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Chrna4 Gene Detail
Summary
  • Symbol
    Chrna4
  • Name
    cholinergic receptor, nicotinic, alpha polypeptide 4
  • Synonyms
    a4 nicotinic receptor, Acra4, Acra-4, alpha4 nAChR, alpha4-nAChR
  • Feature Type
    protein coding gene
  • IDs
    MGI:87888
    NCBI Gene: 11438
  • Gene Overview
    MyGene.info: CHRNA4
Location & Maps
more
  • Sequence Map
    Chr2:181018380-181043546 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      25167 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 103.54 cM
  • Mapping Data
    12 experiments
Homology
more
  • Human Ortholog
    CHRNA4, cholinergic receptor nicotinic alpha 4 subunit
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CHRNA4, cholinergic receptor nicotinic alpha 4 subunit
    Orthology source: HomoloGene
  • Synonyms
    BFNC, EBN, EBN1, NACHR, NACHRA4, NACRA4
  • Links
    NCBI Gene ID: 1137
    neXtProt AC: NX_P43681

  • Chr Location
    20q13.33; chr20:63343310-63361396 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 592
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;2 zebrafish
  • HCOP
    human homology predictions: CHRNA4
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Chrna4 mouse models; 2 with human CHRNA4 associations

Human Disease Mouse Models
       Epilepsy, Nocturnal Frontal Lobe, 1; ENFL1   OMIM: 600513 View 1 "NOT" model
       Tobacco Addiction, Susceptibility to   OMIM: 188890
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    35 phenotypes from 11 alleles in 10 genetic backgrounds
    42 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    18
  • Gene trapped
    1
  • Spontaneous
    1
  • Targeted
    16
  • Genomic Mutations
    1 involving Chrna4
  • Incidental Mutations
Nullizygous mice may show reduced chemically-elicited analgesia, susceptibility to seizures, increased anxiety, and altered behavioral responses to nicotine or a new environment. Homozygotes for any of several knock-in alleles exhibit altered nervous system physiology and/or sensitivity to nicotine.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016395 VEGA Gene Model | MGI Sequence Detail 25167 C57BL/6J ±  kb
transcript OTTMUST00000039489 VEGA | MGI Sequence Detail 2071 Not Applicable  
polypeptide OTTMUSP00000017644 VEGA | MGI Sequence Detail 641 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    161 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    5 Sequences
  • InterPro Domains
    IPR006201 Neurotransmitter-gated ion-channel
    IPR018000 Neurotransmitter-gated ion-channel, conserved site
    IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
    IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
    IPR027361 Nicotinic acetylcholine-gated receptor, transmembrane domain
    IPR002394 Nicotinic acetylcholine receptor
Molecular
Reagents
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  • All nucleic 54
    cDNA 51
    Primer pair 2
    Other 1

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-1057, MGD-MRK-1061
References
more
  • Summaries
    All 104
    Developmental Gene Expression 12
    Diseases 2
    Gene Ontology 23
    Phenotypes 42
  • Earliest
    J:10489 Bessis A, et al., Chromosomal localization of the mouse genes coding for alpha 2, alpha 3, alpha 4 and beta 2 subunits of neuronal nicotinic acetylcholine receptor. FEBS Lett. 1990 May 7;264(1):48-52
  • Latest
    J:225867 Fox AM, et al., The Nicotine Metabolite, Cotinine, Alters the Assembly and Trafficking of a Subset of Nicotinic Acetylcholine Receptors. J Biol Chem. 2015 Oct 2;290(40):24403-12

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory