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Alk Gene Detail
Summary
  • Symbol
    Alk
  • Name
    anaplastic lymphoma kinase
  • Synonyms
    CD246, Tcrz
  • Feature Type
    protein coding gene
  • IDs
    MGI:103305
    NCBI Gene: 11682
  • Gene Overview
    MyGene.info: ALK
Location & Maps
more
  • Sequence Map
    Chr17:71869442-72603709 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      734268 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 43.77 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    ALK, anaplastic lymphoma receptor tyrosine kinase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ALK, anaplastic lymphoma receptor tyrosine kinase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CD246, NBLST3
  • Links
    NCBI Gene ID: 238
    neXtProt AC: NX_Q9UM73

  • Chr Location
    2p23; chr2:29192774-29921611 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 68387
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: ALK
  • Gene Tree
    Alk
Human Diseases
more
  • Diseases
    1 with human ALK associations

Human Disease Mouse Models
       Neuroblastoma, Susceptibility to, 3; NBLST3   OMIM: 613014 View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    5 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    42 phenotypes from 4 alleles in 4 genetic backgrounds
    8 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show increased ethanol consumption and increased sedation in response to ethanol. Male mice homozygous for a different null allele show delayed puberty, hypogonadotropic hypogonadism, reduced serum testosterone levels, and altered seminiferous tubule morphology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000055471 Ensembl Gene Model | MGI Sequence Detail 734268 C57BL/6J ±  kb
transcript ENSMUST00000086639 Ensembl | MGI Sequence Detail 4866 Not Applicable  
polypeptide ENSMUSP00000083840 Ensembl | MGI Sequence Detail 1621 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    8344 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000001282 ALK tyrosine kinase receptor
  • EC
  • InterPro Domains
    IPR026830 ALK tyrosine kinase receptor
    IPR013320 Concanavalin A-like lectin/glucanase domain
    IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
    IPR000998 MAM domain
    IPR017441 Protein kinase, ATP binding site
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
    IPR008266 Tyrosine-protein kinase, active site
    IPR020635 Tyrosine-protein kinase, catalytic domain
    IPR002011 Tyrosine-protein kinase, receptor class II, conserved site
Molecular
Reagents
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  • All nucleic 22
    Genomic 2
    cDNA 19
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-24189
References
more
  • Summaries
    All 48
    Developmental Gene Expression 9
    Diseases 6
    Gene Ontology 9
    Phenotypes 23
  • Earliest
    J:38791 Fujita N, et al., Developmentally regulated alternative splicing of brain myelin-associated glycoprotein mRNA is lacking in the quaking mouse. FEBS Lett. 1988 May 23;232(2):323-7
  • Latest
    J:226955 Witek B, et al., Targeted Disruption of ALK Reveals a Potential Role in Hypogonadotropic Hypogonadism. PLoS One. 2015;10(5):e0123542

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory