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Alk
Gene Detail
 Symbol
Name
ID
Alk
anaplastic lymphoma kinase
MGI:103305
Synonyms CD246, Tcrz
Feature Type protein coding gene
Genetic Map
Chromosome 17
43.77 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr17:71869442-72603709 bp, - strand
From Ensembl annotation of GRCm38

  734268 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68387  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Alk

Human
homologs
Human Homolog ALK, anaplastic lymphoma receptor tyrosine kinase
NCBI Gene ID 238
neXtProt AC  NX_Q9UM73
Human Synonyms  CD246, NBLST3
Human Chr (Location)  2p23; chr2:29192774-29921611 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human ALK
Alleles
and
phenotypes
All alleles(3) : Targeted(3)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process activation of MAPK activity, nervous system development, ...
Component axon, cell body, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (496)    Tissues (348)    Images (87)
Theiler Stages: 17, 19, 20, 21, 22, 23, 24, 28
Assay TypeResults
Immunohistochemistry 280
RNA in situ 216
cDNA source data(19)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(21) Genomic(2) cDNA(19)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000055471 (Evidence)
Entrez Gene11682 (Evidence)
UniGene311854
DFCITC1590974, TC1593456
DoTSDT.101336943, DT.40185336, DT.91358855
NIA Mouse Gene IndexU038044
EC2.7.10.1
Consensus CDS ProjectCCDS37688.1
International Mouse Knockout Project StatusAlk
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000055471 Ensembl Gene Model | MGI Sequence Detail 734268 C57BL/6J ±  kb
transcript ENSMUST00000086639 Ensembl | MGI Sequence Detail 4866 Not Applicable 
polypeptide ENSMUSP00000083840 Ensembl | MGI Sequence Detail 1621 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(5) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(8419 from dbSNP Build 137)    SNPs within 2kb including multiple locations(8421)
Protein-related
information
ResourceIDDescription
InterPro IPR026830 ALK tyrosine kinase receptor
InterPro IPR008985 Concanavalin A-like lectin/glucanases superfamily
InterPro IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
InterPro IPR000998 MAM domain
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR002011 Tyrosine-protein kinase, receptor class II, conserved site
Protein Ontology PR:000001282 ALK receptor tyrosine kinase
References (Earliest) J:38791 Fujita N, et al., Developmentally regulated alternative splicing of brain myelin-associated glycoprotein mRNA is lacking in the quaking mouse. FEBS Lett. 1988 May 23;232(2):323-7
(Latest) J:194542 Ghai R, et al., Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):E643-52
All references(43)
Other
accession IDs
MGD-MRK-24189

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory