Atp1a2
Gene Detail

Symbol Name ID

Atp1a2 ATPase, Na+/K+ transporting, alpha 2 polypeptide MGI:88106

STS

423N13T7

Synonyms

Atpa-3, mKIAA0778

Feature Type

protein coding gene

Genetic Map

Chromosome 1

79.60 cM
Detailed Genetic Map ± 1 cM


Mapping data(21)

Sequence Map

Chr1:172271709-172298064 bp, - strand From VEGA annotation of GRCm38   26356 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:47947  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: Na(+)/K(+)-transporting ATPase alpha chain
Gene Tree: Atp1a2

Human homologs

Human Homolog		ATP1A2, ATPase, Na+/K+ transporting, alpha 2 polypeptide
NCBI Gene ID		477
neXtProt AC		NX_P50993
Human Synonyms		FHM2, MHP2
Human Chr (Location)		1q23.2; chr1:160085520-160113381 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human ATP1A2

Alleles and phenotypes

All alleles(9) : Targeted(7) Gene trapped(2)
 

Homozygous mutants die immediately after birth from breathing failure, lack spontaneous respiratory rhythm activity, have elevated levels of extracellular GABA in the brain, and have abnormal chloride homeostasis in brainstem neurons.

 

Gene Ontology (GO) classifications

All GO classifications: (55 annotations)

Process	adult locomotory behavior, ATP biosynthetic process, ...
Component	caveola, cytoplasm, ...
Function	ATP binding, cation-transporting ATPase activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (19 records)
Data Summary: Results (392)    Tissues (172)    Images (51)
Theiler Stages: 2, 3, 4, 5, 13, 15, 17, 19, 22, 23, 25, 26, 28

Assay Type	Results
Immunohistochemistry	2
RNA in situ	336
Northern blot	10
Western blot	19
RT-PCR	25

cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(52) Genomic(28) cDNA(20) Primer pair(4)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000021834 (Evidence)
Ensembl Gene Model	ENSMUSG00000007097 (Evidence)
Entrez Gene	98660 (Evidence)
DFCI	TC1572796, TC1700399, TC1717045
DoTS	DT.101380884, DT.110942867, DT.526313, DT.60118535, DT.94348868, DT.94353622
EC	3.6.3.9
Consensus CDS Project	CCDS35782.1
International Mouse Knockout Project Status	Atp1a2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021834	VEGA Gene Model | MGI Sequence Detail	26356	C57BL/6J
transcript	OTTMUST00000051816	VEGA | MGI Sequence Detail	6227	Not Applicable
polypeptide	OTTMUSP00000024452	VEGA | MGI Sequence Detail	1020	Not Applicable

All sequences(57) RefSeq(2) UniProt(6)

Polymorphisms

RFLP(3) : SNPs(229 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR023306	ATPase, cation-transporting, domain N
InterPro	IPR008250	ATPase, P-type, ATPase-associated domain
InterPro	IPR006069	ATPase, P-type cation exchange, alpha subunit
InterPro	IPR005775	ATPase, P-type cation exchange, alpha subunit, eukaryotic
InterPro	IPR006068	ATPase, P-type cation-transporter, C-terminal
InterPro	IPR004014	ATPase, P-type cation-transporter, N-terminal
InterPro	IPR023299	ATPase, P-type, cytoplasmic domain N
InterPro	IPR023300	ATPase, P-type, cytoplasmic transduction domain A
InterPro	IPR001757	ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter
InterPro	IPR018303	ATPase, P-type phosphorylation site
InterPro	IPR023298	ATPase, P-type, transmembrane domain
InterPro	IPR023214	HAD-like domain
InterPro	IPR005834	Haloacid dehalogenase-like hydrolase
Protein Ontology	PR:000004436	sodium/potassium-transporting ATPase subunit alpha-2

References

(Earliest) J:7397 Levenson R, et al., Molecular cloning of the mouse ouabain-resistance gene. Proc Natl Acad Sci U S A. 1984 Mar;81(5):1489-93
(Latest) J:193876 Radzyukevich TL, et al., Tissue-specific role of the Na,K-ATPase alpha2 isozyme in skeletal muscle. J Biol Chem. 2013 Jan 11;288(2):1226-37
All references(98)

Other accession IDs

MGD-MRK-1458, MGD-MRK-1472, MGI:2138555