About   Help   FAQ
Capn1 Gene Detail
Summary
  • Symbol
    Capn1
  • Name
    calpain 1
  • Synonyms
    Capa1, Capa-1, mu-calpin
  • Feature Type
    protein coding gene
  • IDs
    MGI:88263
    NCBI Gene: 12333
  • Gene Overview
    MyGene.info: CAPN1
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:5988546-6015825 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 4.34 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    291 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88263
protein coding gene Chr19:5988545-6015825 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024736
protein coding gene Chr19:3010518-3039727 (-)
A/J MGP_AJ_G0024702
protein coding gene Chr19:2842350-2869696 (-)
AKR/J MGP_AKRJ_G0024675
protein coding gene Chr19:2924279-2953903 (-)
BALB/cJ MGP_BALBcJ_G0024702
protein coding gene Chr19:2839091-2866846 (-)
C3H/HeJ MGP_C3HHeJ_G0024470
protein coding gene Chr19:2944674-2976107 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025149
protein coding gene Chr19:3073638-3102330 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022582
protein coding gene Chr19:2771094-2797446 (-)
CAST/EiJ MGP_CASTEiJ_G0023942
protein coding gene Chr19:2952912-2982558 (-)
CBA/J MGP_CBAJ_G0024442
protein coding gene Chr19:3217921-3246577 (-)
DBA/2J MGP_DBA2J_G0024569
protein coding gene Chr19:2828940-2855808 (-)
FVB/NJ MGP_FVBNJ_G0024535
protein coding gene Chr19:2838615-2867636 (-)
LP/J MGP_LPJ_G0024655
protein coding gene Chr19:2983737-3011395 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024565
protein coding gene Chr19:3029644-3065753 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025197
protein coding gene Chr19:2949876-2985061 (-)
PWK/PhJ MGP_PWKPhJ_G0023688
protein coding gene Chr19:2853946-2883892 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023493
protein coding gene Chr19:2920354-2947323 (-)
WSB/EiJ MGP_WSBEiJ_G0024004
protein coding gene Chr19:2958181-2992723 (-)



Homology
more
  • Human Ortholog
    CAPN1, calpain 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CAPN1, calpain 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CANP, CANP1, CANPL1, muCANP, muCL, SPG76
  • Links
    NCBI Gene ID: 823
    neXtProt AC: NX_P07384
    UniProt: P07384

  • Chr Location
    11q13.1; chr11:65181215-65212006 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 3800
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CAPN1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human CAPN1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 4 alleles in 4 genetic backgrounds
    8 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Animals homozygous for a mutation of this gene exhibit decreased platelet aggregation and defective clot retraction although bleeding times remain similar to wild-type.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024942 Ensembl Gene Model | MGI Sequence Detail 27280 C57BL/6J ±  kb
    transcript ENSMUST00000164843 Ensembl | MGI Sequence Detail 3048 Not Applicable  
    polypeptide ENSMUSP00000127498 Ensembl | MGI Sequence Detail 713 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 65
      Genomic 1
      cDNA 62
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1750, MGD-MRK-1754
    References
    more
    • Summaries
      All 114
      Developmental Gene Expression 4
      Gene Ontology 11
      Phenotypes 23
    • Earliest
      J:10756 Moens PB, et al., In situ DNA sequence mapping with surface-spread mouse pachytene chromosomes. Cytogenet Cell Genet. 1990;53(4):219-20
    • Latest
      J:248782 Sugiyama K, et al., Calpain-Dependent Degradation of Nucleoporins Contributes to Motor Neuron Death in a Mouse Model of Chronic Excitotoxicity. J Neurosci. 2017 Sep 6;37(36):8830-8844

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory