Chrna4
Gene Detail

Symbol

Name
ID

Chrna4
cholinergic receptor, nicotinic, alpha polypeptide 4
MGI:87888

Synonyms

a4 nicotinic receptor, Acra4, Acra-4, alpha4 nAChR, alpha4-nAChR

Feature Type

protein coding gene

Genetic Map

Chromosome 2
103.54 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)

Sequence Map

Chr2:181018380-181043546 bp, - strand From VEGA annotation of GRCm38   25167 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:592  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Chrna4

Human
homologs

Human Homolog		CHRNA4, cholinergic receptor, nicotinic, alpha 4 (neuronal)
NCBI Gene ID		1137
neXtProt AC		NX_P43681
Human Synonyms		BFNC, EBN, EBN1, NACHR, NACHRA4, NACRA4
Human Chr (Location)		20q13.33; chr20:63343310-63361396 (-)  GRCh38
Disease Associations		(2) Diseases Associated with Human CHRNA4

Mutations,
alleles, and
phenotypes

All mutations/alleles(17) : Gene trapped(1) Spontaneous(1) Targeted(15)
Genomic Mutations involving Chrna4 (1)
Incidental mutations (data from Mutagenetix , APF )
 

Nullizygous mice may show reduced chemically-elicited analgesia, susceptibility to seizures, increased anxiety, and altered behavioral responses to nicotine or a new environment. Homozygotes for any of several knock-in alleles exhibit altered nervous system physiology and/or sensitivity to nicotine.

 

Interactions

Chrna4 interacts with 251 markers (Mir7-1, Mir7-2, Mir7b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (72 annotations)

Process	action potential, B cell activation, ...
Component	acetylcholine-gated channel complex, cell junction, ...
Function	acetylcholine-activated cation-selective channel activity, acetylcholine binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (11 records)

Data Summary: Results (214)    Tissues (122)    Images (23)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	189
Northern blot	8
RT-PCR	17

cDNA source data(48)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas

Molecular
reagents

All nucleic(54) cDNA(51) Primer pair(2) Other(1)
Microarray probesets(6)

Other database
links

VEGA Gene Model	OTTMUSG00000016395 (Evidence)
Ensembl Gene Model	ENSMUSG00000027577 (Evidence)
Entrez Gene	11438 (Evidence)
UniGene	252369
DFCI	TC1579781
DoTS	DT.60102954
NIA Mouse Gene Index	U023772
Consensus CDS Project	CCDS17192.1
International Mouse Knockout Project Status	Chrna4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016395	VEGA Gene Model | MGI Sequence Detail	25167	C57BL/6J
transcript	OTTMUST00000039489	VEGA | MGI Sequence Detail	2183	Not Applicable
polypeptide	OTTMUSP00000017644	VEGA | MGI Sequence Detail	641	Not Applicable

All sequences(44) RefSeq(4) UniProt(5)

Polymorphisms

RFLP(3) : SNPs within 2kb(162 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR006201	Neurotransmitter-gated ion-channel
InterPro	IPR018000	Neurotransmitter-gated ion-channel, conserved site
InterPro	IPR006202	Neurotransmitter-gated ion-channel ligand-binding
InterPro	IPR006029	Neurotransmitter-gated ion-channel transmembrane domain
InterPro	IPR027361	Nicotinic acetylcholine-gated receptor, transmembrane domain
InterPro	IPR002394	Nicotinic acetylcholine receptor
Protein Ontology	PR:000005457	neuronal acetylcholine receptor subunit alpha-4

References

(Earliest) J:10489 Bessis A, et al., Chromosomal localization of the mouse genes coding for alpha 2, alpha 3, alpha 4 and beta 2 subunits of neuronal nicotinic acetylcholine receptor. FEBS Lett. 1990 May 7;264(1):48-52
(Latest) J:204279 Chatterjee S, et al., The alpha5 subunit regulates the expression and function of alpha4*-containing neuronal nicotinic acetylcholine receptors in the ventral-tegmental area. PLoS One. 2013;8(7):e68300
All references(103)

Other
accession IDs

MGD-MRK-1057, MGD-MRK-1061