		Human	PMID:28473536
Molecular Function	GO:0001221	transcription coregulator binding	CREB3	IPI	UniProtKB:G5EC23	Human	PMID:11711630
Cellular Component	GO:0005829	cytosol	CREB3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005783	endoplasmic reticulum	CREB3	IDA		Human	PMID:16236796
Cellular Component	GO:0005634	nucleus	CREB3	IDA		Human	PMID:20546900
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	CREB3	IPI		Human	PMID:20102225
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	CREB3	IPI		Human	PMID:23661758
Biological Process	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	CREB3	IDA		Human	PMID:16940180
Biological Process	GO:0090026	positive regulation of monocyte chemotaxis	CREB3	IDA		Human	PMID:17296613
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	CREB3	IDA		Human	PMID:16940180
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	CREB3	IMP		Human	PMID:16940180
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	CREB3	IDA		Human	PMID:17296613
Biological Process	GO:0006990	positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response	CREB3	IDA		Human	PMID:16940180

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern