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Alk
Gene Detail
Symbol

Name
ID
Alk
anaplastic lymphoma kinase
MGI:103305
Synonyms
CD246, Tcrz
Feature Type
protein coding gene
Genetic Map
Chromosome 17
43.77 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr17:71869442-72603709 bp, - strand
From Ensembl annotation of GRCm38

  734268 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68387  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ALK
Gene Tree: Alk

Human
homologs
ALK, anaplastic lymphoma receptor tyrosine kinase
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 238
neXtProt AC: NX_Q9UM73

Human Synonyms: CD246, NBLST3

Human Chr (Location): 2p23; chr2:29192774-29921611 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ALK

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(3) Transgenic(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Mutations Annotated to Human Diseases (2)   
Interactions
Alk interacts with 9 markers (Mir26b, Mir96, Mir133a-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process activation of MAPK activity, nervous system development, ...
Component axon, cell body, ...
Function ATP binding, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (496)    Tissues (348)    Images (87)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 280
RNA in situ 216
cDNA source data(19)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA ALK ; Xenbase alk    NEW 
Molecular
reagents
All nucleic(21) Genomic(2) cDNA(19)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000055471 (Evidence)
Entrez Gene 11682 (Evidence)
UniGene 311854
DFCI TC1590974, TC1593456
DoTS DT.101336943, DT.40185336, DT.91358855
NIA Mouse Gene Index U038044
EC 2.7.10.1
Consensus CDS Project CCDS37688.1
International Mouse Phenotyping Consortium Status Alk
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000055471 Ensembl Gene Model | MGI Sequence Detail 734268 C57BL/6J ±  kb
transcript ENSMUST00000086639 Ensembl | MGI Sequence Detail 4866 Not Applicable 
polypeptide ENSMUSP00000083840 Ensembl | MGI Sequence Detail 1621 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(5) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(8419 from dbSNP Build 137)    SNPs within 2kb including multiple locations(8421)
Protein-related
information
ResourceIDDescription
InterPro IPR026830 ALK tyrosine kinase receptor
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
InterPro IPR000998 MAM domain
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR002011 Tyrosine-protein kinase, receptor class II, conserved site
Protein Ontology PR:000001282 ALK tyrosine kinase receptor
References
(Earliest) J:38791 Fujita N, et al., Developmentally regulated alternative splicing of brain myelin-associated glycoprotein mRNA is lacking in the quaking mouse. FEBS Lett. 1988 May 23;232(2):323-7
(Latest) J:216687 Martinengo C, et al., ALK-dependent control of hypoxia-inducible factors mediates tumor growth and metastasis. Cancer Res. 2014 Nov 1;74(21):6094-106
All references(43)
Other
accession IDs
MGD-MRK-24189

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory