Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Chrna4

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes CHRNA4
- Mouse genes Chrna4
- Rat genes Chrna4
- Zfish genes chrna4b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Chrna4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042166	acetylcholine binding	Chrna4	IDA		Rat	PMID:9030613\|RGD:2303190
Molecular Function	GO:0015464	acetylcholine receptor activity	CHRNA4	IDA		Human	PMID:8906617
Molecular Function	GO:0015464	acetylcholine receptor activity	Chrna4	IDA		Mouse	PMID:12871652
Molecular Function	GO:0015464	acetylcholine receptor activity	chrna4b	IDA		Zfish	PMID:22580045
Molecular Function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	CHRNA4	IDA		Human	PMID:8906617
Molecular Function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	Chrna4	IMP		Mouse	PMID:12130686
Molecular Function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	Chrna4	IMP	MGI:MGI:3511287	Mouse	PMID:15528443
Molecular Function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	Chrna4	IGI	MGI:MGI:87891	Mouse	PMID:15569257
Molecular Function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	Chrna4	IMP	MGI:MGI:1926251	Mouse	PMID:11222635
Molecular Function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	Chrna4	IGI	MGI:MGI:87891	Mouse	PMID:15741168
Molecular Function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	Chrna4	IMP		Rat	PMID:11259617\|RGD:8549520
Molecular Function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	Chrna4	IDA		Rat	PMID:12202488\|RGD:727641
Molecular Function	GO:1901363	heterocyclic compound binding	Chrna4	IPI	CHEBI:4803	Rat	PMID:16129735\|RGD:2303195
Molecular Function	GO:1901363	heterocyclic compound binding	Chrna4	IDA		Rat	PMID:22550286\|RGD:8549526
Molecular Function	GO:1901363	heterocyclic compound binding	Chrna4	IDA		Rat	PMID:15016836\|RGD:2303194
Molecular Function	GO:0005216	monoatomic ion channel activity	Chrna4	IDA		Mouse	PMID:11906696
Molecular Function	GO:0005515	protein binding	CHRNA4	IPI	UniProtKB:Q6UXH1-1	Human	PMID:16238698
Molecular Function	GO:0005515	protein binding	CHRNA4	IPI	UniProtKB:Q6UXH1-3	Human	PMID:16238698
Molecular Function	GO:0005515	protein binding	CHRNA4	IPI	UniProtKB:Q86Y78	Human	PMID:27344019
Molecular Function	GO:0005515	protein binding	CHRNA4	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CHRNA4	IPI	UniProtKB:P20042	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CHRNA4	IPI	UniProtKB:P83916	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CHRNA4	IPI	UniProtKB:Q6UY14-3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CHRNA4	IPI	UniProtKB:Q92673	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CHRNA4	IPI	UniProtKB:Q9NZR2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Chrna4	IPI	UniProtKB:Q8BLC3	Mouse	MGI:MGI:5694852\|PMID:26276394
Molecular Function	GO:0005515	protein binding	Chrna4	IPI	PR:Q9R0W9	Mouse	PMID:12944511
Molecular Function	GO:0005515	protein binding	Chrna4	IPI	PR:Q9ERK7	Mouse	PMID:12944511
Molecular Function	GO:0005515	protein binding	Chrna4	IPI	PR:P0DP60	Mouse	PMID:11906696
Molecular Function	GO:0005515	protein binding	Chrna4	IPI	PR:Q8BLC3	Mouse	PMID:19246390
Molecular Function	GO:0005515	protein binding	Chrna4	IPI	PR:Q99KJ0	Mouse	PMID:19474315
Molecular Function	GO:0005515	protein binding	Chrna4	IPI	RGD:3966	Rat	PMID:12202488\|RGD:727641
Molecular Function	GO:0005515	protein binding	Chrna4	IPI	UniProtKB:P12390	Rat	PMID:20566638\|RGD:10047290
Molecular Function	GO:0005515	protein binding	Chrna4	IPI	UniProtKB:P12392	Rat	PMID:20566638\|RGD:10047290
Molecular Function	GO:0005515	protein binding	Chrna4	IPI	UniProtKB:P20420	Rat	PMID:20566638\|RGD:10047290
Molecular Function	GO:0044877	protein-containing complex binding	Chrna4	IDA		Rat	PMID:20796176\|RGD:8549534
Molecular Function	GO:0050997	quaternary ammonium group binding	Chrna4	IDA		Rat	PMID:15016836\|RGD:2303194
Molecular Function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	Chrna4	EXP		Rat	PMID:15044058\|RGD:1600975
Molecular Function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	Chrna4	IDA		Rat	PMID:15044058\|RGD:1600975
Cellular Component	GO:0005892	acetylcholine-gated channel complex	CHRNA4	IDA		Human	PMID:8906617
Cellular Component	GO:0005892	acetylcholine-gated channel complex	Chrna4	IDA		Mouse	PMID:26276394
Cellular Component	GO:0005892	acetylcholine-gated channel complex	Chrna4	IPI	UniProtKB:Q3KP94	Mouse	PMID:17434683
Cellular Component	GO:0005892	acetylcholine-gated channel complex	Chrna4	IDA		Mouse	PMID:12871652
Cellular Component	GO:0005892	acetylcholine-gated channel complex	Chrna4	IDA		Mouse	PMID:12944511
Cellular Component	GO:0005892	acetylcholine-gated channel complex	Chrna4	IDA		Rat	PMID:11259617\|RGD:8549520
Cellular Component	GO:0005892	acetylcholine-gated channel complex	Chrna4	IDA		Rat	PMID:20796176\|RGD:8549534
Cellular Component	GO:0005892	acetylcholine-gated channel complex	Chrna4	IDA		Rat	PMID:9030613\|RGD:2303190
Cellular Component	GO:0005892	acetylcholine-gated channel complex	chrna4b	IDA		Zfish	PMID:22580045
Cellular Component	GO:0098981	cholinergic synapse	Chrna4	IDA		Rat	PMID:10414976\|RGD:13702273
Cellular Component	GO:0098981	cholinergic synapse	Chrna4	EXP		Rat	PMID:15044058\|RGD:1600975
Cellular Component	GO:0098981	cholinergic synapse	Chrna4	IDA		Rat	PMID:15044058\|RGD:1600975
Cellular Component	GO:0030425	dendrite	Chrna4	IDA		Rat	PMID:11297818\|RGD:1643016
Cellular Component	GO:0098691	dopaminergic synapse	Chrna4	IMP		Mouse	PMID:29114204
Cellular Component	GO:0098691	dopaminergic synapse	Chrna4	IDA		Mouse	PMID:29114204
Cellular Component	GO:0098691	dopaminergic synapse	Chrna4	IDA		Mouse	PMID:12944511
Cellular Component	GO:0098691	dopaminergic synapse	Chrna4	IMP		Mouse	PMID:12944511
Cellular Component	GO:0009897	external side of plasma membrane	Chrna4	IDA		Mouse	PMID:15963492
Cellular Component	GO:0016020	membrane	Chrna4	IDA		Mouse	PMID:19246390
Cellular Component	GO:0016020	membrane	Chrna4	IDA		Mouse	PMID:11906696
Cellular Component	GO:0016020	membrane	Chrna4	IDA		Rat	PMID:16129735\|RGD:2303195
Cellular Component	GO:0043025	neuronal cell body	Chrna4	IDA		Rat	PMID:11297818\|RGD:1643016
Cellular Component	GO:0005886	plasma membrane	Chrna4	IDA		Mouse	PMID:15741168
Cellular Component	GO:0005886	plasma membrane	Chrna4	IDA		Mouse	PMID:26276394
Cellular Component	GO:0099634	postsynaptic specialization membrane	Chrna4	IDA		Rat	PMID:10414976\|RGD:13702273
Cellular Component	GO:0042734	presynaptic membrane	Chrna4	IDA		Mouse	PMID:24607281
Cellular Component	GO:0042734	presynaptic membrane	Chrna4	IEP		Mouse	PMID:24607281
Cellular Component	GO:0042734	presynaptic membrane	Chrna4	IMP		Mouse	PMID:29114204
Cellular Component	GO:0042734	presynaptic membrane	Chrna4	IDA		Mouse	PMID:29114204
Cellular Component	GO:0042734	presynaptic membrane	Chrna4	IDA		Rat	PMID:24607281\|RGD:13702281
Cellular Component	GO:0032991	protein-containing complex	Chrna4	IDA		Rat	PMID:16129735\|RGD:2303195
Biological Process	GO:0095500	acetylcholine receptor signaling pathway	Chrna4	IDA		Mouse	PMID:26276394
Biological Process	GO:0042113	B cell activation	Chrna4	IMP	MGI:MGI:1926251	Mouse	PMID:15963492
Biological Process	GO:0035095	behavioral response to nicotine	CHRNA4	IMP		Human	PMID:17955458
Biological Process	GO:0035095	behavioral response to nicotine	Chrna4	IMP	MGI:MGI:3511287	Mouse	PMID:15528443
Biological Process	GO:0006816	calcium ion transport	Chrna4	IGI	MGI:MGI:87891	Mouse	PMID:15569257
Biological Process	GO:0050890	cognition	CHRNA4	IMP		Human	PMID:14623738
Biological Process	GO:0006281	DNA repair	CHRNA4	IMP		Human	PMID:16332175
Biological Process	GO:0035640	exploration behavior	Chrna4	IMP	MGI:MGI:1888964	Mouse	PMID:10964949
Biological Process	GO:0060080	inhibitory postsynaptic potential	Chrna4	IMP	MGI:MGI:3700205	Mouse	PMID:17146052
Biological Process	GO:0060080	inhibitory postsynaptic potential	Chrna4	IMP	MGI:MGI:3700204	Mouse	PMID:17146052
Biological Process	GO:0007626	locomotory behavior	Chrna4	IMP	MGI:MGI:2158758	Mouse	PMID:11226318
Biological Process	GO:0051899	membrane depolarization	Chrna4	IDA		Mouse	MGI:MGI:6810694\|PMID:24144909
Biological Process	GO:0051899	membrane depolarization	Chrna4	IGI	MGI:MGI:87891	Mouse	PMID:15741168
Biological Process	GO:0051899	membrane depolarization	Chrna4	IMP	MGI:MGI:1926251	Mouse	PMID:11222635
Biological Process	GO:0051899	membrane depolarization	Chrna4	IMP	MGI:MGI:2158758	Mouse	PMID:11226318
Biological Process	GO:0051899	membrane depolarization	Chrna4	IMP	MGI:MGI:1926251	Mouse	PMID:12944511
Biological Process	GO:0050877	nervous system process	CHRNA4	IMP		Human	PMID:17613539
Biological Process	GO:0050877	nervous system process	CHRNA4	IMP		Human	PMID:7550350
Biological Process	GO:0050877	nervous system process	Chrna4	IMP	MGI:MGI:3700204	Mouse	PMID:17146052
Biological Process	GO:0050877	nervous system process	Chrna4	IMP	MGI:MGI:3700205	Mouse	PMID:17146052
Biological Process	GO:0019228	neuronal action potential	Chrna4	IMP	MGI:MGI:1926251	Mouse	PMID:10235262
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	Chrna4	IMP		Mouse	PMID:12944511
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	Chrna4	IDA		Mouse	PMID:12944511
Biological Process	GO:1903048	regulation of acetylcholine-gated cation channel activity	Chrna4	IMP		Rat	PMID:11904236\|RGD:704387
Biological Process	GO:0014059	regulation of dopamine secretion	Chrna4	IMP	MGI:MGI:1926251	Mouse	PMID:12944511
Biological Process	GO:0042391	regulation of membrane potential	Chrna4	IGI	MGI:MGI:87891	Mouse	PMID:15569257
Biological Process	GO:0007585	respiratory gaseous exchange by respiratory system	Chrna4	IMP		Mouse	PMID:21606356
Biological Process	GO:1905144	response to acetylcholine	Chrna4	IDA		Rat	PMID:15016836\|RGD:2303194
Biological Process	GO:0001666	response to hypoxia	CHRNA4	IDA		Human	PMID:12189247
Biological Process	GO:0035094	response to nicotine	CHRNA4	IDA		Human	PMID:12189247
Biological Process	GO:0035094	response to nicotine	Chrna4	IGI	MGI:MGI:87891	Mouse	PMID:15741168
Biological Process	GO:0035094	response to nicotine	Chrna4	IMP	MGI:MGI:1926251	Mouse	PMID:10235262
Biological Process	GO:0035094	response to nicotine	Chrna4	IDA		Mouse	PMID:12871652
Biological Process	GO:0035094	response to nicotine	chrna4b	IDA		Zfish	PMID:24862365
Biological Process	GO:0006979	response to oxidative stress	CHRNA4	IMP		Human	PMID:16332175
Biological Process	GO:0019233	sensory perception of pain	Chrna4	IMP	MGI:MGI:1926251	Mouse	PMID:10235262
Biological Process	GO:0007165	signal transduction	CHRNA4	IDA		Human	PMID:8906617
Biological Process	GO:0007271	synaptic transmission, cholinergic	Chrna4	IDA		Mouse	PMID:11906696
Biological Process	GO:0007271	synaptic transmission, cholinergic	Chrna4	IMP	MGI:MGI:2158758	Mouse	PMID:11226318
Biological Process	GO:0007271	synaptic transmission, cholinergic	Chrna4	IMP		Rat	PMID:15026122\|RGD:1358635

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.