Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Capn1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes CAPN1
- Mouse genes Capn1
- Rat genes Capn1
- Zfish genes capn1,capn1a,capn1b,si:dkeyp-50d11.2
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Capn1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005509	calcium ion binding	CAPN1	IDA		Human	PMID:9271093
Molecular Function	GO:0005509	calcium ion binding	Capn1	IMP		Rat	PMID:11893336\|RGD:70442
Molecular Function	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	CAPN1	IDA		Human	PMID:16411745
Molecular Function	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	CAPN1	IDA		Human	PMID:19617626
Molecular Function	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	CAPN1	IDA		Human	PMID:2407243
Molecular Function	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	Capn1	IDA		Mouse	PMID:17529984
Molecular Function	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	Capn1	IMP		Rat	PMID:11893336\|RGD:70442
Molecular Function	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	Capn1	IDA		Rat	PMID:17429681\|RGD:1626249
Molecular Function	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	Capn1	IDA		Rat	PMID:22711986\|RGD:8553623
Molecular Function	GO:0008092	cytoskeletal protein binding	Capn1	IDA		Rat	PMID:17429681\|RGD:1626249
Molecular Function	GO:0019899	enzyme binding	Capn1	IPI	RGD:619993	Rat	PMID:20850499\|RGD:13703063
Molecular Function	GO:0008233	peptidase activity	CAPN1	IDA		Human	PMID:23707407
Molecular Function	GO:0005515	protein binding	CAPN1	IPI	UniProtKB:P18031	Human	PMID:19712109
Molecular Function	GO:0005515	protein binding	CAPN1	IPI	UniProtKB:P40763	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	CAPN1	IPI	UniProtKB:P15311	Human	PMID:22805611
Molecular Function	GO:0005515	protein binding	CAPN1	IPI	UniProtKB:P13569	Human	PMID:31324722
Molecular Function	GO:0005515	protein binding	CAPN1	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CAPN1	IPI	UniProtKB:P30085-3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CAPN1	IPI	UniProtKB:Q92934	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CAPN1	IPI	UniProtKB:Q96CV9	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CAPN1	IPI	UniProtKB:P18031	Human	PMID:9407132
Molecular Function	GO:0005515	protein binding	Capn1	IPI	UniProtKB:P61809	Mouse	MGI:MGI:3829808\|PMID:19118186
Molecular Function	GO:0005515	protein binding	Capn1	IPI	PR:Q01097	Mouse	PMID:17529984
Molecular Function	GO:0005515	protein binding	Capn1	IPI	PR:P49615	Mouse	PMID:17529984
Molecular Function	GO:0005515	protein binding	Capn1	IPI	RGD:68430	Rat	PMID:18559257\|RGD:9999185
Molecular Function	GO:0005515	protein binding	Capn1	IPI	UniProtKB:Q8NE35	Rat	PMID:22711986\|RGD:8553623
Cellular Component	GO:0001533	cornified envelope	Capn1	IDA		Mouse	PMID:26644517
Cellular Component	GO:0005829	cytosol	CAPN1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	CAPN1	IDA		Human	PMID:12150984
Cellular Component	GO:0005829	cytosol	CAPN1	IDA		Human	PMID:14559243
Cellular Component	GO:0005829	cytosol	CAPN1	IDA		Human	PMID:21531719
Cellular Component	GO:0005829	cytosol	CAPN1	IDA		Human	PMID:8769305
Cellular Component	GO:0005829	cytosol	Capn1	IDA		Mouse	PMID:22555453
Cellular Component	GO:0005829	cytosol	Capn1	IDA		Rat	PMID:9469158\|RGD:13792664
Cellular Component	GO:0070062	extracellular exosome	CAPN1	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	CAPN1	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	CAPN1	HDA		Human	PMID:23533145
Cellular Component	GO:0005925	focal adhesion	CAPN1	HDA		Human	PMID:21423176
Cellular Component	GO:0005764	lysosome	Capn1	IDA		Mouse	PMID:22555453
Cellular Component	GO:0016020	membrane	CAPN1	IDA		Human	PMID:14559243
Cellular Component	GO:0016020	membrane	Capn1	IDA		Rat	PMID:9469158\|RGD:13792664
Cellular Component	GO:0005739	mitochondrion	Capn1	IDA		Mouse	PMID:22555453
Cellular Component	GO:0005739	mitochondrion	Capn1	IDA		Rat	PMID:19833151\|RGD:13792654
Cellular Component	GO:0005886	plasma membrane	CAPN1	IDA		Human	PMID:12150984
Cellular Component	GO:0005886	plasma membrane	CAPN1	IDA		Human	PMID:8769305
Biological Process	GO:0007568	aging	Capn1	IEP		Rat	PMID:23006733\|RGD:13792498
Biological Process	GO:0007420	brain development	Capn1	IEP		Rat	PMID:19751724\|RGD:5509802
Biological Process	GO:0007420	brain development	capn1a	IMP	ZFIN:ZDB-MRPHLNO-160725-1	Zfish	PMID:27153400
Biological Process	GO:0021785	branchiomotor neuron axon guidance	capn1a	IMP	ZFIN:ZDB-MRPHLNO-160725-1	Zfish	PMID:27153400
Biological Process	GO:0070301	cellular response to hydrogen peroxide	Capn1	IMP		Rat	PMID:22402252\|RGD:13792584
Biological Process	GO:0060056	mammary gland involution	Capn1	IMP		Mouse	PMID:22555453
Biological Process	GO:0030837	negative regulation of actin filament polymerization	Capn1	IMP		Rat	PMID:25653381\|RGD:13792590
Biological Process	GO:1901223	negative regulation of NIK/NF-kappaB signaling	Capn1	IMP		Rat	PMID:21415394\|RGD:13792556
Biological Process	GO:0010666	positive regulation of cardiac muscle cell apoptotic process	Capn1	IMP		Rat	PMID:22402252\|RGD:13792584
Biological Process	GO:1903238	positive regulation of leukocyte tethering or rolling	Capn1	IMP		Rat	PMID:21415394\|RGD:13792556
Biological Process	GO:0043117	positive regulation of vascular permeability	Capn1	IMP		Rat	PMID:21415394\|RGD:13792556
Biological Process	GO:0016540	protein autoprocessing	Capn1	IDA		Rat	PMID:17182728\|RGD:2303057
Biological Process	GO:0030163	protein catabolic process	Capn1	IMP		Rat	PMID:11893336\|RGD:70442
Biological Process	GO:0030163	protein catabolic process	Capn1	IDA		Rat	PMID:17429681\|RGD:1626249
Biological Process	GO:0006508	proteolysis	CAPN1	IDA		Human	PMID:16411745
Biological Process	GO:0006508	proteolysis	CAPN1	IDA		Human	PMID:21531719
Biological Process	GO:0006508	proteolysis	CAPN1	IDA		Human	PMID:2400579
Biological Process	GO:0006508	proteolysis	CAPN1	IDA		Human	PMID:2407243
Biological Process	GO:0006508	proteolysis	Capn1	IMP		Mouse	PMID:22555453
Biological Process	GO:0006508	proteolysis	Capn1	IDA		Rat	PMID:22711986\|RGD:8553623
Biological Process	GO:0032801	receptor catabolic process	Capn1	IDA		Mouse	PMID:17529984
Biological Process	GO:0050790	regulation of catalytic activity	CAPN1	IDA		Human	PMID:8954105
Biological Process	GO:0050790	regulation of catalytic activity	CAPN1	IDA		Human	PMID:9271093
Biological Process	GO:1990776	response to angiotensin	Capn1	IMP		Rat	PMID:21415394\|RGD:13792556
Biological Process	GO:0046685	response to arsenic-containing substance	Capn1	IEP		Rat	PMID:24641850\|RGD:13792499
Biological Process	GO:0097264	self proteolysis	CAPN1	IDA		Human	PMID:8769305
Biological Process	GO:0097264	self proteolysis	CAPN1	IDA		Human	PMID:8954105

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/21/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.