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Creb3 Gene Detail
Summary
  • Symbol
    Creb3
  • Name
    cAMP responsive element binding protein 3
  • Synonyms
    Luman, LZIP, LZIP-1, LZIP-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:99946
    NCBI Gene: 12913
  • Gene Overview
    MyGene.info: CREB3
Location & Maps
more
  • Sequence Map
    Chr4:43562332-43567060 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4729 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 23.05 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    CREB3, cAMP responsive element binding protein 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CREB3, cAMP responsive element binding protein 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LUMAN, LZIP, sLZIP
  • Links
    NCBI Gene ID: 10488
    neXtProt AC: NX_O43889

  • Chr Location
    9p13.3; chr9:35732320-35737008 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Chemically and radiation induced
    1
  • Gene trapped
    1
  • Targeted
    2
  • Genomic Mutations
    1 involving Creb3
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006960 VEGA Gene Model | MGI Sequence Detail 4729 C57BL/6J ±  kb
transcript OTTMUST00000016122 VEGA | MGI Sequence Detail 1884 Not Applicable  
polypeptide OTTMUSP00000007395 VEGA | MGI Sequence Detail 379 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    31 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000005855 cyclic AMP-responsive element-binding protein 3
  • InterPro Domains
    IPR004827 Basic-leucine zipper domain
    IPR029808 cAMP-responsive element-binding protein 3
    IPR008917 Transcription factor, Skn-1-like, DNA-binding domain
Molecular
Reagents
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  • All nucleic 18
    cDNA 17
    Primer pair 1

    Microarray probesets 7
Other
Accession IDs
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MGD-MRK-16749, MGI:2140496, MGI:2140584, MGI:2140683
References
more
  • Summaries
    All 41
    Developmental Gene Expression 7
    Gene Ontology 4
    Phenotypes 6
  • Earliest
    J:17005 Burbelo PD, et al., LZIP-1 and LZIP-2: two novel members of the bZIP family. Gene. 1994 Feb 25;139(2):241-5
  • Latest
    J:231358 Cameron TL, et al., Cartilage-specific ablation of XBP1 signaling in mouse results in a chondrodysplasia characterized by reduced chondrocyte proliferation and delayed cartilage maturation and mineralization. Osteoarthritis Cartilage. 2015 Apr;23(4):661-70

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory