About   Help   FAQ
Gene Ontology Browser
Term Detail
GO term:non-canonical Wnt signaling pathway
Synonym: beta-catenin-independent Wnt receptor signaling pathway
Synonym: non-canonical Wnt-activated signaling pathway
Synonym: non-canonical Wnt receptor signaling pathway
Synonym: non-canonical Wnt receptor signalling pathway
GO id:GO:0035567
Definition:The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via effectors other than beta-catenin.
CommentsThis term should only be used when Wnt receptor signaling occurs via a beta-catenin-independent route but the downstream effectors are unknown. If the downstream effectors are known, consider instead annotating to one of the children, or requesting a new term.
Number of paths to term: 9

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of cellular process
                                        is-asignal transduction
                                                is-acell surface receptor signaling pathway
                                                        is-aWnt signaling pathway
                                                                is-acanonical Wnt signaling pathway +
                                                                is-anegative regulation of anterior neural cell fate commitment of the neural plate by Wnt signaling pathway
                                                                negatively-regulatesnegative regulation of Wnt signaling pathway +
                                                                is-anon-canonical Wnt signaling pathway [GO:0035567] (38 genes, 93 annotations)
                                                                        negatively-regulatesnegative regulation of non-canonical Wnt signaling pathway +
                                                                        is-anon-canonical Wnt signaling pathway involved in heart development +
                                                                        is-anon-canonical Wnt signaling pathway via MAPK cascade +
                                                                        positively-regulatespositive regulation of non-canonical Wnt signaling pathway +
                                                                        regulatesregulation of non-canonical Wnt signaling pathway +
                                                                        is-aWnt signaling pathway, calcium modulating pathway +
                                                                        is-aWnt signaling pathway, planar cell polarity pathway +
                                                                        is-aWnt signaling pathway, regulating spindle positioning
                                                                is-apositive regulation of posterior neural plate formation by Wnt signaling pathway
                                                                positively-regulatespositive regulation of Wnt signaling pathway +
                                                                regulatesregulation of Wnt signaling pathway +
                                                                is-aWnt signaling pathway involved in animal/vegetal axis specification
                                                                is-aWnt signaling pathway involved in digestive tract morphogenesis +
                                                                is-aWnt signaling pathway involved in dorsal/ventral axis specification +
                                                                is-aWnt signaling pathway involved in forebrain neuroblast division
                                                                is-aWnt signaling pathway involved in heart development +
                                                                is-aWnt signaling pathway involved in kidney development +
                                                                is-aWnt signaling pathway involved in mammary gland specification
                                                                is-aWnt signaling pathway involved in primitive streak formation
                                                                is-aWnt signaling pathway involved in regulation of cell proliferation in dorsal spinal cord
                                                                is-aWnt signaling pathway involved in somitogenesis
                                                                is-aWnt signaling pathway involved in wound healing, spreading of epidermal cells
                                                                is-aWnt-activated signaling pathway involved in forebrain neuron fate commitment


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-aWnt signaling pathway
                                                        is-acanonical Wnt signaling pathway +
                                                        is-anegative regulation of anterior neural cell fate commitment of the neural plate by Wnt signaling pathway
                                                        negatively-regulatesnegative regulation of Wnt signaling pathway +
                                                        is-anon-canonical Wnt signaling pathway [GO:0035567] (38 genes, 93 annotations)
                                                                negatively-regulatesnegative regulation of non-canonical Wnt signaling pathway +
                                                                is-anon-canonical Wnt signaling pathway involved in heart development +
                                                                is-anon-canonical Wnt signaling pathway via MAPK cascade +
                                                                positively-regulatespositive regulation of non-canonical Wnt signaling pathway +
                                                                regulatesregulation of non-canonical Wnt signaling pathway +
                                                                is-aWnt signaling pathway, calcium modulating pathway +
                                                                is-aWnt signaling pathway, planar cell polarity pathway +
                                                                is-aWnt signaling pathway, regulating spindle positioning
                                                        is-apositive regulation of posterior neural plate formation by Wnt signaling pathway
                                                        positively-regulatespositive regulation of Wnt signaling pathway +
                                                        regulatesregulation of Wnt signaling pathway +
                                                        is-aWnt signaling pathway involved in animal/vegetal axis specification
                                                        is-aWnt signaling pathway involved in digestive tract morphogenesis +
                                                        is-aWnt signaling pathway involved in dorsal/ventral axis specification +
                                                        is-aWnt signaling pathway involved in forebrain neuroblast division
                                                        is-aWnt signaling pathway involved in heart development +
                                                        is-aWnt signaling pathway involved in kidney development +
                                                        is-aWnt signaling pathway involved in mammary gland specification
                                                        is-aWnt signaling pathway involved in primitive streak formation
                                                        is-aWnt signaling pathway involved in regulation of cell proliferation in dorsal spinal cord
                                                        is-aWnt signaling pathway involved in somitogenesis
                                                        is-aWnt signaling pathway involved in wound healing, spreading of epidermal cells
                                                        is-aWnt-activated signaling pathway involved in forebrain neuron fate commitment


Gene_Ontology
        is-abiological_process
                is-acellular process
                        regulatesregulation of cellular process
                                is-asignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-aWnt signaling pathway
                                                        is-acanonical Wnt signaling pathway +
                                                        is-anegative regulation of anterior neural cell fate commitment of the neural plate by Wnt signaling pathway
                                                        negatively-regulatesnegative regulation of Wnt signaling pathway +
                                                        is-anon-canonical Wnt signaling pathway [GO:0035567] (38 genes, 93 annotations)
                                                                negatively-regulatesnegative regulation of non-canonical Wnt signaling pathway +
                                                                is-anon-canonical Wnt signaling pathway involved in heart development +
                                                                is-anon-canonical Wnt signaling pathway via MAPK cascade +
                                                                positively-regulatespositive regulation of non-canonical Wnt signaling pathway +
                                                                regulatesregulation of non-canonical Wnt signaling pathway +
                                                                is-aWnt signaling pathway, calcium modulating pathway +
                                                                is-aWnt signaling pathway, planar cell polarity pathway +
                                                                is-aWnt signaling pathway, regulating spindle positioning
                                                        is-apositive regulation of posterior neural plate formation by Wnt signaling pathway
                                                        positively-regulatespositive regulation of Wnt signaling pathway +
                                                        regulatesregulation of Wnt signaling pathway +
                                                        is-aWnt signaling pathway involved in animal/vegetal axis specification
                                                        is-aWnt signaling pathway involved in digestive tract morphogenesis +
                                                        is-aWnt signaling pathway involved in dorsal/ventral axis specification +
                                                        is-aWnt signaling pathway involved in forebrain neuroblast division
                                                        is-aWnt signaling pathway involved in heart development +
                                                        is-aWnt signaling pathway involved in kidney development +
                                                        is-aWnt signaling pathway involved in mammary gland specification
                                                        is-aWnt signaling pathway involved in primitive streak formation
                                                        is-aWnt signaling pathway involved in regulation of cell proliferation in dorsal spinal cord
                                                        is-aWnt signaling pathway involved in somitogenesis
                                                        is-aWnt signaling pathway involved in wound healing, spreading of epidermal cells
                                                        is-aWnt-activated signaling pathway involved in forebrain neuron fate commitment


