Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Alk

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes ALK
- Mouse genes Alk
- Rat genes Alk
- Zfish genes alk,ltk
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Alk

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008201	heparin binding	ALK	IDA		Human	PMID:25605972
Molecular Function	GO:0008201	heparin binding	ALK	IDA		Human	PMID:34646012
Molecular Function	GO:0042802	identical protein binding	ALK	IPI	UniProtKB:Q9UM73	Human	PMID:25517749
Molecular Function	GO:0005515	protein binding	ALK	IPI	UniProtKB:P23471	Human	PMID:17681947
Molecular Function	GO:0005515	protein binding	ALK	IPI	UniProtKB:P08238	Human	PMID:22939624
Molecular Function	GO:0005515	protein binding	ALK	IPI	UniProtKB:Q6UX46	Human	PMID:26418745
Molecular Function	GO:0005515	protein binding	ALK	IPI	UniProtKB:Q6UXT8	Human	PMID:26418745
Molecular Function	GO:0005515	protein binding	ALK	IPI	UniProtKB:P07949	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	Alk	IPI	PR:Q80YV2	Mouse	PMID:12748172
Molecular Function	GO:0004713	protein tyrosine kinase activity	ALK	IDA		Human	PMID:9174053
Molecular Function	GO:0030298	receptor signaling protein tyrosine kinase activator activity	ALK	IDA		Human	PMID:30061385
Molecular Function	GO:0030298	receptor signaling protein tyrosine kinase activator activity	ALK	IDA		Human	PMID:34646012
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	ALK	IDA		Human	PMID:30061385
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	ALK	IDA		Human	PMID:34646012
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	ALK	IDA		Human	PMID:9174053
Cellular Component	GO:0070062	extracellular exosome	ALK	HDA		Human	PMID:19056867
Cellular Component	GO:0005886	plasma membrane	ALK	IDA		Human	PMID:34646012
Cellular Component	GO:0005886	plasma membrane	ALK	IDA		Human	PMID:34819673
Cellular Component	GO:0005886	plasma membrane	ALK	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	ALK	IDA		Human	PMID:9174053
Cellular Component	GO:0032991	protein-containing complex	ALK	IDA		Human	PMID:23382219
Biological Process	GO:0030534	adult behavior	Alk	IMP	MGI:MGI:5700373	Mouse	PMID:17487225
Biological Process	GO:0007420	brain development	Alk	IMP	MGI:MGI:5700373	Mouse	PMID:17487225
Biological Process	GO:0048066	developmental pigmentation	ltk	IMP		Zfish	PMID:18369445\|ZFIN:ZDB-PUB-080331-9
Biological Process	GO:0048066	developmental pigmentation	ltk	IGI	ZFIN:ZDB-GENE-030131-5784	Zfish	PMID:19956727
Biological Process	GO:0048066	developmental pigmentation	ltk	IMP	ZFIN:ZDB-GENO-080812-9	Zfish	PMID:19956727
Biological Process	GO:0048066	developmental pigmentation	ltk	IMP	ZFIN:ZDB-GENO-080812-9	Zfish	PMID:23737760
Biological Process	GO:0097009	energy homeostasis	Alk	IMP		Mouse	MGI:MGI:6442464\|PMID:32442405
Biological Process	GO:0021766	hippocampus development	Alk	IMP	MGI:MGI:5700373	Mouse	PMID:17487225
Biological Process	GO:0050935	iridophore differentiation	ltk	IMP		Zfish	PMID:18369445\|ZFIN:ZDB-PUB-080331-9
Biological Process	GO:0050935	iridophore differentiation	ltk	IMP	ZFIN:ZDB-GENO-120316-52	Zfish	PMID:9007256
Biological Process	GO:0050935	iridophore differentiation	ltk	IMP	ZFIN:ZDB-GENO-120316-47	Zfish	PMID:9007256
Biological Process	GO:0050935	iridophore differentiation	ltk	IMP	ZFIN:ZDB-GENO-190312-2	Zfish	PMID:29078341
Biological Process	GO:0050935	iridophore differentiation	ltk	IMP	ZFIN:ZDB-GENO-120316-48	Zfish	PMID:9007256
Biological Process	GO:0050935	iridophore differentiation	ltk	IMP	ZFIN:ZDB-GENO-080812-9	Zfish	PMID:23737760
Biological Process	GO:0050935	iridophore differentiation	ltk	IMP	ZFIN:ZDB-GENO-080812-10	Zfish	PMID:9007256
Biological Process	GO:0050935	iridophore differentiation	ltk	IMP	ZFIN:ZDB-GENO-120316-51	Zfish	PMID:9007256
Biological Process	GO:0050935	iridophore differentiation	ltk	IMP	ZFIN:ZDB-GENO-080812-11	Zfish	PMID:9007256
Biological Process	GO:0050935	iridophore differentiation	ltk	IMP	ZFIN:ZDB-GENO-120316-46	Zfish	PMID:9007256
Biological Process	GO:0050935	iridophore differentiation	ltk	IMP	ZFIN:ZDB-GENO-120316-50	Zfish	PMID:9007256
Biological Process	GO:0050935	iridophore differentiation	ltk	IMP	ZFIN:ZDB-GENO-120316-49	Zfish	PMID:9007256
Biological Process	GO:0050935	iridophore differentiation	ltk	IMP	ZFIN:ZDB-GENO-120316-54	Zfish	PMID:9007256
Biological Process	GO:0050935	iridophore differentiation	ltk	IMP	ZFIN:ZDB-GENO-080812-9	Zfish	PMID:25535837
Biological Process	GO:0050935	iridophore differentiation	ltk	IMP	ZFIN:ZDB-GENO-080812-12	Zfish	PMID:9007256
Biological Process	GO:0050935	iridophore differentiation	ltk	IMP	ZFIN:ZDB-GENO-120316-53	Zfish	PMID:9007256
Biological Process	GO:0050935	iridophore differentiation	ltk	IMP	ZFIN:ZDB-GENO-080812-9	Zfish	PMID:23821036
Biological Process	GO:0098727	maintenance of cell number	ltk	IMP	ZFIN:ZDB-GENO-160808-2	Zfish	PMID:26801003
Biological Process	GO:0030318	melanocyte differentiation	ltk	IMP	ZFIN:ZDB-GENO-120316-47	Zfish	PMID:24173565
Biological Process	GO:0097324	melanocyte migration	ltk	IMP	ZFIN:ZDB-GENO-120316-47	Zfish	PMID:24173565
Biological Process	GO:0050995	negative regulation of lipid catabolic process	Alk	IMP		Mouse	MGI:MGI:6442464\|PMID:32442405
Biological Process	GO:0007399	nervous system development	Alk	IDA		Rat	PMID:11121404\|RGD:634542
Biological Process	GO:0038083	peptidyl-tyrosine autophosphorylation	ALK	IDA		Human	PMID:30061385
Biological Process	GO:0038083	peptidyl-tyrosine autophosphorylation	ALK	IDA		Human	PMID:34646012
Biological Process	GO:0016310	phosphorylation	ALK	IDA		Human	PMID:9174053
Biological Process	GO:0070285	pigment cell development	ltk	IMP		Zfish	PMID:18369445\|ZFIN:ZDB-PUB-080331-9
Biological Process	GO:0070285	pigment cell development	ltk	IMP	ZFIN:ZDB-GENO-160808-1	Zfish	PMID:26801003
Biological Process	GO:0070285	pigment cell development	ltk	IMP	ZFIN:ZDB-GENO-160808-2	Zfish	PMID:26801003
Biological Process	GO:0043473	pigmentation	ltk	IMP	ZFIN:ZDB-GENO-120316-51	Zfish	PMID:9007256
Biological Process	GO:0043473	pigmentation	ltk	IMP	ZFIN:ZDB-GENO-080812-12	Zfish	PMID:9007256
Biological Process	GO:0043473	pigmentation	ltk	IMP	ZFIN:ZDB-GENO-120316-54	Zfish	PMID:9007256
Biological Process	GO:0043473	pigmentation	ltk	IMP	ZFIN:ZDB-GENO-120316-47	Zfish	PMID:9007256
Biological Process	GO:0043473	pigmentation	ltk	IMP	ZFIN:ZDB-GENO-120316-46	Zfish	PMID:9007256
Biological Process	GO:0043473	pigmentation	ltk	IMP	ZFIN:ZDB-GENO-120316-53	Zfish	PMID:9007256
Biological Process	GO:0043473	pigmentation	ltk	IMP	ZFIN:ZDB-GENO-120316-50	Zfish	PMID:9007256
Biological Process	GO:0043473	pigmentation	ltk	IMP	ZFIN:ZDB-GENO-120316-52	Zfish	PMID:9007256
Biological Process	GO:0043473	pigmentation	ltk	IMP	ZFIN:ZDB-GENO-120316-48	Zfish	PMID:9007256
Biological Process	GO:0043473	pigmentation	ltk	IMP	ZFIN:ZDB-GENO-080812-11	Zfish	PMID:9007256
Biological Process	GO:0043473	pigmentation	ltk	IMP	ZFIN:ZDB-GENO-080812-10	Zfish	PMID:9007256
Biological Process	GO:0043473	pigmentation	ltk	IMP	ZFIN:ZDB-GENO-120316-49	Zfish	PMID:9007256
Biological Process	GO:1900006	positive regulation of dendrite development	Alk	IMP		Mouse	MGI:MGI:6269048\|PMID:30497772
Biological Process	GO:0043410	positive regulation of MAPK cascade	alk	IMP		Zfish	PMID:23667670\|ZFIN:ZDB-PUB-130610-68
Biological Process	GO:0050769	positive regulation of neurogenesis	alk	IMP		Zfish	PMID:23667670\|ZFIN:ZDB-PUB-130610-68
Biological Process	GO:0046777	protein autophosphorylation	ALK	IDA		Human	PMID:9174053
Biological Process	GO:0042127	regulation of cell population proliferation	Alk	IMP	MGI:MGI:5700373	Mouse	PMID:17487225
Biological Process	GO:0048070	regulation of developmental pigmentation	ltk	IMP		Zfish	PMID:18369445\|ZFIN:ZDB-PUB-080331-9
Biological Process	GO:0048070	regulation of developmental pigmentation	ltk	IMP	ZFIN:ZDB-GENO-080812-9	Zfish	PMID:23821036
Biological Process	GO:0060159	regulation of dopamine receptor signaling pathway	Alk	IMP	MGI:MGI:5700373	Mouse	PMID:17487225
Biological Process	GO:0045664	regulation of neuron differentiation	alk	IMP	ZFIN:ZDB-MRPHLNO-130627-1	Zfish	PMID:23667670
Biological Process	GO:0090648	response to environmental enrichment	Alk	IMP	MGI:MGI:5700373	Mouse	PMID:17487225
Biological Process	GO:0006950	response to stress	Alk	IMP	MGI:MGI:5700373	Mouse	PMID:17487225
Biological Process	GO:0036269	swimming behavior	Alk	IMP	MGI:MGI:5700373	Mouse	PMID:17487225
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	ALK	IDA		Human	PMID:25605972
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	ALK	IDA		Human	PMID:30061385
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	ALK	IDA		Human	PMID:34646012

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/07/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.