Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CCDC88C
  • Mouse genes Ccdc88c
  • Rat genes Ccdc88c
  • Zfish genes ccdc88c
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ccdc88c

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005109	frizzled binding	CCDC88C	IPI	UniProtKB:O75084	Human	PMID:26126266
Molecular Function	GO:0001965	G-protein alpha-subunit binding	CCDC88C	IPI	UniProtKB:P08754	Human	PMID:26126266
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	CCDC88C	IDA		Human	PMID:26126266
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	ccdc88c	IDA		Zfish	PMID:30948426|ZFIN:ZDB-PUB-200422-183
Molecular Function	GO:0042802	identical protein binding	Ccdc88c	IPI	UniProtKB:Q6VGS5	Mouse	MGI:MGI:3042001|PMID:14750955
Molecular Function	GO:0030165	PDZ domain binding	Ccdc88c	IPI	UniProtKB:O14640	Mouse	MGI:MGI:3042001|PMID:14750955
Molecular Function	GO:0005515	protein binding	CCDC88C	IPI	UniProtKB:O14640	Human	PMID:26126266
Molecular Function	GO:0005515	protein binding	Ccdc88c	IPI	UniProtKB:O14640	Mouse	MGI:MGI:3042001|PMID:14750955
Molecular Function	GO:0043621	protein self-association	Ccdc88c	IPI	UniProtKB:Q6VGS5	Mouse	MGI:MGI:3042001|PMID:14750955
Cellular Component	GO:0030054	cell junction	CCDC88C	IMP		Human	PMID:30948426
Cellular Component	GO:0005737	cytoplasm	CCDC88C	IDA		Human	PMID:25062847
Cellular Component	GO:0005737	cytoplasm	CCDC88C	IDA		Human	PMID:26126266
Biological Process	GO:0003383	apical constriction	CCDC88C	IDA		Human	PMID:30948426
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	CCDC88C	IMP		Human	PMID:26126266
Biological Process	GO:0001841	neural tube formation	ccdc88c	IMP		Zfish	PMID:30948426|ZFIN:ZDB-PUB-200422-183
Biological Process	GO:0035567	non-canonical Wnt signaling pathway	CCDC88C	IMP		Human	PMID:26126266
Biological Process	GO:0031648	protein destabilization	Ccdc88c	IMP		Mouse	MGI:MGI:3042001|PMID:14750955
Biological Process	GO:0001932	regulation of protein phosphorylation	Ccdc88c	IMP		Mouse	MGI:MGI:3042001|PMID:14750955
Biological Process	GO:0007264	small GTPase mediated signal transduction	CCDC88C	IDA		Human	PMID:26126266
Biological Process	GO:0007264	small GTPase mediated signal transduction	ccdc88c	IDA		Zfish	PMID:30948426|ZFIN:ZDB-PUB-200422-183
Biological Process	GO:0031098	stress-activated protein kinase signaling cascade	CCDC88C	IMP		Human	PMID:25062847

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern