Chrna4 MGI Mouse Gene Detail - MGI:87888 - cholinergic receptor, nicotinic, alpha polypeptide 4

Chrna4 Gene Detail

Symbol

Chrna4
Name

cholinergic receptor, nicotinic, alpha polypeptide 4
Synonyms

a4 nicotinic receptor, Acra4, Acra-4, alpha4 nAChR, alpha4-nAChR

Feature Type

protein coding gene
IDs

MGI:87888
NCBI Gene: 11438
Gene Overview

MyGene.info: CHRNA4
Alliance

gene page

Sequence Map

Chr2:181018380-181043546 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

25167 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 103.54 cM
Mapping Data

12 experiments

Human Ortholog

CHRNA4, cholinergic receptor nicotinic alpha 4 subunit

Vertebrate Orthologs

11

Human Ortholog

CHRNA4, cholinergic receptor nicotinic alpha 4 subunit
Orthology source: HomoloGene, HGNC
Synonyms

BFNC, EBN, EBN1, NACHR, NACHRA4, NACRA4
Links

HGNC:1958

NCBI Gene ID: 1137

neXtProt AC: NX_P43681

UniProt: P43681
Chr Location

20q13.33; chr20:63343310-63375392 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 592
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: CHRNA4
Gene Tree

Chrna4

Diseases

2 with human CHRNA4 associations

Human Disease

Mouse Models

autosomal dominant nocturnal frontal lobe epilepsy 1

IDs

View 1 "NOT" model

nicotine dependence

IDs

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

3 with disease annotations

less

Phenotype Summary

35 phenotypes from 11 alleles in 10 genetic backgrounds
48 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Gene trapped

1
Spontaneous

1
Targeted

16
Genomic Mutations

1 involving Chrna4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Nullizygous mice may show reduced chemically-elicited analgesia, susceptibility to seizures, increased anxiety, and altered behavioral responses to nicotine or a new environment. Homozygotes for any of several knock-in alleles exhibit altered nervous system physiology and/or sensitivity to nicotine.

less

All GO Annotations

94
GO References

25

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

221
Tissues

126
cDNA Data

49
Literature Summary

12

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase chrna4

ZFIN chrna4b

less

Chrna4 interacts with 250 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

less

All Sequences

43
RefSeq

4
UniProt

5
CCDS

CCDS17192.1
UniGene

252369

			Length	Strain/Species	Flank
genomic	OTTMUSG00000016395	VEGA Gene Model \| MGI Sequence Detail	25167	C57BL/6J	± kb
transcript	OTTMUST00000039489	VEGA \| MGI Sequence Detail	2071	Not Applicable
polypeptide	OTTMUSP00000017644	VEGA \| MGI Sequence Detail	641	Not Applicable

less

SNPs within 2kb

161 from dbSNP Build 142

RFLP

3

less

UniProt

5 Sequences
InterPro Domains

IPR006201 Neurotransmitter-gated ion-channel

IPR018000 Neurotransmitter-gated ion-channel, conserved site

IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain

IPR036734 Neurotransmitter-gated ion-channel ligand-binding domain superfamily

IPR006029 Neurotransmitter-gated ion-channel transmembrane domain

IPR036719 Neurotransmitter-gated ion-channel transmembrane domain superfamily

IPR002394 Nicotinic acetylcholine receptor

less

All nucleic 56

cDNA 52

Primer pair 2

Other 2

Microarray probesets 6

less

MGD-MRK-1057, MGD-MRK-1061

Summaries

All 122

Developmental Gene Expression 12

Diseases 3

Gene Ontology 25

Phenotypes 48
Earliest

J:10489 Bessis A, et al., Chromosomal localization of the mouse genes coding for alpha 2, alpha 3, alpha 4 and beta 2 subunits of neuronal nicotinic acetylcholine receptor. FEBS Lett. 1990 May 7;264(1):48-52
Latest

J:257029 Qian J, et al., Nicotinic acetylcholine receptors (nAChRs) are expressed in Trpm5 positive taste receptor cells (TRCs). PLoS One. 2018;13(1):e0190465

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 10/09/2018 MGI 6.12