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Capn1
Gene Detail
 Symbol
Name
ID
Capn1
calpain 1
MGI:88263
Synonyms Capa1, Capa-1, mu-calpin
Feature Type protein coding gene
Genetic Map
Chromosome 19
4.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr19:5988546-6015825 bp, - strand
From Ensembl annotation of GRCm38

  27280 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3800  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Capn1

Human
homologs
Human Homolog CAPN1, calpain 1, (mu/I) large subunit
NCBI Gene ID 823
neXtProt AC  NX_P07384
Human Synonyms  CANP, CANP1, CANPL1, muCANP, muCL
Human Chr (Location)  11q13; chr11:65181215-65212006 (+)  GRCh38
Alleles
and
phenotypes
All alleles(7) : Gene trapped(4) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Animals homozygous for a mutation of this gene exhibit decreased platelet aggregation and defective clot retraction although bleeding times remain similar to wild-type.
 
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process protein autoprocessing, proteolysis, ...
Component cytoplasm, cytosol, ...
Function calcium-dependent cysteine-type endopeptidase activity, calcium ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (39)    Tissues (17)   
Theiler Stages: 22, 24, 26, 28
Assay TypeResults
Immunohistochemistry 24
RT-PCR 15
cDNA source data(61)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(64) Genomic(1) cDNA(61) Primer pair(2)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000024942 (Evidence)
Entrez Gene12333 (Evidence)
UniGene6221
DFCITC1574465, TC1592962, TC1647258
DoTSDT.101408810, DT.101408812, DT.94407739, DT.97371488
NIA Mouse Gene IndexU019025
EC3.4.22.52
Consensus CDS ProjectCCDS37893.1
International Mouse Knockout Project StatusCapn1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024942 Ensembl Gene Model | MGI Sequence Detail 27280 C57BL/6J ±  kb
transcript ENSMUST00000164843 Ensembl | MGI Sequence Detail 3048 Not Applicable 
polypeptide ENSMUSP00000127498 Ensembl | MGI Sequence Detail 713 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(4) UniProt(7)
Polymorphisms SNPs within 2kb(338 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000169 Cysteine peptidase, cysteine active site
InterPro IPR018247 EF-Hand 1, calcium-binding site
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand-like domain
InterPro IPR001300 Peptidase C2, calpain, catalytic domain
InterPro IPR022683 Peptidase C2, calpain, domain III
InterPro IPR022684 Peptidase C2, calpain family
InterPro IPR022682 Peptidase C2, calpain, large subunit, domain III
Protein Ontology PR:000005009 calpain-1 catalytic subunit
References (Earliest) J:10756 Moens PB, et al., In situ DNA sequence mapping with surface-spread mouse pachytene chromosomes. Cytogenet Cell Genet. 1990;53(4):219-20
(Latest) J:206427 Subramanian V, et al., Calpain-2 compensation promotes angiotensin II-induced ascending and abdominal aortic aneurysms in calpain-1 deficient mice. PLoS One. 2013;8(8):e72214
All references(65)
Other
accession IDs
MGD-MRK-1750, MGD-MRK-1754

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory