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Atp1a2
Gene Detail
Symbol

Name
ID
Atp1a2
ATPase, Na+/K+ transporting, alpha 2 polypeptide
MGI:88106
STS
Synonyms
Atpa-3, mKIAA0778
Feature Type
protein coding gene
Genetic Map
Chromosome 1
79.60 cM
Detailed Genetic Map ± 1 cM


Mapping data(20)
Sequence Map
Chr1:172271709-172298064 bp, - strand
From VEGA annotation of GRCm38

  26356 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:47947  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ATP1A2
Protein SuperFamily: Na(+)/K(+)-transporting ATPase alpha chain
Gene Tree: Atp1a2

Human
homologs
ATP1A2, ATPase, Na+/K+ transporting, alpha 2 polypeptide
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 477
neXtProt AC: NX_P50993

Human Synonyms: FHM2, MHP2

Human Chr (Location): 1q23.2; chr1:160115730-160143591 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human ATP1A2

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(2) Targeted(7)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutants die immediately after birth from breathing failure, lack spontaneous respiratory rhythm activity, have elevated levels of extracellular GABA in the brain, and have abnormal chloride homeostasis in brainstem neurons.
 
Interactions
Atp1a2 interacts with 257 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (70 annotations)
Process adult locomotory behavior, ATP hydrolysis coupled proton transport, ...
Component caveola, cell, ...
Function ATP binding, cation-transporting ATPase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (21 records)
Data Summary: Results (382)    Tissues (169)    Images (51)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 336
Northern blot 10
Western blot 19
RT-PCR 17
cDNA source data(15)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase atp1a2 ; ZFIN atp1a2a    NEW 
Molecular
reagents
All nucleic(53) Genomic(28) cDNA(21) Primer pair(4)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000021834 (Evidence)
Ensembl Gene Model ENSMUSG00000007097 (Evidence)
Entrez Gene 98660 (Evidence)
DFCI TC1572796, TC1700399, TC1717045
DoTS DT.101380884, DT.110942867, DT.526313, DT.60118535, DT.94348868, DT.94353622
EC 3.6.3.9
Consensus CDS Project CCDS35782.1
International Mouse Phenotyping Consortium Status Atp1a2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021834 VEGA Gene Model | MGI Sequence Detail 26356 C57BL/6J ±  kb
transcript OTTMUST00000051816 VEGA | MGI Sequence Detail 6227 Not Applicable 
polypeptide OTTMUSP00000024452 VEGA | MGI Sequence Detail 1020 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(2) UniProt(5)
Polymorphisms
RFLP(3) : SNPs within 2kb(430 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001757 Cation-transporting P-type ATPase
InterPro IPR006068 Cation-transporting P-type ATPase, C-terminal
InterPro IPR004014 Cation-transporting P-type ATPase, N-terminal
InterPro IPR023214 HAD-like domain
InterPro IPR008250 P-type ATPase, A domain
InterPro IPR023299 P-type ATPase, cytoplasmic domain N
InterPro IPR018303 P-type ATPase, phosphorylation site
InterPro IPR023298 P-type ATPase, transmembrane domain
InterPro IPR005775 Sodium/potassium-transporting P-type ATPase, subfamily IIC
Protein Ontology PR:000004436 sodium/potassium-transporting ATPase subunit alpha-2
References
(Earliest) J:7397 Levenson R, et al., Molecular cloning of the mouse ouabain-resistance gene. Proc Natl Acad Sci U S A. 1984 Mar;81(5):1489-93
(Latest) J:219419 Gallardo G, et al., An alpha2-Na/K ATPase/alpha-adducin complex in astrocytes triggers non-cell autonomous neurodegeneration. Nat Neurosci. 2014 Dec;17(12):1710-9
All references(98)
Other
accession IDs
MGD-MRK-1458, MGD-MRK-1472, MGI:2138555

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory