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Atp1a2
Gene Detail
 Symbol
Name
ID
Atp1a2
ATPase, Na+/K+ transporting, alpha 2 polypeptide
MGI:88106
STS 423N13T7
Synonyms Atpa-3, mKIAA0778
Feature Type protein coding gene
Genetic Map
Chromosome 1
79.60 cM
Detailed Genetic Map ± 1 cM


Mapping data(21)
Sequence Map
Chr1:172271709-172298064 bp, - strand
From VEGA annotation of GRCm38

  26356 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:47947  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: Na(+)/K(+)-transporting ATPase alpha chain
Gene Tree: Atp1a2

Human
homologs
Human Homolog ATP1A2, ATPase, Na+/K+ transporting, alpha 2 polypeptide
NCBI Gene ID 477
neXtProt AC  NX_P50993
Human Synonyms  FHM2, MHP2
Human Chr (Location)  1q23.2; chr1:160115730-160143591 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human ATP1A2
Alleles
and
phenotypes
All alleles(9) : Targeted(7) Gene trapped(2)
 
Homozygous mutants die immediately after birth from breathing failure, lack spontaneous respiratory rhythm activity, have elevated levels of extracellular GABA in the brain, and have abnormal chloride homeostasis in brainstem neurons.
 
Gene Ontology
(GO)
classifications
All GO classifications: (59 annotations)
Process adult locomotory behavior, ATP biosynthetic process, ...
Component caveola, cytoplasm, ...
Function ATP binding, cation-transporting ATPase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (19 records)
Data Summary: Results (392)    Tissues (172)    Images (51)
Theiler Stages: 2, 3, 4, 5, 13, 15, 17, 19, 22, 23, 25, 26, 28
Assay TypeResults
Immunohistochemistry 2
RNA in situ 336
Northern blot 10
Western blot 19
RT-PCR 25
cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(52) Genomic(28) cDNA(20) Primer pair(4)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000021834 (Evidence)
Ensembl Gene ModelENSMUSG00000007097 (Evidence)
Entrez Gene98660 (Evidence)
DFCITC1572796, TC1700399, TC1717045
DoTSDT.101380884, DT.110942867, DT.526313, DT.60118535, DT.94348868, DT.94353622
EC3.6.3.9
Consensus CDS ProjectCCDS35782.1
International Mouse Knockout Project StatusAtp1a2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021834 VEGA Gene Model | MGI Sequence Detail 26356 C57BL/6J ±  kb
transcript OTTMUST00000051816 VEGA | MGI Sequence Detail 6227 Not Applicable 
polypeptide OTTMUSP00000024452 VEGA | MGI Sequence Detail 1020 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(2) UniProt(6)
Polymorphisms RFLP(3) : SNPs within 2kb(430 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001757 Cation-transporting P-type ATPase
InterPro IPR006068 Cation-transporting P-type ATPase, C-terminal
InterPro IPR004014 Cation-transporting P-type ATPase, N-terminal
InterPro IPR023214 HAD-like domain
InterPro IPR008250 P-type ATPase, A domain
InterPro IPR023299 P-type ATPase, cytoplasmic domain N
InterPro IPR018303 P-type ATPase, phosphorylation site
InterPro IPR023298 P-type ATPase, transmembrane domain
InterPro IPR005775 Sodium/potassium-transporting P-type ATPase, subfamily IIC
Protein Ontology PR:000004436 sodium/potassium-transporting ATPase subunit alpha-2
References (Earliest) J:7397 Levenson R, et al., Molecular cloning of the mouse ouabain-resistance gene. Proc Natl Acad Sci U S A. 1984 Mar;81(5):1489-93
(Latest) J:196689 Rindler TN, et al., Knockout of the Na,K-ATPase alpha2-isoform in cardiac myocytes delays pressure overload-induced cardiac dysfunction. Am J Physiol Heart Circ Physiol. 2013 Apr 15;304(8):H1147-58
All references(100)
Other
accession IDs
MGD-MRK-1458, MGD-MRK-1472, MGI:2138555

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory