Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ATM
  • Mouse genes Atm
  • Rat genes Atm
  • Zfish genes atm
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Atm

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0016303	1-phosphatidylinositol-3-kinase activity	ATM	IMP		Human	PMID:11375976
Molecular Function	GO:0004677	DNA-dependent protein kinase activity	ATM	IDA		Human	PMID:15790808
Molecular Function	GO:0042802	identical protein binding	ATM	IPI	UniProtKB:Q13315	Human	PMID:15790808
Molecular Function	GO:0016301	kinase activity	atm	IDA		Zfish	PMID:15235110
Molecular Function	GO:0005515	protein binding	ATM	IPI	UniProtKB:P00519	Human	PMID:11375976
Molecular Function	GO:0005515	protein binding	ATM	IPI	UniProtKB:P54274	Human	PMID:11375976
Molecular Function	GO:0005515	protein binding	ATM	IPI	UniProtKB:P54274-1	Human	PMID:11375976
Molecular Function	GO:0005515	protein binding	ATM	IPI	UniProtKB:P54274-2	Human	PMID:11375976
Molecular Function	GO:0005515	protein binding	ATM	IPI	UniProtKB:Q14676	Human	PMID:12607005
Molecular Function	GO:0005515	protein binding	ATM	IPI	UniProtKB:P54274	Human	PMID:15314656
Molecular Function	GO:0005515	protein binding	ATM	IPI	UniProtKB:Q15554	Human	PMID:15314656
Molecular Function	GO:0005515	protein binding	ATM	IPI	UniProtKB:Q6PJG6	Human	PMID:16452482
Molecular Function	GO:0005515	protein binding	ATM	IPI	UniProtKB:Q9NY61	Human	PMID:17157788
Molecular Function	GO:0005515	protein binding	ATM	IPI	UniProtKB:O43313	Human	PMID:17525732
Molecular Function	GO:0005515	protein binding	ATM	IPI	UniProtKB:Q9Y4R8	Human	PMID:18160036
Molecular Function	GO:0005515	protein binding	ATM	IPI	UniProtKB:Q9BQ15	Human	PMID:18449195
Molecular Function	GO:0005515	protein binding	ATM	IPI	UniProtKB:Q9Y6K9	Human	PMID:18583959
Molecular Function	GO:0005515	protein binding	ATM	IPI	UniProtKB:P27958:PRO_0000037577	Human	PMID:18667510
Molecular Function	GO:0005515	protein binding	ATM	IPI	UniProtKB:Q92499	Human	PMID:18710941
Molecular Function	GO:0005515	protein binding	ATM	IPI	UniProtKB:Q7LG56	Human	PMID:19015526
Molecular Function	GO:0005515	protein binding	ATM	IPI	UniProtKB:Q5XUX0	Human	PMID:19412162
Molecular Function	GO:0005515	protein binding	ATM	IPI	UniProtKB:Q9Y4R8	Human	PMID:20801936
Molecular Function	GO:0005515	protein binding	ATM	IPI	UniProtKB:O43156	Human	PMID:20810650
Molecular Function	GO:0005515	protein binding	ATM	IPI	UniProtKB:Q9Y4R8	Human	PMID:20864032
Molecular Function	GO:0005515	protein binding	ATM	IPI	UniProtKB:Q12888	Human	PMID:22621922
Molecular Function	GO:0005515	protein binding	ATM	IPI	UniProtKB:Q6PJG6	Human	PMID:22977523
Molecular Function	GO:0005515	protein binding	ATM	IPI	UniProtKB:P11245	Human	PMID:25640309
Molecular Function	GO:0005515	protein binding	ATM	IPI	UniProtKB:Q13007	Human	PMID:25640309
Molecular Function	GO:0005515	protein binding	ATM	IPI	UniProtKB:Q9BZ95	Human	PMID:25640309
Molecular Function	GO:0005515	protein binding	ATM	IPI	UniProtKB:O60934	Human	PMID:25895060
Molecular Function	GO:0005515	protein binding	ATM	IPI	UniProtKB:P46531	Human	PMID:25895060
Molecular Function	GO:0005515	protein binding	ATM	IPI	UniProtKB:Q12888	Human	PMID:29656893
Molecular Function	GO:0005515	protein binding	ATM	IPI	UniProtKB:Q14676	Human	PMID:29656893
Molecular Function	GO:0005515	protein binding	ATM	IPI	UniProtKB:O94874	Human	PMID:30886146
Molecular Function	GO:0005515	protein binding	ATM	IPI	UniProtKB:Q9NRC8	Human	PMID:30944854
Molecular Function	GO:0005515	protein binding	ATM	IPI	UniProtKB:P62508-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ATM	IPI	UniProtKB:P00519	Human	PMID:9168117
Molecular Function	GO:0005515	protein binding	ATM	IPI	UniProtKB:P04637	Human	PMID:9733515
Molecular Function	GO:0005515	protein binding	Atm	IPI	UniProtKB:Q9D1M4	Mouse	MGI:MGI:3573962|PMID:15680327
Molecular Function	GO:0004672	protein kinase activity	Atm	IDA		Mouse	PMID:15364958
Molecular Function	GO:0004672	protein kinase activity	Atm	IDA		Mouse	PMID:10710310
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ATM	IDA		Human	PMID:11375976
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ATM	IDA		Human	PMID:20096447
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ATM	IDA		Human	PMID:26323318
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ATM	IDA		Human	PMID:26344566
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ATM	IDA		Human	PMID:26774286
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ATM	IDA		Human	PMID:30612738
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ATM	IDA		Human	PMID:30886146
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ATM	IDA		Human	PMID:9733515
Molecular Function	GO:0044877	protein-containing complex binding	ATM	IDA		Human	PMID:15790808
Cellular Component	GO:0005813	centrosome	Atm	IDA		Mouse	MGI:MGI:6716962|PMID:25936915
Cellular Component	GO:0000781	chromosome, telomeric region	ATM	IDA		Human	PMID:15149599
Cellular Component	GO:0005737	cytoplasm	Atm	IDA		Mouse	MGI:MGI:6272426|PMID:29955025
Cellular Component	GO:0005737	cytoplasm	Atm	IDA		Rat	PMID:11852039|RGD:1599366
Cellular Component	GO:1990391	DNA repair complex	ATM	IDA		Human	PMID:24217620
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ATM	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005730	nucleolus	ATM	IDA		Human	PMID:27829214
Cellular Component	GO:0005654	nucleoplasm	ATM	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	ATM	IDA		Human	PMID:26323318
Cellular Component	GO:0005634	nucleus	Atm	IDA		Mouse	MGI:MGI:6272426|PMID:29955025
Cellular Component	GO:0005634	nucleus	Atm	IDA		Rat	PMID:11751435|RGD:1599367
Cellular Component	GO:0005782	peroxisomal matrix	ATM	IDA		Human	PMID:26344566
Cellular Component	GO:0005819	spindle	Atm	IDA		Mouse	PMID:15509711
Biological Process	GO:0006915	apoptotic process	Atm	IEP		Rat	PMID:10822387|RGD:1599368
Biological Process	GO:0007420	brain development	Atm	IGI	MGI:MGI:104779	Mouse	PMID:16687486
Biological Process	GO:0071480	cellular response to gamma radiation	ATM	IDA		Human	PMID:16213212
Biological Process	GO:0071480	cellular response to gamma radiation	ATM	IDA		Human	PMID:9925639
Biological Process	GO:0071479	cellular response to ionizing radiation	Atm	IMP		Rat	PMID:28007901|RGD:12879399
Biological Process	GO:0071500	cellular response to nitrosative stress	ATM	IDA		Human	PMID:23878245
Biological Process	GO:0034614	cellular response to reactive oxygen species	ATM	IDA		Human	PMID:26344566
Biological Process	GO:0071300	cellular response to retinoic acid	Atm	IMP		Mouse	MGI:MGI:4837978|PMID:20876357
Biological Process	GO:0071481	cellular response to X-ray	ATM	IDA		Human	PMID:26323318
Biological Process	GO:0070192	chromosome organization involved in meiotic cell cycle	Atm	IMP	MGI:MGI:1926343	Mouse	PMID:8843194
Biological Process	GO:0008340	determination of adult lifespan	Atm	IGI	MGI:MGI:894697	Mouse	PMID:19061978
Biological Process	GO:0008340	determination of adult lifespan	Atm	IGI	MGI:MGI:3605986	Mouse	PMID:19061978
Biological Process	GO:0000077	DNA damage checkpoint signaling	ATM	IDA		Human	PMID:30886146
Biological Process	GO:0000077	DNA damage checkpoint signaling	Atm	IMP		Mouse	PMID:12937170
Biological Process	GO:0000077	DNA damage checkpoint signaling	atm	IDA		Zfish	PMID:15235110
Biological Process	GO:0006974	DNA damage response	ATM	IMP		Human	PMID:24550317
Biological Process	GO:0006974	DNA damage response	ATM	IMP		Human	PMID:15790808
Biological Process	GO:0006974	DNA damage response	ATM	IDA		Human	PMID:16213212
Biological Process	GO:0006974	DNA damage response	ATM	IMP		Human	PMID:17875758
Biological Process	GO:0006974	DNA damage response	ATM	IDA		Human	PMID:9733515
Biological Process	GO:0006974	DNA damage response	Atm	IGI	MGI:MGI:894697	Mouse	PMID:19061978
Biological Process	GO:0006974	DNA damage response	Atm	IGI	MGI:MGI:3605986	Mouse	PMID:19061978
Biological Process	GO:0006974	DNA damage response	Atm	IDA		Rat	PMID:12915485|RGD:1599370
Biological Process	GO:0006974	DNA damage response	Atm	IMP		Rat	PMID:19557000|RGD:2316101
Biological Process	GO:0006974	DNA damage response	atm	IMP	ZFIN:ZDB-MRPHLNO-050628-2	Zfish	PMID:15743681
Biological Process	GO:0006281	DNA repair	Atm	IMP	MGI:MGI:1857132	Mouse	PMID:11679583
Biological Process	GO:0006281	DNA repair	Atm	IDA		Mouse	PMID:15364958
Biological Process	GO:0006281	DNA repair	Atm	IMP	MGI:MGI:2155399	Mouse	PMID:15542845
Biological Process	GO:0000724	double-strand break repair via homologous recombination	Atm	IMP	MGI:MGI:1857132	Mouse	PMID:19061978
Biological Process	GO:0097695	establishment of protein-containing complex localization to telomere	ATM	IMP		Human	PMID:26586433
Biological Process	GO:0097694	establishment of RNA localization to telomere	ATM	IMP		Human	PMID:26586433
Biological Process	GO:0007292	female gamete generation	Atm	IMP	MGI:MGI:1857132	Mouse	PMID:15640358
Biological Process	GO:0008585	female gonad development	Atm	IMP	MGI:MGI:1926343	Mouse	PMID:8843194
Biological Process	GO:0007143	female meiotic nuclear division	Atm	IMP	MGI:MGI:1926343	Mouse	PMID:8843194
Biological Process	GO:0007507	heart development	Atm	IGI	MGI:MGI:104779	Mouse	PMID:16687486
Biological Process	GO:0071044	histone mRNA catabolic process	ATM	IDA		Human	PMID:16086026
Biological Process	GO:0002376	immune system process	Atm	IMP	MGI:MGI:1926343	Mouse	PMID:8843194
Biological Process	GO:0002377	immunoglobulin production	Atm	IMP	MGI:MGI:1926343	Mouse	PMID:8843194
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	Atm	IGI	MGI:MGI:109337	Mouse	PMID:17476307
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	Atm	IMP	MGI:MGI:1933746	Mouse	PMID:16777961
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	Atm	IMP	MGI:MGI:1933746	Mouse	PMID:11040211
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	atm	IGI	ZFIN:ZDB-GENO-050428-1,ZFIN:ZDB-MRPHLNO-050628-2,ZFIN:ZDB-MRPHLNO-080804-1	Zfish	PMID:18510930
Biological Process	GO:0042159	lipoprotein catabolic process	Atm	IGI	MGI:MGI:88057	Mouse	PMID:15863839
Biological Process	GO:0007140	male meiotic nuclear division	Atm	IMP	MGI:MGI:1926343	Mouse	PMID:8843194
Biological Process	GO:0045141	meiotic telomere clustering	Atm	IMP	MGI:MGI:1857132	Mouse	PMID:17010969
Biological Process	GO:0007095	mitotic G2 DNA damage checkpoint signaling	ATM	IMP		Human	PMID:15149599
Biological Process	GO:0007094	mitotic spindle assembly checkpoint signaling	ATM	IMP		Human	PMID:11943150
Biological Process	GO:0035264	multicellular organism growth	Atm	IMP	MGI:MGI:1926343	Mouse	PMID:8843194
Biological Process	GO:0030889	negative regulation of B cell proliferation	ATM	IMP		Human	PMID:17875758
Biological Process	GO:1904354	negative regulation of telomere capping	ATM	IMP		Human	PMID:17694070
Biological Process	GO:1904262	negative regulation of TORC1 signaling	ATM	IMP		Human	PMID:23878245
Biological Process	GO:1904262	negative regulation of TORC1 signaling	Atm	IMP		Mouse	MGI:MGI:5509101|PMID:23878245
Biological Process	GO:0051402	neuron apoptotic process	Atm	IGI	MGI:MGI:99702	Mouse	PMID:10639175
Biological Process	GO:0051402	neuron apoptotic process	Atm	IGI	MGI:MGI:1335098	Mouse	PMID:11248063
Biological Process	GO:0048599	oocyte development	Atm	IMP	MGI:MGI:1926875	Mouse	PMID:11536012
Biological Process	GO:0001541	ovarian follicle development	Atm	IMP	MGI:MGI:1926343	Mouse	PMID:8843194
Biological Process	GO:0036289	peptidyl-serine autophosphorylation	ATM	IMP		Human	PMID:24550317
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ATM	IDA		Human	PMID:26323318
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ATM	IDA		Human	PMID:9733515
Biological Process	GO:0000425	pexophagy	ATM	IDA		Human	PMID:26344566
Biological Process	GO:0043065	positive regulation of apoptotic process	ATM	IMP		Human	PMID:17875758
Biological Process	GO:0045785	positive regulation of cell adhesion	Atm	IMP		Mouse	MGI:MGI:4837978|PMID:20876357
Biological Process	GO:0030335	positive regulation of cell migration	ATM	IMP		Human	PMID:28344092
Biological Process	GO:1903626	positive regulation of DNA catabolic process	Atm	IMP		Rat	PMID:27895165|RGD:12879393
Biological Process	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator	ATM	IMP		Human	PMID:9733515
Biological Process	GO:0010628	positive regulation of gene expression	ATM	IMP		Human	PMID:28344092
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	Atm	IGI	MGI:MGI:99702	Mouse	PMID:10639175
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	Atm	IGI	MGI:MGI:1335098	Mouse	PMID:16777961
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	Atm	IMP		Rat	PMID:20502937|RGD:10053605
Biological Process	GO:1901216	positive regulation of neuron death	Atm	IMP		Rat	PMID:19151707|RGD:10053571
Biological Process	GO:1904884	positive regulation of telomerase catalytic core complex assembly	ATM	IMP		Human	PMID:26586433
Biological Process	GO:0032212	positive regulation of telomere maintenance via telomerase	Atm	IMP		Mouse	MGI:MGI:5705431|PMID:26586427
Biological Process	GO:1904358	positive regulation of telomere maintenance via telomere lengthening	ATM	IMP		Human	PMID:17694070
Biological Process	GO:1904358	positive regulation of telomere maintenance via telomere lengthening	ATM	IMP		Human	PMID:26586427
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Atm	IMP		Mouse	MGI:MGI:4837978|PMID:20876357
Biological Process	GO:0009791	post-embryonic development	Atm	IMP	MGI:MGI:1926343	Mouse	PMID:8843194
Biological Process	GO:0002331	pre-B cell allelic exclusion	Atm	IMP		Mouse	MGI:MGI:3848557|PMID:19448632
Biological Process	GO:0046777	protein autophosphorylation	ATM	IDA		Human	PMID:15790808
Biological Process	GO:0046777	protein autophosphorylation	ATM	IMP		Human	PMID:27664052
Biological Process	GO:0046777	protein autophosphorylation	ATM	IDA		Human	PMID:9733515
Biological Process	GO:0006468	protein phosphorylation	ATM	IDA		Human	PMID:15448695
Biological Process	GO:0006468	protein phosphorylation	ATM	IDA		Human	PMID:15916964
Biological Process	GO:0006468	protein phosphorylation	ATM	IMP		Human	PMID:17694070
Biological Process	GO:0006468	protein phosphorylation	ATM	IMP		Human	PMID:29203878
Biological Process	GO:0006468	protein phosphorylation	Atm	IDA		Mouse	PMID:15364958
Biological Process	GO:0010506	regulation of autophagy	ATM	IMP		Human	PMID:23878245
Biological Process	GO:0010506	regulation of autophagy	Atm	IMP		Mouse	MGI:MGI:5509101|PMID:23878245
Biological Process	GO:0051726	regulation of cell cycle	ATM	IMP		Human	PMID:15149599
Biological Process	GO:0051726	regulation of cell cycle	Atm	IMP		Rat	PMID:19657808|RGD:2316106
Biological Process	GO:0010389	regulation of G2/M transition of mitotic cell cycle	atm	IMP	ZFIN:ZDB-GENO-131126-2,ZFIN:ZDB-MRPHLNO-050628-2	Zfish	PMID:22986406
Biological Process	GO:1903978	regulation of microglial cell activation	Atm	IMP		Rat	PMID:28007901|RGD:12879399
Biological Process	GO:0032210	regulation of telomere maintenance via telomerase	ATM	IGI	UniProtKB:Q9NUX5	Human	PMID:26586433
Biological Process	GO:0090399	replicative senescence	ATM	IMP		Human	PMID:15149599
Biological Process	GO:0001666	response to hypoxia	Atm	IDA		Rat	PMID:16651613|RGD:1599365
Biological Process	GO:0010212	response to ionizing radiation	ATM	IDA		Human	PMID:11375976
Biological Process	GO:0010212	response to ionizing radiation	ATM	IDA		Human	PMID:9733515
Biological Process	GO:0010212	response to ionizing radiation	Atm	IGI	MGI:MGI:894697	Mouse	PMID:19061978
Biological Process	GO:0010212	response to ionizing radiation	Atm	IGI	MGI:MGI:99702	Mouse	PMID:10639175
Biological Process	GO:0010212	response to ionizing radiation	Atm	IGI	MGI:MGI:3605986	Mouse	PMID:19061978
Biological Process	GO:0042770	signal transduction in response to DNA damage	ATM	IDA		Human	PMID:26774286
Biological Process	GO:0042770	signal transduction in response to DNA damage	ATM	IMP		Human	PMID:27664052
Biological Process	GO:0001756	somitogenesis	Atm	IGI	MGI:MGI:104779	Mouse	PMID:16687486
Biological Process	GO:0048538	thymus development	Atm	IMP	MGI:MGI:1926343	Mouse	PMID:8843194
Biological Process	GO:0033151	V(D)J recombination	Atm	IGI	MGI:MGI:104779	Mouse	PMID:23836881

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern