Alk
Gene Detail

Symbol Name ID

Alk anaplastic lymphoma kinase MGI:103305

Synonyms

CD246, Tcrz

Feature Type

protein coding gene

Genetic Map

Chromosome 17

43.77 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr17:71869442-72603709 bp, - strand From Ensembl annotation of GRCm38   734268 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68387  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Alk

Human homologs

Human Homolog		ALK, anaplastic lymphoma receptor tyrosine kinase
NCBI Gene ID		238
neXtProt AC		NX_Q9UM73
Human Synonyms		CD246, NBLST3
Human Chr (Location)		2p23; chr2:29415640-30144477 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ALK

Alleles and phenotypes

All alleles(3) : Targeted(3)

Gene Ontology (GO) classifications

All GO classifications: (26 annotations)

Process	activation of MAPK activity, nervous system development, ...
Component	integral to membrane, integral to plasma membrane, ...
Function	ATP binding, kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (496)    Tissues (348)    Images (87)
Theiler Stages: 17, 19, 20, 21, 22, 23, 24, 28

Assay Type	Results
Immunohistochemistry	280
RNA in situ	216

cDNA source data(19)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(21) Genomic(2) cDNA(19)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000055471 (Evidence)
Entrez Gene	11682 (Evidence)
UniGene	311854
DFCI	TC1590974, TC1593456
DoTS	DT.101336943, DT.40185336, DT.91358855
NIA Mouse Gene Index	U038044
EC	2.7.10.1
Consensus CDS Project	CCDS37688.1
International Mouse Knockout Project Status	Alk

Sequences

Length	Strain/Species
genomic	ENSMUSG00000055471	Ensembl Gene Model | MGI Sequence Detail	734268	C57BL/6J
transcript	ENSMUST00000086639	Ensembl | MGI Sequence Detail	4866	Not Applicable
polypeptide	ENSMUSP00000083840	Ensembl | MGI Sequence Detail	1621	Not Applicable

All sequences(21) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(1) : SNPs(5354 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR026830	ALK tyrosine kinase receptor
InterPro	IPR008985	Concanavalin A-like lectin/glucanases superfamily
InterPro	IPR002172	Low-density lipoprotein (LDL) receptor class A repeat
InterPro	IPR000998	MAM domain
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro	IPR008266	Tyrosine-protein kinase, active site
InterPro	IPR020635	Tyrosine-protein kinase, catalytic domain
InterPro	IPR002011	Tyrosine-protein kinase, receptor class II, conserved site
Protein Ontology	PR:000001282	ALK receptor tyrosine kinase

References

(Earliest) J:38791 Fujita N, et al., Developmentally regulated alternative splicing of brain myelin-associated glycoprotein mRNA is lacking in the quaking mouse. FEBS Lett. 1988 May 23;232(2):323-7
(Latest) J:189960 Madakashira BP, et al., Frs2alpha enhances fibroblast growth factor-mediated survival and differentiation in lens development. Development. 2012 Dec;139(24):4601-12
All references(41)

Other accession IDs

MGD-MRK-24189