About   Help   FAQ
Capn1 Gene Detail
Summary
  • Symbol
    Capn1
  • Name
    calpain 1
  • Synonyms
    Capa1, Capa-1, mu-calpin
  • Feature Type
    protein coding gene
  • IDs
    MGI:88263
    NCBI Gene: 12333
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:6038573-6065855 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 19, 4.34 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    291 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88263
protein coding gene Chr19:6038573-6065927 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024736
protein coding gene Chr19:3010518-3039727 (-)
A/J MGP_AJ_G0024702
protein coding gene Chr19:2842350-2869696 (-)
AKR/J MGP_AKRJ_G0024675
protein coding gene Chr19:2924279-2953903 (-)
BALB/cJ MGP_BALBcJ_G0024702
protein coding gene Chr19:2839091-2866846 (-)
C3H/HeJ MGP_C3HHeJ_G0024470
protein coding gene Chr19:2944674-2976107 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025149
protein coding gene Chr19:3073638-3102330 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022582
protein coding gene Chr19:2771094-2797446 (-)
CAST/EiJ MGP_CASTEiJ_G0023942
protein coding gene Chr19:2952912-2982558 (-)
CBA/J MGP_CBAJ_G0024442
protein coding gene Chr19:3217921-3246577 (-)
DBA/2J MGP_DBA2J_G0024569
protein coding gene Chr19:2828940-2855808 (-)
FVB/NJ MGP_FVBNJ_G0024535
protein coding gene Chr19:2838615-2867636 (-)
LP/J MGP_LPJ_G0024655
protein coding gene Chr19:2983737-3011395 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024565
protein coding gene Chr19:3029644-3065753 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025197
protein coding gene Chr19:2949876-2985061 (-)
PWK/PhJ MGP_PWKPhJ_G0023688
protein coding gene Chr19:2853946-2883892 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023493
protein coding gene Chr19:2920354-2947323 (-)
WSB/EiJ MGP_WSBEiJ_G0024004
protein coding gene Chr19:2958181-2992723 (-)



Homology
more
  • Human Ortholog
    CAPN1, calpain 1
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CAPN1, calpain 1
  • Synonyms
    CANP, CANP1, CANPL1, muCANP, muCL, SPG76
  • Links
    NCBI Gene ID: 823
    neXtProt AC: NX_P07384
    UniProt: P07384

  • Chr Location
    11q13.1; chr11:65180566-65212006 (+)  GRCh38

Human Diseases
more
  • Diseases
    1 with human CAPN1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 3 alleles in 3 genetic backgrounds
    12 phenotypes from multigenic genotypes
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Animals homozygous for a mutation of this gene exhibit decreased platelet aggregation and defective clot retraction although bleeding times remain similar to wild-type.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 12333 NCBI Gene Model | MGI Sequence Detail 27283 C57BL/6J ±  kb
transcript NM_007600 RefSeq | MGI Sequence Detail 3119 ZRU/MplStud  
polypeptide O35350 UniProt | EBI | MGI Sequence Detail 713 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 65
    Genomic 1
    cDNA 62
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-1750, MGD-MRK-1754
References
more
  • Summaries
    All 134
    Developmental Gene Expression 7
    Gene Ontology 11
    Phenotypes 33
  • Earliest
    J:10756 Moens PB, et al., In situ DNA sequence mapping with surface-spread mouse pachytene chromosomes. Cytogenet Cell Genet. 1990;53(4):219-20
  • Latest
    J:317438 Sheng X, et al., The mitochondrial protease LONP1 maintains oocyte development and survival by suppressing nuclear translocation of AIFM1 in mammals. EBioMedicine. 2021 Dec 30;75:103790

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory