Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ATP1A2
  • Mouse genes Atp1a2
  • Rat genes Atp1a2
  • Zfish genes atp1a2a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Atp1a2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	ATP1A2	IMP		Human	PMID:23954377
Molecular Function	GO:0005524	ATP binding	Atp1a2	IMP		Rat	PMID:12529322|RGD:1299865
Molecular Function	GO:0016887	ATP hydrolysis activity	ATP1A2	IMP		Human	PMID:23954377
Molecular Function	GO:0019829	ATPase-coupled monoatomic cation transmembrane transporter activity	ATP1A2	IDA		Human	PMID:19372756
Molecular Function	GO:0019829	ATPase-coupled monoatomic cation transmembrane transporter activity	ATP1A2	IGI	UniProtKB:P05026	Human	PMID:20100892
Molecular Function	GO:0019829	ATPase-coupled monoatomic cation transmembrane transporter activity	Atp1a2	IMP		Rat	PMID:12529322|RGD:1299865
Molecular Function	GO:0005391	P-type sodium:potassium-exchanging transporter activity	ATP1A2	IDA		Human	PMID:10636900
Molecular Function	GO:0005391	P-type sodium:potassium-exchanging transporter activity	ATP1A2	IMP		Human	PMID:12539047
Molecular Function	GO:0005391	P-type sodium:potassium-exchanging transporter activity	ATP1A2	IGI	UniProtKB:P05027	Human	PMID:18052210
Molecular Function	GO:0005391	P-type sodium:potassium-exchanging transporter activity	ATP1A2	IGI	UniProtKB:P05026	Human	PMID:18728015
Molecular Function	GO:0005391	P-type sodium:potassium-exchanging transporter activity	ATP1A2	IGI	UniProtKB:P05026	Human	PMID:20100892
Molecular Function	GO:0005391	P-type sodium:potassium-exchanging transporter activity	ATP1A2	IMP		Human	PMID:23954377
Molecular Function	GO:0005391	P-type sodium:potassium-exchanging transporter activity	Atp1a2	IDA		Rat	PMID:16624992|RGD:2302992
Molecular Function	GO:0030955	potassium ion binding	ATP1A2	IMP		Human	PMID:23954377
Molecular Function	GO:0005515	protein binding	ATP1A2	IPI	UniProtKB:P05026	Human	PMID:23954377
Molecular Function	GO:0005515	protein binding	Atp1a2	IPI	UniProtKB:O35157|UniProtKB:P11881	Mouse	MGI:MGI:3610760|PMID:16292983
Molecular Function	GO:0005515	protein binding	Atp1a2	IPI	UniProtKB:Q8C8R3	Mouse	MGI:MGI:3610760|PMID:16292983
Molecular Function	GO:0005515	protein binding	Atp1a2	IPI	PR:P70414	Mouse	PMID:15485817
Molecular Function	GO:0005515	protein binding	Atp1a2	IPI	RGD:620830	Rat	PMID:12093728|RGD:631775
Molecular Function	GO:0046982	protein heterodimerization activity	Atp1a2	IPI	UniProtKB:P13638	Rat	PMID:28787093|RGD:14995309
Molecular Function	GO:0051087	protein-folding chaperone binding	ATP1A2	IPI	UniProtKB:P05026	Human	PMID:10636900
Molecular Function	GO:0051087	protein-folding chaperone binding	ATP1A2	IPI	UniProtKB:P14415	Human	PMID:10636900
Molecular Function	GO:0051087	protein-folding chaperone binding	ATP1A2	IPI	UniProtKB:P54709	Human	PMID:10636900
Molecular Function	GO:0031402	sodium ion binding	ATP1A2	IMP		Human	PMID:23954377
Molecular Function	GO:0005496	steroid binding	ATP1A2	IPI	CHEBI:472805	Human	PMID:23954377
Molecular Function	GO:1990239	steroid hormone binding	ATP1A2	IDA		Human	PMID:14742675
Molecular Function	GO:1990239	steroid hormone binding	Atp1a2	IDA		Rat	PMID:17442282|RGD:6903343
Cellular Component	GO:0005901	caveola	Atp1a2	IDA		Rat	PMID:16624992|RGD:2302992
Cellular Component	GO:0042995	cell projection	Atp1a2	IDA		Mouse	MGI:MGI:2450206|PMID:12458206
Cellular Component	GO:0042995	cell projection	Atp1a2	IDA		Mouse	MGI:MGI:2664023|PMID:12805306
Cellular Component	GO:0005737	cytoplasm	ATP1A2	IDA		Human	PMID:12539047
Cellular Component	GO:0043197	dendritic spine	Atp1a2	IDA		Rat	PMID:11950769|RGD:727361
Cellular Component	GO:0005768	endosome	Atp1a2	IDA		Rat	PMID:16893515|RGD:1581763
Cellular Component	GO:1903561	extracellular vesicle	ATP1A2	HDA		Human	PMID:24769233
Cellular Component	GO:0014704	intercalated disc	Atp1a2	IDA		Rat	PMID:17442282|RGD:6903343
Cellular Component	GO:0016020	membrane	ATP1A2	IDA		Human	PMID:23954377
Cellular Component	GO:0016020	membrane	Atp1a2	IDA		Rat	PMID:28787093|RGD:14995309
Cellular Component	GO:0043209	myelin sheath	Atp1a2	HDA		Mouse	MGI:MGI:3834050|PMID:17634366
Cellular Component	GO:0043005	neuron projection	Atp1a2	IDA		Rat	PMID:11950769|RGD:727361
Cellular Component	GO:0043025	neuronal cell body	Atp1a2	IDA		Mouse	MGI:MGI:2450206|PMID:12458206
Cellular Component	GO:0043025	neuronal cell body	Atp1a2	IDA		Mouse	MGI:MGI:2664023|PMID:12805306
Cellular Component	GO:0031090	organelle membrane	ATP1A2	IGI	UniProtKB:P05026	Human	PMID:19751721
Cellular Component	GO:0005886	plasma membrane	ATP1A2	IDA		Human	PMID:12539047
Cellular Component	GO:0005886	plasma membrane	ATP1A2	IGI	UniProtKB:P05026	Human	PMID:19372756
Cellular Component	GO:0005886	plasma membrane	ATP1A2	IGI	UniProtKB:P05026	Human	PMID:19751721
Cellular Component	GO:0042383	sarcolemma	Atp1a2	IDA		Mouse	MGI:MGI:3610760|PMID:16292983
Cellular Component	GO:0042383	sarcolemma	Atp1a2	IDA		Mouse	PMID:15485817
Cellular Component	GO:0042383	sarcolemma	Atp1a2	IDA		Rat	PMID:17442282|RGD:6903343
Cellular Component	GO:0005890	sodium:potassium-exchanging ATPase complex	ATP1A2	IDA		Human	PMID:10636900
Cellular Component	GO:0005890	sodium:potassium-exchanging ATPase complex	ATP1A2	IGI	UniProtKB:P05027	Human	PMID:18052210
Cellular Component	GO:0005890	sodium:potassium-exchanging ATPase complex	ATP1A2	IGI	UniProtKB:P05026	Human	PMID:18728015
Cellular Component	GO:0005890	sodium:potassium-exchanging ATPase complex	ATP1A2	IDA		Human	PMID:23954377
Cellular Component	GO:0005890	sodium:potassium-exchanging ATPase complex	Atp1a2	IDA		Rat	PMID:12093728|RGD:631775
Cellular Component	GO:0005890	sodium:potassium-exchanging ATPase complex	Atp1a2	IDA		Rat	PMID:16624992|RGD:2302992
Cellular Component	GO:0005890	sodium:potassium-exchanging ATPase complex	Atp1a2	IDA		Rat	PMID:28787093|RGD:14995309
Cellular Component	GO:0045202	synapse	Atp1a2	IDA		Rat	PMID:11950769|RGD:727361
Cellular Component	GO:0030315	T-tubule	ATP1A2	IGI	UniProtKB:P05026	Human	PMID:19751721
Cellular Component	GO:0030315	T-tubule	Atp1a2	IDA		Mouse	MGI:MGI:3610760|PMID:16292983
Cellular Component	GO:0030315	T-tubule	Atp1a2	IDA		Rat	PMID:17442282|RGD:6903343
Biological Process	GO:0008344	adult locomotory behavior	Atp1a2	IMP	MGI:MGI:2451291	Mouse	PMID:17234593
Biological Process	GO:0021764	amygdala development	Atp1a2	IMP		Mouse	MGI:MGI:2664023|PMID:12805306
Biological Process	GO:0046034	ATP metabolic process	ATP1A2	IMP		Human	PMID:23954377
Biological Process	GO:0001662	behavioral fear response	Atp1a2	IMP		Mouse	MGI:MGI:2664023|PMID:12805306
Biological Process	GO:0071260	cellular response to mechanical stimulus	Atp1a2	IEP		Rat	PMID:16893515|RGD:1581763
Biological Process	GO:0071260	cellular response to mechanical stimulus	Atp1a2	IDA		Rat	PMID:17458903|RGD:6903221
Biological Process	GO:0071383	cellular response to steroid hormone stimulus	ATP1A2	IDA		Human	PMID:14742675
Biological Process	GO:0071383	cellular response to steroid hormone stimulus	Atp1a2	IDA		Mouse	MGI:MGI:3608241|PMID:16243970
Biological Process	GO:0071383	cellular response to steroid hormone stimulus	Atp1a2	IMP		Rat	PMID:17442282|RGD:6903343
Biological Process	GO:0061371	determination of heart left/right asymmetry	atp1a2a	IMP	ZFIN:ZDB-MRPHLNO-060215-2	Zfish	PMID:23097043
Biological Process	GO:0007368	determination of left/right symmetry	atp1a2a	IMP	ZFIN:ZDB-MRPHLNO-070731-4	Zfish	PMID:17442698
Biological Process	GO:0007368	determination of left/right symmetry	atp1a2a	IMP	ZFIN:ZDB-MRPHLNO-060215-2	Zfish	PMID:17442698
Biological Process	GO:0007368	determination of left/right symmetry	atp1a2a	IGI	ZFIN:ZDB-MRPHLNO-060215-2,ZFIN:ZDB-MRPHLNO-070731-2	Zfish	PMID:17442698
Biological Process	GO:0042044	fluid transport	atp1a2a	IMP	ZFIN:ZDB-MRPHLNO-060215-2	Zfish	PMID:17442698
Biological Process	GO:0060047	heart contraction	atp1a2a	IMP	ZFIN:ZDB-MRPHLNO-060215-2	Zfish	PMID:23097043
Biological Process	GO:0007507	heart development	atp1a2a	IMP		Zfish	PMID:14602677
Biological Process	GO:0001947	heart looping	atp1a2a	IMP	ZFIN:ZDB-MRPHLNO-060215-2	Zfish	PMID:17442698
Biological Process	GO:0001947	heart looping	atp1a2a	IMP	ZFIN:ZDB-MRPHLNO-070731-4	Zfish	PMID:17442698
Biological Process	GO:0030007	intracellular potassium ion homeostasis	ATP1A2	IDA		Human	PMID:10636900
Biological Process	GO:0006883	intracellular sodium ion homeostasis	ATP1A2	IDA		Human	PMID:10636900
Biological Process	GO:0040011	locomotion	Atp1a2	IMP	MGI:MGI:2451291	Mouse	PMID:12458206
Biological Process	GO:0035641	locomotory exploration behavior	Atp1a2	IMP		Mouse	MGI:MGI:6368078|PMID:20936682
Biological Process	GO:0098655	monoatomic cation transmembrane transport	ATP1A2	IDA		Human	PMID:19372756
Biological Process	GO:0098655	monoatomic cation transmembrane transport	ATP1A2	IGI	UniProtKB:P05026	Human	PMID:20100892
Biological Process	GO:1903170	negative regulation of calcium ion transmembrane transport	Atp1a2	IMP		Rat	PMID:17442282|RGD:6903343
Biological Process	GO:1903280	negative regulation of calcium:sodium antiporter activity	Atp1a2	IMP		Rat	PMID:17442282|RGD:6903343
Biological Process	GO:0051481	negative regulation of cytosolic calcium ion concentration	Atp1a2	IMP	MGI:MGI:2451291	Mouse	PMID:10360172
Biological Process	GO:0045822	negative regulation of heart contraction	Atp1a2	IMP	MGI:MGI:2451291	Mouse	PMID:10360172
Biological Process	GO:0045988	negative regulation of striated muscle contraction	Atp1a2	IMP	MGI:MGI:2451291	Mouse	PMID:11507009
Biological Process	GO:0001504	neurotransmitter uptake	Atp1a2	IMP	MGI:MGI:2664907	Mouse	PMID:12805306
Biological Process	GO:0021989	olfactory cortex development	Atp1a2	IMP		Mouse	MGI:MGI:2664023|PMID:12805306
Biological Process	GO:1990573	potassium ion import across plasma membrane	ATP1A2	IDA		Human	PMID:10636900
Biological Process	GO:0071805	potassium ion transmembrane transport	ATP1A2	IGI	UniProtKB:P05026	Human	PMID:18728015
Biological Process	GO:0006813	potassium ion transport	Atp1a2	IDA		Rat	PMID:12093728|RGD:631775
Biological Process	GO:0006813	potassium ion transport	Atp1a2	IDA		Rat	PMID:16624992|RGD:2302992
Biological Process	GO:1902600	proton transmembrane transport	Atp1a2	IMP		Rat	PMID:12529322|RGD:1299865
Biological Process	GO:0008217	regulation of blood pressure	Atp1a2	IGI	MGI:MGI:97742	Mouse	PMID:16243970
Biological Process	GO:0086004	regulation of cardiac muscle cell contraction	Atp1a2	IMP		Rat	PMID:17442282|RGD:6903343
Biological Process	GO:0051480	regulation of cytosolic calcium ion concentration	atp1a2a	IMP	ZFIN:ZDB-MRPHLNO-060215-2	Zfish	PMID:17442698
Biological Process	GO:0006937	regulation of muscle contraction	Atp1a2	IMP	MGI:MGI:2451291	Mouse	PMID:10360172
Biological Process	GO:0002087	regulation of respiratory gaseous exchange by nervous system process	Atp1a2	IMP	MGI:MGI:3522421	Mouse	PMID:15564586
Biological Process	GO:0002087	regulation of respiratory gaseous exchange by nervous system process	Atp1a2	IMP	MGI:MGI:2451291	Mouse	PMID:12458206
Biological Process	GO:0006940	regulation of smooth muscle contraction	Atp1a2	IMP	MGI:MGI:2451291	Mouse	PMID:14627611
Biological Process	GO:0006942	regulation of striated muscle contraction	Atp1a2	IMP	MGI:MGI:2451291	Mouse	PMID:15253893
Biological Process	GO:0002026	regulation of the force of heart contraction	Atp1a2	IMP	MGI:MGI:2451291	Mouse	PMID:10360172
Biological Process	GO:0019229	regulation of vasoconstriction	Atp1a2	IMP	MGI:MGI:2451291	Mouse	PMID:14627611
Biological Process	GO:0019229	regulation of vasoconstriction	Atp1a2	IGI	MGI:MGI:98496	Mouse	PMID:14627611
Biological Process	GO:0010996	response to auditory stimulus	Atp1a2	IMP		Mouse	MGI:MGI:6368078|PMID:20936682
Biological Process	GO:1903416	response to glycoside	Atp1a2	IMP		Mouse	MGI:MGI:3608241|PMID:16243970
Biological Process	GO:1903416	response to glycoside	Atp1a2	IMP		Rat	PMID:17442282|RGD:6903343
Biological Process	GO:0035094	response to nicotine	Atp1a2	IDA		Rat	PMID:22442718|RGD:6903341
Biological Process	GO:0007519	skeletal muscle tissue development	atp1a2a	IMP	ZFIN:ZDB-MRPHLNO-060215-2	Zfish	PMID:23097043
Biological Process	GO:0036376	sodium ion export across plasma membrane	ATP1A2	IDA		Human	PMID:10636900
Biological Process	GO:0035725	sodium ion transmembrane transport	ATP1A2	IGI	UniProtKB:P05026	Human	PMID:18728015
Biological Process	GO:0006814	sodium ion transport	Atp1a2	IDA		Rat	PMID:12093728|RGD:631775
Biological Process	GO:0006814	sodium ion transport	Atp1a2	IDA		Rat	PMID:16624992|RGD:2302992
Biological Process	GO:0010084	specification of animal organ axis polarity	atp1a2a	IMP		Zfish	PMID:14602677
Biological Process	GO:0001966	thigmotaxis	atp1a2a	IMP	ZFIN:ZDB-MRPHLNO-060215-2	Zfish	PMID:23097043
Biological Process	GO:0008542	visual learning	Atp1a2	IMP	MGI:MGI:2451291	Mouse	PMID:17234593

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern