Phenotypes Associated with This Genotype

Genotype
MGI:6729923

• Allelic Composition: Atp1a2^tm1.1Gica/Atp1a2⁺
• Genetic Background: B6.Cg-Atp1a2^tm1.1Gica

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal nervous system electrophysiology ( J:307518 )

• mice show increased susceptibility to cortical spreading depression, with a decreased induction of threshold and an increased velocity of propagation of cortical spreading depression

• however, duration of cortical spreading depression and induction of repetitive cortical spreading depression are not affected

behavior/neurological

abnormal response to new environment ( J:307518 )

• transfer arousal testing indicates increased anxiety and fear

• however, mice show no major differences in any other sensory-motor functions

increased anxiety-related response ( J:307518 )

• mice exhibit increased anxiety

increased fear-related response ( J:307518 )

• mice exhibit increased fear

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
familial hemiplegic migraine 2		DOID:0111182	OMIM:602481	J:307518