| GO term: | sodium:potassium-exchanging ATPase activity |
| Synonym: | ATP phosphohydrolase (Na+/K+-exchanging) |
| Synonym: | (Na+ + K+)-activated ATPase activity |
| Synonym: | Na,K-activated ATPase activity |
| Synonym: | (Na+ + K+)-ATPase activity |
| Synonym: | Na(+)/K(+)-ATPase activity |
| Synonym: | Na+,K+-ATPase activity |
| Synonym: | Na+/K+-ATPase activity |
| Synonym: | Na(+)/K(+)-exchanging ATPase activity |
| Synonym: | Na+/K+-exchanging ATPase activity |
| Synonym: | Na,K-pump |
| Synonym: | Na+,K+ pump |
| Synonym: | sodium:potassium exchanging ATPase activity |
| Synonym: | sodium/potassium-exchanging ATPase activity |
| Synonym: | sodium/potassium-transporting ATPase activity |
| Synonym: | sodium pump |
| GO id: | GO:0005391 |
| Definition: | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in). |
| Number of paths to term: | 22 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship
molecular_functioncatalytic activityhydrolase activityhydrolase activity, acting on acid anhydrideshydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substancesATPase activity, coupled to transmembrane movement of substancesATPase activity, coupled to transmembrane movement of ionsATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanismpotassium-transporting ATPase activityhydrogen:potassium-exchanging ATPase activitysodium:potassium-exchanging ATPase activity [GO:0005391] (9 genes, 11 annotations)sodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potentialmolecular_functioncatalytic activityhydrolase activityhydrolase activity, acting on acid anhydrideshydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substancesATPase activity, coupled to transmembrane movement of substancesATPase activity, coupled to transmembrane movement of ionscation-transporting ATPase activitypotassium-transporting ATPase activityhydrogen:potassium-exchanging ATPase activitysodium:potassium-exchanging ATPase activity [GO:0005391] (9 genes, 11 annotations)sodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potentialmolecular_functioncatalytic activityhydrolase activityhydrolase activity, acting on acid anhydrideshydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydridespyrophosphatase activitynucleoside-triphosphatase activityATPase activityATPase activity, coupledATPase activity, coupled to movement of substancesATPase activity, coupled to transmembrane movement of substancesATPase activity, coupled to transmembrane movement of ionsATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanismpotassium-transporting ATPase activityhydrogen:potassium-exchanging ATPase activitysodium:potassium-exchanging ATPase activity [GO:0005391] (9 genes, 11 annotations)sodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potentialmolecular_functioncatalytic activityhydrolase activityhydrolase activity, acting on acid anhydrideshydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydridespyrophosphatase activitynucleoside-triphosphatase activityATPase activityATPase activity, coupledATPase activity, coupled to movement of substancesATPase activity, coupled to transmembrane movement of substancesATPase activity, coupled to transmembrane movement of ionscation-transporting ATPase activitypotassium-transporting ATPase activityhydrogen:potassium-exchanging ATPase activitysodium:potassium-exchanging ATPase activity [GO:0005391] (9 genes, 11 annotations)sodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potentialmolecular_functiontransporter activitysubstrate-specific transporter activitysubstrate-specific transmembrane transporter activityion transmembrane transporter activityATPase activity, coupled to transmembrane movement of ionsATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanismpotassium-transporting ATPase activityhydrogen:potassium-exchanging ATPase activitysodium:potassium-exchanging ATPase activity [GO:0005391] (9 genes, 11 annotations)sodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potentialmolecular_functiontransporter activitysubstrate-specific transporter activitysubstrate-specific transmembrane transporter activityion transmembrane transporter activityATPase activity, coupled to transmembrane movement of ionscation-transporting ATPase activitypotassium-transporting ATPase activityhydrogen:potassium-exchanging ATPase activitysodium:potassium-exchanging ATPase activity [GO:0005391] (9 genes, 11 annotations)sodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potentialmolecular_functiontransporter activitysubstrate-specific transporter activitysubstrate-specific transmembrane transporter activityion transmembrane transporter activitycation transmembrane transporter activitycation-transporting ATPase activitypotassium-transporting ATPase activityhydrogen:potassium-exchanging ATPase activitysodium:potassium-exchanging ATPase activity [GO:0005391] (9 genes, 11 annotations)sodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potentialmolecular_functiontransporter activitysubstrate-specific transporter activitysubstrate-specific transmembrane transporter activityion transmembrane transporter activitycation transmembrane transporter activityinorganic cation transmembrane transporter activitymonovalent inorganic cation transmembrane transporter activitypotassium ion transmembrane transporter activitypotassium-transporting ATPase activityhydrogen:potassium-exchanging ATPase activitysodium:potassium-exchanging ATPase activity [GO:0005391] (9 genes, 11 annotations)sodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potentialmolecular_functiontransporter activitysubstrate-specific transporter activitysubstrate-specific transmembrane transporter activityion transmembrane transporter activitycation transmembrane transporter activityinorganic cation transmembrane transporter activitymonovalent inorganic cation transmembrane transporter activitysodium ion transmembrane transporter activitycalcium, potassium:sodium antiporter activitycalcium:sodium antiporter activity +malate:sodium symporter activitysodium channel activity +sodium ion uniporter activitysodium-exporting ATPase activity, phosphorylative mechanismsodium-transporting ATP synthase activity, rotational mechanismsodium-transporting ATPase activity, rotational mechanismsodium:bicarbonate symporter activitysodium:hydrogen antiporter activity +sodium:phosphate symporter activity +sodium:potassium-exchanging ATPase activity [GO:0005391] (9 genes, 11 annotations)sodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potentialsodium:sulfate symporter activitysolute:sodium symporter activity +molecular_functiontransporter activitysubstrate-specific transporter activitysubstrate-specific transmembrane transporter activityion transmembrane transporter activitycation transmembrane transporter activitymetal ion transmembrane transporter activitypotassium ion transmembrane transporter activitypotassium-transporting ATPase activityhydrogen:potassium-exchanging ATPase activitysodium:potassium-exchanging ATPase activity [GO:0005391] (9 genes, 11 annotations)sodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potentialmolecular_functiontransporter activitysubstrate-specific transporter activitysubstrate-specific transmembrane transporter activityion transmembrane transporter activitycation transmembrane transporter activitymetal ion transmembrane transporter activitysodium ion transmembrane transporter activitycalcium, potassium:sodium antiporter activitycalcium:sodium antiporter activity +malate:sodium symporter activitysodium channel activity +sodium ion uniporter activitysodium-exporting ATPase activity, phosphorylative mechanismsodium-transporting ATP synthase activity, rotational mechanismsodium-transporting ATPase activity, rotational mechanismsodium:bicarbonate symporter activitysodium:hydrogen antiporter activity +sodium:phosphate symporter activity +sodium:potassium-exchanging ATPase activity [GO:0005391] (9 genes, 11 annotations)sodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potentialsodium:sulfate symporter activitysolute:sodium symporter activity +molecular_functiontransporter activitytransmembrane transporter activityactive transmembrane transporter activityprimary active transmembrane transporter activityP-P-bond-hydrolysis-driven transmembrane transporter activityATPase activity, coupled to transmembrane movement of substancesATPase activity, coupled to transmembrane movement of ionsATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanismpotassium-transporting ATPase activityhydrogen:potassium-exchanging ATPase activitysodium:potassium-exchanging ATPase activity [GO:0005391] (9 genes, 11 annotations)sodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potentialmolecular_functiontransporter activitytransmembrane transporter activityactive transmembrane transporter activityprimary active transmembrane transporter activityP-P-bond-hydrolysis-driven transmembrane transporter activityATPase activity, coupled to transmembrane movement of substancesATPase activity, coupled to transmembrane movement of ionscation-transporting ATPase activitypotassium-transporting ATPase activityhydrogen:potassium-exchanging ATPase activitysodium:potassium-exchanging ATPase activity [GO:0005391] (9 genes, 11 annotations)sodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potentialmolecular_functiontransporter activitytransmembrane transporter activityhydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substancesATPase activity, coupled to transmembrane movement of substancesATPase activity, coupled to transmembrane movement of ionsATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanismpotassium-transporting ATPase activityhydrogen:potassium-exchanging ATPase activitysodium:potassium-exchanging ATPase activity [GO:0005391] (9 genes, 11 annotations)sodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potentialmolecular_functiontransporter activitytransmembrane transporter activityhydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substancesATPase activity, coupled to transmembrane movement of substancesATPase activity, coupled to transmembrane movement of ionscation-transporting ATPase activitypotassium-transporting ATPase activityhydrogen:potassium-exchanging ATPase activitysodium:potassium-exchanging ATPase activity [GO:0005391] (9 genes, 11 annotations)sodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potentialmolecular_functiontransporter activitytransmembrane transporter activitysubstrate-specific transmembrane transporter activityion transmembrane transporter activityATPase activity, coupled to transmembrane movement of ionsATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanismpotassium-transporting ATPase activityhydrogen:potassium-exchanging ATPase activitysodium:potassium-exchanging ATPase activity [GO:0005391] (9 genes, 11 annotations)sodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potentialmolecular_functiontransporter activitytransmembrane transporter activitysubstrate-specific transmembrane transporter activityion transmembrane transporter activityATPase activity, coupled to transmembrane movement of ionscation-transporting ATPase activitypotassium-transporting ATPase activityhydrogen:potassium-exchanging ATPase activitysodium:potassium-exchanging ATPase activity [GO:0005391] (9 genes, 11 annotations)sodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potentialmolecular_functiontransporter activitytransmembrane transporter activitysubstrate-specific transmembrane transporter activityion transmembrane transporter activitycation transmembrane transporter activitycation-transporting ATPase activitypotassium-transporting ATPase activityhydrogen:potassium-exchanging ATPase activitysodium:potassium-exchanging ATPase activity [GO:0005391] (9 genes, 11 annotations)sodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potentialmolecular_functiontransporter activitytransmembrane transporter activitysubstrate-specific transmembrane transporter activityion transmembrane transporter activitycation transmembrane transporter activityinorganic cation transmembrane transporter activitymonovalent inorganic cation transmembrane transporter activitypotassium ion transmembrane transporter activitypotassium-transporting ATPase activityhydrogen:potassium-exchanging ATPase activitysodium:potassium-exchanging ATPase activity [GO:0005391] (9 genes, 11 annotations)sodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potentialmolecular_functiontransporter activitytransmembrane transporter activitysubstrate-specific transmembrane transporter activityion transmembrane transporter activitycation transmembrane transporter activityinorganic cation transmembrane transporter activitymonovalent inorganic cation transmembrane transporter activitysodium ion transmembrane transporter activitycalcium, potassium:sodium antiporter activitycalcium:sodium antiporter activity +malate:sodium symporter activitysodium channel activity +sodium ion uniporter activitysodium-exporting ATPase activity, phosphorylative mechanismsodium-transporting ATP synthase activity, rotational mechanismsodium-transporting ATPase activity, rotational mechanismsodium:bicarbonate symporter activitysodium:hydrogen antiporter activity +sodium:phosphate symporter activity +sodium:potassium-exchanging ATPase activity [GO:0005391] (9 genes, 11 annotations)sodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potentialsodium:sulfate symporter activitysolute:sodium symporter activity +molecular_functiontransporter activitytransmembrane transporter activitysubstrate-specific transmembrane transporter activityion transmembrane transporter activitycation transmembrane transporter activitymetal ion transmembrane transporter activitypotassium ion transmembrane transporter activitypotassium-transporting ATPase activityhydrogen:potassium-exchanging ATPase activitysodium:potassium-exchanging ATPase activity [GO:0005391] (9 genes, 11 annotations)sodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potentialmolecular_functiontransporter activitytransmembrane transporter activitysubstrate-specific transmembrane transporter activityion transmembrane transporter activitycation transmembrane transporter activitymetal ion transmembrane transporter activitysodium ion transmembrane transporter activitycalcium, potassium:sodium antiporter activitycalcium:sodium antiporter activity +malate:sodium symporter activitysodium channel activity +sodium ion uniporter activitysodium-exporting ATPase activity, phosphorylative mechanismsodium-transporting ATP synthase activity, rotational mechanismsodium-transporting ATPase activity, rotational mechanismsodium:bicarbonate symporter activitysodium:hydrogen antiporter activity +sodium:phosphate symporter activity +sodium:potassium-exchanging ATPase activity [GO:0005391] (9 genes, 11 annotations)sodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potentialsodium:sulfate symporter activitysolute:sodium symporter activity +Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 06/05/2013 MGI 5.13 |
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