About   Help   FAQ
Capn1 Gene Detail
Summary
  • Symbol
    Capn1
  • Name
    calpain 1
  • Synonyms
    Capa1, Capa-1, mu-calpin
  • Feature Type
    protein coding gene
  • IDs
    MGI:88263
    NCBI Gene: 12333
  • Gene Overview
    MyGene.info: CAPN1
Location & Maps
more
  • Sequence Map
    Chr19:5988546-6015825 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      27280 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 4.34 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    CAPN1, calpain 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CAPN1, calpain 1
    Orthology source: HomoloGene
  • Synonyms
    CANP, CANP1, CANPL1, muCANP, muCL, SPG76
  • Links
    NCBI Gene ID: 823
    neXtProt AC: NX_P07384

  • Chr Location
    11q13; chr11:65181215-65212006 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 3800
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;2 zebrafish
  • HCOP
    human homology predictions: CAPN1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human CAPN1 associations

Human Disease Mouse Models
       Spastic Paraplegia 76, Autosomal Recessive; SPG76   OMIM: 616907
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 4 alleles in 4 genetic backgrounds
    8 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Gene trapped
    4
  • Targeted
    3
  • Transgenic
    1
  • Incidental Mutations
Animals homozygous for a mutation of this gene exhibit decreased platelet aggregation and defective clot retraction although bleeding times remain similar to wild-type.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024942 Ensembl Gene Model | MGI Sequence Detail 27280 C57BL/6J ±  kb
transcript ENSMUST00000025891 Ensembl | MGI Sequence Detail 3100 Not Applicable  
polypeptide ENSMUSP00000025891 Ensembl | MGI Sequence Detail 713 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    291 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 64
    Genomic 1
    cDNA 61
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-1750, MGD-MRK-1754
References
more
  • Summaries
    All 63
    Developmental Gene Expression 4
    Gene Ontology 7
    Phenotypes 19
  • Earliest
    J:10756 Moens PB, et al., In situ DNA sequence mapping with surface-spread mouse pachytene chromosomes. Cytogenet Cell Genet. 1990;53(4):219-20
  • Latest
    J:217727 Zhu G, et al., Different Patterns of Electrical Activity Lead to Long-term Potentiation by Activating Different Intracellular Pathways. J Neurosci. 2015 Jan 14;35(2):621-33

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/19/2016
MGI 6.04
The Jackson Laboratory