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-acell surface receptor signaling pathway
                                                        is-aWnt signaling pathway
                                                                is-acanonical Wnt signaling pathway +
                                                                is-anegative regulation of anterior neural cell fate commitment of the neural plate by Wnt signaling pathway
                                                                negatively-regulatesnegative regulation of Wnt signaling pathway +
                                                                is-anon-canonical Wnt signaling pathway [GO:0035567] (38 genes, 93 annotations)
                                                                        negatively-regulatesnegative regulation of non-canonical Wnt signaling pathway +
                                                                        is-anon-canonical Wnt signaling pathway involved in heart development +
                                                                        is-anon-canonical Wnt signaling pathway via MAPK cascade +
                                                                        positively-regulatespositive regulation of non-canonical Wnt signaling pathway +
                                                                        regulatesregulation of non-canonical Wnt signaling pathway +
                                                                        is-aWnt signaling pathway, calcium modulating pathway +
                                                                        is-aWnt signaling pathway, planar cell polarity pathway +
                                                                        is-aWnt signaling pathway, regulating spindle positioning
                                                                is-apositive regulation of posterior neural plate formation by Wnt signaling pathway
                                                                positively-regulatespositive regulation of Wnt signaling pathway +
                                                                regulatesregulation of Wnt signaling pathway +
                                                                is-aWnt signaling pathway involved in animal/vegetal axis specification
                                                                is-aWnt signaling pathway involved in digestive tract morphogenesis +
                                                                is-aWnt signaling pathway involved in dorsal/ventral axis specification +
                                                                is-aWnt signaling pathway involved in forebrain neuroblast division
                                                                is-aWnt signaling pathway involved in heart development +
                                                                is-aWnt signaling pathway involved in kidney development +
                                                                is-aWnt signaling pathway involved in mammary gland specification
                                                                is-aWnt signaling pathway involved in primitive streak formation
                                                                is-aWnt signaling pathway involved in regulation of cell proliferation in dorsal spinal cord
                                                                is-aWnt signaling pathway involved in somitogenesis
                                                                is-aWnt signaling pathway involved in wound healing, spreading of epidermal cells
                                                                is-aWnt-activated signaling pathway involved in forebrain neuron fate commitment


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of cellular process
                                is-asignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-aWnt signaling pathway
                                                        is-acanonical Wnt signaling pathway +
                                                        is-anegative regulation of anterior neural cell fate commitment of the neural plate by Wnt signaling pathway
                                                        negatively-regulatesnegative regulation of Wnt signaling pathway +
                                                        is-anon-canonical Wnt signaling pathway [GO:0035567] (38 genes, 93 annotations)
                                                                negatively-regulatesnegative regulation of non-canonical Wnt signaling pathway +
                                                                is-anon-canonical Wnt signaling pathway involved in heart development +
                                                                is-anon-canonical Wnt signaling pathway via MAPK cascade +
                                                                positively-regulatespositive regulation of non-canonical Wnt signaling pathway +
                                                                regulatesregulation of non-canonical Wnt signaling pathway +
                                                                is-aWnt signaling pathway, calcium modulating pathway +
                                                                is-aWnt signaling pathway, planar cell polarity pathway +
                                                                is-aWnt signaling pathway, regulating spindle positioning
                                                        is-apositive regulation of posterior neural plate formation by Wnt signaling pathway
                                                        positively-regulatespositive regulation of Wnt signaling pathway +
                                                        regulatesregulation of Wnt signaling pathway +
                                                        is-aWnt signaling pathway involved in animal/vegetal axis specification
                                                        is-aWnt signaling pathway involved in digestive tract morphogenesis +
                                                        is-aWnt signaling pathway involved in dorsal/ventral axis specification +
                                                        is-aWnt signaling pathway involved in forebrain neuroblast division
                                                        is-aWnt signaling pathway involved in heart development +
                                                        is-aWnt signaling pathway involved in kidney development +
                                                        is-aWnt signaling pathway involved in mammary gland specification
                                                        is-aWnt signaling pathway involved in primitive streak formation
                                                        is-aWnt signaling pathway involved in regulation of cell proliferation in dorsal spinal cord
                                                        is-aWnt signaling pathway involved in somitogenesis
                                                        is-aWnt signaling pathway involved in wound healing, spreading of epidermal cells
                                                        is-aWnt-activated signaling pathway involved in forebrain neuron fate commitment


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-aWnt signaling pathway
                                                        is-acanonical Wnt signaling pathway +
                                                        is-anegative regulation of anterior neural cell fate commitment of the neural plate by Wnt signaling pathway
                                                        negatively-regulatesnegative regulation of Wnt signaling pathway +
                                                        is-anon-canonical Wnt signaling pathway [GO:0035567] (38 genes, 93 annotations)
                                                                negatively-regulatesnegative regulation of non-canonical Wnt signaling pathway +
                                                                is-anon-canonical Wnt signaling pathway involved in heart development +
                                                                is-anon-canonical Wnt signaling pathway via MAPK cascade +
                                                                positively-regulatespositive regulation of non-canonical Wnt signaling pathway +
                                                                regulatesregulation of non-canonical Wnt signaling pathway +
                                                                is-aWnt signaling pathway, calcium modulating pathway +
                                                                is-aWnt signaling pathway, planar cell polarity pathway +
                                                                is-aWnt signaling pathway, regulating spindle positioning
                                                        is-apositive regulation of posterior neural plate formation by Wnt signaling pathway
                                                        positively-regulatespositive regulation of Wnt signaling pathway +
                                                        regulatesregulation of Wnt signaling pathway +
                                                        is-aWnt signaling pathway involved in animal/vegetal axis specification
                                                        is-aWnt signaling pathway involved in digestive tract morphogenesis +
                                                        is-aWnt signaling pathway involved in dorsal/ventral axis specification +
                                                        is-aWnt signaling pathway involved in forebrain neuroblast division
                                                        is-aWnt signaling pathway involved in heart development +
                                                        is-aWnt signaling pathway involved in kidney development +
                                                        is-aWnt signaling pathway involved in mammary gland specification
                                                        is-aWnt signaling pathway involved in primitive streak formation
                                                        is-aWnt signaling pathway involved in regulation of cell proliferation in dorsal spinal cord
                                                        is-aWnt signaling pathway involved in somitogenesis
                                                        is-aWnt signaling pathway involved in wound healing, spreading of epidermal cells
                                                        is-aWnt-activated signaling pathway involved in forebrain neuron fate commitment


Gene_Ontology
        is-abiological_process
                is-asignaling
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-aWnt signaling pathway
                                                        is-acanonical Wnt signaling pathway +
                                                        is-anegative regulation of anterior neural cell fate commitment of the neural plate by Wnt signaling pathway
                                                        negatively-regulatesnegative regulation of Wnt signaling pathway +
                                                        is-anon-canonical Wnt signaling pathway [GO:0035567] (38 genes, 93 annotations)
                                                                negatively-regulatesnegative regulation of non-canonical Wnt signaling pathway +
                                                                is-anon-canonical Wnt signaling pathway involved in heart development +
                                                                is-anon-canonical Wnt signaling pathway via MAPK cascade +
                                                                positively-regulatespositive regulation of non-canonical Wnt signaling pathway +
                                                                regulatesregulation of non-canonical Wnt signaling pathway +
                                                                is-aWnt signaling pathway, calcium modulating pathway +
                                                                is-aWnt signaling pathway, planar cell polarity pathway +
                                                                is-aWnt signaling pathway, regulating spindle positioning
                                                        is-apositive regulation of posterior neural plate formation by Wnt signaling pathway
                                                        positively-regulatespositive regulation of Wnt signaling pathway +
                                                        regulatesregulation of Wnt signaling pathway +
                                                        is-aWnt signaling pathway involved in animal/vegetal axis specification
                                                        is-aWnt signaling pathway involved in digestive tract morphogenesis +
                                                        is-aWnt signaling pathway involved in dorsal/ventral axis specification +
                                                        is-aWnt signaling pathway involved in forebrain neuroblast division
                                                        is-aWnt signaling pathway involved in heart development +
                                                        is-aWnt signaling pathway involved in kidney development +
                                                        is-aWnt signaling pathway involved in mammary gland specification
                                                        is-aWnt signaling pathway involved in primitive streak formation
                                                        is-aWnt signaling pathway involved in regulation of cell proliferation in dorsal spinal cord
                                                        is-aWnt signaling pathway involved in somitogenesis
                                                        is-aWnt signaling pathway involved in wound healing, spreading of epidermal cells
                                                        is-aWnt-activated signaling pathway involved in forebrain neuron fate commitment


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-aWnt signaling pathway
                                                        is-acanonical Wnt signaling pathway +
                                                        is-anegative regulation of anterior neural cell fate commitment of the neural plate by Wnt signaling pathway
                                                        negatively-regulatesnegative regulation of Wnt signaling pathway +
                                                        is-anon-canonical Wnt signaling pathway [GO:0035567] (38 genes, 93 annotations)
                                                                negatively-regulatesnegative regulation of non-canonical Wnt signaling pathway +
                                                                is-anon-canonical Wnt signaling pathway involved in heart development +
                                                                is-anon-canonical Wnt signaling pathway via MAPK cascade +
                                                                positively-regulatespositive regulation of non-canonical Wnt signaling pathway +
                                                                regulatesregulation of non-canonical Wnt signaling pathway +
                                                                is-aWnt signaling pathway, calcium modulating pathway +
                                                                is-aWnt signaling pathway, planar cell polarity pathway +
                                                                is-aWnt signaling pathway, regulating spindle positioning
                                                        is-apositive regulation of posterior neural plate formation by Wnt signaling pathway
                                                        positively-regulatespositive regulation of Wnt signaling pathway +
                                                        regulatesregulation of Wnt signaling pathway +
                                                        is-aWnt signaling pathway involved in animal/vegetal axis specification
                                                        is-aWnt signaling pathway involved in digestive tract morphogenesis +
                                                        is-aWnt signaling pathway involved in dorsal/ventral axis specification +
                                                        is-aWnt signaling pathway involved in forebrain neuroblast division
                                                        is-aWnt signaling pathway involved in heart development +
                                                        is-aWnt signaling pathway involved in kidney development +
                                                        is-aWnt signaling pathway involved in mammary gland specification
                                                        is-aWnt signaling pathway involved in primitive streak formation
                                                        is-aWnt signaling pathway involved in regulation of cell proliferation in dorsal spinal cord
                                                        is-aWnt signaling pathway involved in somitogenesis
                                                        is-aWnt signaling pathway involved in wound healing, spreading of epidermal cells
                                                        is-aWnt-activated signaling pathway involved in forebrain neuron fate commitment


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-acell surface receptor signaling pathway
                                                        is-aWnt signaling pathway
                                                                is-acanonical Wnt signaling pathway +
                                                                is-anegative regulation of anterior neural cell fate commitment of the neural plate by Wnt signaling pathway
                                                                negatively-regulatesnegative regulation of Wnt signaling pathway +
                                                                is-anon-canonical Wnt signaling pathway [GO:0035567] (38 genes, 93 annotations)
                                                                        negatively-regulatesnegative regulation of non-canonical Wnt signaling pathway +
                                                                        is-anon-canonical Wnt signaling pathway involved in heart development +
                                                                        is-anon-canonical Wnt signaling pathway via MAPK cascade +
                                                                        positively-regulatespositive regulation of non-canonical Wnt signaling pathway +
                                                                        regulatesregulation of non-canonical Wnt signaling pathway +
                                                                        is-aWnt signaling pathway, calcium modulating pathway +
                                                                        is-aWnt signaling pathway, planar cell polarity pathway +
                                                                        is-aWnt signaling pathway, regulating spindle positioning
                                                                is-apositive regulation of posterior neural plate formation by Wnt signaling pathway
                                                                positively-regulatespositive regulation of Wnt signaling pathway +
                                                                regulatesregulation of Wnt signaling pathway +
                                                                is-aWnt signaling pathway involved in animal/vegetal axis specification
                                                                is-aWnt signaling pathway involved in digestive tract morphogenesis +
                                                                is-aWnt signaling pathway involved in dorsal/ventral axis specification +
                                                                is-aWnt signaling pathway involved in forebrain neuroblast division
                                                                is-aWnt signaling pathway involved in heart development +
                                                                is-aWnt signaling pathway involved in kidney development +
                                                                is-aWnt signaling pathway involved in mammary gland specification
                                                                is-aWnt signaling pathway involved in primitive streak formation
                                                                is-aWnt signaling pathway involved in regulation of cell proliferation in dorsal spinal cord
                                                                is-aWnt signaling pathway involved in somitogenesis
                                                                is-aWnt signaling pathway involved in wound healing, spreading of epidermal cells
                                                                is-aWnt-activated signaling pathway involved in forebrain neuron fate commitment


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory