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Term Detail
GO term:sodium:potassium-exchanging ATPase activity
Synonym: ATP phosphohydrolase (Na+/K+-exchanging)
Synonym: (Na+ + K+)-activated ATPase activity
Synonym: Na,K-activated ATPase activity
Synonym: (Na+ + K+)-ATPase activity
Synonym: Na(+)/K(+)-ATPase activity
Synonym: Na+,K+-ATPase activity
Synonym: Na+/K+-ATPase activity
Synonym: Na(+)/K(+)-exchanging ATPase activity
Synonym: Na+/K+-exchanging ATPase activity
Synonym: Na,K-pump
Synonym: Na+,K+ pump
Synonym: sodium:potassium exchanging ATPase activity
Synonym: sodium/potassium-exchanging ATPase activity
Synonym: sodium/potassium-transporting ATPase activity
Synonym: sodium pump
GO id:GO:0005391
Definition:Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in).
Number of paths to term: 22

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-amolecular_function
                is-acatalytic activity
                        is-ahydrolase activity
                                is-ahydrolase activity, acting on acid anhydrides
                                        is-ahydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
                                                is-aATPase activity, coupled to transmembrane movement of substances
                                                        is-aATPase activity, coupled to transmembrane movement of ions
                                                                is-aATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
                                                                        is-apotassium-transporting ATPase activity
                                                                                is-ahydrogen:potassium-exchanging ATPase activity
                                                                                is-asodium:potassium-exchanging ATPase activity [GO:0005391] (10 genes, 18 annotations)
                                                                                        is-asodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potential


Gene_Ontology
        is-amolecular_function
                is-acatalytic activity
                        is-ahydrolase activity
                                is-ahydrolase activity, acting on acid anhydrides
                                        is-ahydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
                                                is-aATPase activity, coupled to transmembrane movement of substances
                                                        is-aATPase activity, coupled to transmembrane movement of ions
                                                                is-acation-transporting ATPase activity
                                                                        is-apotassium-transporting ATPase activity
                                                                                is-ahydrogen:potassium-exchanging ATPase activity
                                                                                is-asodium:potassium-exchanging ATPase activity [GO:0005391] (10 genes, 18 annotations)
                                                                                        is-asodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potential


Gene_Ontology
        is-amolecular_function
                is-acatalytic activity
                        is-ahydrolase activity
                                is-ahydrolase activity, acting on acid anhydrides
                                        is-ahydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
                                                is-apyrophosphatase activity
                                                        is-anucleoside-triphosphatase activity
                                                                is-aATPase activity
                                                                        is-aATPase activity, coupled
                                                                                is-aATPase activity, coupled to movement of substances
                                                                                        is-aATPase activity, coupled to transmembrane movement of substances
                                                                                                is-aATPase activity, coupled to transmembrane movement of ions
                                                                                                        is-aATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
                                                                                                                is-apotassium-transporting ATPase activity
                                                                                                                        is-ahydrogen:potassium-exchanging ATPase activity
                                                                                                                        is-asodium:potassium-exchanging ATPase activity [GO:0005391] (10 genes, 18 annotations)
                                                                                                                                is-asodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potential


Gene_Ontology
        is-amolecular_function
                is-acatalytic activity
                        is-ahydrolase activity
                                is-ahydrolase activity, acting on acid anhydrides
                                        is-ahydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
                                                is-apyrophosphatase activity
                                                        is-anucleoside-triphosphatase activity
                                                                is-aATPase activity
                                                                        is-aATPase activity, coupled
                                                                                is-aATPase activity, coupled to movement of substances
                                                                                        is-aATPase activity, coupled to transmembrane movement of substances
                                                                                                is-aATPase activity, coupled to transmembrane movement of ions
                                                                                                        is-acation-transporting ATPase activity
                                                                                                                is-apotassium-transporting ATPase activity
                                                                                                                        is-ahydrogen:potassium-exchanging ATPase activity
                                                                                                                        is-asodium:potassium-exchanging ATPase activity [GO:0005391] (10 genes, 18 annotations)
                                                                                                                                is-asodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potential


Gene_Ontology
        is-amolecular_function
                is-atransporter activity
                        is-asubstrate-specific transporter activity
                                is-asubstrate-specific transmembrane transporter activity
                                        is-aion transmembrane transporter activity
                                                is-aATPase activity, coupled to transmembrane movement of ions
                                                        is-aATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
                                                                is-apotassium-transporting ATPase activity
                                                                        is-ahydrogen:potassium-exchanging ATPase activity
                                                                        is-asodium:potassium-exchanging ATPase activity [GO:0005391] (10 genes, 18 annotations)
                                                                                is-asodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potential


Gene_Ontology
        is-amolecular_function
                is-atransporter activity
                        is-asubstrate-specific transporter activity
                                is-asubstrate-specific transmembrane transporter activity
                                        is-aion transmembrane transporter activity
                                                is-aATPase activity, coupled to transmembrane movement of ions
                                                        is-acation-transporting ATPase activity
                                                                is-apotassium-transporting ATPase activity
                                                                        is-ahydrogen:potassium-exchanging ATPase activity
                                                                        is-asodium:potassium-exchanging ATPase activity [GO:0005391] (10 genes, 18 annotations)
                                                                                is-asodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potential


Gene_Ontology
        is-amolecular_function
                is-atransporter activity
                        is-asubstrate-specific transporter activity
                                is-asubstrate-specific transmembrane transporter activity
                                        is-aion transmembrane transporter activity
                                                is-acation transmembrane transporter activity
                                                        is-acation-transporting ATPase activity
                                                                is-apotassium-transporting ATPase activity
                                                                        is-ahydrogen:potassium-exchanging ATPase activity
                                                                        is-asodium:potassium-exchanging ATPase activity [GO:0005391] (10 genes, 18 annotations)
                                                                                is-asodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potential


Gene_Ontology
        is-amolecular_function
                is-atransporter activity
                        is-asubstrate-specific transporter activity
                                is-asubstrate-specific transmembrane transporter activity
                                        is-aion transmembrane transporter activity
                                                is-acation transmembrane transporter activity
                                                        is-ainorganic cation transmembrane transporter activity
                                                                is-ametal ion transmembrane transporter activity
                                                                        is-apotassium ion transmembrane transporter activity
                                                                                is-apotassium-transporting ATPase activity
                                                                                        is-ahydrogen:potassium-exchanging ATPase activity
                                                                                        is-asodium:potassium-exchanging ATPase activity [GO:0005391] (10 genes, 18 annotations)
                                                                                                is-asodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potential


Gene_Ontology
        is-amolecular_function
                is-atransporter activity
                        is-asubstrate-specific transporter activity
                                is-asubstrate-specific transmembrane transporter activity
                                        is-aion transmembrane transporter activity
                                                is-acation transmembrane transporter activity
                                                        is-ainorganic cation transmembrane transporter activity
                                                                is-ametal ion transmembrane transporter activity
                                                                        is-asodium ion transmembrane transporter activity
                                                                                is-acalcium, potassium:sodium antiporter activity
                                                                                is-acalcium:sodium antiporter activity +
                                                                                is-amelibiose:sodium symporter activity
                                                                                is-asodium channel activity +
                                                                                is-asodium ion uniporter activity
                                                                                is-asodium-exporting ATPase activity, phosphorylative mechanism
                                                                                is-asodium-transporting ATP synthase activity, rotational mechanism
                                                                                is-asodium-transporting ATPase activity, rotational mechanism
                                                                                is-asodium:bicarbonate symporter activity
                                                                                is-asodium:phosphate symporter activity +
                                                                                is-asodium:potassium-exchanging ATPase activity [GO:0005391] (10 genes, 18 annotations)
                                                                                        is-asodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potential
                                                                                is-asodium:proton antiporter activity +
                                                                                is-asodium:sulfate symporter activity
                                                                                is-asolute:sodium symporter activity +


Gene_Ontology
        is-amolecular_function
                is-atransporter activity
                        is-asubstrate-specific transporter activity
                                is-asubstrate-specific transmembrane transporter activity
                                        is-aion transmembrane transporter activity
                                                is-acation transmembrane transporter activity
                                                        is-ainorganic cation transmembrane transporter activity
                                                                is-amonovalent inorganic cation transmembrane transporter activity
                                                                        is-apotassium ion transmembrane transporter activity
                                                                                is-apotassium-transporting ATPase activity
                                                                                        is-ahydrogen:potassium-exchanging ATPase activity
                                                                                        is-asodium:potassium-exchanging ATPase activity [GO:0005391] (10 genes, 18 annotations)
                                                                                                is-asodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potential


Gene_Ontology
        is-amolecular_function
                is-atransporter activity
                        is-asubstrate-specific transporter activity
                                is-asubstrate-specific transmembrane transporter activity
                                        is-aion transmembrane transporter activity
                                                is-acation transmembrane transporter activity
                                                        is-ainorganic cation transmembrane transporter activity
                                                                is-amonovalent inorganic cation transmembrane transporter activity
                                                                        is-asodium ion transmembrane transporter activity
                                                                                is-acalcium, potassium:sodium antiporter activity
                                                                                is-acalcium:sodium antiporter activity +
                                                                                is-amelibiose:sodium symporter activity
                                                                                is-asodium channel activity +
                                                                                is-asodium ion uniporter activity
                                                                                is-asodium-exporting ATPase activity, phosphorylative mechanism
                                                                                is-asodium-transporting ATP synthase activity, rotational mechanism
                                                                                is-asodium-transporting ATPase activity, rotational mechanism
                                                                                is-asodium:bicarbonate symporter activity
                                                                                is-asodium:phosphate symporter activity +
                                                                                is-asodium:potassium-exchanging ATPase activity [GO:0005391] (10 genes, 18 annotations)
                                                                                        is-asodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potential
                                                                                is-asodium:proton antiporter activity +
                                                                                is-asodium:sulfate symporter activity
                                                                                is-asolute:sodium symporter activity +


Gene_Ontology
        is-amolecular_function
                is-atransporter activity
                        is-atransmembrane transporter activity
                                is-aactive transmembrane transporter activity
                                        is-aprimary active transmembrane transporter activity
                                                is-aP-P-bond-hydrolysis-driven transmembrane transporter activity
                                                        is-aATPase activity, coupled to transmembrane movement of substances
                                                                is-aATPase activity, coupled to transmembrane movement of ions
                                                                        is-aATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
                                                                                is-apotassium-transporting ATPase activity
                                                                                        is-ahydrogen:potassium-exchanging ATPase activity
                                                                                        is-asodium:potassium-exchanging ATPase activity [GO:0005391] (10 genes, 18 annotations)
                                                                                                is-asodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potential


Gene_Ontology
        is-amolecular_function
                is-atransporter activity
                        is-atransmembrane transporter activity
                                is-aactive transmembrane transporter activity
                                        is-aprimary active transmembrane transporter activity
                                                is-aP-P-bond-hydrolysis-driven transmembrane transporter activity
                                                        is-aATPase activity, coupled to transmembrane movement of substances
                                                                is-aATPase activity, coupled to transmembrane movement of ions
                                                                        is-acation-transporting ATPase activity
                                                                                is-apotassium-transporting ATPase activity
                                                                                        is-ahydrogen:potassium-exchanging ATPase activity
                                                                                        is-asodium:potassium-exchanging ATPase activity [GO:0005391] (10 genes, 18 annotations)
                                                                                                is-asodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potential


Gene_Ontology
        is-amolecular_function
                is-atransporter activity
                        is-atransmembrane transporter activity
                                is-ahydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
                                        is-aATPase activity, coupled to transmembrane movement of substances
                                                is-aATPase activity, coupled to transmembrane movement of ions
                                                        is-aATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
                                                                is-apotassium-transporting ATPase activity
                                                                        is-ahydrogen:potassium-exchanging ATPase activity
                                                                        is-asodium:potassium-exchanging ATPase activity [GO:0005391] (10 genes, 18 annotations)
                                                                                is-asodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potential


Gene_Ontology
        is-amolecular_function
                is-atransporter activity
                        is-atransmembrane transporter activity
                                is-ahydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
                                        is-aATPase activity, coupled to transmembrane movement of substances
                                                is-aATPase activity, coupled to transmembrane movement of ions
                                                        is-acation-transporting ATPase activity
                                                                is-apotassium-transporting ATPase activity
                                                                        is-ahydrogen:potassium-exchanging ATPase activity
                                                                        is-asodium:potassium-exchanging ATPase activity [GO:0005391] (10 genes, 18 annotations)
                                                                                is-asodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potential


Gene_Ontology
        is-amolecular_function
                is-atransporter activity
                        is-atransmembrane transporter activity
                                is-asubstrate-specific transmembrane transporter activity
                                        is-aion transmembrane transporter activity
                                                is-aATPase activity, coupled to transmembrane movement of ions
                                                        is-aATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
                                                                is-apotassium-transporting ATPase activity
                                                                        is-ahydrogen:potassium-exchanging ATPase activity
                                                                        is-asodium:potassium-exchanging ATPase activity [GO:0005391] (10 genes, 18 annotations)
                                                                                is-asodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potential


Gene_Ontology
        is-amolecular_function
                is-atransporter activity
                        is-atransmembrane transporter activity
                                is-asubstrate-specific transmembrane transporter activity
                                        is-aion transmembrane transporter activity
                                                is-aATPase activity, coupled to transmembrane movement of ions
                                                        is-acation-transporting ATPase activity
                                                                is-apotassium-transporting ATPase activity
                                                                        is-ahydrogen:potassium-exchanging ATPase activity
                                                                        is-asodium:potassium-exchanging ATPase activity [GO:0005391] (10 genes, 18 annotations)
                                                                                is-asodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potential


Gene_Ontology
        is-amolecular_function
                is-atransporter activity
                        is-atransmembrane transporter activity
                                is-asubstrate-specific transmembrane transporter activity
                                        is-aion transmembrane transporter activity
                                                is-acation transmembrane transporter activity
                                                        is-acation-transporting ATPase activity
                                                                is-apotassium-transporting ATPase activity
                                                                        is-ahydrogen:potassium-exchanging ATPase activity
                                                                        is-asodium:potassium-exchanging ATPase activity [GO:0005391] (10 genes, 18 annotations)
                                                                                is-asodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potential


Gene_Ontology
        is-amolecular_function
                is-atransporter activity
                        is-atransmembrane transporter activity
                                is-asubstrate-specific transmembrane transporter activity
                                        is-aion transmembrane transporter activity
                                                is-acation transmembrane transporter activity
                                                        is-ainorganic cation transmembrane transporter activity
                                                                is-ametal ion transmembrane transporter activity
                                                                        is-apotassium ion transmembrane transporter activity
                                                                                is-apotassium-transporting ATPase activity
                                                                                        is-ahydrogen:potassium-exchanging ATPase activity
                                                                                        is-asodium:potassium-exchanging ATPase activity [GO:0005391] (10 genes, 18 annotations)
                                                                                                is-asodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potential


Gene_Ontology
        is-amolecular_function
                is-atransporter activity
                        is-atransmembrane transporter activity
                                is-asubstrate-specific transmembrane transporter activity
                                        is-aion transmembrane transporter activity
                                                is-acation transmembrane transporter activity
                                                        is-ainorganic cation transmembrane transporter activity
                                                                is-ametal ion transmembrane transporter activity
                                                                        is-asodium ion transmembrane transporter activity
                                                                                is-acalcium, potassium:sodium antiporter activity
                                                                                is-acalcium:sodium antiporter activity +
                                                                                is-amelibiose:sodium symporter activity
                                                                                is-asodium channel activity +
                                                                                is-asodium ion uniporter activity
                                                                                is-asodium-exporting ATPase activity, phosphorylative mechanism
                                                                                is-asodium-transporting ATP synthase activity, rotational mechanism
                                                                                is-asodium-transporting ATPase activity, rotational mechanism
                                                                                is-asodium:bicarbonate symporter activity
                                                                                is-asodium:phosphate symporter activity +
                                                                                is-asodium:potassium-exchanging ATPase activity [GO:0005391] (10 genes, 18 annotations)
                                                                                        is-asodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potential
                                                                                is-asodium:proton antiporter activity +
                                                                                is-asodium:sulfate symporter activity
                                                                                is-asolute:sodium symporter activity +


Gene_Ontology
        is-amolecular_function
                is-atransporter activity
                        is-atransmembrane transporter activity
                                is-asubstrate-specific transmembrane transporter activity
                                        is-aion transmembrane transporter activity
                                                is-acation transmembrane transporter activity
                                                        is-ainorganic cation transmembrane transporter activity
                                                                is-amonovalent inorganic cation transmembrane transporter activity
                                                                        is-apotassium ion transmembrane transporter activity
                                                                                is-apotassium-transporting ATPase activity
                                                                                        is-ahydrogen:potassium-exchanging ATPase activity
                                                                                        is-asodium:potassium-exchanging ATPase activity [GO:0005391] (10 genes, 18 annotations)
                                                                                                is-asodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potential


Gene_Ontology
        is-amolecular_function
                is-atransporter activity
                        is-atransmembrane transporter activity
                                is-asubstrate-specific transmembrane transporter activity
                                        is-aion transmembrane transporter activity
                                                is-acation transmembrane transporter activity
                                                        is-ainorganic cation transmembrane transporter activity
                                                                is-amonovalent inorganic cation transmembrane transporter activity
                                                                        is-asodium ion transmembrane transporter activity
                                                                                is-acalcium, potassium:sodium antiporter activity
                                                                                is-acalcium:sodium antiporter activity +
                                                                                is-amelibiose:sodium symporter activity
                                                                                is-asodium channel activity +
                                                                                is-asodium ion uniporter activity
                                                                                is-asodium-exporting ATPase activity, phosphorylative mechanism
                                                                                is-asodium-transporting ATP synthase activity, rotational mechanism
                                                                                is-asodium-transporting ATPase activity, rotational mechanism
                                                                                is-asodium:bicarbonate symporter activity
                                                                                is-asodium:phosphate symporter activity +
                                                                                is-asodium:potassium-exchanging ATPase activity [GO:0005391] (10 genes, 18 annotations)
                                                                                        is-asodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potential
                                                                                is-asodium:proton antiporter activity +
                                                                                is-asodium:sulfate symporter activity
                                                                                is-asolute:sodium symporter activity +


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory